Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06443164Enrolling by invitation
Chronic Pain Treatment Before Gender-Affirming Surgery
This study tests a one-session pain management class called Empowered Relief for people with chronic pain who are planning gender-affirming surgery. The goal is to see if learning these skills before surgery helps with pain afterward.
Portland, OregonAges 18–100 - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80 - NCT06350981Enrolling by invitationPhase 2/Phase 3
Pain control after lower back fusion surgery
This study is comparing different ways to manage pain after a specific type of lower back fusion surgery called TLIF. The goal is to find the best pain control plan to make recovery more comfortable.
Tampa, FloridaAges 18 years+ - NCT06133933Enrolling by invitation
Shoulder replacement and pain medication study
This study looks at how your pain tolerance before a total shoulder replacement might relate to how much pain medication you need after surgery. The goal is to help doctors better manage pain medication after surgery.
Camden, New JerseyAges 18 years+ - NCT06068907Enrolling by invitation
Elbow Pain: Sensitivity to Pressure
This study is looking at how people with long-lasting elbow pain (at least 3 months) feel pressure. It aims to understand pain better for future treatments.
Istanbul, BakırkoyAges 18–65 - NCT06019793Enrolling by invitation
Recording brain signals during deep brain stimulation for pain
This study tests whether recording brain activity during deep brain stimulation (DBS) for chronic pain can help improve future treatments. It is for people with long-lasting, severe pain that hasn't been helped by other treatments.
Phoenix, ArizonaAges 22 years+ - NCT05961501Enrolling by invitationPhase 2/Phase 3
CBD and CBN for long-lasting facial pain and muscle headaches
This trial tests whether CBD and CBN can reduce facial pain and headaches caused by muscle-related problems that have lasted more than 3 months. It may help people who have ongoing symptoms find a new treatment option.
WroclawAges 18 years+ - NCT05794373Enrolling by invitation
Training physiotherapists for disabling low back pain
This observational study looks at how well municipality-based physiotherapists manage disabling low back pain after specific training. It focuses on people with significant low back pain symptoms to see what care works best in real-world settings.
MiddelfartAges 18–65 - NCT05474274Enrolling by invitation
Home pain app that teaches treatment after outpatient plastic surgery
This trial tests a home-based “pain coaching” system (using a phone app and a TENS device) to help people manage pain after lower-risk outpatient plastic surgery. It may help you feel more in control of pain at home using guided exercises and device-based pain relief.
Jacksonville, FloridaAges 18 years+ - NCT05212571Enrolling by invitation
IV esketamine to improve long-term pain in CRPS
This study looks at whether giving esketamine through a vein can help reduce long-term pain in people with complex regional pain syndrome (CRPS). You may be able to join if your CRPS diagnosis matches specific international criteria and you can safely take the study medicine.
Rotterdam, South HollandAges 18 years+ - NCT07777627Recruiting
Comparing two spinal pain relievers after lumbar spine surgery
This trial compares two different medications (morphine and dexmedetomidine) given through a spinal injection to see which provides better pain relief after lumbar spine surgery. If you qualify, you will receive one of these treatments or a placebo to help manage your pain after the operation.
Tanta, El-GharbiaAges 21–60 - NCT07776275Recruiting
Headache study comparing neck pain patients with healthy people
This study looks at physical differences between people with cervicogenic headache (a headache that starts in the neck), people with chronic neck pain without headache, and healthy controls. By comparing these groups, researchers hope to better understand what causes the headache and which physical features are specific to it.
Istanbul, SefaköyAges 25–60 - NCT07767747Enrolling by invitation
Neck and shoulder pain relief: comparing two hands-on therapies
This study compares two gentle, hands-on treatments (Emmett and Bowen techniques) to see which works better for long-lasting neck and shoulder pain caused by muscle knots (trigger points). It may help you find a non-invasive way to ease pain and improve movement.
Sialkot, Punjab ProvinceAges 18–45 - NCT04824248Recruiting
Weight-loss program for chronic low back pain
This trial studies whether weight loss can improve long-lasting, non-specific low back pain. It may help people whose back pain is partly related to extra weight by testing a structured approach over time.
BrusselsAges 18–65 - NCT05285007Recruiting
Study tests whether limited ankle motion affects knee squats
This study looks at people with patellofemoral pain (kneecap pain) to see how limited ankle movement may affect how your knee works during single-leg squats. It may help clinicians better understand what to focus on for treatment.
Loma Linda, CaliforniaAges 18–59 - NCT05081596Recruiting
Primary care program for mood and thinking in early Alzheimer’s
This trial tests a psychosocial (talk/behavior/support) program delivered through primary care to improve thinking and depression symptoms in older adults with mild cognitive problems and early Alzheimer’s. It may help if you have early memory/thinking changes plus mild depressive symptoms and you can work with a caregiver or study partner.
White Plains, New YorkAges 60 years+ - NCT06619418Recruiting
Home Device Using Sound and Body Stimulation for Back Pain
This study is testing a take-home device that uses sound and gentle body stimulation to help with long-term back pain. It is for adults with chronic low back pain who live near the University of Minnesota and are not taking certain sleep or anxiety medications.
Minneapolis, MinnesotaAges 18 years+ - NCT07771205Recruiting
Aromatherapy for surgical anxiety and pain
This study tests whether breathing in relaxing scents before surgery can reduce anxiety and pain. If effective, it could offer a simple, drug-free way to help you feel calmer during your procedure.
Stockton, CaliforniaAges 18 years+ - NCT07772141Recruiting
Palmitoylethanolamide for chronic low back pain
This trial tests whether a natural substance called palmitoylethanolamide (PEA) can help reduce chronic low back pain by calming the nervous system and reducing inflammation. It might be an option for people with ongoing pain from a disc problem who haven't had surgery.
Banī SuwayfAges 18–65 - NCT05868668Recruiting
Low-intensity shockwave versus wave therapy for erectile and pelvic pain
This trial compares two types of low-intensity wave therapy to see which works better for erectile dysfunction and/or chronic pelvic pain. Participants may benefit if these therapies improve erection quality and reduce pelvic pain.
Cleveland, OhioAges 40 years+ - NCT06140355Recruiting
Qigong for pain in spinal cord injury
This study tests whether a remote Qigong program can help reduce pain intensity in people with spinal cord injury and health disparities. You would practice gentle movements and breathing exercises from home using a computer or smartphone.
Miami, FloridaAges 18 years+ - NCT07341854Recruiting
Dexamethasone shot for pain after surgery
This study tests a special form of dexamethasone (a steroid) given as a shot before surgery to help control pain after the operation. It may reduce the need for other pain medicines and make recovery more comfortable.
Beijing, ChinaAges 18–65 - NCT06771856Recruiting
Stepped care for insomnia in chronic spinal pain
This trial tests a step-by-step approach to cognitive behavioral therapy for insomnia in people who also have chronic neck or back pain. It aims to see if treating sleep problems can help reduce pain and improve quality of life.
BrusselsAges 18–65 - NCT05277025Recruiting
Brain pain testing in long-term joint pain and fibromyalgia
This study looks at how the brain processes pain in people with long-term pain conditions like fibromyalgia and rheumatoid arthritis. You may be asked to undergo pain-related tasks to help researchers understand differences between inflammatory and non-inflammatory chronic pain.
Gainesville, FloridaAges 18–70
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.