Treatment
Hydrocortisone clinical trials
We’re tracking 41 recruiting studies that include Hydrocortisone, each written for real people, not researchers, below.
Recruiting studies
- NCT02735707RecruitingPhase 3
Adaptive trial for severe pneumonia care in intensive care
This study tests ways to improve treatment for adults with severe pneumonia that lands them in the ICU, adjusting the plan as results come in. It may help your care team find better treatments for lung infection and breathing/heart support needs.
Jacksonville, FloridaAges 18 years+ - NCT07037043RecruitingPhase 3
Steroid medicines for high-risk heart surgery patients
This trial tests whether adding two common medicines, hydrocortisone and fludrocortisone, to standard care can help people who are at higher risk during planned heart surgery. It aims to see if this combination can reduce serious complications after surgery.
AmiensAges 18 years+ - NCT04591990RecruitingPhase 3
Hydrocortisone and vasopressin for shock after cardiac arrest
This Phase 3 trial tests whether hydrocortisone plus vasopressin (or related hormone treatments) can improve shock in adults after a resuscitated cardiac arrest. It targets people who remain very low in blood pressure despite fluids and need strong IV medicines to maintain blood pressure.
AmiensAges 18 years+ - NCT03760835RecruitingPhase 4
Once-daily hydrocortisone for adults with congenital adrenal hyperplasia
This trial studies whether a once-daily hydrocortisone tablet works as well as standard steroid treatment for adults with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. It aims to improve how safely and conveniently hormone replacement is taken each day.
NaplesAges 18 years+ - NCT05435781RecruitingPhase 4
Hydrocortisone added during stress in people on low-dose prednisolone
This study tests whether adding supplemental hydrocortisone during stressful events can prevent problems in people who develop adrenal insufficiency from long-term prednisolone. It is meant to see if “stress dosing” is safer and helps the body respond to stress.
AarhusAges 50 years+ - NCT07763210RecruitingPhase 2
IT therapy for immune cell-related side effects after CAR T
This trial tests a new way to give treatment directly into the spinal fluid for a serious side effect of CAR T cell therapy called ICANS. It may help people with certain types of lymphoma who are getting standard CAR T therapy and experience this brain-related complication.
Nashville, TennesseeAges 18 years+ - NCT07612631RecruitingEarly Phase 1
Brain imaging study of alcohol and stress response
This research uses brain imaging to understand how two brain systems—one involved in stress and one involved in reward—interact in people with alcohol use disorder. The goal is to find new ways to help people reduce heavy drinking.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07383103RecruitingPhase 4
Steroid combination for septic shock
This trial tests whether two medicines (hydrocortisone and fludrocortisone) can help people with severe infections that cause dangerously low blood pressure (septic shock). It's for patients who have just been diagnosed and haven't used steroids recently.
Yangzhou, JiangsuAges 18–90 - NCT06982183RecruitingPhase 4
Propranolol and hydrocortisone effects on military performance
This trial studies how two medications—propranolol (a beta blocker often used for anxiety) and hydrocortisone (a steroid)—affect performance on military tasks. It aims to understand if these drugs help or hinder how soldiers perform under stress.
Silver Spring, MarylandAges 18–40 - NCT06930456Enrolling by invitation
Comparing two drugs to prevent low blood pressure during spinal anesthesia
This study tests if giving hydrocortisone (a type of steroid) or ondansetron (an anti-nausea drug) before spinal anesthesia can better prevent low blood pressure during surgery for your belly or lower leg.
Port Said, Port Said GovernorateAges 21 years+ - NCT06892197RecruitingPhase 4
Comparing two steroids for severe pneumonia
This trial compares two common steroid medicines, hydrocortisone and prednisolone, to see which works better for people with severe community-acquired pneumonia. It aims to find the best treatment to help you recover faster.
Rønne, BornholmAges 18 years+ - NCT06892210RecruitingPhase 4
Steroid comparison for COPD flare-ups
This trial compares two common steroids, hydrocortisone and prednisolone, to see which works better for treating COPD flare-ups. It may help you recover faster from a sudden worsening of your breathing.
Rønne, BornholmAges 40 years+ - NCT06895473RecruitingPhase 2
Spinal injection to prevent nerve side effects from CAR-T therapy
This trial tests if a spinal injection of three common chemotherapy drugs can reduce or prevent serious brain and nerve side effects in people receiving CAR-T cell therapy for cancer.
Portland, OregonAges 18 years+ - NCT06381661RecruitingPhase 2
Personalized treatment for sepsis in children and adults
This trial is testing several different treatments to find the best one for each person with sepsis. It looks at specific 'treatable traits' like inflammation, blood clotting problems, or immune system issues to match you with the right therapy. The goal is to improve recovery and survival.
DijonAges 9 months+ - NCT03401398RecruitingPhase 3
Hydrocortisone for children with septic shock in the ICU
This Phase 3 trial tests whether giving stress-dose hydrocortisone can improve outcomes for children with septic shock in the pediatric intensive care unit (PICU). It is designed for children who are already receiving strong medicines to support blood pressure because of a serious infection.
Tucson, ArizonaAges 1 month–17 years - NCT05836610RecruitingPhase 4
Testing hydrocortisone dosing during newborn cooling
This Phase 4 trial studies the best way to give hydrocortisone (a steroid medicine) to newborns who are being cooled for a specific kind of birth-related lack of oxygen. It’s for babies who have low blood pressure during cooling, aiming to improve their stability while they receive standard treatment.
Budapest, Pest CountyAges Up to 3 days - NCT05193396RecruitingPhase 4
Hydrocortisone trial for adrenal symptoms after stopping steroid pills
This trial tests whether hydrocortisone (a cortisol replacement) helps people who feel symptoms of adrenal insufficiency after they stop long-term prednisolone. It compares hydrocortisone versus placebo to see if symptoms improve and dosing is safer/effective.
AarhusAges 50 years+ - NCT05160506RecruitingPhase 2
Steroids to treat acute pancreatitis in the ICU
This Phase 2 study tests whether corticosteroids (steroid medicines) can improve outcomes for adults with severe acute pancreatitis in the intensive care unit. It’s meant to see if steroids help when the pancreas inflammation is serious.
Boston, MassachusettsAges 18–99 - NCT05008146RecruitingEarly Phase 1
Brain imaging study for cocaine use disorder interactions
This early-phase study uses brain imaging to understand how cocaine use disorder affects brain function. It may help researchers learn more about brain pathways involved in craving and treatment targets.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07387926RecruitingPhase 1/Phase 2
Testing asciminib for children and young adults with a type of leukemia
This trial tests an experimental drug called asciminib for children and young adults whose leukemia (a specific type of B-cell acute lymphoblastic leukemia with certain gene changes) has come back or not responded to treatment. The goal is to see if the drug is safe and effective for these patients.
Sydney, New South WalesAges 1–30 - NCT05139849RecruitingPhase 3
Testing vasopressin and steroids with adrenaline in cardiac arrest
This trial studies whether adding vasopressin and steroids to the standard emergency medicine adrenaline improves survival after out-of-hospital or in-hospital cardiac arrest. If you qualify, the treatment is chosen by chance (randomized) to help doctors learn which approach works best.
GothenburgAges 18 years+ - NCT05476770RecruitingPhase 1
Tagraxofusp for children with CD123-positive leukemia
This study tests tagraxofusp, a medicine that targets a marker called CD123 on cancer cells, in children and young adults whose leukemia or lymphoma has come back or is resistant to treatment. It may help by shrinking the cancer and improving disease control after standard therapies have not worked.
Los Angeles, CaliforniaAges 1–21 - NCT05816226RecruitingPhase 3
Topical cream for jaw joint pain
This Phase 3 study tests a skin-applied treatment (a cream or gel) to reduce pain in the jaw joint (TMJ). You may benefit if you have TMJ pain and can safely use the study medication without conflicting treatments.
San Francisco, CaliforniaAges 18 years+ - NCT07494084RecruitingPhase 4
How sleep loss and body clock disruption affect insulin resistance
This trial studies how losing sleep and disrupting your internal body clock may cause insulin resistance, a condition linked to diabetes. You will stay in a lab for several days to test your body's response to sleep changes and a morning drug called octreotide. The goal is to understand why shift work and jet lag can lead to health problems.
Spokane, WashingtonAges 18–45
What Hydrocortisone is being studied for
Conditions with recruiting Hydrocortisone studies.
Common questions
- Are there clinical trials studying Hydrocortisone?
- Yes. Clin2 currently lists 41 recruiting studies that include Hydrocortisone, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Hydrocortisone trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Hydrocortisone an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Hydrocortisone or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.