Clinical trials
Tobacco Use Disorder clinical trials
Below are recruiting tobacco use disorder clinical trials, each written for real people, not researchers. We’re tracking 115 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07812753Recruiting
Brain stimulation for smoking cessation
This study looks at how a non-invasive brain stimulation technique called TMS (which uses magnetic pulses to stimulate the brain) might affect the brain's reward system in people who smoke. The goal is to understand how to help people quit smoking more effectively.
Newark, New JerseyAges 18–60 - NCT07420283RecruitingPhase 2
Study of Brenipatide for opioid use disorder
This trial tests a new medicine called Brenipatide for people with opioid use disorder who are already taking buprenorphine but still occasionally use non-prescribed opioids. It aims to see if the study drug can help reduce opioid use.
Phoenix, ArizonaAges 18–75 - NCT07044466Recruiting
Social functioning study for people in treatment for opioid use
This study looks at how people recovering from opioid use disorder get along with a close friend or family member (called a CSO). It may help improve social support during early treatment.
Charleston, South CarolinaAges 18 years+ - NCT07029529RecruitingPhase 2
Apremilast for alcohol use disorder
This study tests whether a drug called apremilast can help people who drink heavily reduce their alcohol use. You will take the medication daily for several weeks and attend study visits to track your progress.
New Haven, ConnecticutAges 21–65 - NCT06994338RecruitingPhase 2
Tirzepatide for alcohol use disorder
This study tests whether a medication called tirzepatide (a once-weekly injection) can help people reduce their alcohol consumption. It is for people who drink heavily, have a high BMI, and are actively seeking help to drink less.
Los Angeles, CaliforniaAges 21–65 - NCT06985927Recruiting
Self-Concept and Memory in Alcohol Use Disorder
This study looks at how people with alcohol use disorder remember their past and see themselves. Researchers will ask about your memories and self-image to understand the link between alcohol and thinking patterns.
ReimsAges 24 years+ - NCT07464613Recruiting
Social thinking in severe alcohol use disorder
This study looks at how people with severe alcohol use disorder process social information, like understanding others' emotions or intentions. It uses brain imaging (MRI) and tests on a smartphone. The goal is to learn more about social cognition in recovery.
Reims, ReimsAges 18–65 - NCT07612631RecruitingEarly Phase 1
Brain imaging study of alcohol and stress response
This research uses brain imaging to understand how two brain systems—one involved in stress and one involved in reward—interact in people with alcohol use disorder. The goal is to find new ways to help people reduce heavy drinking.
Pittsburgh, PennsylvaniaAges 18–55 - NCT06660381RecruitingPhase 1
Psilocybin therapy for cannabis use disorder
This study tests if psilocybin (a substance that can change how you think and feel) can help people reduce or stop using cannabis. You will receive support and be monitored closely throughout the trial.
Baltimore, MarylandAges 18 years+ - NCT05957159RecruitingEarly Phase 1
Testing an alcohol brain imaging study based on opioid receptor balance
This early-phase study looks at how the brain’s opioid receptor balance may be different in people with alcohol use disorder (AUD), using brain scans and blood testing. It may help researchers understand why some people respond differently to alcohol and related treatments.
New Haven, ConnecticutAges 21–70 - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75 - NCT07575373Recruiting
Improving Hospital Care for People With Substance Use Disorders
This study tests a new team-based approach to help hospitalized patients with substance use disorders get better care and smoother transitions when leaving the hospital. Researchers want to see if coordinated support from doctors, counselors, and social workers can improve your health outcomes and connection to treatment.
Salt Lake City, UtahAges 18 years+ - NCT07825818RecruitingEarly Phase 1
Brain scan study for heavy drinkers
This study uses a special brain scan to look at how alcohol use affects energy production in brain cells. It may help researchers find new ways to treat alcohol use disorder.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07520292RecruitingPhase 1
Testing NTX-2001 to reduce drinking in alcohol use disorder
This study tests whether a new medication called NTX-2001 can help people with alcohol use disorder drink less. Researchers will measure how the drug affects alcohol consumption and safety in adults aged 21–60.
New Haven, ConnecticutAges 21–60 - NCT07501624Enrolling by invitation
Pharmacist-led tobacco treatment for HIV patients
This study works with pharmacists at six Ryan White HIV clinics to help people with HIV quit smoking or using tobacco. If you have HIV, are 21 or older, and have already met with a pharmacist about tobacco, you may be able to join.
Charleston, South CarolinaAges 21 years+ - NCT06371404Recruiting
Brain imaging study of stress and alcohol use disorders
This study uses a special brain scan to look at how stress and alcohol use affect the brain. It may help people with PTSD, alcohol use disorder, or healthy volunteers understand these conditions better.
New Haven, ConnecticutAges 18–70 - NCT06609109RecruitingPhase 1
Testing how cannabis affects e-cigarette use
This study is for daily e-cigarette users who also use cannabis at least once a week. It tests how cannabis affects vaping behavior. Researchers want to see if using cannabis changes how much or how people vape.
Baltimore, MarylandAges 21 years+ - NCT05934305Recruiting
Help for shame and stigma in HIV and substance use
This study tests whether a program can reduce shame and stigma for people living with HIV who also have a substance use disorder. It may help you feel less judged and cope better, while supporting HIV care.
Miami, FloridaAges 18 years+ - NCT07489443Recruiting
Helping pregnant women reduce tobacco and cannabis use
This study is testing a program to help pregnant women and new mothers cut back on or quit using tobacco and cannabis. It’s designed to see if the program is easy to use and helps improve health for both mom and baby.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07425119Recruiting
Quit smoking trial for people who smoke a little each day
This study tests a text message program to help people who smoke 1-10 cigarettes most days but not daily quit. It uses cues and reminders sent to your phone to support your quit attempt.
Durham, North CarolinaAges 18 years+ - NCT07292883RecruitingPhase 2
Accelerated TMS for smoking cessation
This trial tests whether a rapid form of brain stimulation (TMS) can help people stop smoking. It is designed for adults who are ready to quit within the next month.
Penetanguishene, OntarioAges 18 years+ - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT07576595Recruiting
Lung Cancer Screening and Quit-Smoking Support for African Americans
This study helps African American smokers get lung cancer screening and receive support to quit smoking. Researchers will provide guidance and resources tailored to help you stop smoking and catch lung disease early if needed.
New Orleans, LouisianaAges 50–80 - NCT06614504RecruitingPhase 2
Nicotine control for dual e-cigarette and cigarette users
This study is testing how to help people who both smoke cigarettes and use e-cigarettes. It looks at ways to control nicotine use to help you quit or cut back.
Providence, Rhode IslandAges 21 years+
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Common questions
- Are there clinical trials for tobacco use disorder?
- Yes. Clin2 currently lists 115 recruiting tobacco use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.