Clinical trials
Pregnancy, High Risk clinical trials
Below are recruiting pregnancy, high risk clinical trials, each written for real people, not researchers. We’re tracking 361 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05287321RecruitingPhase 3
Aspirin plus hydroxychloroquine to prevent preeclampsia in high-risk pregnancy
This trial tests whether adding aspirin and hydroxychloroquine can lower the risk of preeclampsia during pregnancy in people considered high-risk. If you qualify, you may be assigned to take the study medicines to help protect you and the baby.
SeoulAges 19–50 - NCT06036446Recruiting
Late cerclage for preventing early birth in high-risk pregnancies
This trial tests if placing a stitch in the cervix (cerclage) between 24 and 27 weeks of pregnancy can help prevent preterm birth in women whose cervix is short. It may be an option for those who find out late in pregnancy that they are at risk.
Charlotte, North CarolinaAges 18–50 - NCT06396078RecruitingPhase 4
Antibiotics for Early Water Breaking Before Delivery
This study tests whether giving antibiotics to pregnant people with early water breaking (PPROM) before delivery improves outcomes. It aims to prevent infections and protect both parent and baby while waiting for delivery.
Columbus, OhioAges 18 years+ - NCT06414655Recruiting
Twin pregnancy study: tracking mothers and babies
This study follows mothers expecting twins from early pregnancy through delivery. It helps doctors learn more about caring for twin pregnancies and their babies in China.
Hefei, AnhuiAges 18–45 - NCT06445946RecruitingPhase 4
Metformin vs insulin for gestational diabetes
This study compares two common medicines (metformin pills and insulin shots) to see which works better for controlling blood sugar in pregnant women with gestational diabetes. The goal is to find the best treatment for both mom and baby, now and in the long term.
Tuscaloosa, AlabamaAges 18 years+ - NCT06826859RecruitingPhase 1/Phase 2
Daily aspirin vs split dosing to prevent preeclampsia
This study compares taking a daily low-dose aspirin (a single pill) versus splitting the same dose into two smaller pills many hours apart to see which way better prevents preeclampsia in pregnant people who are at higher risk.
Philadelphia, PennsylvaniaAges 16–55 - NCT06932250Recruiting
Leg heating for weight and blood pressure in pregnancy
This trial tests if applying heat to the legs can improve blood vessel function in pregnant women with overweight or obesity. It may help manage blood pressure and reduce risks of pregnancy complications.
Dallas, TexasAges 18–45 - NCT07293715RecruitingPhase 4
Comparing glucose management during labor in type 1 diabetes
This trial looks at two ways to manage blood sugar levels during labor in pregnant people with type 1 diabetes. It aims to find the safest approach for both the patient and the baby.
Columbus, OhioAges 18 years+ - NCT07237230Recruiting
Gamma-delta T cells to prevent leukemia relapse after transplant
This trial tests if a special type of immune cell called gamma-delta T cells can help prevent acute myeloid leukemia from coming back after a stem cell transplant. It is for people with high-risk features who have recently had a transplant.
Wuhan, HubeiAges 18–65 - NCT06623110RecruitingPhase 2
RP2 vaccine to prevent mouth cancer in high-risk pre-cancer
This trial tests an injected virus therapy (RP2) to stop pre-cancerous mouth lesions from turning into cancer. It is for people with high-risk oral pre-cancer or a history of early-stage head and neck cancer with certain worrisome features.
Boston, MassachusettsAges 18 years+ - NCT06918652Recruiting
Surgery or endoscopy for high-risk gallbladder inflammation
This trial compares two minimally invasive treatments for people with severe gallbladder inflammation caused by gallstones. It aims to see which approach better helps the immune system and reduces risks for those who are too sick for standard surgery.
Pavia, PaviaAges 18 years+ - NCT07053618Recruiting
Heart pump support for high-risk heart procedures
This trial tests a temporary heart pump to support patients with weak hearts (ejection fraction 35% or less) who need a high-risk stent procedure instead of bypass surgery. The pump may help keep blood flowing during the procedure.
Beijing, Beijing MunicipalityAges 18–90 - NCT06713083Recruiting
Physical activity for high-risk pregnant women on bed rest
This study tests whether a physical activity program can help pregnant women who are hospitalized on bed rest due to high-risk pregnancy. It aims to improve their well-being and possibly their pregnancy outcomes.
BarcelonaAges 18 years+ - NCT06277050RecruitingPhase 3
Toripalimab and capecitabine after chemo-radiation for high-risk nasopharyngeal cancer
This trial tests whether adding the immunotherapy drug toripalimab to the chemotherapy pill capecitabine after standard treatment helps prevent nasopharyngeal cancer from coming back. It is for people with high-risk features who have already had chemo and radiation.
Ganzhou, JiangxiAges 18–70 - NCT07549399RecruitingPhase 3
Radiation, Chemotherapy, and Immunotherapy for Rectal Cancer
This trial tests a combination of radiation, chemotherapy, and immunotherapy drugs before surgery for people with locally advanced rectal cancer. The goal is to shrink the tumor and improve outcomes for patients with higher-risk disease.
Guangzhou, GuangdongAges 18–75 - NCT05877573Recruiting
Toripalimab with chemo-radiation before surgery for rectal cancer
This trial studies whether adding toripalimab (an immunotherapy drug) to standard chemo-radiation before surgery can improve outcomes for people with higher-risk, locally advanced rectal cancer. It is meant for cancers that are mismatch-repair “MSS/pMMR,” and it checks safety plus effectiveness as a first treatment.
Guangzhou, GuangdongAges 18–75 - NCT07481669RecruitingPhase 2
Stem cell transplant for lymphoma at high risk of brain relapse
This trial tests a stem cell transplant with a special chemo combination (TEAM) to see if it can prevent lymphoma from coming back in the brain or spinal cord for people with high-risk non-Hodgkin lymphoma.
Hangzhou, ZhejiangAges 18–70 - NCT07239245RecruitingPhase 2
TACE plus immunotherapy for high-risk liver cancer before surgery
This trial tests whether a combination of two therapies—targeted chemotherapy delivered directly to the liver (TACE) plus immunotherapy (atezolizumab) and a targeted drug (bevacizumab)—can keep liver cancer from coming back after surgery. It is for people whose tumors can be surgically removed but are at high risk of recurrence.
Beijing, Beijing MunicipalityAges 18–75 - NCT07572396RecruitingPhase 2
HPV treatment with vaginal suppositories for mild cervical changes
This study tests a new vaginal medication (Dysplasix) to treat mild cervical cell changes caused by high-risk HPV. The goal is to see if this treatment can help your body clear the virus and prevent these changes from getting worse.
Shatin, New TerritoriesAges 18–65 - NCT06736964Enrolling by invitation
Testing new fillings for gum-line cavities in high-risk adults
This study tests how well two newer, tooth-friendly filling materials work for cavities at the gum line in people who are prone to tooth decay. If you need a couple of these fillings, this trial could help restore your teeth and protect them from future cavities.
CairoAges 25–45 - NCT07779057RecruitingPhase 4
Aspirin dose to prevent preeclampsia
This trial compares two different doses of aspirin (a common safe medication) to see if one works better at preventing preeclampsia, a pregnancy complication, in women at higher risk. Taking part may help doctors find the best way to protect both you and your baby.
Multan, Punjab ProvinceAges 18–45 - NCT07074951Recruiting
Tonsillectomy and immune therapy for high-risk IgA kidney disease
This trial tests whether removing the tonsils (tonsillectomy) plus immune-suppressing therapy can help people with a high-risk form of IgA nephropathy, a kidney disease. It aims to slow down kidney damage and delay the need for dialysis.
Saint PetersburgAges 18–75 - NCT06184009RecruitingPhase 2
Treatment for high-risk childhood leukemia
This trial tests a new treatment approach for children and teens with high-risk acute lymphoblastic leukemia (ALL). It aims to improve outcomes for those with certain genetic changes or cancer that has spread.
Seoul, SeoulAges 1–19 - NCT05557487Recruiting
Real-world low-dose CT screening for people at high lung risk
This study looks at how people at high risk for lung cancer use low-dose CT scans in real life, and what outcomes happen over time. It may help confirm which groups benefit most from regular screening and support safer screening decisions.
Taichung, TaiwanAges 20–80
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Common questions
- Are there clinical trials for pregnancy, high risk?
- Yes. Clin2 currently lists 361 recruiting pregnancy, high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pregnancy, high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pregnancy, high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.