Clinical trials
Phase 1 clinical trials
Below are recruiting phase 1 clinical trials, each written for real people, not researchers. We’re tracking 285 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06784193RecruitingPhase 1
Study of OP-3136 for advanced solid tumors
This trial tests a new drug, OP-3136, alone or with other drugs, for people with advanced breast cancer, prostate cancer, or lung cancer that has stopped responding to other treatments. It aims to see if OP-3136 is safe and effective.
Sarasota, FloridaAges 18 years+ - NCT06786676RecruitingPhase 1
Safety study of AS-S603 in healthy volunteers
This trial tests a new drug called AS-S603 in healthy volunteers to see if it is safe and how the body processes it. It is an early-phase study for people of Korean or Caucasian background.
SeoulAges 19–85 - NCT06789172RecruitingPhase 1
New drug OKN4395 with or without pembrolizumab for solid tumors
This trial tests a new oral drug called OKN4395, which targets a COX2-related immune pathway, alone or with the immunotherapy pembrolizumab, in people with advanced solid tumors. It may be an option if you have certain types of cancer that have stopped responding to other treatments.
Beverly Hills, CaliforniaAges 18 years+ - NCT06799026RecruitingPhase 1
Vaccine plus elranatamab for advanced multiple myeloma
This trial tests a personalized vaccine made from your own immune cells (dendritic cells) mixed with myeloma cells, given together with a drug called elranatamab. It is for people with multiple myeloma that has not responded to at least three prior treatments.
Boston, MassachusettsAges 18 years+ - NCT06800729RecruitingPhase 1
Testing safety of TIX100 in healthy volunteers
This phase 1 study tests an experimental drug called TIX100 in healthy volunteers to check its safety and how the body processes it. The results will help determine if the drug can be studied in future trials for conditions like obesity or metabolic disorders.
Chula Vista, CaliforniaAges 18–70 - NCT06828393RecruitingPhase 1
Study of S-1117 in healthy volunteers
This study tests a new medicine called S-1117 in healthy volunteers to see how safe it is and how it works in the body. It is a first-in-human trial that helps researchers learn about the medication before testing it in people with a condition.
Adelaide, South AustraliaAges 18–65 - NCT06864884RecruitingEarly Phase 1
Study of ARC-001 for wisdom teeth removal
This trial tests a new medicine called ARC-001 in people who are scheduled to have their wisdom teeth taken out. The goal is to see if it's safe and how it affects pain and healing.
Salt Lake City, UtahAges 18–55 - NCT06872866RecruitingPhase 1
Study of sildenafil with and without food in healthy men
This study looks at how taking the study drug Hezkue Turbo (sildenafil) with food affects its levels in the body compared to taking it on an empty stomach. Healthy male volunteers aged 20 to 70 can participate.
New York, New YorkAges 20–70 - NCT06877611RecruitingPhase 1
Testing the drug S-4321 in healthy volunteers for safety
This trial tests a new drug called S-4321 to make sure it's safe and well-tolerated in healthy people. You would take the drug and have regular check-ups to see how your body handles it.
Bayswater, VictoriaAges 18–65 - NCT06916767RecruitingPhase 1
Study of BAFF CAR-T cells for CLL or SLL
This trial tests a new type of immune cell therapy (BAFF CAR-T cells) for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or not responded after at least two prior treatments, including a BTK inhibitor and a BCL2 inhibitor. The goal is to see if these engineered cells can fight the cancer.
Cleveland, OhioAges 18 years+ - NCT06934941RecruitingPhase 1
Single dose safety study of NM-101 in healthy men
This trial tests a single dose of a new medication (NM-101) in healthy male volunteers to see how the body handles it and if it's safe. It is a phase 1 study that requires you to be in good health and have no major medical conditions.
SeoulAges 18–60 - NCT06950034RecruitingPhase 1
Testing STX-0712 for advanced CMML or AML
This early-phase study tests a new drug called STX-0712 for people with certain types of blood cancers (CMML or AML) that have not responded to standard treatments. The goal is to see if the drug is safe and can help shrink or control the cancer.
Stanford, CaliforniaAges 18 years+ - NCT06989840RecruitingPhase 1
Safety study of TVB-3567 for acne
This early-stage study tests a new drug called TVB-3567, which may help treat acne. It checks the drug's safety and how the body processes it, first in healthy people and then in people with moderate to severe acne.
Tempe, ArizonaAges 18–55 - NCT06997029RecruitingPhase 1
Study of BMS-986500 for advanced solid tumors
This trial tests a new drug called BMS-986500, alone or with other treatments, for people with advanced solid tumors that cannot be removed by surgery or have spread. It aims to see if the drug is safe and effective.
Birmingham, AlabamaAges 18 years+ - NCT07029932RecruitingPhase 1
Testing the safety of multiple doses of BWC0977 in healthy people
This study tests an experimental antibiotic called BWC0977 to see if it is safe and well-tolerated when given as single and multiple doses. It is for healthy volunteers to understand how the drug behaves in the body before moving to patient trials.
Melbourne, VictoriaAges 18–55 - NCT07066397RecruitingPhase 1
CAR-T cell therapy for relapsed B-cell ALL
This trial tests a new CAR-T cell therapy (FIT-CD19-CAR-T) for adults with B-cell acute lymphoblastic leukemia that has come back or not responded to treatment. The goal is to see if this treatment is safe and can help control the leukemia.
TaipeiAges 18 years+ - NCT07076550RecruitingPhase 1
Radioactive drug for advanced melanoma
This trial tests a new radioactive drug (A9-3408) for people with advanced melanoma that has not responded to standard treatments. The drug is designed to target and destroy melanoma cells. The study is early phase, so it is mainly checking safety and how well the drug works.
Melbourne, VictoriaAges 18 years+ - NCT07081503RecruitingPhase 1
Testing ADX-626 in healthy adults
This study tests a new investigational drug called ADX-626 in healthy volunteers for the first time in humans. The goal is to see how the drug is processed by the body and whether it is safe, helping to decide if it can be studied in future patients.
LondonAges 18–45 - NCT07081555RecruitingPhase 1
Testing a new radioactive drug for HER2-positive advanced breast cancer
This trial tests a new radioactive drug, [177Lu]Lu-ABY-271, to see how safe it is and where it goes in the body. It is for people with HER2-positive breast cancer that has spread and cannot be removed by surgery.
GothenburgAges 18 years+ - NCT07085676RecruitingPhase 1
CAR-T cell therapy for autoimmune diseases that resist treatment
This study tests a new cell therapy called CAR-T (using your own immune cells) for people with severe autoimmune diseases like lupus, scleroderma, or myositis that have not improved with standard treatments. The goal is to see if it can safely reduce disease activity.
JerusalemAges 18–80 - NCT07100873RecruitingPhase 1
Testing a new drug for rheumatoid arthritis
This trial tests a new medication called ADI-001 to see if it can help people with rheumatoid arthritis. It is for adults who meet the standard criteria for RA and are in generally good health otherwise.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07137338RecruitingPhase 1
Gene therapy for BAG3-related dilated cardiomyopathy
This trial tests a one-time gene therapy called RP-A701 for people with dilated cardiomyopathy caused by a BAG3 gene mutation. The goal is to see if it is safe and can improve heart function.
San Diego, CaliforniaAges 18–65 - NCT07157033RecruitingPhase 1/Phase 2
Testing XER-001 with radiation for advanced pancreatic cancer
This trial tests a new way to deliver a drug called amifostine (XER-001) alongside intense radiation therapy (SBRT) for people with locally advanced pancreatic cancer that can't be surgically removed. The goal is to see if it's safe and effective at protecting healthy tissue while targeting the tumor.
Duarte, CaliforniaAges 18 years+ - NCT07167693RecruitingPhase 1/Phase 2
Testing arginine for diabetic ketoacidosis in type 2 diabetes
This trial tests if an IV medicine called arginine hydrochloride can help manage diabetic ketoacidosis (DKA) in people with type 2 diabetes. It's for those who come to the ER with very high blood sugar and ketones.
Detroit, MichiganAges 18 years+
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Common questions
- Are there clinical trials for phase 1?
- Yes. Clin2 currently lists 285 recruiting phase 1 studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a phase 1 trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a phase 1 trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.