Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06685016Recruiting
Study of dental health after IPR with clear aligners
This study looks at how the teeth and gums are doing after a common orthodontic step called IPR (a slight smoothing between teeth) in people wearing clear aligners. It will help understand if this procedure keeps your mouth healthy.
NaplesAges 17–100 - NCT06543004Recruiting
Comparing pain after root canal with two filling materials
This study is comparing two different materials used to fill the tooth after a root canal to see which one causes less pain afterward. If you need a root canal on a front tooth or a premolar and you don't have pain or swelling, this trial may help find the gentler option for you.
DohaAges 18–60 - NCT07619729Enrolling by invitationPhase 4
Oral Health Program for People With Type 2 Diabetes
This study tests whether a text-message and online program about caring for your teeth and gums can help people with type 2 diabetes. Researchers want to see if better oral health habits improve overall health outcomes.
Long Island City, New YorkAges 18 years+ - NCT07604493Recruiting
Italian Doctors' Survey on Oral Health and General Wellness
This study asks Italian general practitioners (family doctors) about their views on how oral health—like teeth and gum health—affects overall body health. Your answers help researchers understand what doctors know and think about the connection between mouth and systemic diseases.
Roma, RMAges 18 years+ - NCT07611461Enrolling by invitation
How Dental Crowns Affect Gum Health Long-Term
This study follows patients who receive tooth-colored metal crowns to see how these dental restorations affect the health of gums and supporting tissues over time. Understanding this helps dentists place crowns in ways that keep your mouth healthiest.
Riga, Dzirciema Iela 20Ages 20–75 - NCT07603934RecruitingEarly Phase 1
Testing Medications Inside Root Canals to Reduce Pain
This study tests different medications placed inside a tooth's root canal during treatment to see which one best reduces pain afterward. If you have a tooth with a dead nerve (necrotic pulp), this trial might help determine the best way to manage your pain during the healing process.
Cairo, Cairo GovernorateAges 18–40 - NCT07599254RecruitingPhase 4
Pain Relief After Root Canal Retreatment
This study tests two different ways of cleaning and treating a tooth that had a root canal treatment before. Researchers want to see which method causes less pain after the procedure.
KayseriAges 18–60 - NCT07579416Recruiting
Teeth Grinding, Anxiety, and Gum Health in Dental Students
This study looks at the connection between teeth grinding (bruxism), anxiety, and gum health in dental students. Researchers want to understand how stress and grinding habits affect the teeth and gums of students in their final years of dental school.
HomsAges 18 years+ - NCT07555366Recruiting
Healing after tooth extraction: two treatment approaches
This study compares two treatments applied to the socket (the hole left after a tooth is removed) to help it heal better. One treatment uses a product called microRepair, and the other uses chlorhexidine, a common antimicrobial rinse. The goal is to see which helps the extraction site heal faster and with fewer problems.
Roma, RMAges 18–75 - NCT07546279Recruiting
Bone substitutes with gum graft for deep gum pockets
This trial tests two different bone-filling materials combined with a gum graft to repair deep pockets in your gums caused by gum disease. The goal is to help your gums heal and regain support around your teeth.
MilanAges Any age - NCT04848870Recruiting
Check dental and gum health in Sjögren’s disease
This study looks at dental and gum (periodontal) health in adults with Sjögren’s syndrome. It may help researchers understand how Sjögren’s affects the mouth and how patients can be supported better.
Ivry-sur-Seine, Île-de-France RegionAges 18 years+ - NCT07527351Recruiting
Testing a laser imaging tool for gum health assessment
This study tests a new laser imaging technology that measures blood flow in gum tissue to see if it's accurate and reliable. Researchers want to understand if this tool could help dentists better assess gum health and healing after surgery.
Madrid, MadridAges 18 years+ - NCT07518901Enrolling by invitationPhase 4
New Nanoparticle Treatment for Root Canal Therapy
This study tests a new type of nanoparticle (tiny medical particles) called Ferumoxytol to help treat infected tooth roots. Researchers want to see if this approach works better than standard root canal treatments.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07506993Recruiting
Inflammation in clear aligners with attachments
This study looks at gum inflammation in people using clear aligners with or without small attachments on their teeth. It may help understand how aligners affect oral health.
Lincoln, NebraskaAges 14–35 - NCT07501585Recruiting
Hyaluronic acid gel for infected back tooth surgery
This trial tests whether putting hyaluronic acid (a natural gel-like substance) into the bone during root-end surgery helps heal infections in first molars (back teeth) that didn't get better after a root canal. It may be a good option if you have a small, stubborn infection and your gums are healthy.
MoscowAges 18 years+ - NCT07478653Recruiting
Dental health study for teens with severe obesity
This study looks at whether gum health is linked to heart health in teens with severe obesity. It may help find ways to reduce heart risks by improving dental care.
Lexington, KentuckyAges 12–17 - NCT06782035Recruiting
Effect of dressings on donor site comfort after gum graft surgery
This trial tests whether special dressings applied to the area where a gum graft is taken from can improve patient comfort and quality of life after surgery.
IzmirAges 18–85 - NCT07453576Recruiting
Comparing bleach strengths for root canal retreatment pain
This trial tests if different concentrations of sodium hypochlorite (a disinfectant used in root canals) affect pain and certain natural chemicals in the tooth during root canal retreatment. It may help find the best option to reduce discomfort.
Erzurum, ErzurumAges 18–65 - NCT07448571Recruiting
Testing i-PRF for better root canal retreatment healing
This study tests whether using a special platelet-rich concentrate (i-PRF) during a root canal retreatment can help heal infection at the tip of the root better than standard retreatment alone. It is for adults with a previously treated upper front tooth that now shows signs of infection on X-ray.
IstanbulAges 18–50 - NCT07439614Recruiting
Comparing two ways to clean a dead nerve during a root canal
This trial compares two different ways to clean a molar tooth during a root canal when the nerve is dead. The goal is to find which method is better at removing infection without causing discomfort.
Buffalo, New YorkAges 18–70 - NCT06808373Recruiting
Hypnosis for gum disease treatment
This study tests whether hypnosis can help with gum disease treatment. It is for adults who have chronic gum disease but are otherwise healthy.
AfyonkarahisarAges 20–65 - NCT07397312Recruiting
Toothpaste study for gum health
This study tests a new toothpaste to see if it improves gum health. It is for people who have at least 16 natural teeth and get regular dental cleanings.
Halle, Saxony-AnhaltAges 18 years+ - NCT07397884Recruiting
Bone loss and stress markers in implant gum disease
This study looks at markers of bone damage and stress in people with gum disease around dental implants (peri-implantitis). It aims to understand how the body responds, which could help improve treatment.
Keçiören, AnkaraAges 18–65 - NCT07389772Enrolling by invitation
Immune markers in tooth retreatments for diabetics
This study tests whether different ways of activating the immune system during root canal retreatment affect levels of certain immune markers (TLR9, IL6, IL10, TNF-alfa) in people with type 2 diabetes. If you need a repeat root canal on a front tooth or lower premolar, you may be able to join.
Kirikkale, KırıkkaleAges 18–50
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 271 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.