Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 505 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07050277RecruitingPhase 3
Morphine for bladder issues after knee replacement
This study tests whether adding morphine to spinal anesthesia can reduce trouble urinating after a second knee replacement surgery. It may help you avoid needing a catheter after surgery.
Toronto, OntarioAges 21 years+ - NCT07270549RecruitingPhase 1/Phase 2
Gene therapy trial for children with CTNNB1 syndrome
This trial tests a one-time gene replacement therapy given into the fluid around the brain to help children with CTNNB1 neurodevelopmental syndrome. The goal is to see if replacing the faulty gene can improve development and reduce symptoms.
LjubljanaAges 2–12 - NCT03286868Recruiting
Tested knee replacement alignment during knee surgery
This study looks at how a specific computer/measurement approach (“Verasense”) helps position the knee during total knee replacement for people with knee arthritis. It may help improve how the new knee fits and aligns as you recover.
Halifax, Nova ScotiaAges 21–80 - NCT07049991Recruiting
Observatory for Para-Prosthetic Heart Valve Leak Closure
This study collects information from people who are having a procedure to close a leak around a previously placed artificial heart valve. The goal is to better understand how these procedures work and what happens to patients afterwards.
Le Plessis-RobinsonAges 16 years+ - NCT07086716Recruiting
Frailty study for hip or knee replacement patients
This study looks at frailty in people who have had a planned hip or knee replacement. It aims to understand how frailty affects recovery.
Rovato, BSAges 18 years+ - NCT05030220Recruiting
Testing testosterone and a skin bacteria during shoulder surgery
This study looks at how testosterone levels and a common skin bacteria (Cutibacterium) may relate to outcomes around elective shoulder replacement surgery. Results could help improve how doctors prevent and understand infection risk or healing after surgery.
Seattle, WashingtonAges 18–89 - NCT02397668Recruiting
New tricuspid valve replacement for leaky or absent valve
This study tests a special replacement valve (an “ECM valve”) for people whose tricuspid valve is leaky or missing and needs surgery. It may help restore blood flow on the right side of the heart and is designed for certain children born with congenital heart problems.
Mobile, AlabamaAges 1–85 - NCT07365345Recruiting
Electrical Stimulation for Low Blood Pressure During TAVR
This study tests whether electrical stimulation at specific points on the body can help prevent low blood pressure during TAVR, a minimally invasive heart valve procedure. It may help people who are at risk for blood pressure drops during surgery.
Xi'an, ShannxiAges 60 years+ - NCT05125939Recruiting
Testing if one colonoscopy score can replace another
This study looks at whether a colonoscopy “detection score” for overall abnormal growths can stand in for a more specific screening score. It may help improve how screening quality is measured during colonoscopy.
North Hills, CaliforniaAges 50–80 - NCT07043127Recruiting
Strength training after hip replacement with blood flow restriction
This trial tests a new kind of physical therapy after hip replacement. It combines strength exercises with a special technique called blood flow restriction to see if it helps you recover muscle strength faster.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT05279092RecruitingPhase 2
Testing two pain-control injections for knee replacement surgery
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
New Haven, ConnecticutAges 18 years+ - NCT06722482Recruiting
Comparing bone grafts for front tooth implants
This trial compares two types of bone graft materials used when a front tooth is removed and replaced with a dental implant. It aims to see which works better for healing and long-term success.
Rochester, New YorkAges 18 years+ - NCT06369870RecruitingPhase 4
Nerve block for pain after minimally invasive aortic valve surgery
This trial tests a nerve block (injection of numbing medicine near the chest wall) to control pain after aortic valve replacement through a small right-sided chest incision. It may help reduce pain and the need for strong painkillers after surgery.
Ghent, East-FlandersAges 18 years+ - NCT06518317RecruitingPhase 3
Short vs Long Blood Thinner Use After TAVI
This trial compares a short course versus a longer course of antiplatelet medicine (blood thinners) after a TAVI procedure for aortic stenosis. It aims to see which approach is safer and more effective.
CaenAges 18 years+ - NCT07577570Recruiting
Calcium Treatment After Thyroid Surgery
This study tests whether calcium supplements help patients whose parathyroid glands aren't working properly after thyroid surgery. The parathyroid glands control calcium levels in your body, and they can be accidentally injured during thyroid removal.
Tallinn, OtherAges 18 years+ - NCT07500922Recruiting
Menopause effects on brain activity study
This study looks at how menopause affects brain signals controlling movement. It offers combined hormone treatment to eligible women.
JyväskyläAges 50–59 - NCT07489963Recruiting
Does keeping the posterior cruciate ligament help after knee replacement?
This trial compares two ways of doing robotic-assisted knee replacement: one that keeps the posterior cruciate ligament (a natural knee stabilizer) and one that doesn't. Researchers will see if saving the ligament leads to better knee function a year after surgery.
BordeauxAges 18 years+ - NCT06989229Recruiting
Nutritional care before and after joint replacement surgery
This trial tests if special nutritional support before and after hip or knee replacement helps you recover faster. It is for people having planned (not emergency) surgery.
Brno, CzechiaAges 18 years+ - NCT06763536Recruiting
Comparing nicotine pouches vs. nicotine patches or gum to help smokers in rural Appalachia quit
This study tests if oral nicotine pouches work better than nicotine patches or gum to help you smoke less. You’ll use one of these products for a while and check in with the study team. This is for adults who live in rural Appalachian counties and smoke at least 5 cigarettes a day.
Columbus, OhioAges 21 years+ - NCT06724783RecruitingPhase 4
Comparing two collagen membranes for bone growth around dental implants
This study compares two types of collagen membranes used to help rebuild bone around a dental implant. If you need a single implant in the front of your mouth and a bone graft at the same time, this trial may help determine which membrane works best.
Geneva, Canton of GenevaAges 18–90 - NCT07696351RecruitingPhase 4
Ultrasound-guided endometrial preparation for endometriosis
This trial tests whether a 2-3 month hormone treatment before a frozen embryo transfer improves pregnancy success in women with deep endometriosis. It may help your body prepare better for the embryo.
Nanjing, JiangsuAges 18–39 - NCT07183475Recruiting
Returning to sports after knee replacement
This study looks at how well people can get back to sports after having a knee replacement. If you have had a knee replacement and are active in sports, you may be able to join to help researchers learn more about recovery.
Munich, BavariaAges 18–85 - NCT07191262Recruiting
Comparing mouth rinses after tooth extraction and bone graft
This study compares three different mouth rinses (one with EDTA, one with chlorhexidine, and one with essential oils) after tooth extraction and bone grafting. It aims to find which rinse helps keep the area clean and promotes healing.
Birmingham, AlabamaAges 18–85
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 505 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.