Clinical trials
Prolonged Disorders of Consciousness clinical trials
Below are recruiting prolonged disorders of consciousness clinical trials, each written for real people, not researchers. We’re tracking 16 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06473285Recruiting
Esketamine for consciousness in prolonged disorders of consciousness
This trial tests whether a drug called esketamine can help improve brain activity in people with long-term disorders of consciousness. It may help doctors understand how the brain recovers.
BeijingAges 18–65 - NCT07183670Enrolling by invitation
Testing a Voice Valve to Remove Breathing Tubes in Prolonged Consciousness Disorders
This study tests a new way to help people with long-lasting disorders of consciousness get their tracheostomy tube removed using a voice valve. If you qualify, this might help improve recovery and communication.
Beijing, Beijing MunicipalityAges 18–80 - NCT07173634Enrolling by invitation
Speaking valve trial for tracheostomy removal in consciousness disorders
This trial tests whether using a speaking valve (a small one-way valve that lets you breathe and speak) helps people with a tracheostomy and long-term consciousness problems safely remove their tracheostomy tube, compared to a standard capping method.
Beijing, Beijing MunicipalityAges 18–80 - NCT04427241RecruitingPhase 4
Testing Cerebrolysin for prolonged brain injury after bleeding stroke
This study tests whether Cerebrolysin can improve recovery in people who remain in a vegetative or minimally conscious state more than 4 weeks after a bleeding stroke. It also tracks safety, to make sure the treatment is not causing harmful side effects.
SeoulAges 19–120 - NCT05823454Recruiting
Testing brain-connection changes during propofol sedation
This study looks at how the brain network connects during propofol sedation in people with long-lasting disorders of consciousness. It may help doctors understand brain function in these conditions and improve how care is guided during procedures.
BeijingAges 18–65 - NCT06088628Recruiting
Facial micro-expressions in long-term consciousness disorders
This study looks at tiny, unconscious facial expressions in patients who have been in a vegetative or minimally conscious state for over a month after a severe brain injury. The goal is to see if these micro-expressions can help doctors better understand a patient's level of awareness.
Hangzhou, ZhejiangAges 18–80 - NCT06406413Recruiting
Micro-movements in prolonged disorders of consciousness
This trial studies tiny, subconscious movements in people who have been in a coma or minimal consciousness for over a month after a severe brain injury. It aims to understand these movements better, which could help improve care and communication.
Hanzhou, ZhejiangAges 18–80 - NCT07694258Recruiting
Testing a helmet for brain stimulation in consciousness disorders
This study tests a special helmet that uses ultrasound to stimulate the brain in people with disorders of consciousness caused by brain injury. It aims to see if the treatment is safe and possible to do.
Toronto, OntarioAges Any age - NCT06930716Recruiting
Vagus nerve stimulation with physical therapy for consciousness disorders
This trial tests whether a mild electrical stimulation of the vagus nerve (a nerve in the neck) can help people with long-term disorders of consciousness move better during physical therapy. It may be an option if you are still in a coma, vegetative, or minimally conscious state and have been stable for more than 6 weeks.
New York, New YorkAges 22 years+ - NCT06939348Recruiting
Ultrasound therapy for patients with consciousness disorders
This trial tests whether ultrasound stimulation can help people with disorders of consciousness, like coma or a minimally conscious state. It aims to improve brain function and recovery for patients who have been injured for over a month.
Los Angeles, CaliforniaAges 18–79 - NCT07074678Enrolling by invitation
Predicting recovery in early consciousness disorders
This study uses brain scans to understand how people with severe brain injuries may recover consciousness. It is for patients who have had a recent brain injury and are in a coma, vegetative state, or minimally conscious state.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06097013Enrolling by invitation
Brain function study for consciousness disorders
This trial is testing a brain function evaluation system to help understand and possibly improve care for people with disorders of consciousness caused by brain injury, stroke, or lack of oxygen. It is for both acute (recent) and prolonged (lasting) cases.
BeijingAges 14–60 - NCT05682248Enrolling by invitation
Testing a brain assessment and stimulation system for unconsciousness
This trial studies a device and plan to assess brain function and deliver an intervention in people who are in a coma, minimally conscious state, or unresponsive arousal state after brain injury, stroke, or lack of oxygen. If you qualify, it may help doctors understand and potentially improve brain function over time.
BeijingAges 14–80 - NCT06017765Recruiting
Mindfulness for grief after losing a loved one
This study tests whether a mindfulness program can help adults cope with intense grief after the loss of a loved one. If you have been diagnosed with Prolonged Grief Disorder and are not in other grief treatment, this may be an option for you.
Caen, CalvadosAges 18–60 - NCT04050995Recruiting
Testing MuSICCA to measure awareness in children
This study tests a tool called MuSICCA to check awareness in children and teens who are being evaluated for a disorder of consciousness. The results may help clinicians better understand a child’s awareness and guide care decisions.
Atlanta, GeorgiaAges 2–18 - NCT05213169RecruitingPhase 2/Phase 3
Apomorphine for severe unresponsive brain injuries
This trial tests whether apomorphine can improve care or outcomes for people in an unresponsive wakefulness or minimally conscious state after a brain injury. It is designed for patients who are medically stable and not currently on certain brain- or heart- affecting medicines.
Liège, LiegeAges 18–80
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Common questions
- Are there clinical trials for prolonged disorders of consciousness?
- Yes. Clin2 currently lists 16 recruiting prolonged disorders of consciousness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prolonged disorders of consciousness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prolonged disorders of consciousness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.