Clinical trials
Regurgitation clinical trials
Below are recruiting regurgitation clinical trials, each written for real people, not researchers. We’re tracking 204 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05920824Recruiting
Testing treatment for leaking mitral and tricuspid valves
This trial studies people with atrial fibrillation and moderate-to-severe leakiness in the mitral and tricuspid valves in the heart. It likely aims to improve symptoms and heart function by better addressing how these valve leaks happen.
LondonAges 18 years+ - NCT07140562Recruiting
Catheter-based repair for severe tricuspid valve leak
This study tests a new catheter-based device to repair a leaky tricuspid heart valve (tricuspid regurgitation) in people who still have symptoms like shortness of breath or swelling despite taking heart medications. The goal is to see if the procedure is safe and can help reduce the leak.
AsunciónAges 18–90 - NCT07516444Recruiting
Tricuspid valve replacement using a new catheter device
This trial tests a new device that replaces a leaky tricuspid valve (a heart valve) without open-heart surgery. If your tricuspid valve isn't working well and medicines haven't helped enough, this procedure might improve your heart function and symptoms.
Minneapolis, MinnesotaAges 18 years+ - NCT05310461Recruiting
Early or delayed valve surgery for mixed heart valve disease
This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.
BernAges 18 years+ - NCT04570163Recruiting
Registry tracking right-heart valve procedures and outcomes
This is a registry that collects information about people who have planned or recent right-heart valve procedures (such as tricuspid or pulmonary valve problems). It helps researchers understand what care is done and how patients do over time, which may improve future treatment planning.
BerlinAges 18–120 - NCT06805253Recruiting
Heart recovery after surgery for leaky aortic valve
This trial studies how well the heart's main pumping chamber (left ventricle) recovers after surgery to fix a leaky aortic valve. It is for people who also have a leaky mitral valve and an enlarged left ventricle, and who are having their first planned valve surgery.
MoscowAges 18 years+ - NCT06836011Recruiting
Heart valve leakage study in a type of amyloid heart disease
This study looks at how common and how serious heart valve leaks are in people with transthyretin amyloid cardiomyopathy (a condition where abnormal protein builds up in the heart). The goal is to better understand these leaks and how they affect long-term health.
Graz, StyriaAges 18 years+ - NCT06877520Recruiting
Study of a new device for fixing leaky tricuspid valve
This trial tests a new, less-invasive device called 'Pivot Extend' for people with a severe leaky tricuspid valve (tricuspid regurgitation) who still have symptoms despite taking medicines. The goal is to see if the device can safely help reduce the leak and improve symptoms.
Tbilisi, K'alak'i T'bilisiAges 18 years+ - NCT07085650Recruiting
Atrial Fibrillation Ablation Study
This study is for people with atrial fibrillation who are planning to have a catheter ablation procedure. It will look at how well the heart works after the procedure and how to prevent future events.
Shenyang, LiaoningAges 18 years+ - NCT07197736Recruiting
Improving heart ultrasound use at Columbia
This study involves cardiologists who read heart ultrasounds in Columbia's echo lab. It aims to improve how these tests are used to help patients.
New York, New YorkAges 18 years+ - NCT07267117Recruiting
Heart valve disease progression and outcomes study
This study is following people with heart valve disease (leaky or narrowed valves) to understand how the disease changes over time and what problems it may cause. It does not test a new treatment, but helps doctors learn more about valve disease progression.
Fuzhou, FujianAges 18 years+ - NCT05677568Enrolling by invitation
Registry study for Carillon device in leaky mitral valve
This registry collects health information from adults who already have the Carillon device to treat a leaky mitral valve caused by dilated heart muscle. The goal is to better understand how the device performs in real-world care over time.
AachenAges 18 years+ - NCT05628779Enrolling by invitation
Clip procedure to repair a leaking tricuspid valve
This trial studies a minimally invasive “edge-to-edge” clip procedure to reduce severe leakage of the tricuspid valve. It’s for people who still feel unwell despite standard treatments and may be too high-risk for open-heart surgery.
AmsterdamAges 18 years+ - NCT07539298RecruitingPhase 2/Phase 3
Valsartan for Heart-Related Mitral Valve Leaking
This study tests whether a blood pressure medication called valsartan can reduce leaking in the mitral valve (a valve in your heart) caused by an enlarged left chamber. The goal is to see if this medication can improve heart function and reduce symptoms without needing surgery.
Québec, QuebecAges 18–85 - NCT07470788Recruiting
Vesalius TMVr system for leaky heart valve (mitral regurgitation)
This study tests a new device called the Vesalius TMVr system to fix a leaky mitral valve without open-heart surgery. It's for people with severe mitral regurgitation who are not good candidates for surgery.
VancouverAges 19 years+ - NCT06329817Recruiting
Regurgitation risk during intubation: semi-fowler vs supine
This trial compares two positions (semi-fowler and supine) during intubation to see which reduces regurgitation risk. It may help if you are an adult scheduled for intubation.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT07453407Recruiting
Tavi valve vs surgery for severe aortic regurgitation
This trial compares a new catheter-based valve (J-Valve) with open-heart surgery for people with severe aortic regurgitation, a condition where the aortic valve doesn't close tightly. It aims to see which treatment is safer and more effective.
Hefei, AnhuiAges 65 years+ - NCT07677410Recruiting
Aspirin alone vs. aspirin with warfarin after TAVR for aortic regurgitation
This trial tests whether taking aspirin alone is as safe and effective as taking aspirin with warfarin after a TAVR procedure for severe aortic regurgitation. It is for people who do not need long-term blood thinners for other conditions.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07130994Recruiting
Testing a new less invasive mitral valve replacement (SATURN)
This trial tests a new, less invasive device called the SATURN system to replace a severely leaky mitral heart valve without open-heart surgery. It is for people who are too high-risk for traditional surgery and are willing to take blood thinners.
Los Angeles, CaliforniaAges 18 years+ - NCT03389542Recruiting
Early mitral valve repair versus watchful waiting
This trial compares doing mitral valve repair early versus closely monitoring without surgery in people who have severe leakage but no symptoms. It aims to see whether early repair helps prevent future heart problems.
AmiensAges 18–75 - NCT06823700Recruiting
Study of SQ-Kyrin device for leaky mitral valve from heart failure
This trial tests a new device (SQ-Kyrin) to fix a leaky mitral valve without open-heart surgery. It is for people with heart failure whose valve leak causes symptoms, and who are not good candidates for traditional surgery.
Valladolid, ValladolidAges 18 years+ - NCT06583876Recruiting
A new device for leaky mitral valves without open-heart surgery
This trial tests a new device for people whose mitral valve leaks badly (grade 3+ or 4+) and who are not candidates for surgery. The device aims to fix the leak through a less invasive approach, and the study checks if it's safe and works well in daily life.
BudapestAges 18 years+ - NCT04733404Recruiting
Dragonfly device study for functional mitral valve leakage
This trial tests a catheter-based procedure (putting a small device through blood vessels) to repair a leaking mitral valve caused by heart muscle problems. It aims to reduce symptoms and improve heart function and safety in people who are still having heart failure symptoms despite standard treatment.
Hangzhou, ZhejiangAges 18 years+ - NCT06467110Enrolling by invitation
Study of SQ-Kyrin TMVr System for leaky mitral valve
This trial tests a new device called the SQ-Kyrin TMVr System to treat severe mitral regurgitation (a leaky heart valve) in people who are not good candidates for traditional open-heart surgery. The goal is to repair the valve without major surgery, using a catheter-based approach.
Shenyang, LiaoningAges 18 years+
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Common questions
- Are there clinical trials for regurgitation?
- Yes. Clin2 currently lists 204 recruiting regurgitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a regurgitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a regurgitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.