Clinical trials
Proton Pump Inhibitors clinical trials
Below are recruiting proton pump inhibitors clinical trials, each written for real people, not researchers. We’re tracking 26 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07488299Recruiting
Study of acid-reducing drug in pancreatic necrosis drainage
This trial tests whether giving a type of acid-reducing drug (called a PPI) affects the outcome of endoscopic drainage for walled-off pancreatic necrosis (WON). It aims to see if the drug helps or harms recovery.
Jinan, ShandongAges 18–80 - NCT07165444Recruiting
Comparing two acid-blocking drugs for H. pylori treatment
This trial tests if a newer acid-blocking medicine works better than a standard one when given with antibiotics and bismuth for treating H. pylori infection, a bacteria that can cause stomach ulcers. It is for adults who have not had treatment for H. pylori before.
Tanta, El-GharbiaAges 18 years+ - NCT05582174RecruitingPhase 4
IV medicine versus pills to stop bleeding stomach ulcers
This trial compares an IV “acid-suppressing” medicine (PPI infusion) with acid pills (oral PPIs) after doctors treat a bleeding peptic ulcer endoscopically. It may help prevent re-bleeding by keeping stomach acid low while the ulcer heals.
Guangzhou, GuangdongAges 18 years+ - NCT06129474Recruiting
Reducing unnecessary high-dose heartburn medication in adults
This study tests whether it is safe and helpful to reduce or stop daily high-dose heartburn medications (called PPIs) in patients who might not need them anymore. It is for adults who take a strong PPI every day and can communicate in German.
BernAges 18 years+ - NCT06858384Recruiting
Optimizing PPI use through education and intervention
This trial tests whether educating doctors can reduce unnecessary prescriptions of proton pump inhibitors (PPIs, a type of acid-reducing medicine). If you are an adult patient who has been prescribed a PPI that might not be needed, your doctor may join this study to improve your care.
Ras al-KhaimahAges 18 years+ - NCT07293910RecruitingPhase 2
Comparing treatments for H. pylori infection
This trial tests whether a new type of acid-reducing drug (vonoprazan) works better than a common one (proton pump inhibitor) when combined with vitamin D or probiotics to clear H. pylori, a bacteria that can cause stomach problems. If you have H. pylori and haven't been treated for it before, this study may be for you.
TantaAges 18–80 - NCT07550946RecruitingPhase 1
How Food and Stomach Acid Medicine Affect a New Drug
This study tests how a new experimental drug (VRN101099) works in your body when taken with food and with a common stomach acid medication. Researchers want to understand how these factors change how much drug reaches your bloodstream, which helps them figure out the right dose for future patients.
Melbourne, VictoriaAges 18–65 - NCT07750379Recruiting
Acid-reducing medicine for aspiration in children with laryngomalacia
This study tests whether giving a common acid-reducing medicine (a proton pump inhibitor) to children with laryngomalacia can reduce choking and aspiration. It may help if your child has frequent choking episodes.
Minya, Minya GovernorateAges 6 months–5 years - NCT04415983RecruitingPhase 3
Nitazoxanide for stomach infection in children
This trial studies nitazoxanide to treat Helicobacter pylori, a common stomach infection, in children. If you test positive for this infection and haven’t been treated for it before, you may be able to join.
TantaAges Up to 18 years - NCT07516262Recruiting
How Stomach Acid Medication Affects H. Pylori Detection
This study looks at whether a common stomach acid medication (PPIs) affects the accuracy of a stool test for detecting H. pylori, a bacteria that can cause ulcers and stomach inflammation. Understanding this helps doctors know when the stool test works best.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT03596476Recruiting
Test for reflux causes after proton pump pills fail
This study checks whether a special test of the esophagus after meals can find the exact reason for ongoing reflux symptoms when proton pump pills (PPIs) don’t help. It may help doctors choose the right next treatment for people whose reflux symptoms keep coming back.
Chambray-lès-ToursAges 18 years+ - NCT04416581RecruitingPhase 4
Compare two stomach-protecting medicines to prevent bleeding
This trial compares a potassium-competitive acid blocker to a proton pump inhibitor to help prevent stomach or intestinal bleeding in people at high risk who take blood-thinning medicines. It may help reduce dangerous GI bleeding while you stay on heart/stroke medicines.
AnyangAges 19 years+ - NCT04448028RecruitingPhase 4
Stopping acid pills in liver cirrhosis: test placebo effect
This study tests whether stopping proton-pump inhibitor (PPI) acid-reducing medication is safe and works as expected for people with liver cirrhosis. Participants switch to either the study medication or a placebo (inactive pill) under close monitoring.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT05484128Recruiting
Probiotic for kids taking acid-reducing medicine
This trial studies whether a specific probiotic (Lactobacillus reuteri) is helpful for children who need acid-reducing medicine for reflux or stomach discomfort. It may help improve stomach symptoms while they are on or need treatment with proton pump inhibitors.
BariAges 1–14 - NCT05799105RecruitingPhase 4
Open vs intact capsule acid reducers for marginal ulcers
This study compares two ways of taking acid-reducing medicine (proton pump inhibitors) for marginal ulcers that occur after gastric bypass. It may help decide which form works best to heal ulcers and prevent symptoms from coming back.
Cleveland, OhioAges Any age - NCT06283381RecruitingPhase 4
Effect of heartburn drugs on stomach sleeve results
This study looks at whether taking a common heartburn medicine (proton pump inhibitor) affects the long-term results of a weight-loss procedure called Endoscopic Sleeve Gastroplasty (ESG). It might help you if you are planning to have ESG or have already had it and want to understand how acid-reducing drugs could impact your recovery and weight loss.
RomaAges 18–65 - NCT06393868RecruitingPhase 3
Preventing stomach bleeding with omeprazole during blood thinner therapy
This trial tests whether omeprazole (a stomach acid reducer) can help prevent stomach bleeding in older adults who are taking blood thinners for a newly diagnosed blood clot. It may be a good fit if you are 65 or older and starting blood thinners for a clot.
Ottawa, OntarioAges 65 years+ - NCT06531642RecruitingPhase 2/Phase 3
Early acid-reducing drug for kidney injury after severe bleeding
This study tests whether giving a common acid-reducing medication (a proton pump inhibitor, or PPI) early after severe bleeding from trauma can help protect the kidneys from injury. It compares this early treatment to usual care.
Houston, TexasAges 18 years+ - NCT06706258RecruitingPhase 2
Preventing kidney injury after heart surgery with a stomach acid drug
This trial tests whether giving a common stomach acid medication (a proton pump inhibitor) before, during, and after heart surgery can help prevent acute kidney injury. If you are at moderate to high risk for kidney problems after surgery, this study may be a good fit.
Houston, TexasAges 18–90 - NCT06998966Recruiting
Improving PPI prescribing with electronic help
This study tests if a tool in the electronic health record can help doctors prescribe proton pump inhibitors (medicines for heartburn) more effectively. It may lead to better treatment decisions for patients like you.
Los Angeles, CaliforniaAges 50 years+ - NCT03312686Recruiting
Proton pump medicine effect on esophagus in eosinophilia
This pilot study looks at how proton pump inhibitor medicines (acid reducers) change the flexibility of the esophagus in people who have eosinophilia on esophagus biopsy. It may help doctors understand whether acid control could improve esophagus function in this condition.
Indianapolis, IndianaAges 18–65 - NCT07467213RecruitingPhase 3
Acid reflux drug for heart attack recovery
This trial tests if a newer acid-reducing drug is better than standard care for preventing stomach problems in people who recently had a heart attack and a stent placed. It could help those who need stomach protection while on blood thinners.
SeoulAges 19 years+ - NCT06719622Enrolling by invitationPhase 2/Phase 3
Budesonide for Crohn's in the upper gut
This trial tests a budesonide liquid that targets inflammation in the esophagus, stomach, and duodenum (upper digestive tract) in children with Crohn's disease. It aims to see if this treatment can reduce inflammation in those areas without strong side effects.
KrakowAges 6–18 - NCT06349486Recruiting
Comparing new treatments for H. pylori infection
This trial compares three different medication combinations to see which works best for treating H. pylori infection. If you have H. pylori and haven't been treated yet, you may be able to join.
Kaohsiung CityAges 18 years+
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Common questions
- Are there clinical trials for proton pump inhibitors?
- Yes. Clin2 currently lists 26 recruiting proton pump inhibitors studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a proton pump inhibitors trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a proton pump inhibitors trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.