Clinical trials
Procedural Pain clinical trials
Below are recruiting procedural pain clinical trials, each written for real people, not researchers. We’re tracking 86 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06415240Recruiting
Comforting Touches for Newborn Pain in the NICU
This study tests whether gentle touch or wrapping your baby cozily (facilitated tucking) can reduce pain during a first-time arterial blood draw in the NICU. It may help find simple ways to comfort newborns during procedures.
IslamabadAges 1 day–4 weeks - NCT07190625RecruitingEarly Phase 1
Fentanyl spray versus injection for pain in preterm babies
This trial compares giving fentanyl as a nasal spray versus an injection to help preterm babies during painful procedures like placing a central line, inserting a breathing tube, or a spinal tap. The goal is to see which method works better and is safer.
CairoAges Up to 4 weeks - NCT07518953Recruiting
Can Music Help With Pain During a Nail Biopsy?
This study tests whether listening to music during a nail biopsy—a small procedure to remove a sample of nail tissue—can reduce pain and anxiety. You would listen to music during the procedure and answer a few questions about how you felt.
New York, New YorkAges 18 years+ - NCT03489499Recruiting
Genetic testing study of pain after planned surgery
This study looks at whether genetic differences can help predict how much pain you may have after an elective (planned) operation. If you qualify, you may be asked to give consent and share information so researchers can compare pain experiences across people.
BernAges 18 years+ - NCT04130464RecruitingPhase 4
Analgesic placed inside the belly for after-surgery pain
This study tests whether placing a pain medicine inside the abdomen during hysterectomy can reduce postoperative pain. It targets people having specific types of minimally invasive hysterectomy for non-cancer reasons.
Washington D.C., District of ColumbiaAges 18–65 - NCT07288047Recruiting
Virtual reality for pain during early abortion
This study tests if using a virtual reality headset during a first trimester procedural abortion can help reduce pain and anxiety. You may be eligible if you are planning to have an abortion at Planned Parenthood of Western Pennsylvania and meet the criteria below.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07413848Recruiting
Pain response monitor during urology procedures
This study tests a device that measures pain signals during urology procedures like cystoscopy or prostate biopsy. It may help doctors give you the right amount of sedation.
Ankara, AltındağAges 18 years+ - NCT07319806Enrolling by invitation
Two ways to help kids feel better during breathing tube removal
This study tests two different methods to lower pain, fear, and emotional upset when a breathing sample is taken from hospitalized children aged 6 to 12. The goal is to find which approach works best to make the experience easier for your child.
DüzceAges 6–12 - NCT07314450Recruiting
Pain and sedation for fracture and dislocation treatment in the ER
This study tests how well pain and sedation medicines work in the emergency department when treating adults with certain broken bones or dislocated joints that need to be set or casted. It aims to see which approach is safest and most comfortable for patients.
Holbæk, Region SjællandAges 18 years+ - NCT07578324Recruiting
TENS to reduce pain during prostate biopsy
This study tests whether TENS (a gentle electrical stimulation applied to the skin) can help reduce pain when combined with numbing medicine during a prostate biopsy procedure. The goal is to see if this may make the biopsy more comfortable for patients.
Gdansk, Pomeranian VoivodeshipAges 40 years+ - NCT05875571RecruitingPhase 4
Ketorolac IV to reduce pain after IUD placement
This trial tests whether giving ketorolac through an IV can lessen pain after a sedated IUD placement. If you’re scheduled for sedated IUD placement, this may help reduce post-procedure discomfort.
Little Rock, ArkansasAges 13–21 - NCT04305743RecruitingPhase 4
Compare pain after 5 vs 20 bladder botox injections
This study looks at how much discomfort you have after receiving bladder Botox injections, comparing a smaller (5) dose vs a larger (20) dose. It’s only for certain overactive bladder conditions and specifically when the procedure is done without sedation or special anesthesia.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06813937Recruiting
Magnetic stimulation for feeling in upper limb amputation
This study tests whether magnetic stimulation can improve sensation in people who have lost an upper limb. It may help restore feeling in the residual limb.
MoscowAges 18–65 - NCT07676422Recruiting
Stress ball use during mouth care
This study tests if squeezing a stress ball during mouth care can help reduce discomfort or stress. You may be able to join if you can follow instructions and don't have any hand or movement issues.
VanAges 18 years+ - NCT07557108Recruiting
Nerve Blocks to Improve Recovery After Heart Surgery
This study tests whether special numbing injections around nerves in the chest wall (fascial plane blocks) help patients recover better and have less pain after open-heart surgery. The goal is to see if this technique improves how you feel and function in the days after your operation.
Ordu, AltinorduAges 18–70 - NCT07624929Enrolling by invitation
Virtual Reality to Reduce Anxiety During Varicose Vein Treatment
This study tests whether wearing a virtual reality headset during varicose vein treatment (a minimally invasive laser procedure on your legs) can help reduce anxiety and pain. You'd use VR while the doctor treats the problematic veins under local anesthesia.
BydgoszczAges 18 years+ - NCT05970354Enrolling by invitationPhase 4
Numbing cream to reduce pain during gynecologic procedures
This trial studies whether EMLA numbing cream can lessen pain during common outpatient gynecologic procedures like IUD insertion, hysteroscopy, or endometrial biopsy. If it works, it may make these procedures more comfortable.
Charleston, West VirginiaAges 18 years+ - NCT06384664Recruiting
Freezing Nerves to Reduce Pain After Chest Surgery
This study tests whether freezing a nerve (cryoablation) during chest surgery can reduce pain after the operation. It might help patients who are having their first chest surgery and have never used strong painkillers.
Ann Arbor, MichiganAges 18 years+ - NCT04894864RecruitingPhase 4
Opioid-free anesthesia for elective abdominal aortic aneurysm surgery
This trial studies an “opioid-free” anesthesia and pain plan during planned open surgery for an abdominal aortic aneurysm. The goal is to see whether this approach reduces surgical stress and pain compared with usual care.
Heraklion, CreteAges 40–85 - NCT06713044Recruiting
Quran recitation or music for pain after leg surgery
This trial tests whether listening to Quranic recitation or classical music can reduce pain and inflammation after lower-leg orthopedic surgery. It may help Muslim patients manage pain without extra medication.
Purwokerto, Central JavaAges 18–60 - NCT03230565RecruitingPhase 4
Continuous vs bolus pain medication through nerve catheter
This study compares two ways of delivering numbing pain medicine through a nerve catheter after surgery: a steady infusion versus scheduled bolus doses. It aims to see which method works better and is easier to use for post-operative pain control.
Stanford, CaliforniaAges 18 years+ - NCT07113483RecruitingPhase 3
Remimazolam vs. Midazolam for sedation in older adults having orthopedic surgery
This trial compares two sedatives, remimazolam and midazolam, to see which one leads to better recovery of thinking skills after orthopedic surgery. It is for people aged 65 and older who are having surgery on a bone or joint while awake but relaxed.
BucharestAges 65 years+ - NCT07512141Recruiting
Single vs. Double Drains After Breast Cancer Surgery
This study compares using one drain versus two drains to collect fluid after breast cancer removal surgery. The goal is to see which approach works better and causes fewer problems during recovery.
Karachi, SindhAges 18–70 - NCT06827262Recruiting
A procedure for vertebrogenic back pain relief
This trial tests a minimally invasive procedure that uses a special device to target and treat nerve-related back pain coming from the vertebrae (the bones in your spine). It may offer lasting relief without more major surgery.
Flagstaff, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for procedural pain?
- Yes. Clin2 currently lists 86 recruiting procedural pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a procedural pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a procedural pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.