Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 505 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05607966Recruiting
Knee replacement follow-up study for ORIGIN® implant
This study follows people who need a total knee replacement using the ORIGIN® implant. It’s meant to see how well the implant works and how people do over time with routine clinic visits.
AntwerpAges 18–99 - NCT04884542Recruiting
Testing a knee replacement implant for total knee arthroplasty
This study looks at outcomes after surgery using the Multigen Plus H knee replacement system, sometimes with special add-on parts called AMF TT cones. It may help improve how well these knee implants work and how patients recover after total knee replacement.
GhentAges 18 years+ - NCT04728542Recruiting
Observational study comparing two osteoporosis treatment approaches
This is an observational study, meaning researchers watch what happens in real life rather than assigning a treatment by chance. It compares outcomes between people using ORIGIN® and VANGUARD® PS, to better understand how these approaches perform.
MainzAges 18 years+ - NCT05076019Recruiting
Atorvastatin during heart valve surgery for patients over 60
This trial studies whether taking atorvastatin (a cholesterol medicine) around the time of surgical aortic valve replacement can improve outcomes. It is mainly for people who have not taken similar medicines recently and do not have certain heart rhythm or liver/kidney problems.
OdenseAges 60–95 - NCT04954404Recruiting
Mitral valve procedure registry for Chinese patients in one center
This study is a registry (a way to track real-world outcomes) for people with mitral valve disease who receive a mitral valve procedure. It helps doctors understand how well these procedures work and what complications happen in patients like you.
Hangzhou, ZhejiangAges 18 years+ - NCT05044767Recruiting
Hip replacement study using specific implant brands
This study checks how safe and how well specific hip replacement implants work after hip replacement surgery. You might be eligible if your surgeon plans to use an ATF Implants and/or Lapé Médical prosthesis and you don’t have certain health issues that can make surgery riskier.
BordeauxAges Any age - NCT04095637Recruiting
Compare two types of partial knee replacement surgeries
This study compares two implant types used for a partial knee replacement (only the inside/medial part) for people with “wear-and-tear” arthritis in that compartment. It looks to see which option leads to better outcomes after surgery and follow-up.
LondonAges 40–80 - NCT04123431Recruiting
Study of an hip cup implant used in planned hip replacements
This trial studies a specific hip replacement hip “cup” implant used during planned total hip replacement surgery. It may help confirm how well this implant performs in real-world patients who are getting surgery for non-traumatic reasons.
WorthingAges 18 years+ - NCT04914468Recruiting
Study registry for mitral valve replacement by catheter
This study keeps a registry of adults who have a mitral valve problem and are being evaluated for a catheter-based mitral valve replacement. It helps doctors understand what treatments are used and how patients do.
HamburgAges 18–110 - NCT03965143Recruiting
Talus replacement registry for adults who need new ankle bone
This study is a real-world registry that follows adults who need a talus (ankle bone) replacement and are able to participate over time. It helps doctors understand outcomes and safety, especially the risk of infection, and may offer structured follow-up care.
Columbia, MissouriAges 18 years+ - NCT04074863Recruiting
Surgery for painful wrist-joint arthritis with stable joint
This study looks at a surgical procedure to help people with painful arthritis where two forearm bones meet at the wrist. It’s for people whose joint is stable, aiming to improve pain and hand function.
Lillehammer, OpplandAges 30–75 - NCT04432012RecruitingPhase 4
Compare steroid shots versus other delivery after knee replacement
This study compares different ways of giving steroid medicine after a total knee replacement to see which approach works best and is well-tolerated. You may qualify if you’re getting a first (not repeat) knee implant and can follow the study steps.
LuganoAges 50–85 - NCT04277416Enrolling by invitation
Testing a new hip replacement system and how patients do
This study follows people getting a primary total hip replacement using the Entrada hip system to see how long it lasts and how well it works. You may be offered this specific hip implant and would be followed through study visits to measure recovery and outcomes.
Portland, OregonAges 18–80 - NCT04438525Recruiting
BAT test to replace sting challenge in venom allergy care
This study looks at whether a BAT (a blood test) can stand in for sting/venom “challenges” for people already receiving venom immunotherapy. If it works, it could help patients avoid more risky or uncomfortable challenge procedures while still checking whether treatment is working.
GrazAges 18–70 - NCT03746964Recruiting
MRI study of the heart’s aorta before planned surgery
This study uses a special MRI scan to measure how the ascending aorta (a large blood vessel) moves and behaves before planned surgery. It may help doctors better understand the mechanics of an aortic aneurysm and improve future surgical planning.
DijonAges 18 years+ - NCT05599776Recruiting
Smart ring-guided rehab after knee replacement surgery
This study tests whether using a smart ring along with physical therapy after knee replacement helps people recover better. It mainly looks at people’s rehab progress in the weeks after surgery.
Tampere, PirkanmaaAges 18–70 - NCT03747146Recruiting
Enhanced recovery plan for knee replacement pain control
This study tests an “enhanced recovery” approach for people getting total knee replacement, focused on better pain control using regional anesthesia and a home pain medicine plan. It may help you recover more comfortably and follow the care plan more smoothly after surgery.
New York, New YorkAges 18–65 - NCT03713853Recruiting
Compare hip surgery methods for new pelvic bone fractures
This study compares two ways of fixing a recently broken acetabulum (the hip socket): one method keeps/repairs the socket (ORIF) and the other replaces it (THA). It aims to find which surgery approach leads to better outcomes for people who can have surgery soon after the injury.
Toronto, OntarioAges 60 years+ - NCT03002272Recruiting
Long-term follow-up after TAVR or surgical valve replacement
This study checks how well an aortic valve replacement works many years after the procedure. It may help doctors understand long-term valve function and identify people who might need closer monitoring.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07569549Recruiting
Thumb Base Surgery: Joint Replacement vs. Removal Comparison
This study compares two surgical approaches for thumb base arthritis: replacing the damaged joint with an implant or removing the problematic bone. Researchers want to see which approach works better for pain relief and hand function.
ÖrebroAges 40–80 - NCT04507412RecruitingPhase 4
IV steroid before shoulder surgery to reduce inflammation
This trial studies whether giving dexamethasone through a vein (an anti-inflammatory steroid) around the time of total shoulder replacement surgery improves outcomes. It may help lower inflammation and related discomfort, but you must meet specific health and medication safety criteria to join.
LuganoAges 58–85 - NCT02301182Enrolling by invitation
Compare two hip implant types for younger hip arthritis
This trial compares two different hip implant designs in people ages 40–65 with primary hip osteoarthritis. It looks at how well the hip works afterward—especially function and everyday results.
AarhusAges 40–65 - NCT06372119Recruiting
Letrozole vs artificial cycle for embryo transfer preparation
This trial compares two ways to prepare the uterus for a frozen embryo transfer: using the hormone letrozole or a standard artificial cycle. The goal is to see which approach works better for people with irregular periods.
Ho Chi Minh City, Ho Chi Minh CityAges 18–42 - NCT07155837Enrolling by invitation
TENS for pain after first knee replacement surgery
This study tests if a TENS device, which uses mild electrical pulses to relieve pain, helps people recover better after their first total knee replacement. It might reduce pain and improve movement.
Adana, AdanaAges 18 years+
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 505 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.