Treatment
Testosterone clinical trials
We’re tracking 51 recruiting studies that include Testosterone, each written for real people, not researchers, below.
Recruiting studies
- NCT07476001RecruitingPhase 2
High-dose testosterone and PSMA-targeted radiation for prostate cancer
This trial tests whether a short course of high-dose testosterone followed by a radioactive drug (PSMA-617) can help men with advanced prostate cancer that has stopped responding to hormone therapy. The goal is to make cancer cells more sensitive to the radiation.
Tampa, FloridaAges 18 years+ - NCT07076771Recruiting
Testosterone and artery blockage in young men with heart disease
This study looks at whether testosterone levels are linked to how blocked the heart arteries are in young men (under 45) with early heart disease. It involves a one-time blood test during a planned cardiac catheterization.
SohagAges Up to 45 years - NCT07227740Recruiting
Testosterone treatment for blood vessel health after spinal cord injury
This study looks at whether low testosterone affects blood vessel health in men with recent spinal cord injury. It tests if testosterone replacement can help improve blood vessel function.
Englewood, ColoradoAges 18–89 - NCT07142551RecruitingPhase 2
Testosterone priming with darolutamide for metastatic prostate cancer
This trial tests whether giving a high dose of testosterone before standard hormone therapy can help the treatment work longer for men with prostate cancer that has spread. You would receive testosterone injections for a short time, then a hormone blocker (darolutamide) along with continued testosterone shots.
Baltimore, MarylandAges 18 years+ - NCT06720597Recruiting
Testing a device for blood vessel health in erectile dysfunction
This study tests a device called EndoPAT to check how well the blood vessels in your penis are working. It may help doctors better understand erectile dysfunction or low testosterone.
Newport Beach, CaliforniaAges 18 years+ - NCT06594926RecruitingPhase 2
Bipolar androgen therapy for prostate cancer without metastases
This trial tests a treatment called bipolar androgen therapy for men with prostate cancer that has not spread to other parts of the body and is still growing despite taking darolutamide. The goal is to see if this therapy can help control the cancer.
Garran, Australian Capital TerritoryAges 18 years+ - NCT06922318RecruitingPhase 2
Combined suppression of MYC for advanced prostate cancer
This trial tests a new combination of drugs (ZEN-3694 and enzalutamide) for men with advanced prostate cancer that has stopped responding to standard hormonal treatments. It aims to see if this combination can help slow or stop the cancer from growing.
Baltimore, MarylandAges 18 years+ - NCT06096870RecruitingPhase 2
Enzalutamide with a new drug for prostate cancer that is active on PET scan
This trial tests a combination of enzalutamide (a hormone blocker) and an investigational antibody-drug (PDS01ADC) in men whose prostate cancer has come back after initial treatment, but has not yet spread extensively. It does not involve standard hormone therapy that lowers testosterone.
Bethesda, MarylandAges 18–120 - NCT06084338RecruitingPhase 2
Focused Radiation Therapy Without Hormone Therapy for Advanced Prostate Cancer
This trial tests whether giving focused radiation to many cancer spots (SBRT) can work without using testosterone-blocking hormone therapy. It is for men whose prostate cancer has spread and is no longer responding to low testosterone, and who have already tried one of the newer hormone drugs.
West Los Angeles, CaliforniaAges 18 years+ - NCT06100705RecruitingPhase 2
Immunotherapy plus testosterone for advanced prostate cancer
This study combines an immunotherapy drug called sipuleucel-T (which boosts your immune system to fight cancer) with a high-dose testosterone treatment called bipolar androgen therapy. The goal is to see if this combination can help men with advanced prostate cancer that is not responding to usual hormone therapy.
New Haven, ConnecticutAges 18 years+ - NCT06075953RecruitingPhase 2
Testing Active Surveillance for Hormone-Positive DCIS After Surgery
This trial tests whether active surveillance (close monitoring) is a good option for certain patients with hormone-positive DCIS who have positive surgical margins after initial surgery. You would receive no immediate additional treatment—just regular imaging and check-ups.
Berkeley, CaliforniaAges 18 years+ - NCT06072677Recruiting
Mood and testosterone in young teens
This study looks at how mood changes during puberty in young people aged 11 to 14. It tests whether using a mindfulness app (Healthy Minds) can help teens who have been through stress or feel down.
Chapel Hill, North CarolinaAges 11–14 - NCT06039371RecruitingPhase 2
High dose testosterone during chemo for advanced prostate cancer
This trial tests if adding high doses of testosterone to standard chemotherapy (etoposide and carboplatin) can make the chemo work better in men whose prostate cancer has stopped responding to other treatments. It aims to see if this approach can shrink tumors or slow cancer growth.
Seattle, WashingtonAges 18 years+ - NCT05825092RecruitingPhase 2
Early testosterone gel for people on breathing machines
This Phase 2 study tests whether starting testosterone gel soon after ICU admission can improve physical performance in critically ill adults who need a breathing machine for more than 48 hours. It’s also designed to check safety in this setting.
BordeauxAges 18–79 - NCT05649605Recruiting
Testing early response to gender-affirming hormone treatment
This study looks at how people respond early after starting gender-confirming hormones. It may help doctors understand what changes happen soon after treatment starts and how to manage it safely.
StockholmAges 18–99 - NCT05586802RecruitingPhase 3
Balancing sex hormones to improve metabolism and fertility in Klinefelter
This study tests whether adjusting sex-hormone levels can improve body metabolism and reproductive hormone balance in people with Klinefelter syndrome. Depending on the design, you may be looking at fertility preservation and/or metabolic health.
LausanneAges 16–65 - NCT05249634RecruitingPhase 2
Testosterone treatment study for men with chronic kidney disease
This Phase 2 study tests whether testosterone therapy can help men with chronic kidney disease who have low testosterone and related symptoms. It looks to see if treatment is safe and beneficial, while carefully checking heart, blood, prostate, and clotting risks.
St Louis, MissouriAges 18–85 - NCT05030220Recruiting
Testing testosterone and a skin bacteria during shoulder surgery
This study looks at how testosterone levels and a common skin bacteria (Cutibacterium) may relate to outcomes around elective shoulder replacement surgery. Results could help improve how doctors prevent and understand infection risk or healing after surgery.
Seattle, WashingtonAges 18–89 - NCT04760574Recruiting
HIV status and low testosterone in men
This study looks at whether low testosterone (often called male hypogonadism) is linked to having HIV. It compares HIV-positive men with HIV-negative men to better understand what contributes to hormone problems and how common they are.
TaipeiAges 20 years+ - NCT04254354Recruiting
Body identity clinic for transgender men on testosterone
This trial is for transgender men who want care focused on body identity. It likely studies how testosterone treatment and clinic support affect body-related feelings and wellbeing.
OdenseAges 18 years+ - NCT03678025RecruitingPhase 3
Standard treatment for metastatic prostate cancer, with or without local treatment
This Phase 3 trial studies whether using the usual medicines for metastatic prostate cancer, plus a definitive local treatment to the prostate, improves outcomes. It may help determine if treating the prostate directly can benefit people whose cancer has not worsened after initial hormone-based treatment.
Gilbert, ArizonaAges 18 years+ - NCT07143279RecruitingEarly Phase 1
Testosterone for quality of life in men with advanced cancer
This trial tests if testosterone supplements can improve quality of life for men with low testosterone who are no longer receiving active cancer treatment. It aims to help with symptoms like fatigue and low mood.
BrusselsAges 18 years+ - NCT07092527RecruitingPhase 4
Testosterone's effects on hormones in transgender and cisgender people
This study looks at how testosterone affects the brain and reproductive hormones in people who are starting testosterone therapy and those who are not. It aims to understand the body's natural hormone cycles.
San Diego, CaliforniaAges 18–35 - NCT07546435Recruiting
Male experiences with fertility treatment for low sperm quality
This study explores men's experiences undergoing ICSI, a fertility treatment that helps when sperm quality is reduced. Researchers want to understand how the treatment affects you physically and emotionally.
Skive, Midt JyllandAges 18 years+
Common questions
- Are there clinical trials studying Testosterone?
- Yes. Clin2 currently lists 51 recruiting studies that include Testosterone, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Testosterone trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Testosterone an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Testosterone or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.