Treatment clinical trials

Sequential hormone and IBI311 therapy for active TAO

This trial tests a two-step treatment for active, moderate-to-severe thyroid eye disease (TAO). You will first receive hormone therapy, followed by a drug called IBI311. The goal is to see if this sequence works better for people who have not had steroid treatment before.

Analysis of Selected Biochemical Parameters in Cerebrospinal Fluid and Peripheral Blood in the Treatment of Neuropathic Pain Using Spinal Cord Stimulation (SCS)

Laser vs estrogen cream for vaginal dryness in Sjögren's

This trial compares two treatments for vaginal dryness in women with Sjögren's disease: a CO2 laser procedure versus a topical estrogen cream called promestriene. The goal is to see which option works better to relieve dryness and discomfort.

Brain stimulation for swallowing problems in Parkinson's

This study is testing whether a gentle brain-stimulation technique called tDCS can help people with Parkinson's disease who have trouble swallowing. If you have Parkinson's, multiple system atrophy, or progressive supranuclear palsy and a swallowing problem, this trial may be an option.

Lecanemab treatment for early Alzheimer's disease

This study tests how lecanemab works in people with early Alzheimer’s, including those with mild dementia or mild memory problems. It aims to see if the drug can help clear brain plaques and slow down symptoms.

Vebreltinib for advanced clear cell sarcoma

This trial tests the drug vebreltinib for people with advanced or spreading clear cell sarcoma. The goal is to see if it can shrink tumors and help patients live longer.

Immunoadsorption for CIDP treatment study

This trial tests whether a blood-filtering treatment called immunoadsorption can help people with CIDP. It is for adults who are already receiving or starting IVIg or MP therapy.

Evaluating Crosslinked Hyaluronate Canalicular Gel for the Treatment of DED in Patients Undergoing Cataract Surgery

Comparing two types of glue for braces in teens and adults

This early-phase trial tests if a newer, faster-setting glue (bulk-fill composite) works as well as the standard glue for attaching braces. It's for people aged 13 to 40 who are starting or continuing fixed braces treatment.

Testing YntraDose before chemotherapy for advanced pancreas cancer

This trial tests a new treatment called YntraDose, given directly into the pancreas tumor before standard chemotherapy. It is for people with locally advanced pancreatic cancer that cannot be removed by surgery.

Study of SYN818 with olaparib for advanced solid tumors

This trial is testing a new drug, SYN818, combined with olaparib for people with advanced solid tumors that have certain genetic changes (BRCA mutations or related DNA repair problems). It may be an option if you have ovarian or HER2-negative breast cancer and other treatments are no longer working.

Sleep's effects on everyday health and wellbeing

This study tests how improving sleep can help your daily health and mood. If you have insomnia, you may be eligible for a program that focuses on restful sleep and its benefits.

Testing XER-001 with radiation for advanced pancreatic cancer

This trial tests a new way to deliver a drug called amifostine (XER-001) alongside intense radiation therapy (SBRT) for people with locally advanced pancreatic cancer that can't be surgically removed. The goal is to see if it's safe and effective at protecting healthy tissue while targeting the tumor.

Zadek osteotomy for Haglund's syndrome

This trial tests a surgery called Zadek osteotomy for people with Haglund's syndrome (a painful heel condition). It may help those who haven't gotten better after at least six months of non-surgical treatments.

Blood vessel complications after leg artery procedures with SGLT2 inhibitors

This study looks at how a type of medicine called SGLT2 inhibitors (used for diabetes, kidney disease, or heart issues) affects blood vessel complications in people who have had a leg procedure to improve blood flow. It compares patients taking the medicine to those who are not.

Plant-based healing dressing for deep skin wounds

This trial tests a new 'living' dressing made from plant cells that might help deep skin wounds heal faster and better. It could be an option if you have a relatively large, clean wound that needs new skin growth.

Nutrition and exercise support during head and neck cancer treatment

This study tests whether a personalized nutrition and exercise program can help people with head and neck cancer stay stronger during treatment. If you are getting chemotherapy and radiation, the program may help reduce side effects and improve your recovery.

Vaginal estrogen's effect on blood clotting in postmenopausal women

This trial tests if low-dose vaginal estrogen tablets affect blood clotting in postmenopausal women with vaginal atrophy. It includes women both with and without a past blood clot to see if the treatment is safe.

Pain management app for teen cancer survivors

This trial tests a culturally adapted mobile app to help teen cancer survivors manage chronic pain and improve daily functioning. It compares the app to standard care to see if it reduces pain interference.

Sleep apnea and severe asthma study

This study looks at whether people with difficult-to-treat asthma might also have obstructive sleep apnea. If you're on high-dose asthma treatments, this trial could help find out if sleep problems are making your asthma worse.

When to start rehab after UBE spine surgery

This study looks at whether starting rehabilitation exercises earlier or later after a specific type of minimally invasive back surgery (UBE) for a slipped disc improves your recovery. It's for people who have had leg pain for less than a year and are scheduled for this surgery.

OCM treatment for diabetic foot ulcers

This trial tests a special wound dressing called OCM to help heal diabetic foot ulcers. It may be an option if your ulcer hasn't healed much in the last two weeks and you have good blood flow to your foot.

Study of COYA 302 for treating ALS

This trial tests a new drug called COYA 302 to see if it can slow down ALS. People in the study must have a recent diagnosis, a certain level of physical function, and be between 18 and 80 years old.

Ganglion resection for wrist pain

This trial tests if removing a wrist ganglion (a benign fluid-filled lump) helps reduce pain better than other treatments. It is for adults with wrist pain from a confirmed ganglion cyst who have not had wrist surgery before.