Clinical trials
Phantom Limb Pain clinical trials
Below are recruiting phantom limb pain clinical trials, each written for real people, not researchers. We’re tracking 27 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT05009394Recruiting
Surgery options for long-term pain after limb amputation
This trial studies different surgical approaches to reduce persistent pain in the leftover part of an amputated limb. You may be able to join if your post-amputation pain has lasted more than a year and your pain level stays high despite stable pain treatments and prosthesis use.
Chicago, IllinoisAges 18 years+ - NCT05188183Recruiting
Remote brain stimulation plus hand training for phantom limb pain
This trial tests whether remote brain stimulation (tDCS) combined with sensory (hand/limb) training can reduce phantom limb pain. It also uses computer prediction (“machine learning”) to estimate who is most likely to benefit.
Cambridge, MassachusettsAges 18 years+ - NCT05716321Recruiting
Study of pain and function after limb amputation surgery
This study looks at pain and day-to-day functioning after someone has a limb removed due to surgery. The results may help doctors better understand what to expect and how to improve comfort and mobility after amputation.
Hershey, PennsylvaniaAges 18–89 - NCT06045936RecruitingPhase 4
Nerve block for phantom limb pain
This study tests whether a nerve block in the remaining part of your leg can help reduce phantom limb pain or pain in the residual limb. It is for people who have had an amputation more than a year ago and still have pain despite trying other treatments.
Mankato, MinnesotaAges 18 years+ - NCT06106984Recruiting
Home rehab for phantom limb pain in Veterans
This study tests a home-based rehab program for Veterans with phantom limb pain after a below-knee amputation. It uses telehealth to help you manage pain without needing to travel to a clinic.
Minneapolis, MinnesotaAges 18–89 - NCT06167330Recruiting
Titan trial: Reducing phantom limb pain
This trial tests a new method to reduce phantom limb pain (pain felt in a missing limb) using gentle electrical stimulation and simple mental exercises. It is for people with one-sided amputations who have had phantom limb pain for at least three months and still have pain episodes now.
Randwick, New South WalesAges 18 years+ - NCT06483035Recruiting
Treating phantom limb pain with visual simulation therapy
This study tests a computer-based therapy that uses visual exercises to help reduce phantom limb pain after amputation. If you have chronic pain in a missing limb, this treatment might offer relief without medication.
OsloAges 18 years+ - NCT06644807Recruiting
Neuromodulation for phantom limb pain after amputation
This trial tests a new approach to suppress phantom limb pain using neuromodulation methods. It may help people who have had a limb amputated and continue to experience persistent pain.
Moscow, MoscowAges 18–65 - NCT06702904Recruiting
Neuroprosthesis for phantom limb pain relief
This study tests a new type of artificial limb (neuroprosthesis) that sends signals back to your brain to help reduce phantom limb pain and improve your daily life. You may be able to join if you have had an arm or leg amputation at least 6 months ago and have persistent pain.
MoscowAges 18–65 - NCT06813937Recruiting
Magnetic stimulation for feeling in upper limb amputation
This study tests whether magnetic stimulation can improve sensation in people who have lost an upper limb. It may help restore feeling in the residual limb.
MoscowAges 18–65 - NCT07139483Recruiting
Preventing chronic phantom limb pain with mirror therapy and brain stimulation
This study tests whether combining mirror therapy (looking at a reflection of your healthy limb) with a gentle brain stimulation technique called tDCS can prevent phantom limb pain from becoming long-lasting. It is for people who recently had a limb amputated and are already starting to feel phantom pain.
Raanana, IsraelAges 18 years+ - NCT07276542RecruitingPhase 2/Phase 3
Ketamine for phantom limb pain: a six-month outpatient study
This study tests whether ketamine, given as an outpatient treatment, can reduce phantom limb pain over six months. You would come to a clinic for multiple ketamine sessions, with at least a week between each session, and be followed for a year.
Sacramento, CaliforniaAges 18–65 - NCT07324109Recruiting
Testing a system for phantom limb pain after leg amputation
This trial is testing a system called Suralis to see if it can help evaluate phantom limb pain — pain that feels like it's coming from a missing leg. It's for people who have had a leg amputated below or above the knee, use a prosthetic regularly, and have daily pain scoring at least 3 out of 10.
Wiesbaden, HesseAges 18 years+ - NCT07401966Recruiting
Amputation in childhood and nerve pain study
This study looks at nerve pain in children and teens who had an amputation before a certain age. It aims to understand how common and how severe this pain is after amputation, and uses simple questionnaires to find out.
Saint-MauriceAges 5–18 - NCT07420192Recruiting
A study on nerve surgery for pain after leg amputation
This trial tests a surgery called RPNI to treat painful nerve growths (neuromas) in people who have lost a leg. The goal is to reduce severe pain and improve the ability to use a prosthetic limb.
Ankara, AnkaraAges 18–70 - NCT07432685Enrolling by invitation
Can movement predict chronic pain after combat limb injuries?
This study is looking for people with combat-related arm or leg injuries to see if how they move can predict long-term pain. Researchers hope to better understand who might develop chronic pain and help improve treatment.
LvivAges 18–50 - NCT06956508Enrolling by invitation
VR therapy to prevent phantom limb pain after amputation
This study tests whether using virtual reality (VR) daily in the hospital after a major amputation can help prevent phantom limb pain. You'll use a VR headset to do simple exercises that may keep your brain from sending pain signals to the missing limb.
Charlotte, North CarolinaAges 13 years+ - NCT06719245Recruiting
Preventing post-amputation pain with targeted nerve surgery
This trial tests a surgical procedure called targeted muscle reinnervation (TMR) to prevent pain after a leg amputation. The goal is to see if rerouting nerves during amputation can reduce phantom limb pain or stump pain.
Amsterdam, North HollandAges 18–75 - NCT06840262Recruiting
Nerve surgery for pain after cancer amputation
This study tests two surgical techniques—target muscle re-innervation and regenerative peripheral nerve interfaces—alone or together, to help reduce pain felt in the remaining limb or the missing limb (phantom pain) after amputation for cancer. The goal is to find the best way to manage pain and improve quality of life.
Houston, TexasAges 18 years+ - NCT05766059Recruiting
Noninvasive brain stimulation to aid stroke or phantom limb pain rehab
This trial tests new, noninvasive brain stimulation techniques to help recovery after stroke weakness or after arm amputation with phantom limb pain. If you fit the type and timing of your condition, the study may help improve pain or hand/arm function without surgery.
Milan, LombardyAges 18–85 - NCT06077227Recruiting
Virtual reality for phantom limb pain
This study tests whether virtual reality therapy can help reduce phantom limb pain or uncomfortable sensations after amputation. If you have a major limb amputation and feel pain or other sensations in the missing limb, this might be an option to try.
Charlotte, North CarolinaAges 18 years+ - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT07044323Recruiting
Virtual reality for phantom limb pain after leg amputation
This study tests whether using virtual reality at home for 30 minutes a day can reduce phantom limb pain after a leg amputation. It aims to improve how your brain handles pain signals.
Philadelphia, PennsylvaniaAges 18–100
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Common questions
- Are there clinical trials for phantom limb pain?
- Yes. Clin2 currently lists 27 recruiting phantom limb pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a phantom limb pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a phantom limb pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.