Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,068 recruiting studies in this area right now.
By phase
- Not applicable3,005
- Phase 21,062
- Phase 1794
- Phase 1/Phase 2441
- Phase 3435
- Phase 4233
- Phase 2/Phase 398
Top conditions
- Multiple Sclerosis330
- Multiple Myeloma328
- Asthma194
- Lymphoma179
- Rheumatoid Arthritis131
- Type 1 Diabetes131
- Atopic Dermatitis123
- Systemic Lupus Erythematosus121
- Acute Lymphoblastic Leukemia118
- HIV Infections106
- Chronic Lymphocytic Leukemia96
- Autoimmune Diseases79
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)68
- Hodgkin Lymphoma64
- Diabetes Mellitus, Type 163
- Leukemia63
- Type 1 Diabetes Mellitus63
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca64
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- Mayo Clinic50
- City of Hope Medical Center49
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California498
- Maryland198
- Alabama179
- Florida152
- Arizona150
- Massachusetts118
- New York116
- Texas112
- Illinois82
- Colorado81
Recruiting studies6,068 total
- NCT06375993Enrolling by invitationPhase 1
Prula-cel for autoimmune diseases: a phase 1 study
This trial tests a new treatment called prulacabtagene leucel (prula-cel), which is a type of immune cell therapy (CAR T-cells) for people with certain autoimmune diseases. It aims to see if it can reset the immune system and reduce disease activity in conditions like lupus, scleroderma, vasculitis, or myositis.
Redwood City, CaliforniaAges 18–80 - NCT06371417RecruitingPhase 1
Testing RAY121 for several immune diseases (RAINBOW trial)
This trial tests a new medicine called RAY121 (an antibody) for people with certain autoimmune diseases. It aims to see if RAY121 is safe and how the body handles it. If you have one of these conditions and meet the basic health requirements, you might be able to join.
Orange, CaliforniaAges 18–85 - NCT06374264Enrolling by invitation
Music-based walking therapy for NMOSD
This trial tests a music-based walking therapy (called MR-C-014) to see if it is safe and well-tolerated for people with NMOSD who have trouble walking. It may help improve your walking pattern and strength.
Atlanta, GeorgiaAges 18–70 - NCT06361537RecruitingPhase 3
Study of a C1 inhibitor medicine for HAE attacks
This trial tests a plasma-derived C1 esterase inhibitor to treat and prevent acute attacks in people with hereditary angioedema (HAE) types 1 or 2. It aims to see if the medicine can quickly relieve swelling episodes and reduce their frequency.
Centennial, ColoradoAges 2 years+ - NCT06375044RecruitingPhase 1
Study of SIM0500 for relapsed or refractory multiple myeloma
This trial tests a new medication, SIM0500, for people whose multiple myeloma has returned or stopped responding to other treatments. It aims to see if the drug is safe and effective for those who have tried all standard options.
Phoenix, ArizonaAges 18 years+ - NCT06055361RecruitingPhase 1
Studying a new injection for moderate to severe eczema
This trial tests an investigational drug called BxC-I17e, given as an injection under the skin, for people with moderate to severe atopic dermatitis (eczema) that hasn't improved enough with standard creams. The goal is to see if it is safe and works well.
North Little Rock, ArkansasAges 18 years+ - NCT06234384Recruiting
Sarcoidosis advanced registry study
This study is creating a registry of people with sarcoidosis to help researchers better understand the disease and develop new treatments.
Chicago, IllinoisAges 7 years+ - NCT06376149Recruiting
Making Mindfulness Matter for Kids with JIA
This study tests a program called Making Mindfulness Matter (M3) for children with JIA. It is an online program that helps children and their caregivers learn mindfulness skills to manage pain and stress from arthritis.
Hamilton, OntarioAges 4–12 - NCT06377566RecruitingPhase 2
BV-AVD for bulky Hodgkin lymphoma
This trial tests a combination of two drugs (brentuximab vedotin, AVD chemotherapy) for people with newly diagnosed, bulky Hodgkin lymphoma that hasn't spread far. It aims to see if this treatment works well for larger tumors.
Miami, FloridaAges 18 years+ - NCT06370481Recruiting
HIV and addiction training program for Alabama clinics
This study tests a program to help people living with HIV in Alabama who also struggle with opioid or stimulant use. It takes place at your HIV clinic and checks whether a new approach to addiction care can improve your health.
Birmingham, AlabamaAges 18 years+ - NCT06367244Recruiting
Wellness Program for Transplant Wait-List Patients
This trial offers a wellness program to help people waiting for a kidney or liver transplant improve their health and fitness. You'll receive support and guidance through virtual sessions.
Calgary, AlbertaAges 18 years+ - NCT06367348Recruiting
Couples program to cut alcohol use in Malawi
This study tests a program that helps couples in Malawi reduce alcohol use and strengthen their relationship. It is for people living with HIV who are in a long-term relationship and ready to work together with their partner.
ZombaAges 18 years+ - NCT06377462Recruiting
VEXAS syndrome registry with blood sample collection
This study creates a national registry for people with VEXAS syndrome to track the disease and collect blood samples for research. Joining helps doctors learn more about VEXAS so they can better diagnose and treat it in the future.
AachenAges 18 years+ - NCT06376526RecruitingPhase 2
Immunotherapy treatment for newly diagnosed multiple myeloma
This trial tests an immunotherapy drug combination for people newly diagnosed with multiple myeloma who have had some response to initial treatment but still have signs of disease. The goal is to see if this approach can help eliminate remaining cancer cells and potentially improve outcomes.
Miami, FloridaAges 18 years+ - NCT06365411Enrolling by invitation
Genomic medicine study for kidney transplant patients
This study looks at the genes of people who have had or will have a kidney transplant. It aims to learn how genetic information might help improve transplant care over time. Participants will give blood, urine, stool, and possibly kidney tissue samples for research.
Westmead, New South WalesAges 18–80 - NCT06372613Recruiting
LRG protein and ulcerative colitis remission
This study looks at a protein called LRG in your blood or tissue to see if it can tell if your ulcerative colitis is in remission (quiet or not active). This might help doctors better monitor and treat UC in the future.
KomaganeAges 20–90 - NCT06375135Recruiting
Text message and coach program for HIV medication adherence
This study tests a program that uses text messages and a personal health coach to help Latino men with HIV take their medication every day. It's designed for those who have had trouble sticking to their HIV medicine routine.
Miami, FloridaAges 18 years+ - NCT06373926Recruiting
Blood test for Annexin A2 in antiphospholipid syndrome
This study tests how a blood sample can help doctors better understand Antiphospholipid Syndrome (APS) by measuring a protein called Annexin A2 on white blood cells. It may lead to easier diagnosis and monitoring of this condition.
AmiensAges 18 years+ - NCT06367725Recruiting
Dexamethasone in childhood ALL and bone health
This study looks at how the body processes a steroid medicine called dexamethasone in children with ALL, and how it might affect bone strength.
Aalborg, AalborgAges 1–17 - NCT06365671RecruitingPhase 2
CAR-T therapy after stem cell transplant for high-risk B-cell lymphoma
This trial tests a combination treatment: a stem cell transplant followed by CAR-T cell therapy for people with B-cell lymphoma that has come back or not responded to treatment. It is for those with high-risk features like large tumors or certain genetic changes.
ShanghaiAges 18 years+ - NCT06371768Recruiting
Helping Young Cancer Survivors Manage Symptoms & Transition to Care
This study is designed to help adolescent and young adult cancer survivors manage symptoms and smoothly transition to post-treatment care. If you finished treatment for certain cancers within the past 1 to 5 years, you may be able to join.
Durham, North CarolinaAges 18–39 - NCT06378190RecruitingPhase 1/Phase 2
New CAR-T cell therapy for relapsed B-cell lymphoma
This trial tests a new type of CAR-T cell therapy (a treatment that uses your own immune cells to fight cancer) for people with B-cell lymphomas that have come back or not responded to standard treatments. It aims to see if this new manufacturing method is safe and effective.
Barcelona, BarcelonaAges 18–80 - NCT06372249RecruitingPhase 2
Fiber drink for asthma in kids
This trial tests whether a liquid fiber drink can help children with asthma by reducing airway inflammation. Participants will drink either fiber or a placebo and be followed for about 4–6 weeks to see if their asthma improves.
Phoenix, ArizonaAges 6–17 - NCT06342544RecruitingPhase 3
Steroids and rituximab to prevent myasthenia from spreading
This trial tests whether a combination of steroid medicine (corticosteroid) and a targeted immune drug (rituximab) can prevent mild eye-muscle weakness from spreading to other muscles. It is for people newly diagnosed with ocular myasthenia who have not yet taken immune-suppressing treatments.
BordeauxAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,068 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,217 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.