Clinical trials
Rectal Surgery clinical trials
Below are recruiting rectal surgery clinical trials, each written for real people, not researchers. We’re tracking 70 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06326892Recruiting
Natural opening extraction in low rectal cancer surgery
This trial looks back at patients who had surgery for low rectal cancer using a technique where the removed tissue is taken out through a natural opening (like the anus) instead of through a separate cut in the belly. It aims to see how well this approach works.
Rozzano, MIAges 18 years+ - NCT05257746Recruiting
Testing bladder and rectal function after rectal surgery
This study follows people after rectal surgery to check how well the rectum and urinary (bladder) functions work over time. It may help doctors better understand recovery and what can improve quality of life after surgery.
Dresden, SaxonyAges 18 years+ - NCT06936774RecruitingPhase 3
Intensive follow-up after rectal cancer surgery to improve recovery
This study tests whether a more intensive follow-up program after rectal cancer surgery can improve your recovery, daily function, and overall quality of life. If you've had a temporary ileostomy and are waiting for reversal, this extra support may help you feel better faster.
BaselAges 18 years+ - NCT06843174RecruitingPhase 4
Methadone for pain during and after spine surgery
This trial tests if giving a single dose of methadone right before and during spine surgery can help manage pain better. If it works, you might need fewer other pain medicines after surgery.
Toronto, OntarioAges 18–65 - NCT03465982Recruiting
Timing surgery after chemotherapy and radiation for rectal cancer
This trial studies the best time to do surgery after you finish chemotherapy and radiation for rectal cancer. It may help improve how well minimally invasive surgery works and how safely it can be done.
Alessandria, ALAges 18 years+ - NCT07512232Recruiting
Rectal Lavage During Surgery to Lower Cancer Recurrence Risk
This trial tests whether rinsing the rectum with special fluid during minimally invasive surgery for mid-to-low rectal cancer helps prevent the cancer from coming back locally. The procedure aims to wash away cancer cells that might have leaked into the surgical area.
Guangzhou, GuangdongAges 18–75 - NCT07463261Recruiting
Rectal cancer surgery: with or without a temporary stoma
This trial compares two ways of doing rectal cancer surgery: one with a temporary stoma (a bag on the belly) and one without. It aims to see if a stoma helps prevent complications after the bowel is reconnected.
MoscowAges 18–70 - NCT06780787RecruitingPhase 2
Study of chemo plus immunotherapy for localized rectal cancer before surgery
This trial tests a combination of chemotherapy (FOLFOX) and two immunotherapies (botensilimab and balstilimab) before surgery for patients with localized rectal cancer. It aims to see if adding immunotherapy helps shrink the tumor and improve outcomes.
Duarte, CaliforniaAges 18 years+ - NCT07376980Enrolling by invitation
Modified single-stapled anastomosis for rectal cancer surgery
This trial is testing a modified surgical technique (single-stapled anastomosis) for removing part of the rectum in people with rectal cancer. The goal is to see if this approach can improve recovery or outcomes while using minimally invasive methods like laparoscopic or robotic surgery.
Suwon, Gyeonggi-doAges 19 years+ - NCT04103372Recruiting
MRI check for early rectal cancer or large polyps
This trial uses a special MRI before treatment to better understand early rectal cancer or suspicious large polyps. It may help doctors choose care that avoids bigger surgery when possible.
Reading, BerkshireAges 16–100 - NCT03051464RecruitingPhase 2/Phase 3
Testing two ways to boost radiation to prevent rectal surgery
This study looks at whether two different added “boosts” of radiation can work as well for rectal cancer patients, aiming to avoid or reduce the need for rectal cancer surgery. You would receive a specific combination of radiation (including brachytherapy) and chemotherapy, and your tumor’s location and size will determine if you can take part.
Dallas, TexasAges 18–80 - NCT06540027Enrolling by invitation
Minimally invasive surgery for rectal cancer inflammation
This study looks at how different types of surgery (open, laparoscopic, or robotic) affect inflammation throughout the body in people with rectal cancer. It may help doctors understand which approach is gentler on your immune system.
IstanbulAges Any age - NCT07369531Recruiting
Stoma-free survival after new anal-sparing surgery for low rectal cancer
This study compares a two-stage surgical technique (Turnbull-Cutait pull-through) to standard surgery for people with low rectal cancer. The goal is to see which approach helps more patients avoid a permanent stoma (bag) after surgery.
Changchun, JilinAges 18–75 - NCT06824688Recruiting
Comparing robotic surgery types for rectal cancer
This trial compares two robotic surgery methods for rectal cancer: using one small incision (single-port) versus several small incisions (multi-port). The goal is to see which approach offers better outcomes while preserving the sphincter (the muscle that controls bowel movements).
ChongqingAges 18 years+ - NCT06758830RecruitingPhase 2/Phase 3
Total neoadjuvant therapy vs surgery for rectal cancer
This trial tests whether a full course of chemotherapy and radiation before any surgery (called total neoadjuvant therapy) can help you avoid surgery and preserve your rectum. It is for people with a specific early stage of rectal cancer that has not spread.
VilniusAges 18 years+ - NCT04389086RecruitingPhase 3
Chemotherapy before surgery for recurring rectal cancer
This trial tests an “induction chemotherapy” treatment before surgery for people whose rectal cancer has come back in the local area. The goal is to shrink/control the cancer early and improve outcomes after treatment.
GhentAges 18 years+ - NCT06314646Recruiting
Comparing two ways to reconnect the intestine after rectal cancer surgery
This study compares two ways of reconnecting the intestine after rectal cancer surgery. It looks at a newer method called TTSS against the standard double-stapled technique.
Rozzano, MIAges 18 years+ - NCT07616297Recruiting
Higher Radiation Dose to Avoid Surgery in Rectal Cancer
This study tests whether giving a higher dose of radiation to rectal cancer tumors can help patients avoid surgery altogether. The goal is to shrink the tumor enough that surgery is no longer needed, preserving normal bowel function.
Rotterdam, South HollandAges 18 years+ - NCT05569980Enrolling by invitation
Study of rectal prolapse surgery in the Nordic region
This study looks at people who are having surgery for rectal prolapse. The goal is to learn more about outcomes and care for patients after surgery.
Aarhus NAges 18 years+ - NCT06222255Recruiting
Transanal irrigation for sleep issues after rectal cancer surgery
This trial tests if a special irrigation technique can improve sleep problems caused by low anterior resection syndrome (LARS) after rectal cancer surgery. It may help people who have ongoing bowel symptoms that disrupt sleep.
Seoul, Jongro-guAges 19–80 - NCT02966483Recruiting
Transanal or laparoscopic surgery for rectal cancer
This trial compares two surgical approaches to remove rectal cancer tissue while aiming to preserve cure chances. It may help you see which approach fits your tumor location and health situation best.
Beijing, Beijing MunicipalityAges 18–75 - NCT03125343Recruiting
Watch-and-wait after rectal cancer treatment for select patients
This study looks at whether some people with rectal cancer can safely avoid immediate surgery after (chemo)radiation, instead closely monitoring their response. It may help some patients reduce treatment burden if the cancer fully responds.
GothenburgAges 18 years+ - NCT05321134Recruiting
Testing single-port robot surgery for colorectal conditions
This study checks how well a newer single-opening (single-port) robot works for colorectal surgery. It may help surgeons perform operations with the robotic system in carefully selected colorectal conditions.
Sacramento, CaliforniaAges 18 years+ - NCT07194616Recruiting
Rectal cancer blood test study before surgery
This trial is studying a blood test (CTC) for people with rectal cancer that hasn't spread to other parts of the body. It aims to see how the test relates to treatment outcomes after surgery.
OlomoucAges 18 years+
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Common questions
- Are there clinical trials for rectal surgery?
- Yes. Clin2 currently lists 70 recruiting rectal surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rectal surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rectal surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.