Clinical trials
Regurgitation clinical trials
Below are recruiting regurgitation clinical trials, each written for real people, not researchers. We’re tracking 199 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07140562Recruiting
Catheter-based repair for severe tricuspid valve leak
This study tests a new catheter-based device to repair a leaky tricuspid heart valve (tricuspid regurgitation) in people who still have symptoms like shortness of breath or swelling despite taking heart medications. The goal is to see if the procedure is safe and can help reduce the leak.
AsunciónAges 18–90 - NCT05920824Recruiting
Testing treatment for leaking mitral and tricuspid valves
This trial studies people with atrial fibrillation and moderate-to-severe leakiness in the mitral and tricuspid valves in the heart. It likely aims to improve symptoms and heart function by better addressing how these valve leaks happen.
LondonAges 18 years+ - NCT05310461Recruiting
Early or delayed valve surgery for mixed heart valve disease
This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.
BernAges 18 years+ - NCT07516444Recruiting
Tricuspid valve replacement using a new catheter device
This trial tests a new device that replaces a leaky tricuspid valve (a heart valve) without open-heart surgery. If your tricuspid valve isn't working well and medicines haven't helped enough, this procedure might improve your heart function and symptoms.
Minneapolis, MinnesotaAges 18 years+ - NCT06836011Recruiting
Heart valve leakage study in a type of amyloid heart disease
This study looks at how common and how serious heart valve leaks are in people with transthyretin amyloid cardiomyopathy (a condition where abnormal protein builds up in the heart). The goal is to better understand these leaks and how they affect long-term health.
Graz, StyriaAges 18 years+ - NCT07267117Recruiting
Heart valve disease progression and outcomes study
This study is following people with heart valve disease (leaky or narrowed valves) to understand how the disease changes over time and what problems it may cause. It does not test a new treatment, but helps doctors learn more about valve disease progression.
Fuzhou, FujianAges 18 years+ - NCT06877520Recruiting
Study of a new device for fixing leaky tricuspid valve
This trial tests a new, less-invasive device called 'Pivot Extend' for people with a severe leaky tricuspid valve (tricuspid regurgitation) who still have symptoms despite taking medicines. The goal is to see if the device can safely help reduce the leak and improve symptoms.
Tbilisi, K'alak'i T'bilisiAges 18 years+ - NCT07197736Recruiting
Improving heart ultrasound use at Columbia
This study involves cardiologists who read heart ultrasounds in Columbia's echo lab. It aims to improve how these tests are used to help patients.
New York, New YorkAges 18 years+ - NCT07085650Recruiting
Atrial Fibrillation Ablation Study
This study is for people with atrial fibrillation who are planning to have a catheter ablation procedure. It will look at how well the heart works after the procedure and how to prevent future events.
Shenyang, LiaoningAges 18 years+ - NCT06805253Recruiting
Heart recovery after surgery for leaky aortic valve
This trial studies how well the heart's main pumping chamber (left ventricle) recovers after surgery to fix a leaky aortic valve. It is for people who also have a leaky mitral valve and an enlarged left ventricle, and who are having their first planned valve surgery.
MoscowAges 18 years+ - NCT05677568Enrolling by invitation
Registry study for Carillon device in leaky mitral valve
This registry collects health information from adults who already have the Carillon device to treat a leaky mitral valve caused by dilated heart muscle. The goal is to better understand how the device performs in real-world care over time.
AachenAges 18 years+ - NCT05628779Enrolling by invitation
Clip procedure to repair a leaking tricuspid valve
This trial studies a minimally invasive “edge-to-edge” clip procedure to reduce severe leakage of the tricuspid valve. It’s for people who still feel unwell despite standard treatments and may be too high-risk for open-heart surgery.
AmsterdamAges 18 years+ - NCT04570163Recruiting
Registry tracking right-heart valve procedures and outcomes
This is a registry that collects information about people who have planned or recent right-heart valve procedures (such as tricuspid or pulmonary valve problems). It helps researchers understand what care is done and how patients do over time, which may improve future treatment planning.
BerlinAges 18–120 - NCT06307262Recruiting
European registry for tricuspid valve repair
This trial is a registry that collects information on patients who have had a minimally invasive procedure to fix a leaky tricuspid valve. By joining, you help doctors learn more about how well these devices work over time.
Munich, BavariaAges 18 years+ - NCT03975998Recruiting
Early mitral valve repair versus watchful waiting
This trial compares doing mitral valve repair early with closely monitoring symptoms instead, for people who have severe leakage but feel well. It may help determine whether early surgery prevents future heart problems without causing unnecessary risk.
AmsterdamAges 18–75 - NCT04084132Recruiting
Testing earlier vs later valve replacement after repaired Tetralogy
This study compares doing a valve replacement earlier versus later in people born with Tetralogy of Fallot who already had heart surgery as babies. It may help decide the safest timing to protect heart function, especially right-sided pumping and valve leakage.
AarhusAges 12 years+ - NCT04577248Recruiting
Heart valve registry for people considering valve procedures
This study follows adults with leaky or narrowed heart valves who are being considered for a valve procedure. It helps doctors better understand patient outcomes and care decisions for these valve problems.
Munich, BavariaAges 18–110 - NCT04653428Recruiting
German registry for repairing a severely leaky tricuspid valve
This study records patients who get a catheter-based repair for a severely leaky tricuspid heart valve. It helps doctors and researchers learn how these treatments work in real-world care.
MunichAges 18 years+ - NCT04733404Recruiting
Dragonfly device study for functional mitral valve leakage
This trial tests a catheter-based procedure (putting a small device through blood vessels) to repair a leaking mitral valve caused by heart muscle problems. It aims to reduce symptoms and improve heart function and safety in people who are still having heart failure symptoms despite standard treatment.
Hangzhou, ZhejiangAges 18 years+ - NCT04755842Recruiting
Study of severe tricuspid valve leakage in Hamburg
This study focuses on people with severe “tricuspid regurgitation,” which means a valve in the right side of the heart leaks backward. It collects information (including interviews) to better understand this condition and what to do next.
HamburgAges 18 years+ - NCT05610566Recruiting
HighLife valve replacement for severe leaking mitral valve
This trial studies a new catheter-based valve replacement system for people with moderate to severe, or severe, mitral valve regurgitation (a leaky mitral valve). It aims to check whether the procedure is safe and can improve heart function compared with expected care.
Suzhou, JiangsuAges 18 years+ - NCT05667519Recruiting
Ultrasound-guided pacemaker lead placement to prevent valve leak
This trial tests a way to place a pacemaker lead using a special ultrasound view through the esophagus (a transesophageal echocardiogram). The goal is to reduce the chance of developing a serious leak in the tricuspid valve caused by the pacemaker lead.
Munich, BavariaAges 18 years+ - NCT05469165RecruitingPhase 2
Testing serotonin blockers after a first heart attack
This Phase 2 trial tests whether blocking serotonin receptors can help after a first heart attack that has caused a specific type of leaking mitral valve problem. It aims to see if the treatment improves heart function and heart-valve measurements while keeping patients safe.
QuébecAges 18–80 - NCT05455489Recruiting
MitraClip registry for severe mitral valve leakage patients
This registry study collects information on people with severe mitral valve leakage (regurgitation) who are treated with the MitraClip G4 device. It aims to better understand which patients benefit most and how well the procedure works in real-world care.
San Donato Milanese, MilanoAges 18 years+
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Common questions
- Are there clinical trials for regurgitation?
- Yes. Clin2 currently lists 199 recruiting regurgitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a regurgitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a regurgitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.