Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06387706Recruiting
Web-based pain program for older adults
This study tests a fun, web-based program (GAP) to help older adults manage chronic pain through light exercise and coping skills. It's designed for Cantonese speakers who can use a smartphone.
Hong KongAges 60 years+ - NCT06778070Recruiting
Pelvic pain study testing yoga therapy for relief
This trial tests whether yoga therapy can help reduce chronic pelvic pain in women and non-binary individuals over 6 months. You'll join online yoga classes and see if they improve your pain and daily life.
San Francisco, CaliforniaAges 18 years+ - NCT06749964Recruiting
Personalized internet CBT for cancer-related pain
This trial tests a personalized internet-based cognitive behavioral therapy (CBT) program designed to help people with cancer-related chronic pain. It aims to improve how you cope with pain and daily life challenges.
LundAges 18 years+ - NCT07692126Recruiting
Neck pain and hand strength: core vs shoulder exercises
This study compares two types of exercises to see which better improves hand grip strength and neck pain. If you have had chronic myofascial neck pain (trigger points) in the upper shoulder muscle for over 6 months, this trial may help find which exercise works best for you.
Giza, Giza GovernorateAges 25–45 - NCT07400471RecruitingEarly Phase 1
Pain relief before root canal: a medicine combination
This trial tests whether a combination of pain medicines given before a root canal can lower pain afterward. It is for people who have moderate to severe tooth pain and are healthy enough for standard treatment.
Chittagong, ChattogramAges 18 years+ - NCT07568015Recruiting
Nerve-targeted treatment for lateral hip pain
This study tests an experimental treatment that targets nerves around the hip to relieve pain on the outside of the hip. It may help people who have tried other treatments without enough relief.
Sun City, ArizonaAges 22–80 - NCT07694882Recruiting
Gentle pressure techniques for chronic neck pain
This study tests two different types of gentle pressure techniques (myofascial release) to see which one helps relieve long-term neck pain and improve everyday function. It is for people with chronic neck pain that isn't caused by a specific injury or disease.
Famagusta, HatayAges 18–45 - NCT07324343Recruiting
Education for shoulder pain: which patients benefit most?
This study tests whether patients with different types of shoulder pain respond better to learning about their condition through education alone. You will receive information and advice to help you manage your pain without injections or surgery.
IstanbulAges 18–65 - NCT07597343Recruiting
Helping You Stick With Hip Pain Exercise Treatment
This study tests new ways to help people with lateral hip pain (pain on the outer side of the hip) stay motivated and consistent with their exercise program. The goal is to understand what helps patients do their exercises regularly so they can feel better.
Leicester, LeictershaireAges 18 years+ - NCT07275710Recruiting
Alprazolam for tooth pain after root canal
This trial tests if adding alprazolam (a mild anti-anxiety medicine) to standard painkillers can better manage pain after a root canal. It aims to find a more effective way to control post-procedure discomfort.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT06889389Recruiting
Education and exercise for neck pain relief
This study tests if combining education with exercise can reduce pain and improve function for people with non-specific neck pain (pain not caused by a specific injury or disease). Participants will learn about their condition and do guided exercises.
Elche, AlicanteAges 18–65 - NCT07717151Recruiting
Preventing long-term pain after surgery for chronic opioid users
This trial tests a method to prevent chronic pain after surgery in people who already take opioids regularly. It may help reduce long-term pain and improve recovery.
AmiensAges 18 years+ - NCT07251959Enrolling by invitation
Exercise vs. exercise plus manual therapy for chronic back pain
This study tests whether a workplace exercise program, with or without hands-on manual therapy, can help reduce chronic spinal pain in desk workers. It is designed for UCAM University staff who have had persistent back pain for at least 3 months.
Murcia, MurciaAges 18 years+ - NCT04004286Recruiting
Pain registry and blood sample biobank for eligible service members
This trial is building a pain registry biobank to learn more about pain and how different people experience it. If you’re eligible for care in the Military Healthcare System and can consent, you may be able to contribute your information for future research.
San Diego, CaliforniaAges 18–80 - NCT04144972Recruiting
Closed-loop deep brain stimulation for long-lasting nerve pain
This trial tests a “smart” deep brain stimulation device that senses your brain signals and adjusts treatment to reduce severe, long-lasting pain. It may help people whose pain has not improved with multiple pain medicines and surgery cannot fix the cause.
San Francisco, CaliforniaAges 22–80 - NCT04636879Recruiting
Testing dry needling for neck pain expectations
This study looks at how people’s expectations and experiences relate to treatment with dry needling for neck pain. It may help researchers understand who benefits most from this therapy for upper trapezius muscle pain.
Alcalá de Henares, MadridAges 18–65 - NCT04704297RecruitingPhase 4
Trigger point shots for low back muscle pain
This trial tests whether injecting sore “trigger points” in low back muscles helps improve chronic low back pain. It compares treatments in people with specific low back muscle pain patterns and excludes several other causes of pain.
Tacoma, WashingtonAges 18 years+ - NCT04783454Recruiting
Preventing neck and back pain in teleworkers
This study tests ways to prevent neck and back pain in people who work at a computer from home or an office. If you qualify, you may be assigned to an intervention aimed at reducing pain and improving comfort.
Ghent, East FlandersAges 18–69 - NCT04874038RecruitingPhase 3
Lidocaine infusions to prevent long-lasting pain after breast surgery
This Phase 3 study tests whether receiving lidocaine through an IV during breast surgery can lower the chance of ongoing pain afterward. If it works, it may help some people avoid chronic, surgery-related pain in the chest wall, shoulder, or arm.
Calgary, AlbertaAges 18–100 - NCT07076069RecruitingPhase 4
Rotator cuff repair pain study: fewer narcotics
This trial tests a mix of pain medicines (multimodal regimen) to see if it reduces the need for strong narcotics after arthroscopic rotator cuff repair. If you have a torn rotator cuff that hasn't healed with other treatments and you are scheduled for surgery, you may be able to join.
The Bronx, New YorkAges 18 years+ - NCT05232604Recruiting
Exercise vs local pain exercises for jaw and neck pain
This study compares two types of treatment: aerobic exercise versus exercises aimed at the painful jaw/neck area. It may help people with long-term jaw and neck pain by testing which approach improves pain and function.
Osnabrück, Lower SaxonyAges 18–60 - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+ - NCT05674604Recruiting
Cryoneurolysis to reduce knee and shoulder pain in hospital
This trial tests whether a procedure called cryoneurolysis can reduce pain in people recovering from certain recent brain or nerve injuries (like stroke or traumatic brain injury). It may be helpful if you have either hemiplegic shoulder pain or knee pain from osteoarthritis while you’re in inpatient rehab.
Victoria, British ColumbiaAges 18–80 - NCT05814497Recruiting
Brain scan study of how kids process chronic pain
This study looks at how the brain processes pain sensations in children with certain long-lasting pain conditions. It may help researchers understand what’s happening in the nervous system and guide better treatments.
Cincinnati, OhioAges 10–17
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.