Clinical trials · Pennsylvania
Peripheral Arterial Disease clinical trials in Pennsylvania
We’re tracking 19 recruiting peripheral arterial disease studies with a site in Pennsylvania — including Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT07223593RecruitingPhase 3
Orforglipron for peripheral artery disease with leg pain
This trial tests a new oral medication called orforglipron to see if it can improve walking distance in people with peripheral artery disease (PAD) who have leg pain when walking. It may be a good option if you have PAD and your walking is limited by leg cramping, not other health issues.
Camp Hill, PennsylvaniaAges 18 years+ - NCT06182397Recruiting
Drug-coated balloon for leg artery blockages below the knee
This trial tests a special balloon coated with sirolimus (a drug that helps prevent arteries from re-closing) versus a standard balloon for opening blocked arteries below the knee in people with severe leg pain or foot wounds. The goal is to see if the drug-coated balloon works better to keep the artery open longer.
Philadelphia, PennsylvaniaAges 21 years+ - NCT05811364Recruiting
Stent versus bare-metal treatment for blocked leg arteries
This study compares a new balloon-expandable stent to standard bare-metal stenting to treat complex blockages in the iliac arteries (main blood vessels to the legs). It may help people with symptoms like leg pain with walking, pain at rest, or minor tissue injury by improving blood flow and reducing repeat procedures.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05916950Recruiting
Study of a new treatment for blocked leg arteries
This trial studies a device-based treatment approach for people with blocked (narrowed or fully blocked) arteries in the thigh or behind the knee that reduce blood flow to the leg. It may help improve blood flow and walking ability, but you must meet specific artery and imaging requirements.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06041880Recruiting
Calf Stretching for Better Walking in PAD
This study tests whether a simple daily calf-stretching routine can improve walking ability and blood flow in people with peripheral artery disease. It offers a non-drug, non-surgical approach that you can do at home.
University Park, PennsylvaniaAges 40–85 - NCT06686121RecruitingPhase 3
Improving walking after leg artery surgery for PAD
This trial tests whether drinking beetroot juice and doing home-based exercise can improve walking ability after you've had a procedure to open up blocked leg arteries. It's for people who are ready to start a walking program and want to avoid surgery.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07322913Recruiting
Study of Intervascular blood vessel grafts and patches
This study is collecting information from patients who have already had surgery to repair or replace blood vessels using Intervascular grafts or patches. Researchers will look at past medical records to see how well these devices work over time.
Hershey, PennsylvaniaAges 18 years+ - NCT01904851Recruiting
Registry for leg artery procedures and their outcomes
This study collects information about people who had a procedure to improve blood flow in certain leg arteries. It helps researchers understand which treatments work best and what outcomes to expect.
Philadelphia, PennsylvaniaAges Any age - NCT06542432Enrolling by invitation
Genetic risk test for heart disease prevention
This trial uses a polygenic risk score to see if knowing your genetic risk for coronary artery disease can help prevent a first heart attack. If you have an intermediate 10-year risk and no prior heart events, you may be eligible.
Philadelphia, PennsylvaniaAges 40–70 - NCT06315023Enrolling by invitation
A registry study for the DETOUR system
This study is collecting information from people who receive the DETOUR system, a treatment for blocked arteries. The goal is to see how well it works in real-world use.
Wynnewood, PennsylvaniaAges Any age - NCT06687590Recruiting
Serranator POINT FORCE registry for leg and dialysis access
This registry study is following patients whose blocked leg or dialysis access arteries are treated with a special balloon (Serranator) that helps open the vessel. The goal is to see how well the device works in real-world use.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06271590Recruiting
Drug-coated balloon for small heart artery blockages
This trial tests a special balloon coated with a drug (sirolimus) to treat blockages in small heart arteries. If the balloon is successful, it may help keep the artery open without needing a permanent stent.
Pittsburgh, PennsylvaniaAges 18–80 - NCT05313165Recruiting
Stent procedure for poor blood flow in the leg ulcers and gangrene
This trial tests a new minimally invasive procedure (placing a small stent) to improve blood flow to a severely threatened foot or lower leg. It may help people whose ulcers or gangrene are not treatable with standard bypass or other surgeries.
Hershey, PennsylvaniaAges 18–95 - NCT07232069RecruitingPhase 3
Early heart disease trial for women and men with mild plaque buildup
This trial tests whether two medicines, a statin and colchicine, can slow or stop early heart artery plaque from growing in people who have mild plaque but no heart disease symptoms yet. It uses special CT scans to measure plaque over 2 years.
Philadelphia, PennsylvaniaAges 30–60 - NCT07062471Recruiting
Shockwave balloon treatment for hardened carotid arteries before stenting
This study tests a special balloon that uses sound waves to break up calcium buildup in the carotid artery (the main artery in your neck) before placing a stent. It's for people who are at high risk for traditional surgery and have heavy calcium deposits in their artery.
Wynnewood, PennsylvaniaAges 18 years+ - NCT01524276Recruiting
Registry to track outcomes of Medtronic medical devices
This is a follow-up registry that collects information from people who have (or will receive) an eligible Medtronic device. It helps the company and doctors better understand how the device works in real-world use.
Allentown, PennsylvaniaAges Any age - NCT07521007RecruitingPhase 2
YN001 treatment for coronary artery disease
This study tests whether a new drug called YN001 can help people with coronary atherosclerosis (narrowing of heart blood vessels). The trial aims to see if it can improve outcomes in people who have early-stage blockages in their heart arteries.
Camp Hill, PennsylvaniaAges 18–80 - NCT00692939RecruitingPhase 1/Phase 2
Stem cell transplant for people with Crohn’s who need new options
This trial studies whether an “autologous” stem cell transplant (using your own cells) can improve Crohn’s disease that has not responded to standard treatments. It may help people who have ongoing, hard-to-control Crohn’s even after medicines and/or who have complications that make surgery risky.
Pittsburgh, PennsylvaniaAges 10–60 - NCT06615050RecruitingPhase 3
Comparing two drug combinations for stem cell transplant
This trial tests two different combinations of medicines to prevent graft-versus-host disease (when donor cells attack your body) after a stem cell transplant. The goal is to see which approach works better for people with certain blood cancers or lymphomas.
Philadelphia, PennsylvaniaAges 18 years+
Peripheral Arterial Disease trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting peripheral arterial disease studies listed above.
- University of Pennsylvania · 7 studies
- Capital Area Research, LLC · 2 studies
- Lankenau Institute for Medical Research · 2 studies
- Main Line Health NCORP · 2 studies
- Thomas Jefferson University Hospital · 2 studies
- University of Pittsburgh Medical Center · 2 studies
- Allegheny General Hospital
- Einstein Medical Center Philadelphia
What taking part in a peripheral arterial disease study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Peripheral Arterial Disease trials in other states
Common questions
- Are there peripheral arterial disease clinical trials in Pennsylvania?
- Yes. We're currently tracking 19 recruiting peripheral arterial disease studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a peripheral arterial disease study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a peripheral arterial disease trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New peripheral arterial disease studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.