Peptides clinical trials

Peptide vs calcium paste for early cavity spots

This trial tests whether a new peptide treatment or a calcium-phosphate paste works better at reversing early white-spot cavities on front teeth. If you're a young adult with early decay on your front teeth, you may be able to join.

Resin vs peptide gel for white spots on teeth in children

This study compares two treatments for white spots on teeth: a resin (tooth-colored coating) and a special peptide gel that helps rebuild enamel. It is for children and young teens with early white spots that haven't been treated yet.

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

Vaccine for advanced cancers using your tumor’s targets

This trial tests a personalized vaccine made from “neoantigens” (tumor-specific targets) to help your immune system fight advanced, inoperable solid tumors. It may be an option if standard treatment didn’t work or you stopped it and your health is strong enough for trial treatment.

Vaccine plus immunotherapy for a specific liver cancer gene change

This Phase 1 trial tests a personalized peptide vaccine (targeting the DNAJB1-PRKACA fusion) combined with immunotherapy drugs to treat fibrolamellar hepatocellular carcinoma (FLC) or other eligible non-FLC cancers with the same gene fusion. It aims to see whether this immune-based treatment can shrink tumors and improve outcomes safely.

Vaccine, immunotherapy, and radiation for advanced lung cancer

This trial tests a combination of a personalized peptide vaccine, an immunotherapy drug (PD-1 inhibitor), and radiation for people with advanced non-small cell lung cancer whose disease has gotten worse after at least two standard treatments. It aims to see if this triple therapy can help control the cancer.

Vaccine, immunotherapy, and radiation for advanced lung cancer

This trial tests a combination of a personalized vaccine (made from your tumor's unique markers), a drug that boosts your immune system (PD-1 inhibitor), and targeted radiation for people with advanced lung cancer that has progressed after initial treatment. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.

Testing a Peptide Cream on Healthy Skin

This study tests whether a cream containing peptides (small protein fragments) can improve how well your facial skin barrier works. The cream will be tested on one side of your face, compared to the other side, to see if it strengthens and protects your skin.

Test if bitter melon peptides help control blood sugar

This trial is studying peptides from bitter melon (Momordica charantia) to see if they can help manage blood sugar levels in people with prediabetes. You may be eligible if you have higher-than-normal blood sugar but not full diabetes.

Peptide for remineralizing white spot lesions in teens

This trial tests a self-assembling peptide (P11-4) to help reverse early white spots on teeth caused by cavities in teenagers. If effective, it could rebuild enamel without drilling or fillings.

Comparing shockwave therapy and collagen for plantar fasciitis

This study tests whether shockwave therapy or collagen supplements work better for reducing heel pain from plantar fasciitis. If you have heel pain and haven't had foot surgery, you may be able to join.

Collagen Peptides for Memory and Focus in Stressed Adults

This study tests whether a collagen supplement (a protein derived from cows) can help improve attention, focus, and memory in adults aged 35–70 who feel stressed but are otherwise healthy. Researchers want to see if this supplement can help with mild cognitive complaints like trouble concentrating.

GLP-1 drug for period problems in teens with type 1 diabetes

This trial tests whether a GLP-1 receptor agonist can help improve irregular periods in teenage girls with type 1 diabetes. It's for girls aged 12 to 18 who have had their period for at least 2 years, use a continuous glucose monitor, and have higher blood sugar levels (HbA1c of 7% or more).

Personalized cancer vaccine trial for solid tumors

This trial tests a custom-made vaccine designed to train your immune system to fight your specific cancer. It may be an option if you have advanced cancer that stopped responding to treatment or early-stage cancer with a high risk of coming back.

Vaccine to help stop lung cancer drug resistance

This early-phase study tests a personalized peptide vaccine designed to help prevent advanced ALK-positive non-small cell lung cancer from developing resistance to current targeted medicines. If you are stable on an ALK drug and don’t already have the specific resistance changes the vaccine targets, it may help your cancer stay controlled longer.

Personalized vaccine made from your tumor’s new immune targets

This Phase 1 study tests a customized vaccine made from “neo-antigens,” which are new targets found in your tumor. It aims to help your immune system fight certain advanced cancers that have not responded well to prior treatment.

Testing a New mRNA Cancer Treatment for Advanced Solid Tumors

This early-stage trial tests a new mRNA-based drug designed to help your immune system fight advanced cancers that haven't responded to standard treatments. The study measures safety, tolerability, and whether it can slow or shrink your tumor.

Resistance training survey for people on weight loss meds

This trial is an online survey to understand how people taking GLP-1 medications (like Ozempic or Wegovy) are doing with resistance training. If you're an adult on a stable dose of a GLP-1 med for weight or diabetes, your input can help shape better exercise advice.

Testing a hormone supplement to improve heart and metabolic health

This study tests whether adding a natriuretic peptide medicine improves heart health and metabolism in Black adults. It may help with blood pressure and related health markers, but you must meet specific health and safety criteria.

PRRT for advanced neuroendocrine tumors

This trial tests a treatment called PRRT, which delivers a radioactive medicine directly to tumor cells, for advanced neuroendocrine tumors. It may help those whose tumors are growing despite octreotide treatment, especially when scans show tumor uptake of specific tracers.

CALR-mutant blood cancer vaccine for adults with high-risk ET or PMF

This Phase 1 study tests a vaccine made from a CALR mutation (a specific genetic change) to help the immune system recognize and fight your blood cancer. It is mainly focused on early safety and to see if the vaccine can trigger an immune response in people with CALR-mutated myeloproliferative neoplasms.

Study of genetics and heart/metabolic health in adults

This study looks at how genetic markers (DNA) relate to heart health and “metabolic” health (how your body manages sugar and fat). You may be asked to provide genetic samples and follow study health checks and protocols to help researchers understand who is at higher risk.

Vaccine and immunotherapy for KRAS-mutated lung cancer

This Phase 1 study tests a KRAS-targeted vaccine combined with chemo and immunotherapy (nivolumab and ipilimumab) for people with advanced non-small cell lung cancer. It aims to help the immune system recognize and fight tumors with specific KRAS mutations, and to see if the treatment is safe and effective enough to study further.

Personalized vaccine using tumor peptide targets and an immune booster

This early-phase trial tests a personalized immune treatment made from your tumor’s specific “neoantigen” targets (small pieces the immune system can recognize), plus an immune-boosting medicine. It aims to help control certain cancers by training your immune system to attack your tumor.