Clinical trials
Proton Therapy clinical trials
Below are recruiting proton therapy clinical trials, each written for real people, not researchers. We’re tracking 111 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07759999Recruiting
Proton therapy planning software study
This study tests a new software system used to plan and manage proton therapy, a type of radiation treatment that targets tumors precisely. It aims to see if the software works well in routine care, which could improve treatment for future patients.
Madison, WisconsinAges 18 years+ - NCT02986048Recruiting
Proton Therapy Patient Registry
This registry collects information from people who receive proton beam treatment at the UH Proton Therapy Center. It helps the center learn from past and current patients, and may improve care planning in the future.
Cleveland, OhioAges Any age - NCT05856773RecruitingPhase 3
Standard vs shorter radiation to lymph nodes for breast cancer
This trial compares two ways of giving radiation to the breast/chest wall and nearby lymph nodes after breast surgery: a standard schedule versus a shorter “hypofractionated” schedule. It uses proton therapy and may help reduce treatment time while still controlling the cancer.
Scottsdale, ArizonaAges 19 years+ - NCT06462378RecruitingPhase 2
Proton therapy for advanced cervical cancer
This trial tests whether a precise type of radiation called proton therapy can work well for cervical cancer that has spread to lymph nodes. It aims to see if this treatment can shrink tumors with fewer side effects.
CopenhagenAges 18–99 - NCT01255748Recruiting
Registry study tracking outcomes after radiation treatment
This registry study collects information from people who are planning to receive radiation therapy. The goal is to better understand treatment outcomes and help improve radiation care over time.
Scottsdale, ArizonaAges Any age - NCT07412314Recruiting
Proton Therapy for Recurrent Nasopharyngeal Cancer
This trial uses proton therapy (a precise type of radiation) to treat people whose nasopharyngeal cancer has come back. It aims to see if this treatment can help control the cancer while limiting side effects.
Guangzhou, GuangdongAges 18 years+ - NCT05895344Recruiting
Compare proton vs modern radiation effects on thinking
This study compares two types of radiation—proton therapy versus modern fractionated radiation—to see how they affect long-term thinking (cognitive function) and daily abilities in people with a specific skull-base tumor. It may help clarify which radiation approach best protects brain and nerve function over time.
CaenAges 18–70 - NCT06392295RecruitingPhase 2
PSMA-Guided Radiation for Limited Prostate Cancer Return
This trial tests whether targeted radiation to the lymph nodes in the belly can help men whose prostate cancer has returned in just a few spots after prior radiation. You must have had a PSMA PET/CT scan showing the cancer is limited to pelvic or belly lymph nodes.
Miami, FloridaAges 18 years+ - NCT04278118Recruiting
Proton radiation study for non-cancer brain tumor types
This trial tests a radiation plan that gives treatment in fewer, larger “fractions” using proton beams (or sometimes photon beams) for certain non-cancer brain tumor types. It aims to see how well this approach works while keeping side effects manageable.
Atlanta, GeorgiaAges 18 years+ - NCT07135661Recruiting
Comparing two proton radiation schedules for early breast cancer after lumpectomy
This study compares two types of proton radiation after lumpectomy for early breast cancer. It tests whether a shorter, stronger course (ultra-hypofractionated) works as well as a slightly longer moderate course.
ShanghaiAges 40 years+ - NCT06368817RecruitingPhase 2
Lower radiation dose for children with CNS germinoma
This trial will see if giving a lower dose of radiation therapy can still effectively treat children and young adults with a type of brain tumor called germinoma. The goal is to reduce side effects while keeping the cancer under control.
Mobile, AlabamaAges 3–29 - NCT05313191Recruiting
Proton therapy for tumors after prior radiation
This study looks at whether a type of proton beam treatment can be given safely and effectively to tumors that have already been treated with radiation before. It may help people whose tumors came back or persisted after earlier radiation, using a specific proton method called pencil beam scanning.
New York, New YorkAges 18 years+ - NCT05203120Recruiting
Proton beam radiation for liver cancer that can’t be removed
This study tests proton beam radiation for people with liver cancer that is still inside the liver but cannot be treated with surgery or a small-needle procedure. Proton beams aim to better target the tumor while reducing radiation to nearby organs.
Herlev, Capital RegionAges 18 years+ - NCT05055648RecruitingPhase 3
Proton vs photon radiation for esophageal cancer before surgery
This trial compares proton therapy and standard photon therapy given before surgery for esophageal (or stomach–esophagus) cancer. It aims to see which radiation approach works better and is safer as part of a combined treatment plan.
LeuvenAges 18 years+ - NCT03662373Recruiting
Monitoring system study for proton or carbon ion radiation
This trial checks whether a new monitoring system (called INSIDE) can safely work during proton or carbon ion radiation at CNAO. It may help improve how radiation is delivered and checked while treating certain head and skull cancers.
Pavia, PaviaAges 18 years+ - NCT07298642RecruitingPhase 2/Phase 3
Proton therapy for advanced cervical cancer
This trial tests a type of advanced radiation called proton therapy that targets a larger area of the pelvis and abdomen for cervical cancer. It may be an option if your cancer has spread to nearby lymph nodes and you haven't had radiation before.
TaipeiAges 20–85 - NCT07338526Recruiting
Proton therapy for children with brain tumors
This trial tests if a precise type of radiation called proton therapy is safe and effective for children with certain brain tumors. It aims to reduce side effects by focusing radiation only on the tumor.
Mumbai, MaharashtraAges 6–16 - NCT05655078Recruiting
Proton radiation for one-sided malignant pleural mesothelioma
This study tests proton beam radiation aimed at one side of the chest in people with malignant pleural mesothelioma who are not yet having chemotherapy. The goal is to control the cancer while preserving breathing and quality of life for the right patients.
Eastbourne, East SussexAges 18 years+ - NCT05284643Recruiting
MRI-guided radiation and Avastin for recurrent brain glioblastoma
This trial tests whether using special MRI information to plan proton radiation, plus a drug called Avastin (bevacizumab), can help control recurrent glioblastoma (a fast-growing brain tumor) and improve outcomes. It mainly aims to treat tumor that has come back after prior standard radiation, using careful timing and imaging to target it safely.
Miami, FloridaAges 18 years+ - NCT05768087Recruiting
Testing higher-dose proton radiation for new glioblastoma
This trial is testing an escalated dose of proton beam radiation, along with standard chemotherapy and MRI-guided planning, for newly diagnosed glioblastoma. It aims to see whether the higher radiation dose can improve treatment while staying safe for nearby critical brain structures.
Aarhus, Central JutlandAges 18 years+ - NCT07699705Recruiting
Proton Beam Therapy for Localized Prostate Cancer
This study tests a very short course (ultrahypofractionated) of proton beam radiation for localized prostate cancer. It aims to see if it's safe and effective with fewer treatment visits.
Goyang-si, Gyeonggi-doAges 19 years+ - NCT04466124Enrolling by invitation
Study of liver cancer patients getting proton beam therapy
This study follows people with liver cancer who are scheduled to receive proton beam therapy. It looks at how patients do after treatment and what to expect going forward.
Goyang-si, Gyeonggi-doAges 19 years+ - NCT03652428RecruitingPhase 1/Phase 2
Proton radiation plus two chemo drugs for unresectable pancreatic cancer
This trial tests how safe and effective nab-paclitaxel plus gemcitabine chemo is when paired with proton radiation for locally advanced pancreatic cancer that cannot be removed with surgery. It may help shrink the tumor and improve local control.
Washington D.C., District of ColumbiaAges 18–75 - NCT07412327Recruiting
Proton therapy for early stage lung cancer
This trial tests a precise form of proton radiation for people with early stage lung cancer who cannot have surgery. It aims to see if this treatment is effective and safe.
Guangzhou, GuangdongAges 18 years+
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Common questions
- Are there clinical trials for proton therapy?
- Yes. Clin2 currently lists 111 recruiting proton therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a proton therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a proton therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.