Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05751811Recruiting
Virtual reality and music to reduce pain during hysteroscopy
This study tests whether virtual reality plus music therapy can help reduce pain during an outpatient hysteroscopy. If you have your procedure at Prince of Wales Hospital, it may be an option to try non-drug comfort methods.
Hong KongAges 18–80 - NCT05761860RecruitingEarly Phase 1
Oxytocin to lower opioid misuse risk and pain in older adults
This early-phase study tests whether oxytocin (a hormone-like medication) can reduce how “appealing” opioids feel and also reduce pain. It’s aimed at older adults who have used opioids before but are not currently dealing with chronic pain most days.
Gainesville, FloridaAges 45–85 - NCT05764681Recruiting
Study for long-term pain after surgery
This study is for people who have chronic post-surgical pain and have a planned surgery on a leg or the spine. The goal is to better understand this long-term pain and what may help manage it after surgery.
Wilmington, DelawareAges 5–17 - NCT05767619Recruiting
Digital tool to guide care for chest pain calls
This trial tests a digital decision-support tool that helps emergency teams manage people who call for help because of chest pain. It may improve how safely and consistently chest pain is assessed and treated in the ambulance setting.
Kungsbacka, Region HallandAges 18 years+ - NCT05776771Recruiting
Spine movement study for people with back or neck pain
This study measures how your spine and back/neck move using motion testing and equipment. It may help researchers better understand differences between people with spine pain and people without.
Columbus, OhioAges 18 years+ - NCT05777889Recruiting
Infrared imaging for nerve-stimulation pain in one leg
This study uses infrared images to help evaluate spinal cord stimulation for complex regional pain syndrome (CRPS) when it affects one leg. It aims to see whether the imaging approach matches pain and treatment needs in people whose pain hasn’t improved with standard care.
New York, New YorkAges 18–85 - NCT05784857Recruiting
Testing touch methods to reduce pain during suction in preterm babies
This study tests whether different types of gentle touch can lessen pain and stress signals when preterm babies need suction through a breathing tube. If it helps, it could offer a comforting, non-medicine way to improve comfort during this procedure.
Istanbul, AtaşehirAges 6 months–9 months - NCT05795478Recruiting
Oxycodone plus pregabalin for long-term pain after spinal surgery
This trial studies whether taking oxycodone together with pregabalin (both pain medicines) can reduce chronic pain that can linger after spinal surgery. If you qualify, you may be asked to rate your pain and complete questionnaires during recovery.
BeijingAges 18 years+ - NCT05805683Recruiting
Calcitonin for nerve pain after spinal cord injury
This study tests whether calcitonin can prevent or lessen nerve pain after a spinal cord injury. It may help reduce how often neuropathic (nerve-type) pain happens and how severe it becomes.
Tanta, Gharbia GovernorateAges 18 years+ - NCT05811312Recruiting
Spinal cord stimulation and brain changes in chronic pain
This study uses non-invasive brain monitoring to see how spinal cord stimulation may change brain activity in people with chronic nerve pain. It aims to better understand how treatment affects the brain and pain over time.
Cleveland, OhioAges 18 years+ - NCT05816174Recruiting
Study of long-term pain after bone surgery in children
This study follows children and teens to learn how pain can last after planned orthopedic (bone) surgery in the hospital. It may help doctors better understand which kids are more likely to have long-lasting pain and how to support them.
BaselAges 8–18 - NCT05816798RecruitingPhase 2/Phase 3
Laser treatment to reduce chronic knee pain before weight-surgery
This trial tests whether photobiomodulation (a type of laser/light therapy) can reduce chronic pain in both knees for people preparing for bariatric (weight-loss) surgery. If you have knee pain that limits daily life, the treatment may help you feel better while you’re in the pre-surgery rehabilitation period.
Goiânia, GoiásAges 18–70 - NCT05832918Recruiting
Core exercises plus brain tasks for chronic low back pain
This study tests whether doing core (stability) exercises along with simple cognitive (thinking) tasks can reduce long-lasting low back pain. It may help if your pain has lasted at least 3 months and you can safely take part in exercise.
Tehran, Iran (the Islamic Republic Of)Ages 18–55 - NCT05840354Recruiting
Brain stimulation plus steroid shots for chronic spinal pain
This trial studies whether adding rTMS (a non-invasive brain stimulation treatment) to steroid joint injections can better reduce chronic spinal pain. It’s designed for people who already need repeated steroid joint injections to manage pain.
London, OntarioAges 18 years+ - NCT05841290Recruiting
Compare types of dental sealers for post-procedure pain
This study checks how much pain happens after dental procedures using different types of filling/sealing materials. It may help you and future patients understand which sealer options tend to cause less postoperative discomfort.
El Shorouk, Cairo GovernorateAges 18–50 - NCT05841732Recruiting
Behavior program with exercise to prevent low back pain returning
This trial tests a phone-based behavior change exercise program to help stop low back pain from coming back. It is for people who recently recovered from a recent low back pain episode and can safely do exercises.
Setúbal, Setúbal DistrictAges 18–65 - NCT06029075Recruiting
Brain stimulation for nerve pain after spinal injury
This study tests whether a gentle electrical current applied to the scalp can help relieve nerve pain that continues after an injury to the spinal cord, arm or leg amputation, or brain injury. Participants will continue their usual pain medications during the trial.
Houston, TexasAges 18–75 - NCT05853640Recruiting
Education and exercise for long-term hip or groin pain
This trial tests whether a program of education plus exercise can reduce long-term hip or groin pain. It may help by improving movement and function, especially when pain has lasted more than 3 months.
MalmöAges 18–55 - NCT05873894Recruiting
Testing pain changes during brain surgery under anesthesia
This trial studies how pain levels change during planned brain surgery while you are fully asleep, using special brain-monitoring recordings. The goal is to better understand acute pain signals during general anesthesia, which may help anesthesiologists manage pain more effectively.
ValenciaAges 18 years+ - NCT05895383RecruitingPhase 4
Nitrous oxide breathing during vasectomy: a feasibility study
This study looks at whether self-adjusting nitrous oxide (a calming gas) with oxygen can be safely and comfortably used during a vasectomy, and how people experience it. You may be offered the gas to see how it fits into care during the procedure.
Boston, MassachusettsAges 21–85 - NCT05897632Recruiting
Rapid chest-pain evaluation for moderate-risk adults
This trial tests a faster “ambulatory rapid evaluation” approach for adults who come in with chest pain that could be heart-related, but is not clearly an emergency. It may help doctors quickly sort who is safe to send home and who needs urgent heart testing, using specific ECG and blood test results.
Detroit, MichiganAges 21 years+ - NCT05906134RecruitingPhase 1/Phase 2
Pain control plan after minimally invasive esophagus surgery
This trial tests a pain-control method (using an epidural/nerve pain-block through the back, called neuraxial anesthesia) for people having minimally invasive esophagus removal surgery. It may help reduce pain after surgery and improve comfort during recovery.
Seattle, WashingtonAges 18 years+ - NCT05917626Recruiting
Digital program for teens with long-lasting pain
This trial studies whether a digital (phone or computer) program can help teens (ages 12–17) manage chronic pain over time. It’s designed with input from patients and may also show how well the program can be used in real life with families.
Almería, AlmeríaAges 12–17 - NCT05919745RecruitingPhase 4
Ibuprofen before mouth surgery to reduce pain sensing
This trial studies whether taking ibuprofen before tooth extraction and bone graft surgery can lower how much pain you feel afterward. It may help by changing the body’s pain response during healing.
Milwaukee, WisconsinAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.