Clinical trials
Rectal Cancer Stage II clinical trials
Below are recruiting rectal cancer stage ii clinical trials, each written for real people, not researchers. We’re tracking 93 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06162650RecruitingPhase 2
Pre-surgery chemo-radiation therapy for rectal cancer
This trial tests a combination of chemotherapy and radiation therapy before surgery for people with mid or low rectal cancer that hasn't spread. The goal is to see if this approach works better than current treatments.
TainanAges 20 years+ - NCT06254521RecruitingPhase 2
Tislelizumab plus chemo before surgery for MSS rectal cancer
This trial tests a combination of an immunotherapy drug (tislelizumab) plus chemotherapy before surgery for people with a specific type of rectal cancer that has not spread to other organs. The goal is to see if this approach can shrink the tumor more effectively than standard treatment.
Nanning, GuangxiAges 18 years+ - NCT06565052Recruiting
Exercise and nutrition before rectal cancer surgery study
This trial tests whether a personalized exercise and nutrition program before rectal cancer surgery can help you recover faster and have fewer complications. If you are not very active right now, you may be able to join.
Boston, MassachusettsAges 18 years+ - NCT06589388Recruiting
Using a blood test to predict rectal cancer treatment success
This trial is looking at whether a simple blood test (ctDNA monitoring) can help predict how well total neoadjuvant therapy (chemo and radiation before surgery) works for rectal cancer. It may help doctors tailor treatment to your specific needs.
Ho Chi Minh CityAges 18–80 - NCT06613165Recruiting
Short vs long treatment for stage II-III rectal cancer with dMMR
This trial tests how long you need a PD-1 immunotherapy before surgery for a specific type of rectal cancer (dMMR/MSI-H). It looks at whether a shorter or longer course works best. This could mean fewer side effects and a quicker path to surgery.
Xi'an, ShaanxiAges 18–80 - NCT06746012Recruiting
Health app study for colorectal cancer survivors and their caregivers
This study tests a mobile health program to help colorectal cancer survivors and their family caregivers stick to healthy lifestyle habits. It's for survivors who are at least 6 months past treatment and have a smartphone.
Columbus, OhioAges 18 years+ - NCT06765616RecruitingPhase 2
Immunotherapy with chemo and radiation for rectal cancer before surgery
This trial tests a combination of a PD-L1 inhibitor (adebrelimab), short-course radiation, and chemotherapy given before surgery for locally advanced rectal cancer. The goal is to see if this approach can shrink the tumor and improve outcomes.
Jinan, ShandongAges 18–85 - NCT06834126RecruitingPhase 1
Papaverine with radiation for advanced rectal cancer
This trial tests if adding papaverine (a drug) to radiation therapy can help people with locally advanced rectal cancer avoid surgery and keep their rectum. It is for patients who have already had chemotherapy and want a non-surgical approach.
Duarte, CaliforniaAges 18 years+ - NCT06850090RecruitingPhase 3
Comparing two chemo drugs before radiation for rectal cancer
This trial tests if a newer chemo pill (TAS-102) works better than the standard pill (capecitabine) when given before radiation and surgery for rectal cancer. It is for people with stage II or III rectal cancer that has certain high-risk features.
Jinan, ShandongAges 18–75 - NCT06958432RecruitingPhase 2/Phase 3
Short-course radiation plus chemo and immunotherapy for rectal cancer
This trial tests a treatment plan that uses a short course of radiation to the lymph nodes-sparing area, followed by chemotherapy and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of mid or low rectal cancer (pMMR/MSS). The goal is to see if this approach can shrink the tumor and improve outcomes without needing extensive surgery.
Guangzhou, GuangdongAges 18–75 - NCT07095439RecruitingPhase 2
Sandwich treatment for stage 2 and 3 rectal cancer
This trial tests a new way of giving radiation and chemotherapy before surgery for rectal cancer that hasn't spread. It aims to see if this 'sandwich' approach is safe and works better than standard treatment.
CairoAges 18–70 - NCT07108127RecruitingPhase 2
Targeted drugs plus chemo for HER2-positive rectal cancer
This trial tests whether a combination of two targeted drugs (trastuzumab and pertuzumab biosimilars) plus chemotherapy can shrink advanced HER2-positive rectal cancer before surgery. It aims to improve response and potentially reduce the need for more aggressive treatments.
BeijingAges 18 years+ - NCT07176182RecruitingPhase 2
Chemotherapy with alvenor for rectal cancer with high YWHAB
This trial tests adding the drug alvenor to standard chemotherapy before surgery for rectal cancer patients whose tumors have high levels of a protein called YWHAB. The goal is to see if this combination can improve treatment outcomes.
Guangzhou, GuangdongAges 18–75 - NCT07284992RecruitingPhase 2
Comparing short vs long radiation with immunotherapy for rectal cancer
This trial tests whether a short course of radiation followed by an immunotherapy drug (PD-L1 inhibitor) plus chemotherapy works as well as or better than a longer radiation course for locally advanced rectal cancer. The goal is to shrink tumors before surgery.
Jinan, ShandongAges 18–80 - NCT07352280Recruiting
Immunotherapy before surgery for certain colorectal cancers
This trial tests a new immunotherapy drug (tislelizumab) given before surgery for people with stage II or III colorectal cancer that has a specific DNA repair problem (dMMR/MSI-High). The drug aims to shrink the tumor and improve treatment outcomes.
Beijing, UndefinedAges 18 years+ - NCT02107105Recruiting
Study how surgery affects life quality in rectal cancer
This trial studies how surgical treatment for rectal cancer affects patients’ quality of life and other day-to-day impacts. It may help doctors understand what to expect after surgery and how to better support patients.
Houston, TexasAges 18 years+ - NCT03051464RecruitingPhase 2/Phase 3
Testing two ways to boost radiation to prevent rectal surgery
This study looks at whether two different added “boosts” of radiation can work as well for rectal cancer patients, aiming to avoid or reduce the need for rectal cancer surgery. You would receive a specific combination of radiation (including brachytherapy) and chemotherapy, and your tumor’s location and size will determine if you can take part.
Dallas, TexasAges 18–80 - NCT07405476RecruitingPhase 2
Zanidatamab before surgery for HER2 positive colon or rectal cancer
This trial tests if the drug zanidatamab, given before surgery, can help treat colon or rectal cancer that has a specific marker called HER2. The goal is to see if this approach can shrink tumors and improve outcomes for people whose cancer has not spread to other parts of the body.
Atlanta, GeorgiaAges 18 years+ - NCT07458529RecruitingPhase 2
Chemoradiation plus immunotherapy with or without probiotics for rectal cancer
This trial tests adding an immunotherapy drug (tislelizumab) and a probiotic to standard chemoradiation for locally advanced rectal cancer that has not spread. The goal is to see if the probiotic helps the treatment work better.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07528209RecruitingPhase 3
Chemotherapy with or without immunotherapy for advanced rectal cancer
This study tests whether adding an immunotherapy drug (pucotenlimab) to standard chemotherapy (CAPOX) before surgery helps treat locally advanced rectal cancer better. The goal is to shrink tumors and improve survival while preserving bowel function when possible.
Guangzhou, GuangdongAges 18–75 - NCT07594925RecruitingPhase 2
Short-course radiation plus immunotherapy and chemotherapy for rectal cancer
This trial tests a combination of brief radiation therapy followed by immunotherapy and chemotherapy for locally advanced rectal cancer that hasn't spread. The goal is to see if this approach helps patients avoid or reduce surgery while controlling their cancer.
TianjinAges 18–75 - NCT07669298Recruiting
Monitoring vs chemoradiation for early rectal cancer
This study compares two approaches after early-stage rectal cancer is removed: either careful monitoring or a follow-up treatment with chemotherapy and radiation. The goal is to see which strategy works better to keep the cancer from returning.
LimogesAges 18 years+ - NCT06883084Enrolling by invitation
How lymph node changes affect rectal cancer outcomes
This trial looks at how much the lymph nodes respond to chemoradiation before surgery in people with locally advanced rectal cancer. It aims to understand if that response can predict long-term results and guide future treatment choices.
Ages 18–65 - NCT05316103Recruiting
Optical biopsy of rectal scars after cancer treatment
This trial tests a targeted “optical biopsy” (using a special light-based exam to sample tissue) to better assess rectal scars after standard chemotherapy and radiation before surgery. It may help surgeons choose the most appropriate way to operate on rectal cancer.
Guangzhou, GuangdongAges 18–80
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Common questions
- Are there clinical trials for rectal cancer stage ii?
- Yes. Clin2 currently lists 93 recruiting rectal cancer stage ii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rectal cancer stage ii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rectal cancer stage ii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.