Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07071350RecruitingPhase 2/Phase 3
Optimizing heart rate for persistent concussion symptoms in military veterans
This trial tests a treatment designed to improve heart rate variability, which may help reduce long-term concussion symptoms like headaches, dizziness, and trouble sleeping. It is for military veterans who have had a mild concussion more than a year ago and still have ongoing symptoms.
Richmond, VirginiaAges 18 years+ - NCT07080892Recruiting
Comparing two ways to give a knee nerve block for pain after knee replacement
This study compares two different ways of giving a nerve block (called iPACK) to see which works better for pain after total knee replacement. The goal is to find the best spot for the injection to help you feel more comfortable after surgery.
BratislavaAges 18–80 - NCT07082972RecruitingPhase 4
Study of splint therapy and Botox for jaw muscle pain
This trial compares two treatments—a dental splint and Botox injections into the jaw muscle (masseter)—to see which one better relaxes head and neck muscles in people with myofascial pain syndrome. It may help you if you have facial pain related to muscle tension.
Istanbul, VeznecilerAges 18–55 - NCT07085065Recruiting
Virtual reality for pain and anxiety during blood cancer procedures
This trial tests whether watching a virtual reality experience during a medical procedure can help reduce pain and anxiety for people with blood cancers. You may be able to take part if you are getting a bone marrow biopsy, spinal tap, blood draw, or chemotherapy.
Tunis, Sfax GovernorateAges 6 years+ - NCT07089628Recruiting
Core stability and hand-eye coordination in rotator cuff injury
This study looks at how a rotator cuff tear affects your core stability, reaction time, hand-eye coordination, pain, and daily function. It compares people with rotator cuff problems to healthy individuals to understand these connections better.
AnkaraAges 18–65 - NCT07091981Recruiting
Effect of file count on MB2 canal access and post-treatment pain
This trial tests whether using different numbers of rotary files affects the ability to find and clean a small extra canal (MB2) in upper first molars and how much pain patients feel afterward. It may help dentists choose a better treatment approach.
Antakya, HatayAges 20–65 - NCT07094451Recruiting
Virtual reality for pain during needle procedures
This study tests whether using a virtual reality headset can help reduce pain during ultrasound-guided needle procedures in pregnancy. It may offer a drug-free way to feel more comfortable during the procedure.
New York, New YorkAges 18 years+ - NCT07098390Recruiting
Relaxation to Reduce Fear and Pain After Joint Replacement
This study tests whether a simple relaxation technique (progressive muscle relaxation) can help reduce fear of falling, pain, and anxiety after hip or knee replacement surgery. It may be a safe, drug-free way to feel better during recovery.
AnkaraAges 18 years+ - NCT07098741Recruiting
Physical therapy for low back pain and pelvic tilt
This study looks at different physical therapy treatments for people with chronic, non-specific low back pain and a forward-tilted pelvis (anterior pelvic tilt). It aims to find which type of exercise or therapy works best to improve posture and reduce pain.
Chak Four Hundred Fifty-four, Punjab ProvinceAges 20–40 - NCT07098754Recruiting
Physical therapy for neck pain and posture improvement
This study compares different physical therapy techniques to improve neck posture and reduce pain in people with myofascial pain syndrome. It may help if you have mild to moderate neck pain from muscle knots and are open to physiotherapy.
Bahawalpur, Punjab ProvinceAges 20–40 - NCT07100782RecruitingPhase 3
Estrogen & pain trial for endometriosis pelvic pain
This study tests whether a drug called relugolix CT can reduce pelvic pain from endometriosis. You'll have brain scans and pain tests to measure how your body processes pain. It might help if other treatments haven't worked well.
Ann Arbor, MichiganAges 18–49 - NCT07101250RecruitingPhase 4
Study of acetazolamide before laparoscopic hysterectomy
This trial tests a medication called acetazolamide given before surgery to see if it can help prevent shoulder pain after a laparoscopic hysterectomy. If you are a woman scheduled for this type of hysterectomy, you may be able to join.
Greenville, South CarolinaAges 21–65 - NCT07102446Recruiting
Opioid safety program for chronic pain patients without cancer
This trial tests a program to help manage opioid use safely for people with chronic non-cancer pain. If you take opioids for long-term pain and do not have cancer, this study may help improve your care.
Seoul, SeoulAges 19–79 - NCT07102641RecruitingPhase 4
Comparing pain relief methods after c-section
This study compares two ways of giving pain medication after a cesarean section to see which works better. It may help find the best approach to manage pain after surgery while reducing the need for stronger medications.
Philadelphia, PennsylvaniaAges 16 years+ - NCT07103135RecruitingPhase 1
Testing an accelerated TMS for chronic pain
This study tests an accelerated form of Transcranial Magnetic Stimulation (TMS) — a non-invasive treatment that uses magnetic pulses to stimulate the brain — to see if it can reduce chronic pain. If you have long-term pain that hasn't responded well to at least two medications, this trial might be a good option for you.
Minneapolis, MinnesotaAges 18 years+ - NCT07109882RecruitingPhase 4
Comparing two muscle relaxants for bruxism pain
This study compares two muscle relaxant medications—chlorzoxazone and orphenadrine citrate—to see which works better for relieving pain caused by teeth grinding or jaw clenching (bruxism). If you have jaw or face pain and no other major health issues, you may be able to join.
BaghdadAges 15 years+ - NCT07110324Recruiting
Understanding long-term pain after hip or knee replacement
This study looks at people who still have moderate to severe pain months after a hip or knee replacement. The goal is to learn more about what causes this pain and how it feels, which could help improve future treatments.
Østerbro, København ØAges 18 years+ - NCT07116109Recruiting
Brain Stimulation Plus Therapy for Pain and PTSD
This study tests whether a brain-stimulation headband (called tDCS) combined with a proven talk therapy for PTSD can help reduce both chronic pain and PTSD symptoms. It is for adults who have had chronic pain for at least 6 months and also have PTSD.
Charleston, South CarolinaAges 21 years+ - NCT07118722Recruiting
Quiet focus: mindfulness for pain and depression
This study compares two programs—mindfulness-based therapy and a general health program—to see which better helps older Black adults manage long-term pain and mild depression. It aims to find new ways to improve well-being.
Boston, MassachusettsAges 50–120 - NCT07120763RecruitingPhase 3
Better pain control for kids with broken wrists
This trial compares different ways to manage pain for children who come to the emergency room with a broken wrist that needs to be reset. The goal is to find which pain medicine or numbing method works best and is safest for kids.
Buffalo, New YorkAges 3–17 - NCT07122453RecruitingPhase 1
Study of CNTX-3001 for severe chronic low back pain
This trial tests a medicine called CNTX-3001, given as a spinal injection, for people with long-term, severe low back pain that hasn't improved with other treatments.
Napa, CaliforniaAges 18–75 - NCT07122843Recruiting
VR and AI meditation for hospital pain relief
This study tests if a virtual reality (VR) meditation program can help reduce pain in hospitalized patients. If you have at least moderate pain (4 out of 10 or higher) and can speak English or Spanish, you may be able to join.
Los Angeles, CaliforniaAges 18 years+ - NCT07122973Recruiting
Mapping itch and pain receptors on the skin
This study looks at how the skin senses itch and pain by applying a small amount of chili cream (capsaicin) to different spots. It may help doctors better understand pain and itch conditions in the future.
Gistrup, AalborgAges 18–60 - NCT07125027Recruiting
A mind-body program for leg pain from back issues
This trial tests a program called Move-MORE that combines movement and mindfulness to help people with long-lasting leg pain caused by a nerve problem in the lower back. It involves daily activities, weekly virtual group meetings, and tracking your progress with a wearable device.
Portland, OregonAges 18–66
Hear when a new Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.