Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 507 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT05607966Recruiting
Knee replacement follow-up study for ORIGIN® implant
This study follows people who need a total knee replacement using the ORIGIN® implant. It’s meant to see how well the implant works and how people do over time with routine clinic visits.
AntwerpAges 18–99 - NCT07720882Recruiting
Brain implant study to restore hand function after spinal cord injury
This trial tests a fully implanted wireless brain-computer interface (BCI) to help people with paralysis from a neck-level spinal cord injury regain hand and arm movement. The BCI reads brain signals and sends them to your arm, bypassing the damaged spinal cord.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07718464Recruiting
AKI risk test for children in the ICU
This study tests a new way to find children in the pediatric ICU who are at risk for serious kidney injury early, so doctors can start treatment sooner. Your child's kidney stress markers will be checked from a blood or urine sample.
Cincinnati, OhioAges Any age - NCT07704710Enrolling by invitation
Changing Pulse Oximeter Probe Placement to Prevent Skin Injury in the ICU
This study looks at whether changing the position of the pulse oximeter clip on the finger every so often can help prevent skin injuries (like pressure sores) in ICU patients. It is for adults in intensive care who are deeply unconscious and will be there for several days.
AnkaraAges 18 years+ - NCT07691307Recruiting
TruGamma tricuspid valve replacement study
This trial tests a new device called TruGamma to replace the tricuspid valve without open-heart surgery. It is for older adults with severe tricuspid regurgitation who cannot have surgery and still have symptoms despite medication.
Beijing, Beijing MunicipalityAges 65 years+ - NCT07690202Recruiting
Living with kidney disease without dialysis or transplant
This study looks at the experiences of women of childbearing age who have chronic kidney disease but are not on dialysis or have not had a kidney transplant. The goal is to understand how the disease affects their lives.
CaenAges 18 years+ - NCT07696351RecruitingPhase 4
Ultrasound-guided endometrial preparation for endometriosis
This trial tests whether a 2-3 month hormone treatment before a frozen embryo transfer improves pregnancy success in women with deep endometriosis. It may help your body prepare better for the embryo.
Nanjing, JiangsuAges 18–39 - NCT07689461Recruiting
Virtual reality for pain after hip replacement
This trial tests if using virtual reality can help reduce pain after hip replacement surgery. It may be a good option if you are having a hip replacement and have moderate to severe pain.
MalatyaAges 18–99 - NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT07672808Recruiting
Pain relief after hip replacement without opioids
This study tests a combination of non-opioid pain medicines to reduce the need for opioids after hip replacement surgery. It aims to help patients manage pain with fewer risks of addiction and side effects.
Detroit, MichiganAges 18 years+ - NCT07666789Recruiting
Second Islet Transplant for type 1 diabetes
This study looks at how well a second islet transplant works in people with type 1 diabetes whose first transplant stopped producing insulin or caused dangerous low blood sugar. It aims to see if getting another transplant can help control blood sugar again.
MontpellierAges 18 years+ - NCT06685367Recruiting
AI software for predicting acute kidney injury in ICU
This trial tests software that uses artificial intelligence to predict if a patient in the ICU might develop acute kidney injury (sudden kidney damage). It aims to see if the software is cost-effective and could help doctors catch problems earlier.
TaichungAges 20 years+ - NCT07648693Recruiting
Brain Protection Device During Aortic Valve Replacement
This trial tests a new device called CHORDS that protects your brain during transcatheter aortic valve replacement (TAVR), a minimally invasive procedure to fix a narrow aortic valve. The device works by blocking debris that might travel to your brain during the procedure.
Bengbu, AnhuiAges 18 years+ - NCT07650058Recruiting
How Fresh Mango Affects Blood Sugar in Breakfast
This study tests whether eating fresh mango instead of sugar in breakfast affects how your body handles blood sugar. Researchers want to understand if mango is a healthier breakfast option for young, generally healthy adults.
Muncie, IndianaAges 18–45 - NCT07643597Recruiting
Managing fluid removal in critically ill patients with acute kidney injury
This study looks at how to safely remove excess fluid from patients in the ICU who have sudden kidney failure and are on a special blood-filtering machine (CRRT). Researchers want to understand which patients have trouble tolerating fluid removal and how to prevent complications.
SalvadorAges 18 years+ - NCT05824845Recruiting
Join a study collecting information for hip or knee replacement care
This study asks people in the UK who are getting their first hip or knee replacement to answer questionnaires and let researchers use linked health data. The goal is to improve understanding of outcomes and help set up future studies for better care.
AshingtonAges 18 years+ - NCT07629388Recruiting
Nerve block for pain after knee replacement surgery
This trial tests whether adding a nerve block (a numbing injection near the nerve) to the usual pain plan can better control pain after a total knee replacement. The goal is to help you recover with less pain and fewer side effects.
DijonAges 18 years+ - NCT07625956Enrolling by invitationPhase 4
Nicotine Pouches as a Smoking Substitute Study
This study tests whether nicotine pouches (small pouches you place in your mouth) can help smokers quit or reduce combustible cigarettes. You'll use the pouches as a substitute and attend visits in Charleston, SC to see if this approach works better with new support strategies.
Charleston, South CarolinaAges 21 years+ - NCT06374121Recruiting
Kidney preservation with or without machine perfusion
This study compares two ways of preserving kidneys from older or less healthy donors before transplant – one using a machine that pumps fluid through the kidney, and one without. It may help improve how well these kidneys work after transplant.
Bergamo, BGAges 50 years+ - NCT06021288Recruiting
Standard vs. lower dose dialysis for kidney failure in intensive care
This trial compares the usual dose of continuous dialysis with a lower dose to see if a lower dose is just as safe and effective for critically ill patients with sudden kidney failure.
MünsterAges 18 years+ - NCT03966716Recruiting
Hip screws or hip replacement for small hip fractures
This study compares two treatments for certain small, stable hip fractures in older adults: using hip screws versus replacing part or all of the hip. It may help find which option works best for healing and returning to movement.
Uppsala, Uppsala CountyAges 75 years+ - NCT03900286Recruiting
Testing a low-calorie diet for partial fat loss diabetes
This trial studies whether a low-calorie (low energy) diet can improve diabetes control in adults with familial partial lipodystrophy. It likely helps by changing how your body handles blood sugar and fat use, but you must meet specific safety and eligibility checks.
CambridgeAges 18–99 - NCT07584356Recruiting
Comparing Shoulder Replacement Methods for Arthritis
This study compares two different surgical approaches for replacing a shoulder damaged by arthritis, but only in patients whose rotator cuff (the muscles that stabilize the shoulder) is still working well. The goal is to find which method works better for your specific situation.
Rochester, MinnesotaAges 60–85
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 507 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.