Treatment
COVID-19 vaccine clinical trials
We’re tracking 68 recruiting studies that include COVID-19 vaccine, each written for real people, not researchers, below.
Recruiting studies
- NCT07464314RecruitingPhase 1
Testing a combined flu and COVID-19 mRNA vaccine in older adults
This trial is testing whether a new mRNA vaccine that targets both seasonal flu and COVID-19 is safe and creates a strong immune response. It may offer an easier way to protect against two illnesses with one shot.
Anniston, AlabamaAges 65–85 - NCT07400848Recruiting
Symptoms and recovery after COVID-19 vaccine
This study looks at people who developed new, long-lasting symptoms after a COVID-19 vaccine. It aims to understand their symptoms, do lab tests, and see how they recover over time.
BernAges 18 years+ - NCT07445971RecruitingPhase 1
Study of MDX2301 for healthy adults and those at higher risk for severe COVID-19
This trial tests an investigational drug called MDX2301 to see if it's safe in healthy adults and in adults who are at higher risk for severe COVID-19. Higher risk means you have conditions like asthma, diabetes, heart disease, or other listed health issues.
Las Vegas, NevadaAges 18–64 - NCT07655180RecruitingPhase 3
Testing a new COVID-19 vaccine with or without another vaccine
This trial tests a new COVID-19 vaccine called VYD2311, alone or with another COVID-19 vaccine, in healthy adults. The goal is to see if it is safe and helps your body fight the virus.
Overland Park, KansasAges 18–49 - NCT04579588Recruiting
Study flu vaccine immunity in people after COVID-19
This study looks at how well your immune system (your body’s infection-fighting system) responds to a flu vaccine after you’ve had COVID-19. It may help doctors understand why some people have different protection after vaccines.
Palo Alto, CaliforniaAges 9–64 - NCT04448145Recruiting
Study why COVID lasts after recovery
This study looks at what factors may make COVID-19 symptoms or infection effects last after someone has recovered. It also collects certain body samples to better understand why this persistence happens.
New York, New YorkAges 7 years+ - NCT05213000Recruiting
Exercise program study to boost vaccine immune response
This study looks at whether regular light-to-moderate exercise around the time of getting an mRNA COVID-19 vaccine can improve your immune response. It may help researchers understand how stress and exercise affect how well vaccines work.
Ames, IowaAges 18–64 - NCT06821126RecruitingPhase 1/Phase 2
Nasal spray COVID-19 vaccine booster study for healthy adults
This study tests a new nasal spray COVID-19 vaccine to see how it compares to an mRNA booster shot. It is for healthy adults who have already had at least 3 doses of an mRNA COVID-19 vaccine (or 2 doses plus a confirmed COVID infection) and are looking for a needle-free booster option.
DijonAges 18–60 - NCT05610423Enrolling by invitation
Study of heart inflammation after COVID-19 vaccination in Norway
This study looks at people who may have developed myocarditis or pericarditis (inflammation of the heart muscle or the lining around the heart) shortly after a COVID-19 vaccine. It compares their health records to vaccination records to understand who is affected and when, which may help improve future care.
OsloAges 5 years+ - NCT07536308RecruitingPhase 1
Nasal COVID-19 booster vaccine safety trial
This trial tests a new nasal spray COVID-19 booster vaccine. It aims to see if the vaccine is safe and produces a strong immune response when given through the nose and inhaled, in people who have already been vaccinated.
Decatur, GeorgiaAges 18–64 - NCT07123727RecruitingPhase 2
Testing Anktiva for long COVID symptoms
This study tests if the drug Anktiva can help people with long COVID. To join, you must have had at least one confirmed COVID-19 infection and now have lasting symptoms that started or got worse after that infection.
El Segundo, CaliforniaAges 18–70 - NCT07013474RecruitingPhase 3
Study of ibuzatrelvir for immunocompromised adults with COVID-19
This trial tests an investigational medicine called ibuzatrelvir for adults with COVID-19 who have a weakened immune system. The study aims to see if it helps them recover and avoid severe illness.
Canoga Park, CaliforniaAges 18 years+ - NCT05046002Recruiting
COVID vaccine heart inflammation symptom registry
This study is a “registry,” meaning it collects medical information about people who develop possible heart inflammation after a COVID-19 vaccine. It may help doctors understand how often this happens and which findings are linked to it.
Ottawa, OntarioAges 5 years+ - NCT06864156Recruiting
Molecules and vitamin levels in long COVID with brain fog
This study looks at certain molecules (called microRNAs) and vitamin B12 levels in people who have ongoing brain-related symptoms like depression, anxiety, or fatigue after a COVID-19 infection. It may help understand why some people have long-lasting symptoms and could lead to better treatments.
Mexico City, Mexico CityAges 18–65 - NCT07076862RecruitingEarly Phase 1
PET scan study for long COVID symptoms
This study uses a special PET scan to look at inflammation in the body of people with long COVID (symptoms lasting 3+ months after infection). The goal is to understand why symptoms persist and find better ways to help.
Sacramento, CaliforniaAges 18 years+ - NCT06825819Recruiting
Dysbiosis and long COVID study
This study looks at gut bacteria changes in people with and without long COVID symptoms after a confirmed COVID infection. It may help find why some people have long-term health problems.
Chicago, IllinoisAges 18–80 - NCT05689034RecruitingPhase 2/Phase 3
Azvudine for early COVID-19 in higher-risk adults
This trial studies azvudine in adults with early COVID-19 symptoms to see if it can prevent the illness from getting severe. You may qualify if you’re within about 5 days of symptom start and have risk factors for worsening disease.
Beijing, Beijing MunicipalityAges 18–120 - NCT06585241RecruitingPhase 4
Study of Updated COVID-19 Vaccines for High-Risk Groups
This trial tests updated COVID-19 vaccines designed to better protect against current variants. It's for people who have already been vaccinated and are at higher risk for severe COVID-19.
Atlanta, GeorgiaAges 6 months+ - NCT06679140RecruitingPhase 3
Study of Ibuzatrelvir for COVID-19 in high-risk patients
This trial tests if a new medicine called ibuzatrelvir can help people with COVID-19 who have certain health risks avoid severe illness. It is for patients who cannot or choose not to take another COVID-19 pill called Paxlovid.
Little Rock, ArkansasAges 12 years+ - NCT06667700RecruitingPhase 3
A study of the antiviral molnupiravir for high-risk people with COVID-19
This study tests an antiviral pill called molnupiravir to see if it can prevent severe COVID-19 in people who are at high risk and cannot take Paxlovid. If you have mild to moderate COVID-19 symptoms and certain health risks, you may be able to join.
Cullman, AlabamaAges 18 years+ - NCT04746183RecruitingPhase 1/Phase 2
Early trial testing treatments for COVID-19 in the first days
This early-stage study tests COVID-19 treatments in people who have recently developed symptoms and who test positive for the virus. It aims to find safer, more effective options for preventing worsening disease, especially in higher-risk groups.
Cape TownAges 18 years+ - NCT07157007RecruitingPhase 2
Testing a New COVID-19 Drug for Mild to Moderate Cases
This trial tests a new drug, ratutrelvir, for people with mild to moderate COVID-19. It aims to find a safe and effective dose to help you feel better faster.
Charlestown, New South WalesAges 18 years+ - NCT06511063RecruitingPhase 2
Antiviral trial for treating long covid symptoms
This study tests whether antiviral drugs (Truvada and Selzentry) can help people with long COVID. You may qualify if you have had long COVID symptoms for at least 6 months, including fatigue and post-exertional malaise.
New York, New YorkAges 18 years+ - NCT07108036RecruitingPhase 2
Testing Anktiva for Long COVID Symptoms
This trial tests a medicine called Anktiva to see if it can help people with Long COVID. It's for adults who had a confirmed COVID-19 infection and now have lasting symptoms like fatigue, brain fog, or trouble breathing.
San Francisco, CaliforniaAges 18–70
Common questions
- Are there clinical trials studying COVID-19 vaccine?
- Yes. Clin2 currently lists 68 recruiting studies that include COVID-19 vaccine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a COVID-19 vaccine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is COVID-19 vaccine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether COVID-19 vaccine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.