Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05345015Recruiting
Radio waves for muscle or low back pain and function
This trial tests whether a high-frequency radio-wave treatment can reduce pain and improve movement in adults with a muscle strain (hamstring) or acute or chronic low back pain. It may help you feel less pain and function better, depending on your specific injury and medical details.
KavalaAges 18–65 - NCT05351099Recruiting
Nerve-block shot for emergency dental pain relief
This study tests whether a dental nerve-block shot can safely help reduce pain for adults who come to the emergency department with tooth pain. If the ED clinician plans to use the block, you may be asked to rate your pain during the visit.
Fresno, CaliforniaAges 18 years+ - NCT05351801RecruitingPhase 2
Test cannabis-based treatment for nerve pain
This Phase 2 study tests cannabis-derived products to see if they reduce neuropathic (nerve-related) pain in veterans. It may help people whose pain is persistent and causes significant daily impact, especially if certain exam tests show allodynia (pain from normally non-painful touch).
San Diego, CaliforniaAges 21 years+ - NCT05382845Recruiting
Screening for pelvic pain in early pregnancy
This study looks to identify pregnancy-related pelvic girdle pain in pregnant people early in pregnancy (before 20 weeks). It may help doctors spot who is likely to develop pelvic pain and guide earlier support.
Karlskrona, Blekinge CountyAges Any age - NCT05382962Recruiting
Using an app to help teens cope with post-surgery pain
This trial tests whether a phone app (iCanCope) can help teens better manage pain after surgery for scoliosis or certain chest conditions (pectus carinatum/excavatum). If you’re having one of these surgeries soon, the app may help with coping and day-to-day comfort after the operation.
Boston, MassachusettsAges 12–18 - NCT05404581Recruiting
Insula brain stimulation for long-term nerve pain
This trial tests whether stimulating a specific brain area (the insula) can reduce chronic nerve pain. It is for people whose pain has lasted at least 6 months and has not improved enough with several pain medicines and other procedures.
Charlottesville, VirginiaAges 18–80 - NCT05407610Recruiting
Compare two types of nerve pain treatments for knee pain
This study compares conventional versus cooled radiofrequency treatments for long-lasting knee pain. It aims to see which method reduces pain better and helps patients function more comfortably.
AntwerpAges 18 years+ - NCT05417737Recruiting
Ozone therapy for chronic pain when standard treatments fail
This study offers a palliative (comfort-focused) ozone treatment to adults with chronic pain when usual treatments don’t work or are too risky. Researchers will check whether adding ozone can help symptoms and whether it’s safe for selected patients.
Las Palmas, Las PalmasAges 18 years+ - NCT05421273Recruiting
Testing two spinal stimulation patterns for long-term back pain
This study compares two ways of delivering spinal cord stimulation to see which better reduces pain in people with persistent spinal pain syndrome type 2. You would be assigned to one of the stimulation “burst” patterns and followed for changes in your pain experience.
Arnhem, GelderlandAges 18–70 - NCT05458037Recruiting
Testing fast versus slow numbing during IUD or biopsy
This study compares two ways of applying a numbing tool (“tenaculum”) during an IUD insertion or an endometrial biopsy to see which one causes less pain. If you’re scheduled for one of these procedures, it may help improve how discomfort is managed.
Providence, Rhode IslandAges 18 years+ - NCT05492188Recruiting
Testing training and skin reflex changes for nerve pain after SCI
This study looks at how a training program affects skin reflexes and nerve pain in people with spinal cord injury (SCI). It may help researchers find better ways to manage nerve pain by changing how the body responds to touch and training.
Charleston, South CarolinaAges 18 years+ - NCT05494502Recruiting
Nerve block to reduce long-term pain after breast surgery
This trial tests whether a specific pain-numbing nerve block given during mastectomy can reduce chronic (long-lasting) pain after breast cancer surgery. It may help some people use less pain medicine later by lowering nerve-related pain after surgery.
Beijing, Beijing MunicipalityAges 18–85 - NCT05505188Recruiting
Predicting long-term pain after head and neck radiotherapy
This study looks for ways to predict and improve pain you may have months after radiotherapy for first head and neck cancer. It may help doctors better anticipate pain and support patients during recovery.
CaenAges 18 years+ - NCT05540548Recruiting
Podiatry assessment for balance and pain in chronic back pain
This study looks at whether a foot and posture specialist can help measure how balance relates to the pain you feel in chronic low back pain. It may help doctors better understand what to focus on for pain that lasts for months.
ValenciennesAges 18 years+ - NCT05612750Recruiting
Online therapy for chronic pain: CBT vs one-session relief
This study compares two online treatments for chronic pain: an 8-session cognitive behavioral therapy (CBT) program versus a single “empowered relief” session. It aims to see which approach helps people manage pain better over time.
Phoenix, ArizonaAges 18 years+ - NCT05618002Recruiting
Study compares sleep medicines for chronic pain insomnia
This trial tests different treatments to help people with long-term (chronic) pain and severe insomnia sleep better. It’s looking at three options—one medicine (lemborexant) compared with existing sleep medicines (zopiclone and clonidine)—and whether they improve sleep when non-medicine sleep strategies haven’t worked.
Surrey, British ColumbiaAges 20–99 - NCT05654012Recruiting
Study of migraine risk in teens and kids
This study looks at how migraine may start or affect children by comparing young people who either have migraine symptoms or are at higher risk. It may help researchers understand migraine patterns and who could benefit from early prevention.
St Louis, MissouriAges 10–13 - NCT05677412Recruiting
Studying sleep, stress, and pain in teens with ongoing pain
This study looks at how sleep and stress relate to pain that keeps coming back in teens. It may help researchers understand what could improve comfort and daily functioning when pain lasts more than three months.
HelsinkiAges 15–17 - NCT05689944Recruiting
Dance therapy for teens with chronic pain
This trial studies whether dance therapy can help reduce chronic pain in teens when usual pain treatments haven’t worked well. It may be helpful if you’re followed in a pain clinic and are able to participate in movement-based sessions.
BronAges 12–20 - NCT05700279Recruiting
PTSD treatment to help prevent future chronic pain
This study tests whether treating post-traumatic stress disorder (PTSD) right when you come to the emergency room for new, acute pain can lower the chance you develop long-term (chronic) pain. It may help people whose pain and trauma symptoms start around the same time.
Chicago, IllinoisAges 18–70 - NCT05716321Recruiting
Study of pain and function after limb amputation surgery
This study looks at pain and day-to-day functioning after someone has a limb removed due to surgery. The results may help doctors better understand what to expect and how to improve comfort and mobility after amputation.
Hershey, PennsylvaniaAges 18–89 - NCT05721027RecruitingPhase 4
Ibuprofen alone or with a steroid for new sciatica pain
This trial compares ibuprofen alone versus ibuprofen plus dexamethasone (a steroid) for short-term relief of acute nerve-related low back pain that shoots into the buttock or leg. It aims to see which approach reduces pain and improves function after an emergency visit.
The Bronx, New YorkAges 18–70 - NCT05726331Recruiting
Tai chi and chiropractic for long-term neck pain
This trial looks at whether a program of tai chi and chiropractic care can improve chronic, non-specific neck pain and daily function. It may help people who have had neck pain for months and want a structured exercise-and-care approach.
Chestnut Hill, MassachusettsAges 18–65 - NCT05761392Recruiting
App-guided care plan for long-lasting hard-to-treat pain
This trial tests an app-based system to help manage chronic pain using precise treatment planning, including an implanted pain device. It may help by improving follow-up, adjusting care over time, and aiming to reduce pain when usual treatments didn’t work.
BeijingAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.