Clinical trials
Systemic Therapy clinical trials
Below are recruiting systemic therapy clinical trials, each written for real people, not researchers. We’re tracking 397 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07030920RecruitingPhase 2
Reducing inflammation in people living with HIV
This trial tests if a drug can lower inflammation in people with HIV who are on effective treatment. It may help reduce the risk of heart disease and other problems related to chronic inflammation.
Montreal, QuebecAges 18 years+ - NCT06794073Recruiting
Combination therapy for advanced liver cancer
This trial is testing a combination of treatments for liver cancer that cannot be removed by surgery. It combines a targeted therapy pill (lenvatinib), an immunotherapy that boosts your immune system (PD-1 blocker), a procedure that destroys tumors with heat or cold (ablation), and a chemo procedure that delivers medicine directly to the liver (TACE). The goal is to see if this mix is safe and effective.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06579248RecruitingEarly Phase 1
Cooling device to protect taste during radiation
This trial tests a special mouthpiece that cools the tongue during radiation therapy for advanced larynx cancer. It may help prevent taste loss caused by treatment.
Detroit, MichiganAges 18 years+ - NCT06342453Recruiting
Art therapy for children with cancer
This study tests whether art activities can help children with cancer cope and feel better. Kids will take part in four creative art sessions while receiving treatment.
Portland, OregonAges 8–13 - NCT06353191Recruiting
Blood markers to predict heart problems from cancer therapy
This study looks for early warning signs (biomarkers) of heart damage caused by cancer treatments. It is for people who have had cancer treatment, may have heart issues, or are about to start a treatment that could affect the heart.
Scottsdale, ArizonaAges 18 years+ - NCT05301140Recruiting
Registry study for paired VNS after stroke
This study follows people who already have the Vivistim device implanted after an ischemic stroke affecting arm or hand function. It may help researchers better understand how paired nerve stimulation therapy works in real-world care.
Orlando, FloridaAges 22 years+ - NCT06511518Recruiting
Talking therapy for fatigue in advanced cancer
This study tests whether cognitive behavioral therapy, a type of talking therapy, can help reduce severe fatigue in people with advanced solid tumors or gliomas who are receiving or have completed palliative treatment. The goal is to see if this approach improves energy levels and quality of life.
Amsterdam, North HollandAges 18 years+ - NCT06285162Recruiting
Nerve health monitor during ICU dialysis
This trial uses a special monitor (called ANI) to check how well your nervous system is working while you are on continuous kidney dialysis in the ICU. It may help doctors better understand your body's response to fluid removal.
BronAges 18 years+ - NCT07150546RecruitingPhase 1
Radiation and Peptide Therapy for Large Gut Neuroendocrine Tumors
This trial combines external radiation with a targeted radioactive drug (PRRT) to treat large, slow-growing neuroendocrine tumors in the gut that have spread and are not removable by surgery. It aims to see if this combination works better than either treatment alone.
Atlanta, GeorgiaAges 18 years+ - NCT01706692Recruiting
Study registry for targeted treatments in psoriasis patients
This trial is a registry that collects information from adults with plaque psoriasis or psoriatic arthritis who are starting a new biologic or other systemic treatment. It helps researchers understand how these treatments are used in real life and what outcomes they may have.
AarauAges 18 years+ - NCT04732065RecruitingPhase 1
ONC206 for certain brain tumors in children and young adults
This Phase 1 study tests ONC206, a new targeted medicine, for diffuse midline gliomas (DMG) with a specific gene change (H3K27 altered) and for some other recurrent brain/spinal cord cancers. It is designed to find the right dose and see whether it can control or shrink tumors after initial treatment or when the cancer returns.
San Francisco, CaliforniaAges 2–21 - NCT07746336RecruitingPhase 4
Guiding heart ablation with 3D heart mapping
This trial tests a new heart-mapping technique to help doctors treat a fast heart rhythm caused by heart disease. It might improve the precision of the procedure, making it safer and more effective for patients with this condition.
BarcelonaAges 18–99 - NCT07430553Recruiting
Comparing pacemakers for better heart function in heart failure
This trial compares three types of advanced pacemakers (cardiac resynchronization therapy devices) to see which works best for improving heart function and reducing abnormal heart rhythms in people with heart failure.
London, Greater LondonAges 18 years+ - NCT06824714Recruiting
Predicting blood vessel damage in large vessel vasculitis
This study uses PET and MRA scans to predict damage to large blood vessels in people who have or may have large vessel vasculitis (LVV). It aims to find at-risk patients early so they can get better care. You'll need to be willing to have both scans and come back for long-term check-ups.
Nanjing, JiangsuAges 18 years+ - NCT06832267Recruiting
RMTT chemo for newly diagnosed PCNS lymphoma
This trial tests a combination of four chemotherapy drugs (Rituximab, Methotrexate, Temozolomide, and Thiotepa) as the first treatment for people newly diagnosed with primary central nervous system diffuse large B-cell lymphoma. It aims to see if this regimen is safe and effective for patients who have not had any prior systemic therapy.
Hangzhou, ZhejiangAges 18–75 - NCT07077122Recruiting
Comparing five gum disease treatments
This trial tests five different non-surgical gum treatments to see how they affect overall health. It may be a good fit for people with advanced gum disease who do not smoke heavily or take certain medications.
AthensAges Any age - NCT07036107Recruiting
Exoskeleton rehab for spinal cord injury in Spain
This trial tests whether a wearable exoskeleton can help people with recent spinal cord injury improve their walking ability and quality of life. It focuses on patients treated in the Spanish healthcare system.
Toledo, Castille-La ManchaAges 18–70 - NCT07031713RecruitingPhase 1
Testing CT1192 cells for lupus that hasn't responded to treatment
This trial tests a new treatment called CT1192, which uses your own immune cells (T-cells) that are modified to target and calm overactive immune cells causing lupus. It is designed for people with moderate to severe lupus that hasn't improved with standard therapies like steroids, immunosuppressants, or biologics.
Wuhan, HubeiAges 18–60 - NCT06940635Recruiting
Hand therapy for stroke: may help speech and swallowing
This study tests whether a special hand therapy using brain-computer interface and electrical stimulation can also help improve speech and swallowing problems after a stroke. You may be eligible if you're at least 3 months past your stroke, have some arm weakness, and have aphasia or dysphagia.
Innsbruck, TyrolAges 18 years+ - NCT06640010Recruiting
Studying why cancer treatments cause side effects
This study uses special cells grown in a lab to understand why some cancer treatments cause side effects. It may help researchers find ways to predict and prevent these side effects in the future.
Jacksonville, FloridaAges 18 years+ - NCT05942339Recruiting
Testing ARC-IM lumbar therapy to help walking after spinal cord injury
This study tests a therapy using an implanted spinal array and a lumbar system (ARC-IM) to support mobility in people with chronic spinal cord injury. It focuses on whether the approach is safe and may improve walking or movement over time.
Lausanne, Canton of VaudAges 18–65 - NCT02880631Recruiting
Barostim therapy for resistant hypertension
This trial is evaluating a device called BAROSTIM NEO, which sends electrical signals to help lower high blood pressure. It is for people who have recently had the device implanted and still have high blood pressure despite taking multiple medications.
BerlinAges Any age - NCT06246955Recruiting
Online group therapy to improve wellbeing in cancer patients
This study tests two types of online group therapy—Acceptance and Commitment Therapy and Compassion-Based Therapy—to help people with cancer feel better emotionally. You'll join a small group with a therapist to learn skills for handling stress and finding peace.
Scottsdale, ArizonaAges 18 years+ - NCT06208514Recruiting
Brief Pain Exposure Therapy for chronic pain conditions
This study tests a type of talk therapy called Brief Pain Exposure Therapy (BPET) for people with certain chronic pain conditions like fibromyalgia, lupus, or chronic low back pain. It aims to help reduce pain by changing how your brain responds to it.
Ann Arbor, MichiganAges 18 years+
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Common questions
- Are there clinical trials for systemic therapy?
- Yes. Clin2 currently lists 397 recruiting systemic therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a systemic therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a systemic therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.