Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05501210Recruiting
Knee vibration therapy for ongoing front-of-knee pain after ACL surgery
This trial studies whether a vibrating device on the front of the knee can reduce persistent pain after ACL reconstruction. It may help people whose pain is focused in one knee and isn’t caused by arthritis or other knee problems.
Hong KongAges 18–60 - NCT05507853Recruiting
Study of body pain sensitivity during pregnancy
This study looks at “central sensitization,” which means the nervous system may become more sensitive to pain, in pregnant people. It aims to understand pain changes during pregnancy and how different factors may affect them.
GothenburgAges 18 years+ - NCT05511012Recruiting
Testing movement-control assessment in low back pain
This study checks whether a therapist’s judgment about how your back controls movement matches objective measurements (more technical testing). It may help improve how low back pain rehabilitation is assessed and planned.
Brest, FinistèreAges 18–99 - NCT05537935RecruitingPhase 4
Low-dose naltrexone for nerve pain in people with HIV
This trial studies whether a low dose of naltrexone can reduce long-lasting nerve-related pain in adults living with HIV. It may help if your pain has been ongoing and you have stable HIV control.
Atlanta, GeorgiaAges 18–75 - NCT05537662Recruiting
Testing a wearable system to reduce diabetic nerve back pain
This study tests an Abbott device that uses sensing and electrical stimulation to help reduce chronic back and/or leg pain. It also tracks pain changes and diabetic control using wearables and regular questionnaires to see if the system improves outcomes.
Chicago, IllinoisAges 18 years+ - NCT05540106Recruiting
Art therapy to reduce pain and anxiety in the ER waiting room
This trial studies whether guided art therapy can lower the pain and anxiety you feel while waiting to be seen in the emergency department. It may help you feel more calm and comfortable during the waiting time.
Stony Brook, New YorkAges 18 years+ - NCT05555576Recruiting
Vitamin C to reduce opioid use after an ER visit
This trial tests whether taking vitamin C after an emergency room visit for a new, short-term muscle or joint pain can lower how many opioid pain pills you use. It may help by reducing opioid consumption while you recover.
Montreal, QuebecAges 18 years+ - NCT05607381Recruiting
Meditation program study for opioid-treated chronic low back pain
This trial studies how meditation may change brain activity and help people with long-lasting low back pain who are already taking prescription opioids. The goal is to understand the “neural” (brain) effects of meditation to improve pain treatment.
La Jolla, CaliforniaAges 18–65 - NCT05617365RecruitingPhase 1/Phase 2
Study treatment for chronic neck-related head and neck pain
This early-stage study tests a new treatment for people (women) who have long-lasting headaches and pain coming from the neck. It may help reduce symptoms, but you must match specific safety and diagnosis requirements.
East Lansing, MichiganAges 18–65 - NCT05617027Recruiting
tDCS for long-term muscle and joint pain in older adults
This study tests whether a non-invasive brain stimulation treatment (tDCS) can reduce chronic muscle and joint pain in people age 65+. If you have pain for at least 6 months, this trial may help by targeting the brain signals involved in pain.
Montreal, QuebecAges 65 years+ - NCT05623111RecruitingPhase 2
Nerve-area Botox shots for diabetic foot nerve pain
This Phase 2 trial tests whether injecting incobotulinumtoxin-A near painful nerves can reduce nerve-type pain in the feet for people with diabetes. If you have lasting, fairly symmetrical pain in both feet, the injections may help calm the nerve pain signals.
Glostrup MunicipalityAges 18 years+ - NCT05645003Recruiting
Brain stimulation therapy for nerve pain after spinal cord injury
This trial tests whether painless magnetic stimulation of the brain (non-surgical) can reduce long-lasting nerve pain after spinal cord injury. It may help people whose spinal cord injury-related pain has been present for at least six months.
AfyonkarahisarAges 20–70 - NCT05653778Recruiting
Nerve-stimulation treatment for painful corticobasal syndrome
This trial tests “scrambler therapy,” a type of skin-based nerve stimulation, to reduce ongoing pain from corticobasal syndrome. You may be eligible if your average pain is moderate to severe and you can safely take part in the treatment schedule.
Baltimore, MarylandAges 50–89 - NCT05666726Recruiting
Study how stress and body feelings affect choices
This study tests how changes in your internal body feelings (like heart rate and awareness of bodily sensations) and stress can affect decision-making and self-reflection. It may help researchers understand how thoughts, feelings, and body signals connect—especially in people vulnerable to anxiety or depression.
Bethesda, MarylandAges 18–55 - NCT05667090Recruiting
High-dose vitamin D3 to ease chronic pain in dialysis patients
This study tests whether taking a very high dose of vitamin D3 can reduce moderate to severe chronic pain in people on hemodialysis. It may help by improving vitamin D-related pathways that could affect pain, but you must also meet specific health and testing requirements.
TaipeiAges 20 years+ - NCT05669027Recruiting
Mobile brain training to help low back pain
This study tests whether mobile “neurofeedback” training can reduce low back pain and improve how much it affects your daily life. You would likely use sensors that measure brain and body signals to guide the training.
Durham, North CarolinaAges 18–90 - NCT05679167Recruiting
Digital training program for long-lasting low back pain
This trial tests an online (phone/tablet/computer) training program for people with low back pain lasting more than 3 months. It may help you learn exercises and self-management steps through digital instructions.
VänersborgAges 18–50 - NCT05689788Recruiting
High-intensity laser treatment for chronic neck pain
This trial tests whether high-intensity laser therapy can reduce long-lasting neck pain and improve daily function. It may help people whose neck pain has lasted at least 3 months and who meet specific pain and disability scores.
Santiago, Las CondesAges 18 years+ - NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80 - NCT05701852Recruiting
Study brain scans during tasks in chronic nerve pain
This study looks at how brain activity changes in people with long-lasting nerve pain using an MRI scan while you do simple behavioral tasks. It may help researchers understand brain function in chronic neuropathic pain and how it affects day-to-day abilities.
ParisAges 18 years+ - NCT05701982Recruiting
Walking plus Tai Chi coach via video for COPD and pain
This study tests whether a phone/computer program that combines walking training with Tai Chi improves physical function (how well you move) in people who have COPD and long-term body or muscle pain. It may help you build strength, balance, and safer movement—especially if pain makes activity hard.
Boston, MassachusettsAges 40–100 - NCT05706103Recruiting
Exercise therapy for recurrent low back pain with brain changes
This trial studies whether a specific exercise program can improve recurrent low back pain by changing activity in muscles and the brain. If you have non-specific low back pain that comes and goes over time, you may be asked to do exercises and undergo brain and muscle testing (including MRI).
Ghent, Oost-VlaanderenAges 18–45 - NCT05723081Recruiting
Study of stress, coping, and pain risk in Native Americans
This study looks at how stress and coping (“resilience”) may affect risk for pain. It may help researchers understand why some people develop ongoing, bothersome pain and how stress might play a role.
Tulsa, OklahomaAges 18 years+ - NCT05741788Recruiting
Telefitting spinal cord stimulation for chronic pain
This study checks a “remote fitting” process to set up spinal cord stimulation for people with high levels of pain. You may be a fit if you are planning a stimulation trial and have severe pain right now.
Minneapolis, MinnesotaAges 22 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.