Clinical trials
Systemic Therapy clinical trials
Below are recruiting systemic therapy clinical trials, each written for real people, not researchers. We’re tracking 408 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06424158Recruiting
Massage therapy after upper or lower back surgery
This study tests if massage therapy can help children recover after their first back surgery (thoracic or lumbar fusion). It's for kids who can talk and don't have certain health problems like chronic pain or bleeding disorders.
Fort Worth, TexasAges 7–19 - NCT06796504Recruiting
Nerve stimulation for relapsing-remitting multiple sclerosis
This trial tests a device that stimulates a nerve in the neck, which may help repair the protective coating around nerves in the brain and spinal cord. It is for people with relapsing-remitting MS who are stable on their current medication and have some vision problems due to MS.
Irvine, CaliforniaAges 22–60 - NCT07534358Recruiting
VA and Community Care Coordination for Suicide Prevention
This study tests whether coordinated case management between VA and community care providers can better support veterans at risk for suicide. You'll work with a care coordinator who helps make sure your VA and non-VA doctors communicate and work together.
Aurora, ColoradoAges 18–80 - NCT06342453Recruiting
Art therapy for children with cancer
This study tests whether art activities can help children with cancer cope and feel better. Kids will take part in four creative art sessions while receiving treatment.
Portland, OregonAges 8–13 - NCT06353191Recruiting
Blood markers to predict heart problems from cancer therapy
This study looks for early warning signs (biomarkers) of heart damage caused by cancer treatments. It is for people who have had cancer treatment, may have heart issues, or are about to start a treatment that could affect the heart.
Scottsdale, ArizonaAges 18 years+ - NCT05301140Recruiting
Registry study for paired VNS after stroke
This study follows people who already have the Vivistim device implanted after an ischemic stroke affecting arm or hand function. It may help researchers better understand how paired nerve stimulation therapy works in real-world care.
Orlando, FloridaAges 22 years+ - NCT06324682Recruiting
Comparing heart pacemaker types for better treatment
This trial looks at different ways to pace the heart (like left, right, or both sides) to see which works best for people who need a pacemaker. If you have a heart condition requiring a pacemaker, this study may help find the safest and most effective option for you.
Ferrara, FEAges 18 years+ - NCT06579248RecruitingEarly Phase 1
Cooling device to protect taste during radiation
This trial tests a special mouthpiece that cools the tongue during radiation therapy for advanced larynx cancer. It may help prevent taste loss caused by treatment.
Detroit, MichiganAges 18 years+ - NCT06794073Recruiting
Combination therapy for advanced liver cancer
This trial is testing a combination of treatments for liver cancer that cannot be removed by surgery. It combines a targeted therapy pill (lenvatinib), an immunotherapy that boosts your immune system (PD-1 blocker), a procedure that destroys tumors with heat or cold (ablation), and a chemo procedure that delivers medicine directly to the liver (TACE). The goal is to see if this mix is safe and effective.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07030920RecruitingPhase 2
Reducing inflammation in people living with HIV
This trial tests if a drug can lower inflammation in people with HIV who are on effective treatment. It may help reduce the risk of heart disease and other problems related to chronic inflammation.
Montreal, QuebecAges 18 years+ - NCT07162246RecruitingPhase 2
Radiosurgery for large brain tumors and metastases
This trial tests a special high-dose radiation treatment for people who have up to two large brain tumors (metastases) and possibly other smaller ones. The treatment aims to control the tumors while limiting radiation to healthy brain tissue.
Toronto, OntarioAges 18 years+ - NCT06285162Recruiting
Nerve health monitor during ICU dialysis
This trial uses a special monitor (called ANI) to check how well your nervous system is working while you are on continuous kidney dialysis in the ICU. It may help doctors better understand your body's response to fluid removal.
BronAges 18 years+ - NCT06511518Recruiting
Talking therapy for fatigue in advanced cancer
This study tests whether cognitive behavioral therapy, a type of talking therapy, can help reduce severe fatigue in people with advanced solid tumors or gliomas who are receiving or have completed palliative treatment. The goal is to see if this approach improves energy levels and quality of life.
Amsterdam, North HollandAges 18 years+ - NCT07150546RecruitingPhase 1
Radiation and Peptide Therapy for Large Gut Neuroendocrine Tumors
This trial combines external radiation with a targeted radioactive drug (PRRT) to treat large, slow-growing neuroendocrine tumors in the gut that have spread and are not removable by surgery. It aims to see if this combination works better than either treatment alone.
Atlanta, GeorgiaAges 18 years+ - NCT01706692Recruiting
Study registry for targeted treatments in psoriasis patients
This trial is a registry that collects information from adults with plaque psoriasis or psoriatic arthritis who are starting a new biologic or other systemic treatment. It helps researchers understand how these treatments are used in real life and what outcomes they may have.
AarauAges 18 years+ - NCT04732065RecruitingPhase 1
ONC206 for certain brain tumors in children and young adults
This Phase 1 study tests ONC206, a new targeted medicine, for diffuse midline gliomas (DMG) with a specific gene change (H3K27 altered) and for some other recurrent brain/spinal cord cancers. It is designed to find the right dose and see whether it can control or shrink tumors after initial treatment or when the cancer returns.
San Francisco, CaliforniaAges 2–21 - NCT06832267Recruiting
RMTT chemo for newly diagnosed PCNS lymphoma
This trial tests a combination of four chemotherapy drugs (Rituximab, Methotrexate, Temozolomide, and Thiotepa) as the first treatment for people newly diagnosed with primary central nervous system diffuse large B-cell lymphoma. It aims to see if this regimen is safe and effective for patients who have not had any prior systemic therapy.
Hangzhou, ZhejiangAges 18–75 - NCT06824714Recruiting
Predicting blood vessel damage in large vessel vasculitis
This study uses PET and MRA scans to predict damage to large blood vessels in people who have or may have large vessel vasculitis (LVV). It aims to find at-risk patients early so they can get better care. You'll need to be willing to have both scans and come back for long-term check-ups.
Nanjing, JiangsuAges 18 years+ - NCT07492420Recruiting
Sleep position therapy for mild sleep apnea
This study tests if a special sleep system that keeps you on your side can improve mild obstructive sleep apnea. You may qualify if you have mild sleep apnea and are looking for a non-surgical treatment option.
St Louis, MissouriAges 18 years+ - NCT06640010Recruiting
Studying why cancer treatments cause side effects
This study uses special cells grown in a lab to understand why some cancer treatments cause side effects. It may help researchers find ways to predict and prevent these side effects in the future.
Jacksonville, FloridaAges 18 years+ - NCT05942339Recruiting
Testing ARC-IM lumbar therapy to help walking after spinal cord injury
This study tests a therapy using an implanted spinal array and a lumbar system (ARC-IM) to support mobility in people with chronic spinal cord injury. It focuses on whether the approach is safe and may improve walking or movement over time.
Lausanne, Canton of VaudAges 18–65 - NCT06940635Recruiting
Hand therapy for stroke: may help speech and swallowing
This study tests whether a special hand therapy using brain-computer interface and electrical stimulation can also help improve speech and swallowing problems after a stroke. You may be eligible if you're at least 3 months past your stroke, have some arm weakness, and have aphasia or dysphagia.
Innsbruck, TyrolAges 18 years+ - NCT07031713RecruitingPhase 1
Testing CT1192 cells for lupus that hasn't responded to treatment
This trial tests a new treatment called CT1192, which uses your own immune cells (T-cells) that are modified to target and calm overactive immune cells causing lupus. It is designed for people with moderate to severe lupus that hasn't improved with standard therapies like steroids, immunosuppressants, or biologics.
Wuhan, HubeiAges 18–60 - NCT07036107Recruiting
Exoskeleton rehab for spinal cord injury in Spain
This trial tests whether a wearable exoskeleton can help people with recent spinal cord injury improve their walking ability and quality of life. It focuses on patients treated in the Spanish healthcare system.
Toledo, Castille-La ManchaAges 18–70
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Common questions
- Are there clinical trials for systemic therapy?
- Yes. Clin2 currently lists 408 recruiting systemic therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a systemic therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a systemic therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.