Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03987334Recruiting
Virtual reality rehab for chronic neck pain
This trial studies whether virtual reality exercises can help reduce pain and improve function in people with chronic neck pain or whiplash. You may be invited to take part in guided VR rehab sessions if you meet the safety and health requirements.
Milan, MIAges 18–70 - NCT03829631Recruiting
Test of a back brace for non-dangerous low back pain in ER
This trial studies whether using a lumbar brace in the emergency department helps people with non-serious low back pain recover better. You may be asked to try the brace when you come to the ER for back pain that is not caused by a dangerous underlying condition.
PerthAges 18–65 - NCT03675386Recruiting
Help reducing opioid use after surgery for chronic pain
This trial tests a program to help people with long-term (chronic) pain use less opioid medicine after surgery. It may help you reduce opioid doses while still managing your pain.
Toronto, OntarioAges 18 years+ - NCT03258580Recruiting
Studying how culture and mind affect how we feel pain
This study looks at how beliefs, mood, and social factors affect how people express and judge pain. It mainly uses pain/heat testing and—if chosen—brain scans to understand why pain reports can differ between people.
Bethesda, MarylandAges 18–60 - NCT03270631Enrolling by invitation
Exercises and soft-tissue work for chronic low back pain
This study tests whether a combination of guided movement exercises and “fascial manipulation” (hands-on work on soft tissue) can help people with long-lasting low back pain. It may be an option if your back pain has not improved with non-surgery treatments or if you have post-surgery back pain.
OuluAges Any age - NCT02707029Recruiting
Study of how people report pain and painful conditions
This study looks at how accurately people can describe their pain and related symptoms. It may help researchers improve how pain is measured in future studies.
Bethesda, MarylandAges 12–120 - NCT02890485Recruiting
Dry needling for knee pain with stair or squat pain
This study tests whether dry needling can reduce ongoing knee pain in people who feel pain around the kneecap when going up or down stairs, squatting, or running. You may be able to join if your knee pain has lasted at least 3 months and you’re referred to physical therapy.
Columbus, OhioAges 18–40 - NCT02446262Recruiting
Study of how the brain and mind shape pain in healthy adults
This study tests how people sense heat and pain, and how the brain and emotions may influence that experience. It is designed for healthy adults and may involve training sessions and (for some parts) MRI scanning.
Bethesda, MarylandAges 18–50 - NCT02083835Recruiting
Study to improve pain after surgery using patient questionnaires
This trial studies how to better understand and improve pain after surgery by asking patients to complete short questionnaires. It may help hospitals find ways to reduce postoperative pain and better track recovery.
JenaAges 4 years+ - NCT00499317Recruiting
Genetic study of chronic pelvic pain and bladder symptoms
This study looks for genetic (inherited) factors behind chronic pelvic pain and related urinary and sexual symptoms. You may be able to help researchers by providing a few samples and answering short questions, which could improve understanding of these conditions.
Boston, MassachusettsAges Any age - NCT07879313Recruiting
Smartphone use and neck pain study for university students
This study looks at how heavy smartphone use might be linked to ongoing neck pain in university students. If you have neck pain that has lasted at least three months, you may be able to help researchers understand this connection.
CairoAges 18–25 - NCT07857733RecruitingPhase 3
Extended treatment study for complex regional pain syndrome
This study gives an extended course of neridronate infusions to people who completed the earlier AMBTX-01-301 trial, to see if longer treatment safely keeps easing their chronic pain and other symptoms of complex regional pain syndrome (a long-lasting pain condition, often after an injury).
Phoenix, ArizonaAges 18 years+ - NCT07777172Recruiting
Pain relief injections for gallbladder surgery
This trial tests two types of numbing injections (nerve blocks) around the ribs and abdomen to see if they reduce pain after laparoscopic gallbladder removal surgery. It may help you have better pain control and a smoother recovery.
Ankara, Yenimahalle\AnkaraAges 18–75 - NCT07403331Recruiting
Nerve pain in legs: spinal cord stimulation plus team care
This trial tests a treatment bundle that combines a spinal cord stimulator (a device that sends mild electrical pulses to your spine to block pain signals) with a team of specialists (like a psychologist and physical therapist) to reduce chronic nerve pain in the legs and improve your ability to move and function.
OsloAges 18–60 - NCT07875738Recruiting
Jaw pain relief with oral splint therapy
This study looks at whether a special mouth guard (called a gnathological splint) can help reduce jaw pain and teeth grinding. It aims to see if this treatment is effective for people with jaw joint problems.
RomaAges 18–79 - NCT07876960Recruiting
Virtual reality games versus spinal adjustment for chronic back pain
This study compares two treatments for chronic low back pain: playing interactive virtual reality games and receiving spinal manipulation (a hands-on adjustment by a therapist). It aims to see which approach helps reduce pain and improve daily function.
Giza, Giza GovernorateAges 20–55 - NCT05780450Recruiting
Brain stimulation for long covid headaches and pain
This trial tests a safe, non-invasive brain stimulation technique (transcranial direct current stimulation, or tDCS) to see if it can reduce persistent headaches and chronic pain in people with long covid. If you have ongoing pain after a confirmed covid infection, this could offer a new way to find relief.
Paiporta, ValenciaAges 16 years+ - NCT07846878Recruiting
Predicting pain after orthopedic surgery
This study tests a tool that doctors can use before surgery to predict whether you might have longer-lasting pain after bone or joint surgery. Knowing this in advance could help your care team plan better pain relief for you.
ChongqingAges 18–90 - NCT06685107Recruiting
Virtual reality for pain relief in older ER patients
This trial tests if using virtual reality along with standard pain medication helps reduce pain better than medication alone for older adults with muscle or joint pain in the emergency room.
Brooklyn, New YorkAges 65–120 - NCT06010251Recruiting
Body awareness therapy for spinal cord injury pain
This trial tests a multisensory approach to help people with spinal cord injury better perceive their body and reduce long-term nerve pain. It combines body awareness exercises with sensory feedback to see if it can ease pain and improve quality of life.
Miami, FloridaAges 18–70 - NCT04102566RecruitingPhase 4
Better pain control during TURP surgery
This trial tests whether a pain-control approach can make TURP (prostate surgery through the urine tube) more comfortable. It may help you manage pain with the study medicines during and after your procedure.
Seattle, WashingtonAges 18 years+ - NCT05172739RecruitingPhase 4
Opioid-free anesthesia during lung surgery for early lung cancer
This study tests whether an opioid-free pain/anesthesia plan during elective lung surgery can reduce surgical “stress” on the body and affect the immune system. You may be eligible if you have early-stage non-small cell lung cancer and are scheduled for a specific type of surgery (VATS lobectomy).
Heraklion, CreteAges 18–80 - NCT04791891Recruiting
Study collecting information about low back pain
This study asks adults with low back pain to complete an online questionnaire so researchers can better understand how low back pain affects daily life. Your answers may help build a larger “core dataset” for future research.
Montreal, QuebecAges 18 years+ - NCT05069363Recruiting
Light therapy for widespread chronic pain
This trial tests whether using a whole-body light treatment (photobiomodulation) can reduce widespread chronic pain. It may help if you have long-lasting, widespread pain and can safely use the device for about 6 weeks.
BirminghamAges 18–100
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.