Clinical trials
Prostate Cancer Surgery clinical trials
Below are recruiting prostate cancer surgery clinical trials, each written for real people, not researchers. We’re tracking 461 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07667400RecruitingPhase 1/Phase 2
Docetaxel plus SX-682 for advanced head and neck or prostate cancer
This trial studies a combination of the chemotherapy drug docetaxel and an investigational drug called SX-682 for people with certain advanced head and neck cancers or prostate cancer. The goal is to see if the combination is safe and effective.
Bethesda, MarylandAges 18–120 - NCT04086290RecruitingPhase 1/Phase 2
Surgery plus targeted radiation for prostate cancer spread
This study looks at whether combining prostate surgery with a highly focused radiation treatment (SBRT) can control prostate cancer that has spread to a limited number of bones. It may help patients by treating the main tumor and the specific metastatic spots in a controlled way.
HerlevAges 18 years+ - NCT03294889RecruitingPhase 1/Phase 2
Single-dose SBRT for early prostate cancer
This trial tests a very short, one-time form of radiation (SBRT) to treat prostate cancer. It aims to see whether treating the prostate in one shot is safe and effective for carefully selected patients.
GenevaAges 18–85 - NCT03541928RecruitingPhase 2
Gene therapy with standard treatment for high-risk prostate cancer
This trial combines gene therapy with hormone therapy, radiation, and possibly surgery to treat high-risk prostate cancer. It aims to improve outcomes by adding gene therapy to standard treatments and will require additional biopsies.
Houston, TexasAges 18 years+ - NCT03787056Recruiting
Blood test marker study in many cancer types
This study measures a blood marker called progastrin (at diagnosis and during treatment) to see how well it predicts response or outcomes. It may help doctors choose or monitor treatment more precisely for several cancer types.
BronAges 18 years+ - NCT05022914Recruiting
PSMA PET/CT scan for PSA relapse after prostate surgery
This trial looks at using a PSMA PET/CT scan to better re-check cancer activity in men whose PSA has started rising after prostate removal. If you qualify, the scan may help doctors choose the next best treatment step.
FlorenceAges 18 years+ - NCT03753243RecruitingPhase 2
Pembrolizumab and hormone blocker before prostate surgery
This Phase 2 trial studies whether pembrolizumab plus a hormone “androgen axis” blocker taken before prostate surgery can improve outcomes for people with high-risk, non-metastatic prostate cancer. It’s designed for patients who are planning prostate removal with an extended lymph node dissection.
Portland, OregonAges 18 years+ - NCT05557604RecruitingPhase 2
Tested a targeted prostate cancer radiation plan for higher-risk patients
This Phase 2 trial studies whether a specific radiation approach (including detailed targeting and tracking) can work better for men with intermediate-risk to high-risk prostate cancer. You may be eligible if your scans show no spread beyond the prostate area and you can safely complete the required imaging and treatments.
Rome, LazioAges 18–90 - NCT05698576Recruiting
Laser treatment through the skin for men with prostate cancer
This trial tests a laser procedure done through the skin between the scrotum and anus, guided by MRI and ultrasound, for men with certain prostate cancer types. It aims to heat and treat prostate cancer while checking safety and outcomes over follow-up visits.
Hialeah, FloridaAges 50–80 - NCT05241236Recruiting
Laser ablation guided by MRI and ultrasound for prostate cancer
This trial looks at a treatment that uses MRI and ultrasound to guide a laser to destroy prostate cancer. It may help men with low- or intermediate-risk prostate cancer who do not have spread beyond the prostate.
Miami Lakes, FloridaAges 50 years+ - NCT05019846RecruitingPhase 3
Radiation alone versus radiation plus hormone therapy for prostate cancer
This Phase 3 trial compares two treatment approaches: stereotactic radiation therapy by itself versus the same radiation plus hormone therapy (ADT). It aims to see which plan works better for men with higher-risk prostate cancer without spread to lymph nodes or distant sites.
Brescia, BSAges 18–80 - NCT05832736Recruiting
Robot surgery for one-sided prostate cancer with urethra preserved
This study looks at a robotic prostate operation that aims to remove only the affected side while keeping the urethra (the tube for urination) to help preserve urinary function. It’s for people with low- to intermediate-risk, one-sided prostate cancer and no spread to lymph nodes, bones, or other organs.
Candiolo, TOAges 40 years+ - NCT03908684Recruiting
Ultrasound tests to predict early response to prostate and head/neck radiation
This study uses special ultrasound imaging to look for early signs of how well radiation treatment is working in prostate, rectum, and head/neck cancers. It may help doctors spot response sooner and adjust care earlier if needed.
Toronto, OntarioAges Any age - NCT05851365RecruitingEarly Phase 1
MRI scan to measure prostate acidity before surgery
This study tests a new MRI technique that measures acidity in prostate tumors. It may help doctors better understand the cancer before surgery, potentially guiding treatment decisions.
San Francisco, CaliforniaAges 18 years+ - NCT07860047RecruitingPhase 2
Peptide vaccine with antibody therapy for prostate cancer
This trial tests a combination of a personalized peptide vaccine and an antibody therapy for men with prostate cancer that has returned after initial treatment. The goal is to see if this approach can control the cancer without needing stronger hormone therapy.
Heidelberg, Baden-WurttembergAges 18–80 - NCT06223295Recruiting
Focal therapy for medium-risk prostate cancer
This trial tests a gentler treatment called focal therapy that targets only the part of the prostate with cancer. It's for men whose prostate cancer has a Gleason score of 7, low PSA, and hasn't spread outside the prostate.
Nijmegen, GelderlandAges 45 years+ - NCT06305832RecruitingPhase 2
Salvage radiation plus hormone therapy with or without rezvilutamide for rising PSA
This trial tests whether adding a new oral hormone blocker (rezvilutamide) to standard salvage radiation and hormone therapy can better control prostate cancer that has come back (rising PSA) after surgery.
Nanjing, JiangsuAges 40 years+ - NCT06387056RecruitingPhase 2
Gene-guided hormone therapy before prostate cancer surgery
This trial tests whether giving a combination of hormone treatments before surgery can improve outcomes for men with prostate cancer that has spread locally or to a few bone spots. It uses genetic testing to match participants with the most effective treatment.
Xiamen, FujianAges 18 years+ - NCT06397755Recruiting
Study of patients with prostate biopsy or prostate removal surgery
This study looks at patients who have had a prostate biopsy or surgery to remove the prostate (radical prostatectomy). It aims to learn more about these procedures and how patients are doing.
MilanAges 18 years+ - NCT07847385Recruiting
MRI-guided nerve-sparing for prostate cancer surgery
This study tests whether using special MRI scans to map nerves before surgery helps keep erectile function after prostate removal. It may help men who are having surgery for prostate cancer and want to preserve sexual function.
Geneva, Canton of GenevaAges 18 years+ - NCT07831824RecruitingPhase 2/Phase 3
Imaging drug to find prostate cancer spread before or after treatment
This trial tests an imaging agent that helps find cancer that has spread beyond the prostate, either when first diagnosed or if it comes back after treatment. The goal is to see what dose works best for clear pictures.
Grand Rapids, MichiganAges 18 years+ - NCT05352178RecruitingPhase 3
Targeted treatment for few-spread prostate cancer spots
This Phase 3 trial tests whether treating only a small number of prostate cancer metastases can help people with “oligorecurrent” (limited repeat) prostate cancer. It may reduce cancer activity while avoiding broader whole-body treatment for some patients.
LeuvenAges 18 years+ - NCT07801664RecruitingPhase 2
Short course hormone therapy for prostate cancer
This trial tests a short course of hormone therapy (androgen deprivation therapy) for men with a certain type of prostate cancer that is considered high-risk. The goal is to see if a shorter treatment period can still control the cancer while reducing side effects.
New York, New YorkAges 18 years+ - NCT07792590Recruiting
Focal therapy registry for prostate cancer
This study is a registry for people who have already had focal therapy (targeted treatment) for prostate cancer at Queen Mary Hospital. It aims to collect information about these treatments, which may help improve future care.
Hong Kong, Hong KongAges 18 years+
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Common questions
- Are there clinical trials for prostate cancer surgery?
- Yes. Clin2 currently lists 461 recruiting prostate cancer surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prostate cancer surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prostate cancer surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.