Clinical trials
Aortic Regurgitation Disease clinical trials
Below are recruiting aortic regurgitation disease clinical trials, each written for real people, not researchers. We’re tracking 53 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07453407Recruiting
Tavi valve vs surgery for severe aortic regurgitation
This trial compares a new catheter-based valve (J-Valve) with open-heart surgery for people with severe aortic regurgitation, a condition where the aortic valve doesn't close tightly. It aims to see which treatment is safer and more effective.
Hefei, AnhuiAges 65 years+ - NCT07677410Recruiting
Aspirin alone vs. aspirin with warfarin after TAVR for aortic regurgitation
This trial tests whether taking aspirin alone is as safe and effective as taking aspirin with warfarin after a TAVR procedure for severe aortic regurgitation. It is for people who do not need long-term blood thinners for other conditions.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07350629Recruiting
Checking heart valve disease with a finger sensor
This study uses a finger sensor to measure artery waves to assess heart valve problems like aortic regurgitation or stenosis. If you have one of these conditions or are a healthy volunteer, you may help improve noninvasive heart disease detection.
Hefei, AnhuiAges 18–80 - NCT04126018Recruiting
MRI scan comparison for certain leaking or narrowed heart valves
This trial studies how well different MRI images can assess heart valve problems—like leaking (regurgitation) or narrowing (stenosis). It may help doctors get clearer information, especially in people who may not respond well to cardiac resynchronization therapy (CRT).
Cleveland, OhioAges 18–90 - NCT04864145Recruiting
Valve procedure trial for severe leaking aortic valve
This trial studies a less invasive heart valve procedure that places a new valve through a catheter, to treat severe leakage of the aortic valve. It may help people who have symptoms or heart enlargement and who are at higher risk for open-heart surgery.
Nanjing, JiangsuAges 60–90 - NCT05438862Recruiting
Early aortic valve surgery versus watchful waiting
This trial compares two approaches for people with a leaking aortic valve but no symptoms: early surgery or careful monitoring (“watchful waiting”). It aims to see which strategy better prevents future heart problems and when surgery is most helpful.
AalstAges 18 years+ - NCT05506293Recruiting
Registry study for sealing leaking heart valve devices
This is a study that collects information from people who are having a minimally invasive procedure to close a leak around a heart valve replacement device. It may help doctors better understand how well this procedure works and what outcomes to expect.
CharleroiAges 16–110 - NCT06235385Recruiting
European study on multiple and mixed valve disease
This study looks at people with multiple or mixed heart valve disease (moderate or severe) using echocardiography. It aims to learn more about how these conditions affect patients and help guide future care.
Paris, Île-de-France RegionAges 18 years+ - NCT06455787Recruiting
J-Valve study for leaky aortic valve patients
This study tests a new, less invasive device called J-Valve for people with severe aortic regurgitation (a leaky aortic valve). It is placed through a tube in the leg artery, avoiding open-heart surgery, and may help those who are at high risk for surgery.
Scottsdale, ArizonaAges 18 years+ - NCT06595992Recruiting
Observing moderate aortic valve disease over time
This study follows people with moderate aortic valve disease to learn how their condition changes. It does not test a new treatment but will help doctors better understand the disease.
Hangzhou, ZhejiangAges 18 years+ - NCT06688448Recruiting
New biologic aortic valve replacement study
This study is testing a new generation of biologic (tissue) replacement valves for the aortic valve in adults aged 18 to 65. It aims to see how well these newer devices work compared to standard options.
São Paulo, São PauloAges 18–65 - NCT06608823Recruiting
Comparing surgery vs. the Trilogy valve for aortic regurgitation
This trial compares a new less-invasive valve replacement (Trilogy TAVR) with standard open-heart surgery for people with significant aortic regurgitation. It aims to see which treatment works better for patients who are eligible for both procedures.
Burlingame, CaliforniaAges Any age - NCT06780241Recruiting
Sex differences in valvular heart disease
This study uses special MRI scans to look at how valvular heart disease (like leaky or narrowed aortic valves) affects men and women differently. It aims to find unique biological patterns that could lead to better treatments.
Cleveland, OhioAges 18–90 - NCT06818084RecruitingPhase 4
TAVR for severe aortic regurgitation using VitaFlow Liberty
This trial tests the VitaFlow Liberty device, a catheter-based treatment for people with severe aortic regurgitation (a leaky heart valve). If you have symptoms or your heart is starting to weaken, this procedure might help avoid open-heart surgery.
Shanghai, Shanghai MunicipalityAges 60 years+ - NCT06835946Recruiting
How anesthesia and imaging affect heart valve leak assessment
This study looks at how anesthesia, breathing machines, and imaging methods change the way doctors measure a leaky heart valve. It aims to make sure the severity of aortic regurgitation is accurately measured before surgery.
LiègeAges 18 years+ - NCT06869954Recruiting
Bicuspid aortic valve repair: comparing two surgical techniques
This trial tests two different ways to repair a leaky bicuspid aortic valve (a valve with two flaps instead of three). The goal is to see which repair method works better. If you need surgery for a severely leaking valve and your valve is the right shape, you may be able to join.
Augsburg, BavariaAges 18 years+ - NCT07021612Recruiting
Registry study of TAVI for severe aortic regurgitation
This study is for people with a severe leaking aortic valve (aortic regurgitation) who are too high-risk for open-heart surgery. It tracks how well a less-invasive valve replacement (TAVI) using the JenaValve or J-Valve works for them.
Hong Kong, ShatinAges 18 years+ - NCT07097740Recruiting
Study of a new polymer heart valve for mitral or aortic replacement
This study tests a new type of prosthetic heart valve made from a special polymer material. It is for adults who need surgical replacement of either the mitral or aortic valve.
Shanghai, Shanghai MunicipalityAges 50 years+ - NCT07099859RecruitingPhase 4
Losartan after aortic valve surgery for severe leakage
This trial tests if the drug losartan can help the heart recover better after surgery to replace a leaky aortic valve. It may reduce strain on the heart and improve long-term outcomes.
São Paulo, São PauloAges 18–85 - NCT07197736Recruiting
Improving heart ultrasound use at Columbia
This study involves cardiologists who read heart ultrasounds in Columbia's echo lab. It aims to improve how these tests are used to help patients.
New York, New YorkAges 18 years+ - NCT07267117Recruiting
Heart valve disease progression and outcomes study
This study is following people with heart valve disease (leaky or narrowed valves) to understand how the disease changes over time and what problems it may cause. It does not test a new treatment, but helps doctors learn more about valve disease progression.
Fuzhou, FujianAges 18 years+ - NCT07486271Recruiting
AI in Aortic Regurgitation trial
This trial uses artificial intelligence to help measure aortic regurgitation, a heart valve problem. It aims to improve how doctors assess and treat this condition.
Hong Kong, New TerritoriesAges 18 years+ - NCT07398911Enrolling by invitation
3D simulated TAVR for aortic valve leak
This trial tests whether a 3D computer simulation can help guide a less invasive procedure (TAVR) to replace a leaky aortic valve. It may be an option for people with severe aortic regurgitation who are at least 65 years old.
Xi’an, ShanxiAges 65 years+ - NCT06518681Enrolling by invitation
Testing a new polymer heart valve for aortic disease
This trial tests a new type of artificial heart valve made of polymer (a special plastic-like material) for people with severe aortic valve disease. It aims to see if the valve is safe and works well, giving you an option for a replacement valve that might last longer.
Shanghai, Shanghai MunicipalityAges 18 years+
Hear when a new Aortic Regurgitation Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for aortic regurgitation disease?
- Yes. Clin2 currently lists 53 recruiting aortic regurgitation disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic regurgitation disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic regurgitation disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.