Clinical trials
Posttraumatic Stress clinical trials
Below are recruiting posttraumatic stress clinical trials, each written for real people, not researchers. We’re tracking 102 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06210711Recruiting
Prolonged exposure therapy for trauma injury patients
This study tests if prolonged exposure therapy can help people who were injured in a trauma and admitted to a Level I trauma center. It aims to reduce the psychological impact of the traumatic event, such as PTSD symptoms.
Dallas, TexasAges 18–75 - NCT06219408Recruiting
Stepped care for chronic pain and PTSD
This study tests a stepped-care program that combines complementary health approaches for people who have both chronic pain and PTSD. It aims to help patients manage both conditions together using treatments like acupuncture, massage, or mind-body therapy.
Seattle, WashingtonAges 18 years+ - NCT06127342Recruiting
Exercise and emotional learning for PTSD
This study tests whether exercise can help people with PTSD learn to feel safer in their bodies. You will do some exercise sessions and emotional learning tasks, and have an MRI brain scan to see how your brain changes.
Lexington, KentuckyAges 18–64 - NCT06094933Recruiting
Mobile anger reduction for veterans with PTSD
This study tests a mobile app that helps veterans with PTSD manage anger. If you often feel angry or irritable, this app might help you learn ways to feel calmer and more in control.
Durham, North CarolinaAges Any age - NCT06093906Recruiting
Positive processes and transition to health (PATH) study
This study tests a new therapy that may help people recover after a stressful life event. Over about 6 weeks, you'll work with a coach to retrain your brain's patterns and feel more in control again, as well as reconnect with positive activities.
Newark, DelawareAges 18–65 - NCT06047691Recruiting
Couples therapy for veterans with PTSD
This study compares two types of couples counseling for military couples where one partner has PTSD. It aims to see if intensive couples therapy improves relationships and PTSD symptoms better than a relationship education program.
San Antonio, TexasAges 18 years+ - NCT05989841RecruitingPhase 1/Phase 2
Helping women after sexual assault who use cannabis
This study tests a new approach to help women who have recently experienced a sexual assault and use cannabis. It explores whether reducing anxiety about physical symptoms can help prevent long-term PTSD and cannabis problems.
Minneapolis, MinnesotaAges 18 years+ - NCT05959434RecruitingPhase 2
Therapy program to reduce drinking relapse and PTSD symptoms
This Phase 2 study tests a combined therapy approach for people who have both alcohol use disorder and post-traumatic stress disorder (PTSD). It aims to help you process stressful memories and lower the chances of relapse back to heavy drinking.
Charleston, South CarolinaAges 18 years+ - NCT05843695Recruiting
Therapy study for PTSD and anxiety in veterans
This trial tests a psychotherapy approach to help veterans and service members who have PTSD and/or anxiety disorders. You may be randomly assigned to different therapy conditions, and the study aims to improve quality of life and reduce anxiety and PTSD symptoms.
Houston, TexasAges 18 years+ - NCT05786157Recruiting
Couples alcohol and safety support for drinking and relationship harm
This study tests a patient-focused approach to help couples where alcohol misuse and relationship physical harm may be happening. You may be asked to take part in sessions focused on safety, coping, and relationship communication, and some components may include controlled alcohol exposure.
Charleston, South CarolinaAges 21 years+ - NCT05776056RecruitingPhase 4
Methylphenidate for PTSD with memory and thinking problems
This study tests whether methylphenidate, a medication commonly used for attention issues, can help veterans with PTSD who also have memory or concentration problems. The goal is to see if it improves these cognitive symptoms.
Birmingham, AlabamaAges 18–65 - NCT05700201Recruiting
Study of heart health in adults with trauma symptoms
This study looks at how trauma-related symptoms (like PTSD symptoms) may affect heart health. You may be asked to do light activity—so your study team can see how your body responds.
Fort Lauderdale, FloridaAges 18 years+ - NCT05651295Recruiting
Smartphone precision study to improve emotion regulation
This trial tests a precision approach delivered through a smartphone to better track and target how you manage strong emotions. It may help if you have ongoing difficulty regulating emotions day to day.
Columbus, OhioAges 18 years+ - NCT05624931Recruiting
Helping pregnant women stay on PrEP after starting it
This study tries to reduce the psychological barriers that make it hard for pregnant or postpartum women to keep taking PrEP. It may help by offering support tailored to stress, trauma symptoms, or depression—especially soon after PrEP is started.
Boston, MassachusettsAges 15 years+ - NCT05497115Recruiting
Care model to improve access to mental health after trauma
This trial tests a practical care plan to help people get mental health support after a traumatic injury, especially if screening suggests risk for PTSD or depression. It may help you connect faster to the right kind of treatment after your injury.
Washington, VirginiaAges 16 years+ - NCT05486793Recruiting
Study of treatment for PTSD symptoms during pregnancy
This study looks at a treatment approach for post-traumatic stress disorder (PTSD) or PTSD-like symptoms in pregnant people. It may help reduce PTSD symptoms during pregnancy, as long as you meet the symptom and care-planning requirements.
Boston, MassachusettsAges 18–50 - NCT05457985Recruiting
Adaptive app coaching for PTSD in community health clinics
This study tests a flexible (adaptive) approach using a mobile app to help improve treatment outcomes for posttraumatic stress disorder (PTSD) for people getting care at participating community health clinics. It may help you get more tailored support between visits.
Baldwin, MichiganAges 18 years+ - NCT05427500Enrolling by invitationPhase 3
Nerve block treatment for PTSD with strong stress-and-alertness symptoms
This Phase 3 study tests whether a procedure called a stellate ganglion block can reduce PTSD symptoms, especially feeling highly “on edge” (hyperarousal). You may join if you have PTSD despite appropriate usual treatments and are able to go through the procedure safely.
Ottawa, OntarioAges 18–69 - NCT05327504Recruiting
Writing therapy for PTSD and substance use in veterans
This study tests a structured “written exposure” therapy to help veterans with PTSD who also have a substance use disorder (SUD). It may help reduce PTSD symptoms while also supporting safer, more stable recovery.
West Haven, ConnecticutAges 18 years+ - NCT05267665Recruiting
Family-involved PTSD therapy coaching for Veterans
This study tests a brief way to include a Veteran’s family member to improve PTSD treatment results and help people stay engaged in care. It’s for Veterans who are just starting evidence-based PTSD therapy and have a closely involved family member who can participate too.
Boston, MassachusettsAges 18 years+ - NCT05133804RecruitingPhase 2
Testing two medications for PTSD attention and emotions
This Phase 2 study tests whether reboxetine or methylphenidate can improve attention and emotional or sensory problems in adults with post-traumatic stress disorder (PTSD). You may be eligible if you have a confirmed PTSD diagnosis and are able to meet medication and safety requirements.
AfulaAges 20–60 - NCT04959695Recruiting
PE Coach app for veterans with PTSD therapy
This study tests whether a mobile app called “PE Coach” can support PTSD treatment (Prolonged Exposure therapy) for veterans. It may help you stay engaged with therapy sessions done in-person or by video/telehealth using a phone or tablet.
Seattle, WashingtonAges 18–65 - NCT04877093RecruitingPhase 3
Low-dose clonidine for PTSD nightmares in veterans
This Phase 3 study tests whether low-dose clonidine can reduce PTSD symptoms and especially nightmares in U.S. veterans. You’d be screened for PTSD severity and current treatments, then asked to visit the clinic as scheduled to see if the treatment helps.
Wauwatosa, WisconsinAges 18 years+ - NCT04887116RecruitingEarly Phase 1
Virtual reality sessions to treat PTSD in healthcare workers
This early-phase study tests whether guided virtual reality experiences can reduce symptoms of PTSD (post-traumatic stress disorder) or near-PTSD in healthcare workers. It may help people who have stress reactions related to work during the COVID-19 era.
New York, New YorkAges 18 years+
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Common questions
- Are there clinical trials for posttraumatic stress?
- Yes. Clin2 currently lists 102 recruiting posttraumatic stress studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a posttraumatic stress trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a posttraumatic stress trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.