Treatment
Comparator clinical trials
We’re tracking 1,754 recruiting studies that include Comparator, each written for real people, not researchers, below.
Recruiting studies
- NCT06742996RecruitingPhase 3
Sonrotoclax plus zanubrutinib for relapsed mantle cell lymphoma
This trial tests a new combination of two targeted therapies for people with mantle cell lymphoma that has come back or hasn't responded to prior treatment. It aims to see if adding sonrotoclax to zanubrutinib works better than zanubrutinib alone.
Birmingham, AlabamaAges 18 years+ - NCT04935164Recruiting
Study of gender dysphoria versus a control group
This study compares people with gender dysphoria to people without it. It looks at differences in symptoms or outcomes and may help researchers better understand how gender dysphoria affects mental well-being.
PoitiersAges 18–60 - NCT04965025Recruiting
Two-step urethral repair using oral lining graft placement timing
This study compares doing a graft in the first versus the second step of a two-stage urethral repair in men with a penile urethral narrowing. It uses oral lining tissue as the graft and aims to see which timing approach works best for healing and function.
GhentAges 18 years+ - NCT04967183Recruiting
Compare a stool blood test versus colonoscopy follow-up after precancer removal
This study compares two ways of checking for colorectal cancer risk after advanced polyps are removed. It may help determine whether a stool test can safely replace some colonoscopy surveillance for certain people.
OurenseAges 50–65 - NCT04970888Recruiting
Exercise program to improve thinking and brain blood flow in heart failure
This trial tests whether doing a combined mental (cognitive) and physical exercise program can improve thinking and how well blood flows to the brain in people with chronic heart failure. It may help by strengthening both brain function and physical capacity while your heart condition stays stable.
Montreal, QuebecAges 50 years+ - NCT04992572RecruitingEarly Phase 1
Comparing two types of anesthesia for back decompression surgery
This early study compares two anesthesia approaches during lumbar decompression (back surgery to relieve pressure on nerves). It may help improve comfort and safety during surgery, but whether you personally benefit is not yet known.
Redwood City, CaliforniaAges 40–95 - NCT05000983RecruitingPhase 1/Phase 2
Test Plurogel skin gel versus standard burn dressings
This early-phase study tests whether Plurogel, a medicated skin gel, works better than the usual dressing care for certain burn wounds. It aims to improve healing in people who have partial-thickness face burns or one-sided limb burns that need hospital treatment.
Winnipeg, ManitobaAges 18 years+ - NCT05015660Recruiting
Testing left bundle pacing versus usual right pacing
This study compares a newer heart pacing method (left bundle branch pacing) to the standard method (right ventricular pacing) in people who need most of their heartbeats paced. It may help improve how well the heart pumps over time.
Montreal, QuebecAges 18 years+ - NCT05033288Recruiting
Compare radiation types and surgery for pelvic bone sarcomas
This study compares three treatment approaches—carbon ion radiation, proton radiation, and surgery—for sarcomas in the pelvis that involve bone. It looks to see which option best controls the tumor while helping protect nearby tissues.
Scottsdale, ArizonaAges 15 years+ - NCT05033691Recruiting
Osimertinib plus early brain radiation versus osimertinib alone
This trial tests whether starting focused radiation to brain spots early (called SRS) along with osimertinib works better than taking osimertinib alone. It is for people with lung cancer that has an EGFR mutation and has not yet caused major brain symptoms.
JerusalemAges 18–120 - NCT05040204RecruitingPhase 1
Test supplements to change how sugars attach to blood proteins
This early (Phase 1) study tests how adding specific dietary supplements affects “protein glycosylation,” which means how sugar molecules attach to proteins in your blood. It’s meant to see how the supplements change these blood measurements and whether the approach is tolerable in generally healthy adults.
Sacramento, CaliforniaAges 18–45 - NCT05040711Recruiting
Mindfulness app for serious illness patients and caregivers
This study tests whether a mindfulness training delivered through a phone or tablet can help people and their caregivers cope with serious illness. You may be eligible if you’re 60 or older (as a patient) or an adult caregiver, and if simple screening questionnaires suggest you could benefit.
Livingston, New JerseyAges 21 years+ - NCT05042687Recruiting
Compare a breast imaging scan with MRI in high-risk women
This study compares two ways of imaging the breast—molecular breast imaging (a scan that uses a small radioactive tracer) and standard breast MRI—to better find or rule out breast cancer. You may join if you are considered high risk and already have a breast MRI planned, and you can do both tests close together.
Houston, TexasAges 18 years+ - NCT05079711Recruiting
Compare a vaginal yeast test for women with symptoms
This study compares how well a new vaginal yeast (Candida) test matches a standard yeast culture test. It may help clinicians choose the most accurate, convenient way to tell whether vaginal symptoms are caused by yeast.
Fort Bragg, North CarolinaAges 18 years+ - NCT05087667Recruiting
Polymer wiring for arm or thigh fractures: tested vs standard care
This trial compares a new type of polymer cerclage (a strong wire used to support a fracture) against standard cerclage wiring used in routine care. It may help doctors learn which option works better for healing in certain arm (humerus) or thigh (femur) fractures.
Agen, FranceAges 18 years+ - NCT05102747Recruiting
Surgery-like brain radiation for up to 5 metastases
This trial compares two ways of giving focused radiation to the brain for people with a limited number of brain metastases. It aims to see which schedule works best (and is likely best for costs and quality of life).
BordeauxAges 18 years+ - NCT05108259RecruitingPhase 1
Safety and blood-level study of PBP1502 versus Humira
This Phase 1 study tests how a new medicine (PBP1502) behaves in the body and checks safety, comparing it to Humira. It is done in healthy adults to see dosing, side effects, and blood levels before moving to studies in patients.
MadridAges 18–55 - NCT05109936RecruitingPhase 3
Febuxostat given right away versus later for gout flare
This Phase 3 study compares starting febuxostat immediately during a gout flare versus delaying the start. It aims to see which timing helps control gout better and safely.
CaenAges 18 years+ - NCT05111405Recruiting
Compare two surgeries for thumb CMC arthritis
This trial compares two different operations for thumb CMC (carpometacarpal) arthritis. It looks at which surgery works better when other non-surgery treatments have not helped you.
Calgary, AlbertaAges 50 years+ - NCT05125146Recruiting
Internet CBT for insomnia versus medicines
This study compares an online form of CBT (a structured therapy for sleep) with sleep medicines for adults with insomnia. It may help you see which approach improves how easily you fall asleep and stay asleep.
Kingston, OntarioAges 18 years+ - NCT05126810Recruiting
Standard versus personalized counseling for TP53 test results
This trial compares standard genetic counseling with a more personalized approach for people considering or receiving TP53 genetic testing. It may help by seeing which counseling style better supports you before and after testing for a TP53 inherited change.
Houston, TexasAges Any age - NCT05132179Recruiting
Testing two antiseptic creams for diabetic foot ulcers
This study compares two topical (applied on the skin) antimicrobial agents—Dakin’s and Prontosan—to help heal diabetic foot ulcers. You may be eligible if you have a diabetic foot ulcer that has been present for at least 3 weeks and is large enough.
Uddevalla, TrollhattanAges 18–100 - NCT05135091RecruitingPhase 3
Cell therapy trial for hard-to-control one-sided temporal lobe epilepsy
This Phase 3 study tests a neural cell therapy (NRTX-1001) for adults whose seizures come from one side of the hippocampus and have not improved with standard seizure medicines. The goal is to reduce seizure frequency and improve seizure control where other treatments have not worked.
Birmingham, AlabamaAges 18–75 - NCT05152472RecruitingPhase 2
Imatinib plus atezolizumab versus imatinib alone for advanced GIST
This Phase 2 trial tests whether adding atezolizumab (an immune medicine) to imatinib works better than imatinib by itself in people with advanced gastrointestinal stromal tumors (GIST) that can’t be fully removed and have progressed after standard treatments. It may help by improving how well tumors respond and how long disease stays under control.
Lyon, RhôneAges 18 years+
Common questions
- Are there clinical trials studying Comparator?
- Yes. Clin2 currently lists 1,754 recruiting studies that include Comparator, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Comparator trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Comparator an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Comparator or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.