Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,135 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01788410Recruiting
MRI-guided freezing treatment for neck, head, and spine pain
This trial studies an MRI-guided procedure that “freezes” targeted nerves or joints to reduce pain in the head, neck, or spine. It may help if your pain comes from a joint problem or a compressed/damaged nerve and you can safely have MRI scans before and after the treatment.
Boston, MassachusettsAges 18 years+ - NCT05996367Recruiting
Single radiation dose for painful myeloma bone lesions
This trial is testing whether a single dose of radiation can effectively relieve bone pain caused by multiple myeloma. It is designed for people who have a painful bone lesion and are stable on or off treatment.
São Paulo, São PauloAges 18–85 - NCT06071637RecruitingPhase 3
Preventing mouth sores with laser therapy in stem cell transplant
This trial tests if a low-power laser can prevent painful mouth sores and throat pain in people getting a stem cell transplant from a donor. The laser is applied to the mouth before sores start, aiming to reduce pain and speed healing.
Rio de Janeiro, Rio de JaneiroAges 18–100 - NCT05986370Recruiting
Study on back pain and spinal manipulation
This trial tests whether spinal manipulation therapy (a type of hands-on treatment) can help people with long-term low back pain. It also compares their results to healthy volunteers of the same age and sex.
Trois-Rivières, QuebecAges 18–60 - NCT07855159Recruiting
Testing an arm support device for ear, nose, and throat surgeons
This study looks at whether a wearable arm support (exoskeleton) helps reduce strain for surgeons who perform procedures through the mouth or neck. It measures muscle activity during surgery to see if the device is helpful.
StevenageAges 18 years+ - NCT07854951Recruiting
Hypnosis for pain and nausea relief in scoliosis surgery
This trial tests if hypnosis can reduce pain and nausea after scoliosis surgery. Adolescents aged 12-18 who are having scoliosis surgery may be eligible to participate.
TrondheimAges 12–18 - NCT06081998Recruiting
How lack of sleep affects itch and pain
This study looks at how not sleeping affects your sensitivity to itch and pain. Researchers want to understand the connection between sleep and these sensations, which could help treat conditions like chronic itching or pain.
AalborgAges 18–60 - NCT07859397Recruiting
Pain relief options for knee ligament surgery
This study compares two nerve-block approaches to see which provides better pain relief after knee ligament reconstruction surgery. If you are having this surgery, joining could help manage your pain more effectively.
AnkaraAges 18–65 - NCT07867405Recruiting
Sheep tail fat for knee arthritis pain
This study tests whether applying sheep tail fat to the knee can reduce pain, stiffness, and make daily activities easier for people with knee arthritis (gonarthrosis). It may be an option if you have had knee pain for at least three months and want a natural, non-drug treatment to try at home.
BitlisAges 18 years+ - NCT07863232Recruiting
Melatonin and nutrition for fibromyalgia pain relief
This study tests whether taking melatonin, a sleep and pain hormone, along with special nutrition supplements, can help reduce fibromyalgia pain. It may offer a new way to manage symptoms.
LarissaAges 18 years+ - NCT07872215Recruiting
AI-assisted teaching before stitches for minor cuts
This study tests whether using artificial intelligence to explain stitches before the procedure helps patients feel more informed and at ease. It is for adults with minor cuts that can be closed with stitches in the emergency room.
AnkaraAges 18 years+ - NCT07869680Recruiting
Comparing knee function in people with similar knee arthritis pain
This study looks at how knee osteoarthritis (a common condition where the cushioning in the knee joint wears down) affects physical function, even when people report similar levels of pain. It aims to understand why some people with the same pain might have more difficulty with daily activities, which could lead to better targeted treatments.
MardinAges 40–75 - NCT07872826Enrolling by invitationPhase 3
Study of pain relief injection after hip replacement surgery
This study tests a new pain-relief injection given during hip replacement surgery to reduce pain after the operation. The goal is to help patients recover with less discomfort and possibly reduce the need for other pain medications.
ChangshaAges 18–80 - NCT06205355Recruiting
Pain measurement tool for jaw surgery patients
This study tests a device that measures your body's response to pain during jaw surgery. It may help doctors better manage your pain during and after the procedure.
SeoulAges 18 years+ - NCT06243718Recruiting
Surgery for paralyzed diaphragm nerve
This trial looks at how patients feel and recover after surgery to fix the nerve that controls the diaphragm. It aims to learn about people's experiences to improve care for diaphragmatic paralysis.
Red Bank, New JerseyAges 18–70 - NCT07856173Recruiting
Comparing two hands-on therapies for frozen shoulder pain
This study compares two gentle hands-on therapies to see which works better for reducing pain, improving movement, and helping you use your shoulder again. It is for people with frozen shoulder who have had pain for more than 6 months.
Islamabad, Punjab ProvinceAges 40–60 - NCT06264297Recruiting
Nerve radiofrequency treatment for chronic leg pain
This trial tests a new type of treatment (high-voltage pulsed radiofrequency) that uses a special needle to deliver energy to the nerve root in your lower back. The goal is to see if it can reduce chronic leg pain caused by a pinched or irritated nerve.
Terrassa, BarcelonaAges 18 years+ - NCT07868315Recruiting
Single-visit root canal pain and success comparison
This study compares pain after a single-visit root canal treatment using different sealers (materials used to fill the root canal) in asymptomatic (pain-free) teeth. It aims to find which sealer causes less discomfort and has a better success rate.
Istanbul, EsenlerAges 18–65 - NCT07856433Recruiting
Biofeedback training for forward head posture and neck pain
This study compares two types of biofeedback training (using pressure or visual cues) to help correct forward head posture and reduce neck pain, disability, and improve neck movement. If you have neck pain and a forward head posture, this therapy might help you.
Islamabad, FederalAges 19–44 - NCT07855549Enrolling by invitation
Nerve blocks for pain relief after chest surgery
This study compares two types of nerve blocks (numbing injections) to see which one works better for pain relief after chest surgery. The goal is to help you feel more comfortable and use less pain medicine after your operation.
Minya, Minya GovernorateAges 18–70 - NCT06270121Recruiting
Mobile health app for healthy aging at home
This study is testing a mobile health app designed to help seniors live independently at home. If you join, you will use the app and answer surveys to see if it supports healthy aging.
SeoulAges 65 years+ - NCT07861906Recruiting
Wearable device for jaw muscle pain
This study tests a 24-hour wearable device that tracks jaw muscle activity to better understand and manage chronic jaw muscle pain. You would wear the device for a day to see how your muscles behave, which could help improve future treatments.
Downers Grove, IllinoisAges 18 years+ - NCT07872670Recruiting
Virtual reality to help recovery after hip or knee replacement
This study uses virtual reality (a computer-generated 3D environment you wear a headset for) alongside your usual care to help with recovery after hip or knee replacement surgery. It may help reduce pain or improve how well you move after surgery.
Inverness, HighlandsAges 18 years+ - NCT07854028Recruiting
Muscle release techniques for low back pain
This study tests two hands-on treatments—strain counter strain and muscle energy technique—to ease low back pain and improve movement. It may help if you have had low back pain for 3–6 months and have specific tender spots in your back muscles.
Lahore, Punjab ProvinceAges 20–40
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,135 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.