Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 502 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07105670Recruiting
Replacing high-protein foods in chronic kidney disease
This study looks at how replacing high-protein foods affects people with chronic kidney disease. If you join, you will eat a carefully controlled diet to help researchers understand if changing your protein intake can improve your kidney health.
West Lafayette, IndianaAges 40–70 - NCT07466745Recruiting
New Pulmonary Valve Study for Kids Needing Replacement
This study tests a new type of replacement valve for children who need a new pulmonary valve (the valve between the heart and lungs). Researchers want to see if the valve works safely and well in real-world use.
Los Angeles, CaliforniaAges 1.5 years–16 years - NCT07130994Recruiting
Testing a new less invasive mitral valve replacement (SATURN)
This trial tests a new, less invasive device called the SATURN system to replace a severely leaky mitral heart valve without open-heart surgery. It is for people who are too high-risk for traditional surgery and are willing to take blood thinners.
Los Angeles, CaliforniaAges 18 years+ - NCT06469073Recruiting
Nerve block for pain after heart valve surgery
This study tests a special nerve block (ultrasound-guided) to see if it can better control pain after heart valve replacement surgery. It may help you recover more comfortably if you are having your first mitral or aortic valve replacement.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05628389Recruiting
Phone-based help to quit smoking or waterpipe
This study offers phone support to help people quit smoking cigarettes and/or waterpipe. It may help you build a quit plan and get regular encouragement and coaching from a distance.
BeirutAges 18 years+ - NCT05290818Recruiting
Robotic vs standard knee replacement for inner-joint wear
This trial compares robotic-assisted knee replacement with the usual (non-robotic) approach for people with severe arthritis on the inner (medial) side of the knee. It aims to see which method works better for pain and function while matching the right knee anatomy for certain implant types.
Edinburgh, LothianAges 50–75 - NCT04677907Recruiting
Testing a metal knee implant feature in osteoarthritis surgery
This trial studies a specific type of knee replacement and how well it works after surgery for people with knee osteoarthritis. It may help doctors understand which implant approach leads to better outcomes and recovery.
Glasgow, ScotlandAges 18 years+ - NCT03806881Enrolling by invitation
Follow-up after shoulder replacement using a patient-specific implant
This study follows people after a primary or revision shoulder joint replacement when the shoulder socket bone has severe damage. It checks long-term outcomes and how well the patient-specific implant and required therapy work for recovery.
HerentalsAges 18 years+ - NCT06861361Recruiting
Surgery versus transcatheter valve replacement in younger patients
This trial compares two ways to replace a narrowed aortic heart valve in patients aged 65 to 75. It aims to find which approach—surgical valve replacement or a catheter-based procedure—works better for people in this age group.
GrazAges 65–75 - NCT06758297Recruiting
AI motivational talk after knee replacement
This study tests whether an artificial intelligence-guided motivational conversation can help reduce fear of moving after knee replacement surgery, and improve how much you can move.
Samsun, SamsunAges 18 years+ - NCT06591000Recruiting
Comparing two types of tricuspid valve replacements
This trial compares two types of replacement valves for the tricuspid valve: a donated human valve (allograft) and a stented biological valve (made from animal tissue). The goal is to see which works better and lasts longer.
ChelyabinskAges 18–70 - NCT06203756Enrolling by invitation
Robotic-Assisted Knee Replacement Outcomes Study
This study tests a robotic-assisted system for knee replacement surgery. It aims to see how well patients do with the robotic help.
Flagstaff, ArizonaAges Any age - NCT05992064Recruiting
Wearable sensors to track recovery after knee replacement
This study uses a small wearable sensor placed on your leg after knee replacement surgery to track your recovery. It helps doctors see how well you are moving and healing, without extra visits to the hospital.
Frederikshavn, North DenmarkAges 18 years+ - NCT06127589Recruiting
Quit for Kids: help parents quit smoking and protect children
This study offers a program to help parents who smoke quit for good, while protecting their young children from secondhand smoke. It uses text messaging and support to make quitting easier.
Hong KongAges 18 years+ - NCT05831709Recruiting
Hormone therapy and supervised exercise in menopausal women
This study looks at how hormone replacement therapy and a supervised exercise program may change body composition, heart health risk, and insulin sensitivity in postmenopausal women. It may help participants understand which combination works best for metabolic and cardiovascular health after menopause.
GhentAges 45–65 - NCT05736549RecruitingPhase 2
Tested stronger pain-blocking shot for knee replacement surgery
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
New Haven, ConnecticutAges 18 years+ - NCT05815199Recruiting
E-cigarettes to help smokers with serious mental illness cut down
This study tests whether e-cigarettes can help people who smoke a lot reduce cigarette use (without requiring them to quit completely). It is designed for adults with serious mental illness and focuses on harm reduction and follow-up over time.
New York, New YorkAges 21 years+ - NCT07107581Enrolling by invitation
Exactech knee replacement follow-up study
This study is following patients who have or will receive an Exactech total knee replacement. It looks at how well the knee works over time and helps doctors understand long-term results.
DeLand, FloridaAges 18 years+ - NCT05575024Recruiting
Monitoring blood pressure and heart rhythm during kidney support in sepsis
This study looks at how stable blood pressure and heart rhythm are in people with sepsis who need continuous kidney filtration. If you qualify, it may help researchers better improve care for critically ill patients receiving this treatment.
SeoulAges 18 years+ - NCT05607966Recruiting
Knee replacement follow-up study for ORIGIN® implant
This study follows people who need a total knee replacement using the ORIGIN® implant. It’s meant to see how well the implant works and how people do over time with routine clinic visits.
AntwerpAges 18–99 - NCT04884542Recruiting
Testing a knee replacement implant for total knee arthroplasty
This study looks at outcomes after surgery using the Multigen Plus H knee replacement system, sometimes with special add-on parts called AMF TT cones. It may help improve how well these knee implants work and how patients recover after total knee replacement.
GhentAges 18 years+ - NCT04728542Recruiting
Observational study comparing two osteoporosis treatment approaches
This is an observational study, meaning researchers watch what happens in real life rather than assigning a treatment by chance. It compares outcomes between people using ORIGIN® and VANGUARD® PS, to better understand how these approaches perform.
MainzAges 18 years+ - NCT05076019Recruiting
Atorvastatin during heart valve surgery for patients over 60
This trial studies whether taking atorvastatin (a cholesterol medicine) around the time of surgical aortic valve replacement can improve outcomes. It is mainly for people who have not taken similar medicines recently and do not have certain heart rhythm or liver/kidney problems.
OdenseAges 60–95
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 502 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.