Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05689944Recruiting
Dance therapy for teens with chronic pain
This trial studies whether dance therapy can help reduce chronic pain in teens when usual pain treatments haven’t worked well. It may be helpful if you’re followed in a pain clinic and are able to participate in movement-based sessions.
BronAges 12–20 - NCT05676827Enrolling by invitation
Study pain and stress in people with long-term jaw muscle pain
This trial looks at how long-lasting jaw (masticatory) muscle pain relates to the nervous system and emotional stress. It may help researchers understand why symptoms persist and guide future treatments.
WroclawAges 18–80 - NCT05654012Recruiting
Study of migraine risk in teens and kids
This study looks at how migraine may start or affect children by comparing young people who either have migraine symptoms or are at higher risk. It may help researchers understand migraine patterns and who could benefit from early prevention.
St Louis, MissouriAges 10–13 - NCT05612750Recruiting
Online therapy for chronic pain: CBT vs one-session relief
This study compares two online treatments for chronic pain: an 8-session cognitive behavioral therapy (CBT) program versus a single “empowered relief” session. It aims to see which approach helps people manage pain better over time.
Phoenix, ArizonaAges 18 years+ - NCT05563038Recruiting
Scrambler therapy for pain after stroke
This trial studies whether “scrambler therapy” can reduce ongoing pain in the body areas affected by a past stroke. It may help people who are at least a month past stroke and still have stroke-related pain.
Baltimore, MarylandAges 18 years+ - NCT05474274Enrolling by invitation
Home pain app that teaches treatment after outpatient plastic surgery
This trial tests a home-based “pain coaching” system (using a phone app and a TENS device) to help people manage pain after lower-risk outpatient plastic surgery. It may help you feel more in control of pain at home using guided exercises and device-based pain relief.
Jacksonville, FloridaAges 18 years+ - NCT05404581Recruiting
Insula brain stimulation for long-term nerve pain
This trial tests whether stimulating a specific brain area (the insula) can reduce chronic nerve pain. It is for people whose pain has lasted at least 6 months and has not improved enough with several pain medicines and other procedures.
Charlottesville, VirginiaAges 18–80 - NCT05351801RecruitingPhase 2
Test cannabis-based treatment for nerve pain
This Phase 2 study tests cannabis-derived products to see if they reduce neuropathic (nerve-related) pain in veterans. It may help people whose pain is persistent and causes significant daily impact, especially if certain exam tests show allodynia (pain from normally non-painful touch).
San Diego, CaliforniaAges 21 years+ - NCT04439552Recruiting
MRI study during cornea cross-linking for keratoconus
This trial uses an MRI scan (and a close-up eye scan) to study what happens in the cornea during treatment for keratoconus. It may help doctors better understand how treatment works and who benefits most.
Boston, MassachusettsAges 8–35 - NCT05345015Recruiting
Radio waves for muscle or low back pain and function
This trial tests whether a high-frequency radio-wave treatment can reduce pain and improve movement in adults with a muscle strain (hamstring) or acute or chronic low back pain. It may help you feel less pain and function better, depending on your specific injury and medical details.
KavalaAges 18–65 - NCT05204472Recruiting
Deep brain stimulation for ongoing nerve pain after stroke or facial nerve issues
This trial studies whether a special brain device (deep brain stimulation, or DBS) can reduce long-lasting nerve pain. It focuses on one-sided pain after certain brain injuries or specific facial nerve pain causes, especially when medicines haven’t helped enough.
BernAges 18–75 - NCT05212571Enrolling by invitation
IV esketamine to improve long-term pain in CRPS
This study looks at whether giving esketamine through a vein can help reduce long-term pain in people with complex regional pain syndrome (CRPS). You may be able to join if your CRPS diagnosis matches specific international criteria and you can safely take the study medicine.
Rotterdam, South HollandAges 18 years+ - NCT05196503RecruitingPhase 3
PRF gel in spine surgery to reduce nerve pain after herniation
This Phase 3 study tests whether applying a healing material called platelet-rich fibrin (PRF) around the nerve during disc herniation surgery can reduce leftover nerve pain afterward. If you qualify, your team will compare pain intensity between standard care and PRF during the operation.
Strasbourg, Bas-RhinAges 18 years+ - NCT05147948Recruiting
Online therapy for PTSD plus chronic pain symptoms
This trial tests an iACT program (a structured, online skills-based therapy) for people who have both PTSD symptoms and chronic pain that affects daily life. It may help you learn ways to better handle distress and improve everyday functioning.
LundAges 18–65 - NCT05009459Recruiting
App-based program to help chronic pain and daily activity
This study tests an eVIS tool that combines information about physical activity and pain to help people with long-lasting pain improve how pain affects daily life. You may be a good fit if you have chronic pain and can complete the program in Swedish using your own device.
FalunAges 18–67 - NCT05052541RecruitingPhase 3
Oral cannabis for long-term spine pain
This trial studies whether taking cannabis by mouth can safely reduce chronic spine pain and improve daily comfort. You may be eligible if you have long-lasting spine pain and can follow study rules about stopping or limiting other cannabis and certain other treatments.
Aurora, ColoradoAges 21–84 - NCT04923477Recruiting
Exercise study for shoulder tendon pain and pinching
This trial studies a specific therapeutic exercise program for rotator cuff tendon pain and subacromial pain (a pinching-type shoulder problem). It also looks at what changes in your symptoms and body function after the exercises.
Los Angeles, CaliforniaAges 18–55 - NCT04907643Recruiting
Virtual reality program to reduce stomach-cancer pain
This trial tests whether virtual reality (VR) can improve pain and other day-to-day symptoms in people with certain gastrointestinal cancers. You’d use VR for pain relief while researchers measure how you’re feeling.
Los Angeles, CaliforniaAges 18–99 - NCT04720846Recruiting
Physical therapy for hip and groin pain without arthritis
This trial studies a categorized physical therapy approach for people with hip impingement and hip/groin pain that is not caused by arthritis. It may help by testing whether a structured PT plan improves pain and function for the right type of hip problem.
New York, New YorkAges 18–60 - NCT04556890Recruiting
Brain stimulation for treatment-resistant depression and chronic pain
This study tests a non-invasive brain stimulation treatment, called transcranial magnetic stimulation (TMS), to see if it can help people who have both major depression that hasn't improved with medication and chronic pain from fibromyalgia or chronic fatigue syndrome. It aims to reduce both depression and pain symptoms.
Los Angeles, CaliforniaAges 18–75 - NCT04267588Recruiting
Using technology to track your chronic pain
This trial uses technology to follow how your pain changes over time and how it affects your daily life. It may help researchers understand pain patterns and improve pain care, as long as you can safely and consistently take part.
Baltimore, MarylandAges 21 years+ - NCT04226716Recruiting
Studying pelvic pain causes in multiple or first pregnancies
This study looks at why pelvic girdle pain happens during pregnancy, focusing on body sensing (proprioception), stress factors, and inflammation. You may be able to help researchers understand the causes and who is most at risk.
HasseltAges 18–40 - NCT04142177Recruiting
Test which pain treatments work best for chronic low back pain
This study compares how well different pain treatments reduce low back pain and improve daily life. You may be asked to start or continue care through the VA and attend in-person sessions while completing pain and activity questionnaires.
Phoenix, ArizonaAges 18 years+ - NCT04046562Recruiting
Testing a teen pain-and-weight program
This trial studies a program meant to help teens manage weight when they also have ongoing muscle or joint pain. It may help by targeting pain feelings and supporting healthier weight habits at the same time.
Hartford, ConnecticutAges 12–18
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.