Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 502 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06514365Recruiting
Comparing nerve blocks for pain after knee replacement
This trial compares two different ways of numbing the leg to provide better pain relief after total knee replacement surgery. It tests whether adding a popliteal sciatic nerve block (behind the knee) to a saphenous block (inner thigh) works better than adding an IPACK block (back of the knee).
Badalona, BarcelonaAges 18 years+ - NCT06524180Recruiting
Can telehealth replace doctor visits for controlled high blood pressure?
This trial tests if a telemedicine system can safely replace face-to-face doctor appointments to keep your blood pressure under control. If you have high blood pressure that is well-managed with medication, this study may help you manage your health from home.
Hong Kong, Hong KongAges 18–80 - NCT06534047RecruitingPhase 4
Brain stimulation or nicotine patch to help you quit smoking
This study tests whether a brain stimulation treatment called rTMS can help people with psychiatric conditions quit smoking. You will be randomly assigned to get either rTMS or a nicotine patch, and your progress will be tracked to see which treatment works better.
Toronto, OntarioAges 18–70 - NCT06545565RecruitingPhase 3
Preventing acid buildup in preterm babies on IV nutrition
This trial tests if replacing sodium chloride with sodium acetate in IV nutrition can prevent metabolic acidosis (too much acid in the blood) in preterm babies born before 33 weeks. If your baby is in the NICU and needs IV nutrition, this study may help keep their blood chemistry balanced.
Karachi, SindhAges 1 day–3 days - NCT06551337RecruitingPhase 4
Vitamin D for bronchiectasis patients
This trial tests if taking vitamin D can help people with bronchiectasis have fewer flare-ups. It is only for patients who were in an earlier study that checked their vitamin D levels.
Hong KongAges 18 years+ - NCT06552689Recruiting
Testing Sutra Hemi-valve for leaky mitral valve
This trial tests a new, less invasive heart valve (Sutra Hemi-valve) for people with a leaky mitral valve who cannot have standard surgery. The valve is delivered through a vein in your leg, so you avoid open-heart surgery.
HamiltonAges 18 years+ - NCT06557798Recruiting
Second TAVI for failing aortic valve replacement
This trial is for people who have already had a TAVI (a minimally invasive aortic valve replacement) and now need a second procedure because the valve is failing. The study will test how well a redo TAVI works to fix the failing valve.
AalborgAges 18 years+ - NCT06559332Recruiting
Heart artery checks during aortic valve replacement
This study tests different ways to check for blocked heart arteries in patients getting a new aortic valve through a tube in the leg. It aims to find the best approach to guide treatment.
BernAges 70 years+ - NCT06569602Recruiting
EVOQUE valve study for leaky tricuspid valve
This study is testing a new way to replace the tricuspid valve (the valve that controls blood flow from the heart's right upper chamber to the right lower chamber) without open-heart surgery. The goal is to see how safe and effective the EVOQUE valve is for people with a leaky tricuspid valve.
Bad OeynhausenAges Any age - NCT06578182RecruitingPhase 3
Can colchicine reduce knee or hip replacement?
This study tests whether a low-dose medicine called colchicine can lower the chance that people with knee or hip arthritis will need a joint replacement. If you have arthritis in your knee or hip and are not already scheduled for surgery, you may be able to join.
NijmegenAges 45–80 - NCT06579001RecruitingPhase 4
Nasal spray to prevent confusion after hip replacement
This trial tests if a nasal spray called dexmedetomidine can prevent confusion (emergence delirium) after a hip replacement. It may help older adults wake up more calmly from anesthesia.
HangzhouAges 60 years+ - NCT06579547Recruiting
Testing MRI instead of CT for joint imaging
This study tests if a new, radiation-free MRI method can replace standard CT scans for checking joint problems like arthritis. You would get both an MRI and a CT scan, and researchers compare the results to see if the MRI works just as well without radiation.
ZurichAges 18 years+ - NCT06581471Recruiting
New device for severe leaky heart valve
This study tests a new device to fix a leaky tricuspid valve without open-heart surgery. It is for people with severe leakage who are considered too high-risk for traditional surgery.
AalstAges 18 years+ - NCT06581965RecruitingPhase 4
Personalized blood clot prevention for hip or knee replacement
This trial compares a personalized approach to preventing blood clots after hip or knee replacement surgery with the standard one-size-fits-all method. The goal is to see if tailoring prevention to each patient works better and is safer.
Apeldoorn, GelderlandAges 18 years+ - NCT07007195RecruitingEarly Phase 1
Smart smell app to help you quit smoking
This study tests a smartphone app that uses your sense of smell to help you quit smoking. You'll use nicotine replacement therapy (like patches or gum) and the app to avoid relapse.
Houston, TexasAges 18 years+ - NCT07691307Recruiting
TruGamma tricuspid valve replacement study
This trial tests a new device called TruGamma to replace the tricuspid valve without open-heart surgery. It is for older adults with severe tricuspid regurgitation who cannot have surgery and still have symptoms despite medication.
Beijing, Beijing MunicipalityAges 65 years+ - NCT07690202Recruiting
Living with kidney disease without dialysis or transplant
This study looks at the experiences of women of childbearing age who have chronic kidney disease but are not on dialysis or have not had a kidney transplant. The goal is to understand how the disease affects their lives.
CaenAges 18 years+ - NCT07689461Recruiting
Virtual reality for pain after hip replacement
This trial tests if using virtual reality can help reduce pain after hip replacement surgery. It may be a good option if you are having a hip replacement and have moderate to severe pain.
MalatyaAges 18–99 - NCT07643597Recruiting
Managing fluid removal in critically ill patients with acute kidney injury
This study looks at how to safely remove excess fluid from patients in the ICU who have sudden kidney failure and are on a special blood-filtering machine (CRRT). Researchers want to understand which patients have trouble tolerating fluid removal and how to prevent complications.
SalvadorAges 18 years+ - NCT06603103Recruiting
Comparing two knee implants in total knee replacement
This study compares two types of knee implants (SpheriKA and Origin) used in total knee replacement surgery with a specific alignment technique. The goal is to see which one may lead to better outcomes for patients needing a first knee replacement.
MérignacAges 18 years+ - NCT06603454Recruiting
Chest CT before aortic valve replacement surgery
This study looks at whether a CT scan of the chest before aortic valve replacement surgery (with or without bypass) can help doctors plan the procedure better. It is for people with severe aortic valve stenosis who are already scheduled for surgery.
Nieuwegein, UtrechtAges 18 years+ - NCT06611579Recruiting
Study of the MonarQ System for Leaky Tricuspid Valve
This study tests a new device called the MonarQ TTVR System, which is placed through a small tube in a blood vessel to fix a leaky tricuspid valve without open-heart surgery. It is for people with severe tricuspid regurgitation symptoms that are not relieved by heart failure medicines alone.
Los Angeles, CaliforniaAges 18 years+ - NCT06614010RecruitingPhase 1
Testing drugs for hip replacement recovery
This trial studies how giving a sedative drug (dexmedetomidine) through different routes, combined with a numbing shot for the hip, can help reduce confusion and agitation right after hip replacement surgery. The goal is to find which method works best for a smoother wake-up.
Jinan, ShandongAges 18–65 - NCT06641505Recruiting
Deep breathing test to guide fluid before surgery in older adults
This trial uses a simple breathing test to see how the internal jugular vein (a large vein in the neck) changes with deep breaths. The goal is to guide how much fluid to give before surgery, which may help older patients stay stable during the operation.
Jiaxing, ZhejiangAges 60–80
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 502 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.