Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 281 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06731465Enrolling by invitation
Clear aligners vs braces for crowded lower front teeth
This study compares clear aligners (removable trays) to traditional braces for treating crowded lower front teeth. It aims to see which method works better and is more comfortable for patients.
Sharjah city, Emirate of SharjahAges 16–45 - NCT07397884Recruiting
Bone loss and stress markers in implant gum disease
This study looks at markers of bone damage and stress in people with gum disease around dental implants (peri-implantitis). It aims to understand how the body responds, which could help improve treatment.
Keçiören, AnkaraAges 18–65 - NCT07059481Recruiting
Root canal sealers and oxidative stress study
This study is looking at how different types of root canal filling materials (sealers) affect oxidative stress markers in the body. It is for people with a single tooth that has a chronic infection at the root tip and needs a root canal.
Ordu, Ordu- AltınorduAges 18–45 - NCT06587048Recruiting
New bone window surgery for root canal infections
This trial tests a new way to perform root-end surgery using a special ultrasound device. It aims to treat infections at the tip of a tooth root by making a small opening in the bone, which may help you heal faster.
Rohtak, HaryanaAges 18–60 - NCT06048042RecruitingPhase 4
Comparing tooth graft vs bone graft for gum disease bone loss
This trial tests if using a tooth that is removed (like a wisdom tooth) to fill deep gum pockets works as well as using a piece of your own bone. It may help rebuild the bone around a damaged tooth.
CairoAges 18–50 - NCT05442034RecruitingPhase 1/Phase 2
Two gum treatments for deep bone defects in teeth
This study tests whether one of two treatments can improve healing of “intra-bony” gum/bone defects around teeth after deep cleaning. It may help some people with periodontal disease who have pockets deep enough to involve the bone but with certain health and dental conditions.
Davie, FloridaAges 18 years+ - NCT07666100Recruiting
Study of medication side effects in a periodontology clinic
This study looks at side effects from medications prescribed in a gum disease clinic. It aims to understand what types of side effects patients experience, which can help doctors choose safer medicines.
SivasAges 16 years+ - NCT07107100Recruiting
Comparing two types of retainers after braces
This study compares two types of retainers (a wire that keeps teeth in place) after braces are removed: one that is directly bonded to the teeth and one that is made indirectly. It looks at which type keeps gums healthy, lasts longer, and how likely it is to break.
Karachi, SindhAges 13–40 - NCT07506993Recruiting
Inflammation in clear aligners with attachments
This study looks at gum inflammation in people using clear aligners with or without small attachments on their teeth. It may help understand how aligners affect oral health.
Lincoln, NebraskaAges 14–35 - NCT07527351Recruiting
Testing a laser imaging tool for gum health assessment
This study tests a new laser imaging technology that measures blood flow in gum tissue to see if it's accurate and reliable. Researchers want to understand if this tool could help dentists better assess gum health and healing after surgery.
Madrid, MadridAges 18 years+ - NCT07388901Recruiting
Comparing two root canal sealers for infection treatment
This trial compares two materials (iRoot SP and nRoot SP) used to fill root canals after infection. It aims to see which works better for healing apical periodontitis, an infection around the tooth root.
Hangzhou, ZhejiangAges 18 years+ - NCT06543004Recruiting
Comparing pain after root canal with two filling materials
This study is comparing two different materials used to fill the tooth after a root canal to see which one causes less pain afterward. If you need a root canal on a front tooth or a premolar and you don't have pain or swelling, this trial may help find the gentler option for you.
DohaAges 18–60 - NCT07256691Recruiting
Bioceramic vs. resin sealer for root canal pain
This study tests two types of sealing materials used in root canals (a newer bioceramic one vs. a standard resin one) to see which causes less pain after treatment. If you have an infected, pain-free tooth that needs a root canal, this trial may help guide better care.
Lahore, Punjab ProvinceAges 18–55 - NCT07030088Recruiting
Testing a new two-sided toothbrush for healthier gums
This trial tests a special toothbrush that cleans both sides of your teeth at once. It compares this new brush to a regular one to see if it improves gum health in dentists.
RiyadhAges 25–40 - NCT07198919Enrolling by invitationPhase 1/Phase 2
Pain relief during root canal for infected tooth: gel vs. antibiotic paste
This trial compares two medicines placed inside a tooth after root canal cleaning to see which reduces pain better between appointments. If you have an infected single-root tooth and are between 16-45 years old, you may be able to join.
Karachi, SindhAges 16–45 - NCT07722390Recruiting
Injection treatment for deep gum pockets
This study tests whether injecting a special substance made from your own blood can help treat deep gum pockets without surgery. It may be an option for people with advanced gum disease who have already had initial cleaning.
CairoAges Any age - NCT07327060Recruiting
Camera-Assisted Parent Training for Children's Teeth
This study tests whether teaching parents with a small intraoral camera can help improve their child's toothbrushing habits. It focuses on children ages 5–7 who have a new permanent molar coming in.
AydinAges 5–7 - NCT07611461Enrolling by invitation
How Dental Crowns Affect Gum Health Long-Term
This study follows patients who receive tooth-colored metal crowns to see how these dental restorations affect the health of gums and supporting tissues over time. Understanding this helps dentists place crowns in ways that keep your mouth healthiest.
Riga, Dzirciema Iela 20Ages 20–75 - NCT07555366Recruiting
Healing after tooth extraction: two treatment approaches
This study compares two treatments applied to the socket (the hole left after a tooth is removed) to help it heal better. One treatment uses a product called microRepair, and the other uses chlorhexidine, a common antimicrobial rinse. The goal is to see which helps the extraction site heal faster and with fewer problems.
Roma, RMAges 18–75 - NCT07734987Recruiting
Root tip surgery accuracy with a 3D-printed guide
This trial tests whether using a custom 3D-printed guide helps make root-end surgery more accurate and improves healing. It may be right for you if you have an infected or damaged root tip that needs surgery.
Ho Chi Minh CityAges 16 years+ - NCT07725913Recruiting
Gel for gum treatment after deep cleaning
This trial tests if a special gel placed in the gums after deep cleaning helps treat periodontitis (advanced gum disease). You may qualify if you have gum pockets of 5mm or deeper that bleed when probed.
Bologna, BOAges 18 years+ - NCT07718932Recruiting
Healing gel for wisdom tooth extraction recovery
This trial tests a regenerative gel placed in the socket after wisdom tooth removal to improve healing. It may reduce pain, swelling, and speed up recovery.
ThessalonikiAges 18–35 - NCT05763420Enrolling by invitation
Testing a bioceramic root-canal sealer in adult molar teeth
This trial tests how well a bioceramic sealer works for primary (first-time) root canal treatment in permanent back teeth. It may help by improving the chances that the treated tooth heals and stays functional.
Janūb as Surrah, Hawalli GovernateAges 18–65 - NCT07603934RecruitingEarly Phase 1
Testing Medications Inside Root Canals to Reduce Pain
This study tests different medications placed inside a tooth's root canal during treatment to see which one best reduces pain afterward. If you have a tooth with a dead nerve (necrotic pulp), this trial might help determine the best way to manage your pain during the healing process.
Cairo, Cairo GovernorateAges 18–40
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 281 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.