Treatment
Systemic therapy clinical trials
We’re tracking 397 recruiting studies that include Systemic therapy, each written for real people, not researchers, below.
Recruiting studies
- NCT06685042RecruitingPhase 1/Phase 2
CAR T-cell therapy for severe autoimmune diseases
This study tests a new treatment called CAR T-cell therapy for people with severe autoimmune diseases that haven't gotten better with standard treatments. The goal is to see if it can help control the disease by reprogramming your immune cells.
Rome, LazioAges 18–65 - NCT04486495Recruiting
Minimally invasive lymph node treatment after chemo for node-positive breast cancer
This study looks at a less invasive way to check and treat lymph nodes in the armpit after you receive chemotherapy (and sometimes immunotherapy) before breast surgery. It may help people with cancer that has already spread to armpit lymph nodes by improving how staging and treatment are done.
's-HertogenboschAges 18 years+ - NCT06655259RecruitingPhase 2
TURP with standard therapy for metastatic prostate cancer
This trial tests whether adding a surgery called TURP (transurethral resection of the prostate) to the usual hormone therapy and chemotherapy can help men with metastatic prostate cancer that has spread to lymph nodes, bone, or other organs. The surgery helps relieve urinary symptoms and may improve how well the cancer responds to treatment.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07822945Recruiting
Diabetes technology knowledge among healthcare workers
This study asks healthcare workers at a specific hospital about what they know about diabetes technology. It aims to find gaps in knowledge so better training can be given.
ThessalonikiAges Any age - NCT07432334RecruitingPhase 1
CAR T-cell therapy for hard-to-treat lupus
This trial tests a personalized treatment called CD19 CAR T-cell therapy for people with severe lupus that hasn't improved with standard treatments. It uses your own immune cells to target and destroy the faulty cells causing lupus symptoms.
HanoiAges 16–55 - NCT06769997Recruiting
Comparing Optilume and Rezum for enlarged prostate
This study compares two treatments for an enlarged prostate: Optilume (a catheter-based system) and Rezum (water vapor therapy). It's for men with moderate symptoms who haven't tried other treatments before.
Montreal, QuebecAges 18 years+ - NCT06328777RecruitingPhase 2/Phase 3
Testing a new immune cell therapy for systemic sclerosis (scleroderma)
This trial tests a new treatment called CABA-201, which uses your own immune cells to target and calm the overactive immune system causing scleroderma. It aims to reduce symptoms and slow or stop the disease's progression.
New Haven, ConnecticutAges 18–75 - NCT07696000Recruiting
Nutrition therapy for inflammation in schizophrenia
This trial tests whether a structured medical nutrition plan can reduce inflammation in people with schizophrenia who are on stable antipsychotic medication. If you are hospitalized and able to eat normally, this study may help you understand how diet affects your health.
MedanAges 18–60 - NCT07492979Recruiting
Pacemaker placement study for heart failure
This trial compares two types of pacemaker placement to improve heart function in people with heart failure. One method paces the heart's natural conduction system, while the other paces the lower chambers of the heart. The goal is to find which approach works better for heart resynchronization therapy.
AarhusAges 18–99 - NCT06590259RecruitingPhase 2
Ablation plus drug therapy for colorectal cancer liver metastases
This trial tests a combination treatment that uses heat or cold (ablation) to destroy liver tumors along with medicines that boost your immune system to fight cancer. It is for people whose colorectal cancer has spread to the liver and who could not have surgery, or whose first treatment stopped working.
ShanghaiAges 18–75 - NCT07588425Recruiting
Monitoring heart health during breast cancer treatment
This study watches how chemotherapy and HER2-targeted drugs affect your heart during early-stage breast cancer treatment. Researchers use heart scans to catch any changes early and understand how to protect heart health.
Ankara, AnkaraAges 18 years+ - NCT06004336RecruitingPhase 2
Maintenance therapy after radiation for limited spread kidney cancer
This trial tests whether giving a maintenance medication (pembrolizumab) after targeted radiation helps keep kidney cancer that has spread to a few spots (5 or fewer) from growing. You would receive radiation to each spot and then be randomly assigned to receive either the medication or a placebo (inactive substance) for up to about 2 years.
Houston, TexasAges 18 years+ - NCT05444270Recruiting
Radiation and medicine for recurrent ovarian cancer
This trial studies a “salvage” (next-line) cancer treatment for recurrent epithelial ovarian cancer, with or without a focused type of radiation. It may help by shrinking or controlling limited spots of cancer that have come back after prior standard treatment.
SeoulAges 19 years+ - NCT07124078RecruitingPhase 2
Study of axatilimab for young people with chronic graft-versus-host disease
This study tests a new drug called axatilimab for children and teens with chronic graft-versus-host disease (cGVHD) that hasn't improved with standard treatments. The goal is to see if axatilimab works better than the usual care options. Participants will be randomly assigned to receive either axatilimab or one of several standard treatments.
Duarte, CaliforniaAges 2–17 - NCT07019259Recruiting
Light therapy for nerve pain in childhood cancer survivors
This study tests whether shining light on the feet and legs can help reduce nerve damage caused by chemotherapy in people who had cancer as children. If you have ongoing numbness, tingling, or pain in your hands or feet from past chemo, this trial may offer a gentle, drug-free treatment.
New Haven, ConnecticutAges 5 years+ - NCT06956248Recruiting
Access to new treatments for advanced solid tumors
This trial offers access to experimental or non-standard cancer treatments for people with advanced solid tumors who have run out of standard options. The goal is to find new ways to treat cancers that are hard to manage.
SingaporeAges 21–99 - NCT06249438RecruitingPhase 1
CAR-T cell therapy for hard-to-treat autoimmune diseases
This trial tests a new CAR-T cell therapy (C-CAR168) for people with several autoimmune diseases that have not responded to standard treatments. It aims to see if this therapy can control the disease when other medicines have failed.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT07407920RecruitingPhase 2
Optimizing treatment for early HER2+ and triple-negative breast cancer
This trial aims to see if patients who had a complete response to chemo before surgery can safely stop or reduce their targeted therapy afterward. It includes people with early-stage HER2-positive or triple-negative breast cancer who had no cancer cells left in the tissue removed at surgery (a pathological complete response).
Houston, TexasAges 18 years+ - NCT05334459Recruiting
Radiation and medicines after surgery for new metastatic breast cancer
This trial looks at giving radiation and anti-cancer medicines after surgery to treat newly diagnosed (de novo) metastatic breast cancer. It may help patients by improving local control of the breast area while also treating cancer throughout the body.
AnkaraAges 18–80 - NCT04293796Recruiting
Skipping breast surgery after complete response
This trial looks at whether some people with breast cancer can safely avoid breast surgery after they respond completely to treatment before surgery. If you have no remaining cancer in the tissue and lymph node tests, this study checks whether the “watch-and-wait” approach is feasible and safe.
Saint PetersburgAges 18–70 - NCT05861505RecruitingPhase 3
Treatment for new liver spread from colon cancer recurrence
This Phase 3 trial studies a treatment approach for people whose colorectal cancer has come back in the liver within 12 months and can be treated with local procedures. It aims to see whether the study treatment can improve outcomes compared with standard care for people with a limited number of liver tumors.
AmsterdamAges 18 years+ - NCT03621137Recruiting
Registry for people with moderate-to-severe eczema
This registry collects information about people with atopic eczema who begin light therapy (phototherapy) or medicine that changes the immune system. It may help doctors better understand how these treatments work in everyday care in the Netherlands.
Amsterdam, North HollandAges Any age - NCT07870577Recruiting
Nerve health during bladder cancer treatment
This study looks at nerve problems (peripheral neuropathy) in people with muscle-invasive bladder cancer who receive a combination of two drugs, enfortumab vedotin and pembrolizumab, before or after surgery. The goal is to understand how these treatments affect nerves and to help manage side effects.
Munich, BavariaAges 18 years+ - NCT07829848Recruiting
Skip extra radiation for breast cancer patients who respond well to treatment
This trial tests whether women and men with advanced, non-metastatic breast cancer can safely skip an extra radiation boost to the lymph nodes if their tumors respond well to pre-surgery chemotherapy or targeted therapy. The goal is to reduce side effects while keeping cancer control.
Shanghai, Shanghai MunicipalityAges 18–75
Common questions
- Are there clinical trials studying Systemic therapy?
- Yes. Clin2 currently lists 397 recruiting studies that include Systemic therapy, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Systemic therapy trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Systemic therapy an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Systemic therapy or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.