Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05851326Recruiting
Ultrasound and gentle stimulation for stubborn muscle pain
This trial tests whether low-energy ultrasound and electrical/magnetic stimulation can reduce long-lasting myofascial pain in the low back, neck, or tension-type headaches. It may help if your pain has lasted at least 3 months and is still noticeable despite your current treatment plan.
GrazAges 18–99 - NCT05858996RecruitingPhase 2
Testing a pain care guideline for older adults with dementia
This trial tests a clinical guideline to improve how pain is identified and managed. It may help if you or your loved one has dementia and ongoing pain, with a focus on better pain care in nursing homes.
Baltimore, MarylandAges 60 years+ - NCT05917262Recruiting
Mindfulness breathing vs heart-rate training after shoulder surgery pain
This trial compares two non-drug techniques—mindful breathing and heart-rate (HR) biofeedback—to see which helps reduce pain after shoulder surgery. You may be able to join if you have ongoing shoulder pain after surgery and haven’t been using these practices very often.
TaoyuanAges 18 years+ - NCT05920382Recruiting
Radiofrequency treatment for long-term knee pain after knee surgery
This trial studies whether a radiofrequency procedure can reduce chronic knee pain after knee replacement surgery. It may help people who still have bothersome pain between 6 months and 5 years after their operation, as long as their pain pattern and medications are stable.
Barcelona, CataloniaAges 18 years+ - NCT06058624Recruiting
Digital pain management program for veterans
This study tests a new digital program that helps veterans with long-term pain learn to accept and cope with it. You would use a computer at home to complete the program and share your feedback.
West Haven, ConnecticutAges 18 years+ - NCT06076889Recruiting
Online pain relief program for Canadian youth with chronic pain
This trial tests a virtual program called Power Over Pain Portal, designed to help Canadian youth with chronic pain manage their symptoms from home. It offers step-by-step support through a smartphone or computer over two months.
Toronto, OntarioAges 12–18 - NCT06123715RecruitingPhase 2
Vitamin C to reduce pain after knee replacement
This study tests whether taking vitamin C before and after knee replacement surgery can reduce long-term pain. You may be eligible if you are having knee replacement for osteoarthritis and are generally healthy.
Toronto, OntarioAges 18 years+ - NCT06206148Recruiting
Comparing ways to record pain after surgery
This study compares different methods of recording pain after surgery to see which is easiest and most accurate. If you have surgery and can use a smartphone or a button, you may be able to help.
San Francisco, CaliforniaAges 18 years+ - NCT06212349Recruiting
Physiotherapy for pain and quality of life in endometriosis
This trial tests a combined therapy and education program for women with endometriosis. It aims to reduce pelvic pain, improve muscle function, and enhance quality of life. If you have persistent pelvic pain and certain muscle issues, this study may help.
ValenciaAges 18–45 - NCT06224829Recruiting
Massage therapy for long-term neck pain
This study tests whether massage can help people with neck pain that has lasted at least 3 months. You will receive massage sessions, and researchers will track how your pain changes.
Gainesville, FloridaAges 18–60 - NCT06246526Recruiting
Spinal cord stimulator for chronic pain study
This study tests a new type of spinal cord stimulator (a device that sends gentle electrical pulses to your spine to block pain signals) for people with chronic pain in their back, chest, or arms or legs. The goal is to see how well it works in real-life settings.
Charleston, West VirginiaAges 18 years+ - NCT06310096Recruiting
Stretching for chronic low back pain
This study tests whether a special stretching technique for the connective tissue in your lower back can help reduce pain and improve function in people with chronic low back pain (pain lasting 3 months or more). You would attend physiotherapy sessions and do regular stretches.
AnkaraAges 20–60 - NCT06350786Recruiting
Using a placebo to help reduce opioid pain medication
This trial tests whether a special placebo pill, given with your knowledge, can help you reduce your opioid pain medication. You'll work with your own doctor to safely lower your dose while taking the placebo.
Zurich, Canton of ZurichAges 18 years+ - NCT06360965Recruiting
Acupoint patch for pelvic pain after PID
This trial tests a skin patch treatment (acupoint application) placed on specific points of the body to help relieve ongoing pelvic pain from pelvic inflammatory disease. It may be a good option if you have moderate pain and ultrasound findings of tubal thickening or fluid.
BeijingAges 18–50 - NCT06381063RecruitingPhase 3
Anti-inflammatory for heart surgery
This trial is testing whether a non-steroidal anti-inflammatory drug (NSAID) given during heart surgery can reduce complications. It's for people having planned open-heart surgery with a heart-lung machine.
AmiensAges 18 years+ - NCT06395428RecruitingPhase 4
Haloperidol for severe back pain in the ER
This study tests whether the medication haloperidol, given in the emergency room, can help relieve severe back pain that started on its own (not from an injury). It compares haloperidol to a common pain reliever called ketorolac.
Kalamazoo, MichiganAges 18–65 - NCT06512727Recruiting
Pain management study for Black older adults with long-term joint pain
This study tests two different approaches to help Black adults aged 50–92 manage chronic muscle or joint pain in their hips, knees, lower back, or ankles. It aims to find which method works better to reduce pain and improve daily life.
Gainesville, FloridaAges 50–92 - NCT06537219Recruiting
Fascia stiffness and pain in young adults with chronic back pain
This study looks at how stiffness in the connective tissue (fascia) of the lower back relates to pain in young people with chronic low back pain. It may help find new ways to treat this common problem.
AnkaraAges 18–50 - NCT06569953RecruitingPhase 4
Numbing Medicine for Pain After Lung Surgery
This study tests whether a long-lasting numbing medicine (liposomal bupivacaine) injected near the spine can better control pain after lung surgery. It compares this to a standard numbing medicine, and aims to help patients recover with less pain after surgery.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT06671132RecruitingPhase 2
Computer training for pain relief using smell exercises
This trial tests a computer program that uses smell training to help people with chronic low back pain. It aims to reduce pain by retraining brain connections.
Washington D.C., District of ColumbiaAges 18–85 - NCT06679205Recruiting
Multidisciplinary care for long-term low back pain
This study tests a team-based, non-drug treatment program for long-term low back pain. It combines physical therapy, education, and support to help reduce pain and improve daily function.
Barcelona, BarcelonaAges 18 years+ - NCT06696300Recruiting
Breathing muscle training for chronic low back pain
This study tests whether training the muscles you use to breathe can help reduce chronic low back pain. You will practice specific breathing exercises and see if they improve your pain and function.
Kırşehir, CenterAges 18–65 - NCT07685418Recruiting
Pressure therapy and home exercises for neck pain
This trial tests whether a hands-on technique called ischemic compression (applying gentle pressure to trigger points) plus home exercises helps relieve long-term neck pain that has no specific medical cause.
Istanbul, BakırköyAges 17–65 - NCT06785909Recruiting
Understanding why pregnancy back and pelvic pain persists
This study looks at why some women develop ongoing pain in the lower back or pelvis during pregnancy. It tests how your body's sense of movement, fear of pain, and inflammation might be related. You may join if you are early in a single pregnancy and do not have that pain yet.
HasseltAges 18–40
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.