Clinical trials
pMMR/MSS Adenocarcinoma of the Colon or Rectum clinical trials
Below are recruiting pmmr/mss adenocarcinoma of the colon or rectum clinical trials, each written for real people, not researchers. We’re tracking 107 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04109755RecruitingPhase 2
Pembrolizumab plus radiation before surgery for rectal cancer
This trial tests whether giving pembrolizumab (an immunotherapy medicine) together with short-course radiation before surgery helps people with localized rectal cancer. It is mainly for tumors that are microsatellite stable (MSS).
GenevaAges 18 years+ - NCT05112016Recruiting
Study of surgery outcomes after rectal cancer
This study follows people who had surgery for rectal cancer to understand long-term recovery and quality of life. You may be asked to complete questionnaires before surgery and again after the stoma is reversed, and your answers help researchers improve care.
Winterthur, Canton of ZurichAges 18 years+ - NCT04527861Recruiting
Minimally invasive single-incision surgery for colon cancer
This trial compares a single-incision laparoscopic operation versus the usual laparoscopic operation for colorectal (colon or “high rectum”) cancer. It looks at cancer outcomes and may help determine which approach is safer and works better for the right patients.
Lanzhou, GansuAges 18–85 - NCT05202314Recruiting
Camrelizumab plus chemo after stent for left bowel cancer
This study tests whether adding camrelizumab (an immune therapy) to chemotherapy—after a stent is placed to open a blocked left-sided colon—improves outcomes. It’s meant for people whose cancer can still be removed with surgery after the blockage is treated.
Beijing, Beijing MunicipalityAges 18–80 - NCT06116019Recruiting
Online adaptive radiotherapy for cancer patients
This trial tests a new radiation therapy machine that adjusts the radiation plan in real-time based on changes in your body. It may help make treatment more precise and reduce side effects.
BerlinAges 18 years+ - NCT03908684Recruiting
Ultrasound tests to predict early response to prostate and head/neck radiation
This study uses special ultrasound imaging to look for early signs of how well radiation treatment is working in prostate, rectum, and head/neck cancers. It may help doctors spot response sooner and adjust care earlier if needed.
Toronto, OntarioAges Any age - NCT04936581Recruiting
Quality of life after rectal cancer surgery
This study looks at patient-reported outcomes—how you feel and function—after surgery for rectal cancer. It may help doctors better understand recovery and well-being after different surgical approaches and treatments.
MadridAges 18–100 - NCT05912075RecruitingPhase 1
New pre-surgery radiation plus ASTX660 for rectal cancer
This early-phase trial tests adding ASTX660 (a new drug) to pre-surgery radiation for locally advanced rectal cancer. It aims to improve control of the tumor before surgery, making it more likely that the surgeon can remove it with clear margins.
Lyon, RhöneAges 18 years+ - NCT06057350Recruiting
Surgery versus endoscopy for early colon cancer with uncertain margins
This trial compares surgery versus an endoscopic procedure for people who had a colon polyp removed but some cancer cells may still be present at the edges. The goal is to see which approach leads to better outcomes and fewer side effects for early-stage colon cancer.
Oslo, AkershusAges 40 years+ - NCT06337760Recruiting
Young Adults with Digestive and Neuroendocrine Cancers
This trial studies treatments for young adults (ages 18-39) with cancers of the digestive system or neuroendocrine tumors. It aims to find better ways to help this age group, no matter the cancer stage or grade.
MilanAges 18–39 - NCT05927584Recruiting
Local removal for early rectal cancer without extra treatment
This trial studies removing an early rectal cancer tumor locally (through the rectum/anal area) with no additional therapy afterward. The goal is to preserve organs and maintain quality of life while still trying to cure the cancer.
MadridAges 18 years+ - NCT02292641Recruiting
MRI study for repeat pelvic colorectal cancer
This study uses a special MRI to help understand and stage colorectal cancer that has come back in the pelvis. The goal is to improve how doctors make treatment decisions after previous surgery.
OsloAges 16 years+ - NCT05436054RecruitingPhase 4
Plenvu vs Picoprep bowel prep for colonoscopy
This study compares two bowel-cleansing products (Plenvu and Picoprep) to see which works better and is easier to tolerate before a colonoscopy. It may help patients by improving the chance of a clear exam and reducing unpleasant side effects.
Aalborg, North JutlandAges 18 years+ - NCT06631443Recruiting
Asian Watch-and-Wait Study for Rectal Cancer
This study is for people with rectal cancer who have had treatment like radiation or chemo and their tumor has disappeared or nearly disappeared. Instead of surgery right away, doctors will closely monitor the cancer with regular check-ups to make sure it stays gone.
Mumbai, MaharashtraAges 18 years+ - NCT07589205RecruitingPhase 1
Testing IBI3028 for Advanced Solid Tumors
This early-stage trial tests a new drug called IBI3028 in people with advanced cancers that cannot be removed by surgery or have spread. The study aims to find the right dose and understand how the drug works in your body.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07535112RecruitingPhase 1
Study of a new drug for advanced colorectal cancer with KRAS G12D mutation
This trial tests an experimental drug (BAY 3771249) for people with advanced or metastatic colorectal cancer that has a specific genetic change called KRAS G12D. The goal is to see if the drug is safe and if it can help shrink tumors.
Phoenix, ArizonaAges 18 years+ - NCT07489820Recruiting
Vacuum dressing for healing after rectal cancer surgery
This trial is testing whether a special vacuum-type wound dressing (called negative pressure therapy) helps the surgical area heal better after removal of the rectum and anus for rectal cancer. If you've had chemotherapy and radiation before surgery, this study may help improve your recovery.
AmiensAges 18 years+ - NCT07467980Recruiting
Measuring oxygen in the colon during bowel surgery
This study tests a new way to measure oxygen levels inside the colon during surgery, right after the surgeon reconnects the bowel. It may help doctors see if the new connection is healing well.
Nashville, TennesseeAges 18 years+ - NCT06793137RecruitingPhase 2
Antibiotics before surgery for advanced rectal cancer
This trial tests if taking antibiotics before standard treatment can improve outcomes for people with advanced rectal cancer that requires surgery.
São Paulo, São PauloAges 18 years+ - NCT06805045Recruiting
Image-guided surgery for rectal cancer
This trial uses special imaging to guide surgery for rectal cancer. It studies whether detailed scans taken before surgery can help doctors remove the cancer more precisely.
BolognaAges 18–80 - NCT04006951Recruiting
Registry study for people with rectal cancer in Montpellier
This is a hospital-based study that builds a clinical and biological database for people treated for rectal cancer at the Montpellier Cancer Institute. It helps researchers organize health information to better understand rectal cancer and improve future care.
MontpellierAges 18 years+ - NCT06812728RecruitingPhase 2
Chemo and radiation before surgery for advanced rectal cancer
This trial tests giving a strong chemotherapy combination (FOLFIRINOX) followed by radiation before surgery for locally advanced rectal cancer. If you have stage 3 or high-risk stage 2 rectal cancer that has not spread, this approach may shrink the tumor and improve outcomes.
Shibīn al Kawm, MenoufiaAges 18–70 - NCT07283939Recruiting
Testing a tool to adjust chemo doses and reduce treatment delays
This trial tests a computer algorithm called PAGODA that helps doctors adjust chemotherapy doses for people with gastrointestinal cancers. The goal is to prevent unplanned treatment delays while keeping the treatment effective.
Fairbanks, AlaskaAges 18 years+ - NCT07245095RecruitingPhase 2
Pre-medication for better views during upper endoscopy
This trial tests whether taking two medicines (N-acetylcysteine and simethicone) before an upper endoscopy helps the doctor see the stomach lining more clearly. It may be an option for people having their first endoscopy, without active bleeding.
Mexicali, Estado de Baja CaliforniaAges 18–99
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Common questions
- Are there clinical trials for pmmr/mss adenocarcinoma of the colon or rectum?
- Yes. Clin2 currently lists 107 recruiting pmmr/mss adenocarcinoma of the colon or rectum studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pmmr/mss adenocarcinoma of the colon or rectum trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pmmr/mss adenocarcinoma of the colon or rectum trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.