Clinical trials
Substance Use (Drugs, Alcohol) clinical trials
Below are recruiting substance use (drugs, alcohol) clinical trials, each written for real people, not researchers. We’re tracking 100 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06701500Recruiting
Study on decision making in alcohol use disorder
This study looks at how people with alcohol use disorder make decisions based on habits, goals, and automatic cues. It may help understand what drives drinking behavior.
DresdenAges 18–65 - NCT06803706Recruiting
Gut bacteria changes during smoking quit attempt
This study looks at how quitting smoking changes your body's gut bacteria and metabolism. It is for people with a substance use disorder who want to stop smoking.
FehringAges 18 years+ - NCT06856161Recruiting
Blood test to help diagnose mental health conditions
This study is testing a new blood test that might help doctors better understand and diagnose conditions like depression, psychosis, or schizophrenia. If you are 19 or older and have one of these conditions, you may be able to join.
New Westminster, British ColumbiaAges 19 years+ - NCT06939088RecruitingPhase 2
Tirzepatide for alcohol reduction in schizophrenia
This trial tests if tirzepatide, a once-weekly injection, can help reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. If you struggle with alcohol and have stable schizophrenia, this study may offer a new treatment option.
Aalborg, DenmarkAges 18–70 - NCT06959342Recruiting
Brain stimulation to reduce cravings in alcohol use disorder
This trial tests if a gentle brain stimulation technique (tDCS) can help people with alcohol use disorder control their cravings and drinking habits. It is an add-on to your regular treatment.
MannheimAges 18–65 - NCT06969937RecruitingPhase 2
Ketamine and Neurofeedback for Alcohol Use Disorder
This study tests whether combining ketamine with a brain-training technique called neurofeedback can help people reduce or stop drinking alcohol. It may offer a new treatment option for alcohol use disorder.
ZurichAges 18–65 - NCT06994338RecruitingPhase 2
Tirzepatide for alcohol use disorder
This study tests whether a medication called tirzepatide (a once-weekly injection) can help people reduce their alcohol consumption. It is for people who drink heavily, have a high BMI, and are actively seeking help to drink less.
Los Angeles, CaliforniaAges 21–65 - NCT07025083Recruiting
Parenting program for Latinx families of teens
This study is testing an online program to help parents connect better with their pre-teen or young teen. It is designed for Spanish-speaking Latinx parents and their children ages 11 to 14.
Eugene, OregonAges 11–14 - NCT07071779Recruiting
Online training to help young people resist alcohol or cocaine
This study tests a web-based training program to help teens and young adults (ages 14–35) improve their ability to say no to alcohol or cocaine. The training could make it easier to resist cravings during treatment.
BernAges 14–35 - NCT07330349Recruiting
Trauma and substance use in penetrating abdominal injury
This study looks at alcohol, drug use, and painkiller use in people with a penetrating abdominal injury (like a stab or gunshot wound to the belly). It aims to understand how these substances affect patient outcomes.
Cali, Valle del Cauca DepartmentAges 15 years+ - NCT07340554Recruiting
Brain imaging study for teens who use cannabis
This study looks at the brains of teenagers who use cannabis using an MRI scanner. It aims to understand how cannabis affects the developing brain, which might help improve treatment options.
Indianapolis, IndianaAges 14–17 - NCT07460973Recruiting
Wellness program for American Indian youth
This study tests a program designed to improve health and reduce disparities for American Indian youth ages 12–18. It includes educational activities and cultural teachings.
Bozeman, MontanaAges 12–18 - NCT05015881Enrolling by invitationPhase 2/Phase 3
Brain and heart scans in alcohol use disorder
This study uses special brain and heart scans to see how sugar (glucose) is used in people with alcohol use disorder compared with people without it. It may help researchers understand the brain–heart connection in alcohol use disorder.
Philadelphia, PennsylvaniaAges 21–65 - NCT03764098RecruitingPhase 2
Guanfacine to reduce heavy drinking in adults with alcohol use disorder
This Phase 2 study tests whether guanfacine can reduce drinking in women and men who drink heavily and meet criteria for alcohol use disorder. It also looks at how the medicine affects drinking patterns in a controlled setting.
New Haven, ConnecticutAges 21–70 - NCT04066192RecruitingPhase 2
Brexpiprazole trial for alcohol use disorder in adults
This study tests whether brexpiprazole can help adults with alcohol use disorder. You must currently not be taking alcohol-focused treatment or alcohol medicines, and you’ll likely complete questionnaires and brain scans.
Aurora, ColoradoAges 21–65 - NCT05781009RecruitingPhase 2
Pregnenolone treatment for alcohol use disorder
This Phase 2 study tests pregnenolone to help reduce or improve alcohol use disorder symptoms. It looks for adults who drink regularly and meet diagnostic criteria for moderate to severe alcohol use disorder, while excluding people with certain other substance use, medicines, or serious mental/medical conditions.
New Haven, ConnecticutAges 18–70 - NCT05988632RecruitingPhase 1/Phase 2
Insulin nasal spray for alcohol use disorder
This trial tests whether a nasal spray with insulin can help people with alcohol use disorder. It may affect how the brain responds to alcohol and reduce drinking.
Providence, Rhode IslandAges 21 years+ - NCT06512389RecruitingPhase 2
Testing CBD for alcohol cravings
This study tests whether a medication called cannabidiol (CBD) can help reduce cravings for alcohol. Over several weeks, you will take the study pill and attend lab sessions where you can choose to drink alcohol in a safe setting.
Toronto, OntarioAges 19 years+ - NCT06866379Recruiting
Brain study on alcohol use disorder: septal nuclei
This study uses brain scans (fMRI) to look at a small area deep in the brain called the septal nuclei, which may play a role in alcohol use disorder. It aims to understand how the brain's structure and activity relate to heavy drinking, which could lead to better treatments.
FrederiksbergAges 30–65 - NCT07029529RecruitingPhase 2
Apremilast for alcohol use disorder
This study tests whether a drug called apremilast can help people who drink heavily reduce their alcohol use. You will take the medication daily for several weeks and attend study visits to track your progress.
New Haven, ConnecticutAges 21–65 - NCT07211867Recruiting
Reducing self-stigma in pregnant women and new mothers with substance use
This trial tests a digital tool called Enhearten that aims to decrease self-stigma (negative feelings about yourself) in pregnant women and new mothers who have used substances (other than alcohol or tobacco). The study hopes to help participants feel better about themselves and seek support.
St Louis, MissouriAges 18 years+ - NCT07612631RecruitingEarly Phase 1
Brain imaging study of alcohol and stress response
This research uses brain imaging to understand how two brain systems—one involved in stress and one involved in reward—interact in people with alcohol use disorder. The goal is to find new ways to help people reduce heavy drinking.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07218354RecruitingPhase 3
Medication for reducing alcohol use in veterans
This study tests whether a medication (semaglutide) can help veterans reduce or stop drinking alcohol. It is for veterans who drink heavily and have alcohol use disorder, and who are interested in cutting down.
Long Beach, CaliforniaAges 18–80 - NCT05042102RecruitingPhase 2
Donepezil plus brain training for alcohol use disorder
This Phase 2 study tests whether donepezil, along with structured cognitive (brain) training, can improve outcomes for people with alcohol use disorder. It will measure whether this combination helps after recent heavy drinking, while tracking safety over about 13 weeks.
West Haven, ConnecticutAges 18–80
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Common questions
- Are there clinical trials for substance use (drugs, alcohol)?
- Yes. Clin2 currently lists 100 recruiting substance use (drugs, alcohol) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use (drugs, alcohol) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use (drugs, alcohol) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.