Clinical trials
pMMR/MSS Adenocarcinoma of the Colon or Rectum clinical trials
Below are recruiting pmmr/mss adenocarcinoma of the colon or rectum clinical trials, each written for real people, not researchers. We’re tracking 115 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06293625RecruitingPhase 3
Chemotherapy before surgery for colon cancer in older adults
This trial tests whether giving 6 weeks of chemotherapy (FOLFOX) before surgery can help people aged 70 and older with locally advanced colon cancer. It aims to make treatment safer and more effective for older adults.
DijonAges 70 years+ - NCT07534852Recruiting
Nutrition and exercise support for colon cancer surgery patients
This study tests whether nutrition support and exercise help patients with early-stage colon cancer recover better after surgery. Researchers will provide dietary guidance and a supervised exercise program tailored to your needs.
Málaga, MalagaAges 18–75 - NCT04674267Recruiting
REACH study for older adults with GI cancer and support needs
This study looks at how to improve health and care support for people age 70 and older with gastrointestinal (GI) cancer. It may help by offering a structured way to address practical and emotional challenges that can affect aging and cancer care.
Boston, MassachusettsAges 70 years+ - NCT04756453Recruiting
Tested clip traction during endoscopy to remove colon polyps faster
This study looks at whether using small clips (called clip-traction) helps doctors remove colon or rectum lesions using a technique called ESD more quickly. If you have a suitable lesion, this may help shorten the procedure time while still aiming for complete removal.
StockholmAges 18–95 - NCT05476263Recruiting
Negative pressure wound therapy for esophagus or rectum
This trial studies whether a device called Suprasorb CNPendo helps healing of certain full-thickness (through-and-through) injuries or wounds in the esophagus or rectum. It may be an option if your medical team is already considering negative pressure wound therapy for these specific problems.
BerlinAges 18 years+ - NCT06369610RecruitingPhase 2
Less hormone therapy with radiation for prostate cancer
This trial tests whether some men with high-risk prostate cancer can safely receive less hormone therapy when combined with radiation. It aims to reduce side effects while still effectively treating the cancer.
Scottsdale, ArizonaAges 18 years+ - NCT06317727Recruiting
Pulsed field ablation for removing colon polyps
This study tests a new way to remove colon polyps using short bursts of energy (pulsed field ablation) instead of standard methods. It may help people with polyps in the lower part of the colon that are not too large or complex.
LondonAges 18 years+ - NCT07535112RecruitingPhase 1
Testing BAY 3771249 for Advanced Colorectal Cancer With KRAS Mutation
This early-stage study tests a new drug called BAY 3771249 in people with advanced colorectal cancer that has a specific genetic change (KRAS G12D mutation). Researchers want to learn if it's safe and whether it helps shrink tumors.
Phoenix, ArizonaAges 18 years+ - NCT04815694Recruiting
MRI-guided radiotherapy for rectal cancer
This trial tests whether using MRI scans to guide radiotherapy can improve treatment for people with a certain type of rectal cancer. It focuses on patients whose tumors have not spread to other parts of the body and who have specific tumor features seen on MRI.
Roma, RomaAges 18 years+ - NCT07467980Recruiting
Measuring oxygen in the colon during bowel surgery
This study tests a new way to measure oxygen levels inside the colon during surgery, right after the surgeon reconnects the bowel. It may help doctors see if the new connection is healing well.
Nashville, TennesseeAges 18 years+ - NCT05912075RecruitingPhase 1
New pre-surgery radiation plus ASTX660 for rectal cancer
This early-phase trial tests adding ASTX660 (a new drug) to pre-surgery radiation for locally advanced rectal cancer. It aims to improve control of the tumor before surgery, making it more likely that the surgeon can remove it with clear margins.
Lyon, RhöneAges 18 years+ - NCT07026422RecruitingPhase 2
Combination immunotherapy with chemoradiation for high-risk rectal cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus standard chemotherapy and radiation before surgery for people with a specific type of high-risk rectal cancer. The goal is to see if adding these drugs can improve treatment results.
Jinan, ShandongAges 18–75 - NCT04999761RecruitingPhase 1
Study testing new drug combinations for advanced cancers
This study tests new drug combinations for people with various advanced cancers that have progressed after standard treatment, or in some cases, as a first treatment. It aims to see if these combinations are safe and effective. The study is divided into groups based on cancer type and treatment history, so not everyone will qualify for every group.
AichiAges 18 years+ - NCT07283939Recruiting
Testing a tool to adjust chemo doses and reduce treatment delays
This trial tests a computer algorithm called PAGODA that helps doctors adjust chemotherapy doses for people with gastrointestinal cancers. The goal is to prevent unplanned treatment delays while keeping the treatment effective.
Fairbanks, AlaskaAges 18 years+ - NCT06238713Recruiting
New vs. standard robotic prostate surgery for early cancer
This study compares two ways of doing robot‑assisted prostate removal surgery. It aims to see if a newer, less invasive method through a single small cut is as safe and effective as the standard method. If you have early‑stage prostate cancer and are eligible, you could help improve surgical recovery.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07124000Recruiting
T-DXd for advanced HER2-positive solid tumors
This trial is for people with advanced HER2-positive solid tumors (cancers that cannot be removed by surgery or have spread). It tests the drug T-DXd (also called Enhertu) when your doctor has already decided it's the right treatment for you and you have no other good options.
Birmingham, AlabamaAges 18–130 - NCT07489820Recruiting
Vacuum dressing for healing after rectal cancer surgery
This trial is testing whether a special vacuum-type wound dressing (called negative pressure therapy) helps the surgical area heal better after removal of the rectum and anus for rectal cancer. If you've had chemotherapy and radiation before surgery, this study may help improve your recovery.
AmiensAges 18 years+ - NCT03616041Recruiting
Capsule camera test for severe rectal bleeding
This trial tests a swallowable camera (capsule endoscopy) to look inside the gut in people with severe ongoing rectal bleeding. It may help doctors find the bleeding source when symptoms are serious and blood counts are dropping.
Los Angeles, CaliforniaAges 18 years+ - NCT03908684Recruiting
Ultrasound tests to predict early response to prostate and head/neck radiation
This study uses special ultrasound imaging to look for early signs of how well radiation treatment is working in prostate, rectum, and head/neck cancers. It may help doctors spot response sooner and adjust care earlier if needed.
Toronto, OntarioAges Any age - NCT04006951Recruiting
Registry study for people with rectal cancer in Montpellier
This is a hospital-based study that builds a clinical and biological database for people treated for rectal cancer at the Montpellier Cancer Institute. It helps researchers organize health information to better understand rectal cancer and improve future care.
MontpellierAges 18 years+ - NCT04095299RecruitingPhase 3
Standard vs high-dose radiotherapy for rectal cancer
This Phase 3 trial compares standard-dose and higher-dose radiotherapy given along with chemotherapy in people with rectal cancer. The goal is to see whether a higher dose can improve rectal cancer outcomes while keeping the rectum functioning and avoiding too much harm.
AalborgAges 18 years+ - NCT04109755RecruitingPhase 2
Pembrolizumab plus radiation before surgery for rectal cancer
This trial tests whether giving pembrolizumab (an immunotherapy medicine) together with short-course radiation before surgery helps people with localized rectal cancer. It is mainly for tumors that are microsatellite stable (MSS).
GenevaAges 18 years+ - NCT04527861Recruiting
Minimally invasive single-incision surgery for colon cancer
This trial compares a single-incision laparoscopic operation versus the usual laparoscopic operation for colorectal (colon or “high rectum”) cancer. It looks at cancer outcomes and may help determine which approach is safer and works better for the right patients.
Lanzhou, GansuAges 18–85 - NCT04570943RecruitingPhase 2
Pancreatic cancer treatment: chemo first, then targeted MRI-guided radiation
This Phase 2 trial tests giving specific chemotherapy in sequence, then using MRI-guided focused radiation to treat locally advanced, non-removable pancreatic cancer. It may help shrink or control the tumor while aiming radiation more precisely using MRI.
Marseille, Bouches-du-RhôneAges 18–75
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Common questions
- Are there clinical trials for pmmr/mss adenocarcinoma of the colon or rectum?
- Yes. Clin2 currently lists 115 recruiting pmmr/mss adenocarcinoma of the colon or rectum studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pmmr/mss adenocarcinoma of the colon or rectum trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pmmr/mss adenocarcinoma of the colon or rectum trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.