Clinical trials
Tolerance clinical trials
Below are recruiting tolerance clinical trials, each written for real people, not researchers. We’re tracking 952 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07421167RecruitingPhase 2
Ianalumab with TPO-RA for immune thrombocytopenia
This trial tests a new drug called ianalumab combined with a standard platelet-boosting medicine (TPO-RA) for adults with immune thrombocytopenia (ITP) or Evans syndrome. The goal is to see if the combination is well-tolerated and helps raise platelet counts.
Stamford, ConnecticutAges 18 years+ - NCT06503211RecruitingPhase 1
UTAA09 cell therapy for lymphoma
This trial tests a new cell therapy called UTAA09 for people with certain types of lymphoma that have not been treated with CAR T-cells before. It aims to see if the treatment is safe and works against tumors that have CD19 or CD20 proteins.
Hefei, AnhuiAges 18–75 - NCT06504290RecruitingPhase 1
Safety study of VV119 for healthy adults and people with schizophrenia
This trial tests if a new drug called VV119 is safe and how it works in the body. It is for healthy volunteers and for people who have had schizophrenia for at least a year and are currently having worsening symptoms.
Beijing, Beijing MunicipalityAges 18–65 - NCT06507722Recruiting
Night Owl Metabolism Study
This study from Johns Hopkins looks at how your body's metabolism works when you're an overweight teen or young adult who sleeps enough. It aims to learn more about your 'night owl' internal clock and how it affects your health.
Baltimore, MarylandAges 18–23 - NCT06508216RecruitingPhase 1/Phase 2
New drug combo for early relapsed triple-negative breast cancer
This trial tests experimental drugs for people with triple-negative breast cancer that came back within 12 months of finishing initial treatment. The goal is to see if these drugs are safe and can shrink or slow the cancer.
VillejuifAges 18 years+ - NCT06515470RecruitingPhase 1
Testing BTX-9341 for advanced breast cancer
This trial tests a new oral drug, BTX-9341, for people with advanced or metastatic hormone receptor-positive, HER2-negative breast cancer who have already had certain treatments, including a CDK4/6 inhibitor. The goal is to see if it is safe and effective.
Rochester, MinnesotaAges 18 years+ - NCT06519552RecruitingPhase 1
Gene therapy study for adults with MPS type I
This study tests a new gene therapy called JWK008 for adults with MPS type I. The goal is to see if it is safe and can help improve symptoms. You may be able to join if you are 18 or older and have not had serious side effects from enzyme replacement therapy.
Chengdu, SichuanAges 18 years+ - NCT06524505Recruiting
Deep brain stimulation for bipolar depression
This trial tests a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) to see if it improves depression in people with bipolar disorder. dTMS uses magnetic pulses to stimulate brain areas involved in mood regulation.
TianjinAges 18–65 - NCT06524830RecruitingPhase 2
Testing VLS-01 film for treatment-resistant depression
This trial tests an experimental film placed inside the cheek (VLS-01) against a placebo to see if it helps people whose depression hasn't improved with standard antidepressants. If you have tried at least two antidepressants without success, this study may be an option for you.
Tucson, ArizonaAges 18–65 - NCT06525168RecruitingPhase 1
Safety study of DA414 in healthy volunteers
This trial tests a new medicine called DA414 in healthy people to see if it is safe and how the body processes it. It may help researchers understand the right dose for future studies.
Wuhan, Hubei.ChinaAges 18–45 - NCT06532942RecruitingPhase 1
Safety study of an inhaled drug in healthy adults
This study tests a new inhaled drug (MKND-201) in healthy volunteers to see if it's safe and how the body processes it. If you are a generally healthy adult between 40 and 65, you might be able to help researchers understand if this medicine is safe for future studies.
San Antonio, TexasAges 40–65 - NCT06539507RecruitingPhase 1
Study of BCX17725 for Netherton syndrome safety
This trial tests a new drug called BCX17725 in people with Netherton syndrome to see if it is safe and how the body handles it. It may help by reducing skin symptoms like redness and scaling.
Palo Alto, CaliforniaAges 12–65 - NCT06547528RecruitingPhase 1
Testing ONO-4685 for T cell lymphoma and CLL/SLL
This trial tests a new drug, ONO-4685, for people with certain types of T cell lymphoma or chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) that has not responded to standard treatments or cannot tolerate them. The goal is to see if the drug is safe and tolerable.
Nagoya, Aichi-kenAges 18 years+ - NCT06552598RecruitingPhase 1
KD01 for advanced gynecologic cancers
This trial tests a new drug called KD01 for women with advanced gynecologic cancers (like cervical or endometrial cancer) that haven't responded to other treatments. It also has a separate part for younger women who want to preserve their fertility.
Wuhan, HubeiAges 18 years+ - NCT06556394RecruitingPhase 1
Testing RAG-17 for ALS with SOD1 gene mutation
This trial tests a new drug, RAG-17, for people with ALS who have a specific SOD1 gene mutation. The goal is to see if it's safe and how it affects the body, which may help slow the disease.
BeijingAges 18 years+ - NCT06558708RecruitingPhase 2
Comparing two once-daily insulins for type 2 diabetes
This trial compares two once-daily insulin injections to see which works better and is safer for people with type 2 diabetes. Both are new types of insulin designed to help control blood sugar with fewer side effects.
TianjinAges 18–75 - NCT06564584RecruitingPhase 2
Study of TLC-2716 for high triglycerides and fatty liver disease
This trial tests an investigational drug called TLC-2716 for people with very high triglycerides and a type of fatty liver disease (NAFLD or NASH). The goal is to see if it is safe and can help lower fat levels in the blood and liver.
Guadalajara, JaliscoAges 18–70 - NCT06569758RecruitingPhase 1
A study of GenSci098 for active thyroid eye disease
This study tests a new medication called GenSci098 for people with active thyroid eye disease. It aims to reduce eye symptoms like redness, swelling, and bulging, and improve quality of life.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06578156Recruiting
Nasal high flow breathing support during exercise for COPD
This study tests whether a special nasal breathing device (nasal high flow) can help people with COPD exercise longer and more comfortably. It compares the device to standard low-flow oxygen or no oxygen at all.
Miami, FloridaAges 18–100 - NCT06593392RecruitingPhase 2
Safety of difelikefalin for itching in teens on dialysis
This trial tests a drug called difelikefalin to see if it safely reduces moderate-to-severe itching in teenagers who are on hemodialysis. Itching is common in kidney disease, and this study aims to find a new treatment option.
ChengduAges 12–18 - NCT07448155RecruitingPhase 1
Testing a new drug in healthy volunteers
This study tests a new medicine (INCA033989) given as a shot or IV in healthy adults to see how the body processes it and if it's safe.
Tempe, ArizonaAges 18–55 - NCT07465653RecruitingPhase 1
Study of HJB647 for heart failure with reduced pumping ability
This trial tests a new medicine, HJB647, in people with heart failure who have a weak heart pump. It aims to see if the drug is safe and well-tolerated. You may qualify if your heart's pumping ability is reduced and you are on a specific standard therapy.
Bradenton, FloridaAges 18–100 - NCT07566195RecruitingPhase 3
Long-term Safety of Tozorakimab in COPD Patients
This study follows patients who previously took part in a tozorakimab trial to see how safe the drug is over time. Tozorakimab is an antibody treatment designed to reduce flare-ups (exacerbations) in people with COPD, a chronic lung disease.
Aix-en-ProvenceAges 18–99 - NCT06604728Recruiting
IV vs. shot biologics for IBD: which works better?
This study compares intravenous (IV) and under-the-skin (subcutaneous) biologic drugs for people with Crohn's disease or ulcerative colitis. It helps doctors understand if switching from the IV form to a shot is as effective and well-tolerated.
RomaAges 18 years+
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Common questions
- Are there clinical trials for tolerance?
- Yes. Clin2 currently lists 952 recruiting tolerance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tolerance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tolerance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.