Clinical trials
Pregnancy, High Risk clinical trials
Below are recruiting pregnancy, high risk clinical trials, each written for real people, not researchers. We’re tracking 362 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03848962Recruiting
Share leftover or collected samples for research
This study helps collect and share human samples (like blood or other specimens) so researchers can do new studies. It’s mainly about providing samples for research use, not testing a treatment on you.
Huntsville, AlabamaAges 1 month–89 years - NCT06414655Recruiting
Twin pregnancy study: tracking mothers and babies
This study follows mothers expecting twins from early pregnancy through delivery. It helps doctors learn more about caring for twin pregnancies and their babies in China.
Hefei, AnhuiAges 18–45 - NCT07293715RecruitingPhase 4
Comparing glucose management during labor in type 1 diabetes
This trial looks at two ways to manage blood sugar levels during labor in pregnant people with type 1 diabetes. It aims to find the safest approach for both the patient and the baby.
Columbus, OhioAges 18 years+ - NCT06932250Recruiting
Leg heating for weight and blood pressure in pregnancy
This trial tests if applying heat to the legs can improve blood vessel function in pregnant women with overweight or obesity. It may help manage blood pressure and reduce risks of pregnancy complications.
Dallas, TexasAges 18–45 - NCT06826859RecruitingPhase 1/Phase 2
Daily aspirin vs split dosing to prevent preeclampsia
This study compares taking a daily low-dose aspirin (a single pill) versus splitting the same dose into two smaller pills many hours apart to see which way better prevents preeclampsia in pregnant people who are at higher risk.
Philadelphia, PennsylvaniaAges 16–55 - NCT06445946RecruitingPhase 4
Metformin vs insulin for gestational diabetes
This study compares two common medicines (metformin pills and insulin shots) to see which works better for controlling blood sugar in pregnant women with gestational diabetes. The goal is to find the best treatment for both mom and baby, now and in the long term.
Tuscaloosa, AlabamaAges 18 years+ - NCT06396078RecruitingPhase 4
Antibiotics for Early Water Breaking Before Delivery
This study tests whether giving antibiotics to pregnant people with early water breaking (PPROM) before delivery improves outcomes. It aims to prevent infections and protect both parent and baby while waiting for delivery.
Columbus, OhioAges 18 years+ - NCT04861103RecruitingPhase 4
Testing a blood thinner plan during pregnancy
This study looks at how people’s blood and clotting behave during pregnancy when taking a specific blood thinner called low molecular weight heparin (LMWH) three times a day. It may help doctors fine-tune how safely and effectively LMWH is used during pregnancy.
Orange, CaliforniaAges 18 years+ - NCT06036446Recruiting
Late cerclage for preventing early birth in high-risk pregnancies
This trial tests if placing a stitch in the cervix (cerclage) between 24 and 27 weeks of pregnancy can help prevent preterm birth in women whose cervix is short. It may be an option for those who find out late in pregnancy that they are at risk.
Charlotte, North CarolinaAges 18–50 - NCT05904145Recruiting
Study of mother and baby health during early pregnancy
This study follows pregnant women to better understand health needs for mothers and newborns, starting in the first part of pregnancy. You may be able to join if you live nearby, are at least the required age, and your pregnancy is confirmed to be under 20 weeks.
KintampoAges 15 years+ - NCT05287321RecruitingPhase 3
Aspirin plus hydroxychloroquine to prevent preeclampsia in high-risk pregnancy
This trial tests whether adding aspirin and hydroxychloroquine can lower the risk of preeclampsia during pregnancy in people considered high-risk. If you qualify, you may be assigned to take the study medicines to help protect you and the baby.
SeoulAges 19–50 - NCT07237230Recruiting
Gamma-delta T cells to prevent leukemia relapse after transplant
This trial tests if a special type of immune cell called gamma-delta T cells can help prevent acute myeloid leukemia from coming back after a stem cell transplant. It is for people with high-risk features who have recently had a transplant.
Wuhan, HubeiAges 18–65 - NCT06918652Recruiting
Surgery or endoscopy for high-risk gallbladder inflammation
This trial compares two minimally invasive treatments for people with severe gallbladder inflammation caused by gallstones. It aims to see which approach better helps the immune system and reduces risks for those who are too sick for standard surgery.
Pavia, PaviaAges 18 years+ - NCT07053618Recruiting
Heart pump support for high-risk heart procedures
This trial tests a temporary heart pump to support patients with weak hearts (ejection fraction 35% or less) who need a high-risk stent procedure instead of bypass surgery. The pump may help keep blood flowing during the procedure.
Beijing, Beijing MunicipalityAges 18–90 - NCT06623110RecruitingPhase 2
RP2 vaccine to prevent mouth cancer in high-risk pre-cancer
This trial tests an injected virus therapy (RP2) to stop pre-cancerous mouth lesions from turning into cancer. It is for people with high-risk oral pre-cancer or a history of early-stage head and neck cancer with certain worrisome features.
Boston, MassachusettsAges 18 years+ - NCT06713083Recruiting
Physical activity for high-risk pregnant women on bed rest
This study tests whether a physical activity program can help pregnant women who are hospitalized on bed rest due to high-risk pregnancy. It aims to improve their well-being and possibly their pregnancy outcomes.
BarcelonaAges 18 years+ - NCT07549399RecruitingPhase 3
Radiation, Chemotherapy, and Immunotherapy for Rectal Cancer
This trial tests a combination of radiation, chemotherapy, and immunotherapy drugs before surgery for people with locally advanced rectal cancer. The goal is to shrink the tumor and improve outcomes for patients with higher-risk disease.
Guangzhou, GuangdongAges 18–75 - NCT06277050RecruitingPhase 3
Toripalimab and capecitabine after chemo-radiation for high-risk nasopharyngeal cancer
This trial tests whether adding the immunotherapy drug toripalimab to the chemotherapy pill capecitabine after standard treatment helps prevent nasopharyngeal cancer from coming back. It is for people with high-risk features who have already had chemo and radiation.
Ganzhou, JiangxiAges 18–70 - NCT07572396RecruitingPhase 2
HPV treatment with vaginal suppositories for mild cervical changes
This study tests a new vaginal medication (Dysplasix) to treat mild cervical cell changes caused by high-risk HPV. The goal is to see if this treatment can help your body clear the virus and prevent these changes from getting worse.
Shatin, New TerritoriesAges 18–65 - NCT07481669RecruitingPhase 2
Stem cell transplant for lymphoma at high risk of brain relapse
This trial tests a stem cell transplant with a special chemo combination (TEAM) to see if it can prevent lymphoma from coming back in the brain or spinal cord for people with high-risk non-Hodgkin lymphoma.
Hangzhou, ZhejiangAges 18–70 - NCT07239245RecruitingPhase 2
TACE plus immunotherapy for high-risk liver cancer before surgery
This trial tests whether a combination of two therapies—targeted chemotherapy delivered directly to the liver (TACE) plus immunotherapy (atezolizumab) and a targeted drug (bevacizumab)—can keep liver cancer from coming back after surgery. It is for people whose tumors can be surgically removed but are at high risk of recurrence.
Beijing, Beijing MunicipalityAges 18–75 - NCT06736964Enrolling by invitation
Testing new fillings for gum-line cavities in high-risk adults
This study tests how well two newer, tooth-friendly filling materials work for cavities at the gum line in people who are prone to tooth decay. If you need a couple of these fillings, this trial could help restore your teeth and protect them from future cavities.
CairoAges 25–45 - NCT07779057RecruitingPhase 4
Aspirin dose to prevent preeclampsia
This trial compares two different doses of aspirin (a common safe medication) to see if one works better at preventing preeclampsia, a pregnancy complication, in women at higher risk. Taking part may help doctors find the best way to protect both you and your baby.
Multan, Punjab ProvinceAges 18–45 - NCT07074951Recruiting
Tonsillectomy and immune therapy for high-risk IgA kidney disease
This trial tests whether removing the tonsils (tonsillectomy) plus immune-suppressing therapy can help people with a high-risk form of IgA nephropathy, a kidney disease. It aims to slow down kidney damage and delay the need for dialysis.
Saint PetersburgAges 18–75
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Common questions
- Are there clinical trials for pregnancy, high risk?
- Yes. Clin2 currently lists 362 recruiting pregnancy, high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pregnancy, high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pregnancy, high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.