Clinical trials
Placebo - Control clinical trials
Below are recruiting placebo - control clinical trials, each written for real people, not researchers. We’re tracking 3,904 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03954899Recruiting
Melatonin test for brain health in older adults
This study tests whether taking 5 mg of melatonin can improve thinking and brain health over time in older adults with early, mild symptoms. You may help researchers learn which brain changes and measures improve with melatonin.
Iowa City, IowaAges 56–85 - NCT03972124RecruitingPhase 2
Cannabis to prevent migraine attacks before they start
This Phase 2 trial tests whether using cannabis can prevent migraine attacks from happening. It specifically looks at people with chronic migraine who have tried and not benefited from other prevention medicines.
Calgary, AlbertaAges 25 years+ - NCT03947450RecruitingPhase 2
Injection of your own skin cells into below-knee amputation site
This Phase 2 study tests whether injecting a patient’s own fibroblast cells (skin-support cells) into the wound area after a below-knee amputation can help the stump skin heal and work better. It’s intended for people who already have (or are close to having) a prosthetic fitting.
Baltimore, MarylandAges 18–65 - NCT03835767RecruitingPhase 2
Predicting food allergy from blood IgE levels in eczema patients
This study looks for blood test patterns that may predict whether a child with eczema (atopic dermatitis) is likely to have a food allergy. If you join, you may do supervised oral food challenges with a placebo and the suspected foods to see what triggers symptoms.
Bethesda, MarylandAges 3–21 - NCT03769766RecruitingPhase 3
Curcumin to help keep low-risk prostate cancer from worsening
This study tests whether curcumin (a supplement made from turmeric) can prevent low-risk prostate cancer from progressing while you stay on active surveillance. If you qualify, you would take curcumin and be monitored closely with regular checkups.
Dallas, TexasAges 40–89 - NCT03736538Enrolling by invitationPhase 1
Nitrous oxide for suicidal thoughts in depression
This Phase 1 study tests whether breathing nitrous oxide can safely reduce suicidal thoughts in adults with major depression. It may help people whose depression is causing moderate to severe suicidal thinking, by studying a fast-acting treatment approach.
St Louis, MissouriAges 18–65 - NCT03843463RecruitingPhase 2
Escitalopram plus language therapy after left stroke
This trial tests whether the antidepressant medicine escitalopram, along with language therapy, can improve language skills after a recent stroke that affected the left side of the brain. It may help some people with stroke-related aphasia (language difficulty) regain words and communication.
Baltimore, MarylandAges 18–99 - NCT03819608Recruiting
Brain stimulation and rehab after mild concussion with PTSD or cognitive issues
This trial studies whether brain stimulation plus targeted brain rehabilitation can improve symptoms after a mild concussion (mTBI). You may be invited if your concussion happened at least 3 months ago and your symptoms are affecting thinking or mood, with or without PTSD.
Chicago, IllinoisAges 18–80 - NCT03860233RecruitingPhase 1
Oxytocin added to CPAP for obstructive sleep apnea
This early study tests whether adding oxytocin to your usual CPAP treatment improves obstructive sleep apnea. It may help see if oxytocin changes how well CPAP works or how people feel while using it.
Washington D.C., District of ColumbiaAges 18 years+ - NCT03865290RecruitingPhase 2
Ondansetron for stomach nerve and motion problems in diabetes
This trial tests whether ondansetron can improve stomach “sensorimotor” problems—how the gut senses food and moves it—especially in people with diabetes and troubling indigestion. It may help reduce symptoms like early fullness, nausea, and discomfort after eating.
Rochester, MinnesotaAges 18–75 - NCT03783416RecruitingPhase 1
Ixazomib safety study for people with multiple sclerosis
This early-phase study tests how safe ixazomib is for people with multiple sclerosis (MS). It focuses on targeting certain immune cells in MS and checks whether the treatment can be given safely.
London, Greater LondonAges 18–65 - NCT03866408RecruitingEarly Phase 1
Testing how insulin affects fat breakdown proteins
This early study looks at how insulin changes the body’s fat breakdown and related proteins. You might join if you’re within a certain body-weight range and can safely take the study medication.
Rochester, MinnesotaAges 18–55 - NCT03875378RecruitingPhase 2
Transdermal estrogen treatment for anorexia-related bone loss
This trial studies whether estrogen delivered through the skin can help improve bone health in women with anorexia nervosa. It may be considered if your body weight is low and you have signs of bone thinning.
Pittsburgh, PennsylvaniaAges 19–45 - NCT03552705RecruitingPhase 2
Tranexamic acid to reduce knee inflammation after ACL injury
This Phase 2 study tests whether tranexamic acid can reduce swelling and protect knee cartilage after an ACL injury. It may help by limiting bleeding-related inflammation in the injured joint soon after injury.
Stanford, CaliforniaAges 18–30 - NCT03621553RecruitingPhase 4
Vitamin D balance study in people with sarcoidosis
This Phase 4 study looks at how your body keeps vitamin D levels balanced in sarcoidosis. It may help researchers understand what affects calcium and vitamin D in sarcoidosis, and guide safer care.
Dallas, TexasAges 21 years+ - NCT03675724Enrolling by invitationPhase 2
Fisetin for frailty and inflammation in older adults
This trial studies whether fisetin, a supplement-like drug, can reduce frailty and inflammation in people age 70 and older. It may help improve health measures related to aging, but you must meet several safety and medication rules to join.
Rochester, MinnesotaAges 70 years+ - NCT03553186RecruitingPhase 3
Tranexamic acid to reduce bleeding in spine surgery
This Phase 3 trial tests whether tranexamic acid can reduce bleeding during major spine fusion surgery for adults with scoliosis or spine degeneration. It may help lessen blood loss and the need for transfusions, while monitoring safety.
New York, New YorkAges 18–80 - NCT03406611RecruitingPhase 1/Phase 2
Enzyme replacement for classical homocystinuria in children
This study tests a new enzyme replacement therapy called pegtibatinase for children with classical homocystinuria (HCU). The enzyme helps break down homocysteine, which may lower its levels in the blood and reduce symptoms.
Aurora, ColoradoAges 5–65 - NCT03407079RecruitingPhase 2
Study of sucralose’s effects on digestion of drugs
This study tests whether the sugar substitute sucralose changes how your body absorbs and breaks down certain medicines. You’d take sucralose or a placebo for 4 weeks, visit the clinic, and complete required samples and medicine doses during visits.
Bethesda, MarylandAges 18–60 - NCT03418038RecruitingPhase 2
Vitamin C with chemotherapy for lymphoma and blood disorders
This trial tests whether adding high-dose vitamin C (ascorbic acid) to standard chemotherapy helps treat lymphomas that have come back or not responded, as well as two related blood disorders (CCUS and CMML). The goal is to see if the vitamin C makes the chemo work better.
Mankato, MinnesotaAges 18 years+ - NCT03430037Enrolling by invitationPhase 2
Fisetin study to reduce frailty and inflammation in older women
This Phase 2 trial tests whether fisetin, a supplement, can reduce frailty and inflammation in postmenopausal women age 70 and older. If it works, it may help older adults feel stronger and have healthier body signals related to aging and inflammation.
Rochester, MinnesotaAges 70 years+ - NCT03338387Enrolling by invitationPhase 2
Test effects of gut hormones in bulimia
This trial studies how growth-related and gut hormones affect ghrelin, a hunger-related hormone, in people with bulimia. It may help researchers understand the body changes behind bulimia and how hormones and appetite signals work.
Ages 18–30 - NCT03368092RecruitingPhase 3
Inhaled medication to prevent lung failure after severe trauma
This trial tests whether inhaled dornase alfa can reduce the risk of respiratory (lung) failure in adults with severe trauma who are on a breathing machine in the ICU. If it works, it may help patients spend less time with dangerous breathing complications.
StrasbourgAges 18 years+ - NCT03438526RecruitingPhase 4
Melatonin treatment for low-activity delirium in ICU patients
This trial tests whether giving melatonin (or a placebo) can help adults in the intensive care unit who have a specific type of confusion called low-activity delirium. It aims to improve recovery by supporting sleep–wake regulation in the ICU.
BaselAges 55 years+
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Common questions
- Are there clinical trials for placebo - control?
- Yes. Clin2 currently lists 3,904 recruiting placebo - control studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a placebo - control trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a placebo - control trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.