Clinical trials
Acute Brain Injury clinical trials
Below are recruiting acute brain injury clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05049057RecruitingPhase 2
Testing a nerve-blocking shot for recent mild TBI
This Phase 2 study tests a medication that blocks a pain signal (a CGRP receptor antibody) in people who recently had a mild traumatic brain injury (mTBI) and are also dealing with post-traumatic headache (PTH). The goal is to see if it can reduce symptoms and improve recovery after the injury.
Fort Bragg, North CarolinaAges 18–50 - NCT04602325Recruiting
Blood and brain injury biomarker study for inherited metabolic disorders
This trial studies blood and other measurable signs (biomarkers) that may reflect brain injury after certain inherited metabolic conditions. Results may help doctors better detect and understand brain effects from these illnesses, especially episodes that affect the brain.
Washington D.C., District of ColumbiaAges 7–18 - NCT07852728RecruitingPhase 2
Oxygen therapy for first responders after head injuries
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve thinking, mood, and overall well-being in first responders who have had a traumatic brain injury and still have symptoms. If you are a first responder dealing with ongoing brain injury symptoms, this study could help you find new ways to feel better.
Boise, IdahoAges 18–75 - NCT07849465RecruitingPhase 2
Oxygen therapy for veterans with brain injury and lasting symptoms
This study tests whether breathing high-pressure oxygen (hyperbaric oxygen therapy) can help veterans who have had a traumatic brain injury (TBI) and are dealing with ongoing issues like memory or concentration problems. It also looks at whether this treatment affects certain markers in the blood that may relate to brain health.
Boise, IdahoAges 18–75 - NCT07732374RecruitingPhase 2
Long-term results after hyperbaric oxygen therapy in veterans
This study follows veterans who previously finished a 40-session hyperbaric oxygen therapy (HBOT) program. It tracks how their memory, mood, and daily function are doing 12 weeks later, to understand long-term benefits.
Boise, IdahoAges 18 years+ - NCT06454591Recruiting
Using fast MRI to understand brain injury recovery
This study uses a quick MRI scan to check brain function and predict recovery after a traumatic brain injury. It may help researchers develop better ways to assess and treat TBI patients.
Calgary, AlbertaAges 18 years+ - NCT07694258Recruiting
Testing a helmet for brain stimulation in consciousness disorders
This study tests a special helmet that uses ultrasound to stimulate the brain in people with disorders of consciousness caused by brain injury. It aims to see if the treatment is safe and possible to do.
Toronto, OntarioAges Any age - NCT07614074Recruiting
Understanding Recovery from Coma and Unconsciousness
This study follows patients who have been in a coma (deep unconsciousness) for at least 24 hours due to a brain injury. Researchers will track how patients recover over time to better understand which factors help predict who will wake up and how well they'll recover.
San Francisco, CaliforniaAges 18 years+ - NCT05589064Recruiting
Diet and nutrition program for lingering concussion symptoms
This study tests whether a dietary and nutrition intervention can improve symptoms that linger after a concussion. It may help people whose post-concussion symptoms have lasted a short to medium time (at least 2 weeks).
Moncton, New BrunswickAges 16 years+ - NCT07493096Recruiting
Intensive therapy program for children with brain-based conditions
This trial tests an intensive therapy program designed to help children with brain-based conditions like cerebral palsy or autism improve their skills in movement, thinking, and daily activities. The program runs for 2 weeks with daily sessions, and researchers will check for changes in your child's abilities.
The Woodlands, TexasAges 4–12 - NCT07456020Recruiting
Measuring awareness after brain injury in the ICU
This study checks how awake and aware you are using two standard checklists (CRS-R and SECONDs). It's for people with recent brain injuries in intensive care who are still very dependent.
Hessisch Oldendorf, Lower SaxonyAges 18 years+ - NCT06241482Recruiting
Enhanced recovery after brain surgery in intensive care
This study tests a special recovery program for people with serious brain injuries or strokes who need intensive care. The program focuses on helping you heal faster after surgery.
ShanghaiAges 18–75 - NCT07311486Recruiting
Blood test for better care after mild head injury
This study uses a blood test to help doctors better understand and manage mild traumatic brain injury (concussion). If you had a mild head injury in the past 12 hours and have certain symptoms, researchers want to check if a new blood-based approach can improve care.
Madrid, MadridAges 18 years+ - NCT06589362Recruiting
Nerve stimulation plus cognitive training for brain injury recovery
This study tests if a gentle, noninvasive nerve stimulation (on the neck) combined with computerized thinking exercises can help people recovering from a traumatic brain injury improve memory and attention. It is for adults currently in inpatient rehab who can use a keyboard and are medically stable.
Chicago, IllinoisAges 18–65 - NCT07214415RecruitingPhase 2
Hyperbaric oxygen therapy for veterans with brain injury or mental health issues
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve thinking, mood, and quality of life in veterans with mild traumatic brain injury, PTSD, anxiety, or depression. You must have already tried at least one evidence-based therapy like CBT or EMDR.
Boise, IdahoAges 18–75 - NCT05533060Recruiting
Collecting brain injury data from people treated soon
This study collects medical and test information from people who have a confirmed brain injury (TBI) and arrive at the emergency room within 12 hours. Doctors hope the collected clinical and lab data will help better understand TBI and improve future care.
ShanghaiAges Any age - NCT07127224Recruiting
Predicting recovery with smell tests in coma
This study tests whether a simple smell test can help predict recovery of consciousness in patients who remain in a coma or minimally conscious state after a severe brain injury. If you or your loved one has been unresponsive for several days after sedation is stopped, this trial may provide useful information about prognosis.
Paris, GHU Psychiatrie Et NeurosciencesAges 18 years+ - NCT06562127Recruiting
Water exercise and cognitive training for veterans with TBI
This trial tests if combining water-based exercise with cognitive training over eight months can help improve thinking and memory in veterans with a past mild or moderate brain injury. It may benefit veterans aged 50-89 who have ongoing cognitive complaints.
Palo Alto, CaliforniaAges 50–89 - NCT07044596Recruiting
Non-invasive brain stimulation to slow cognitive decline
This study tests whether a gentle, non-invasive electrical stimulation can help slow memory loss or thinking problems. It is looking for healthy volunteers and people who have had a mild traumatic brain injury within the past year.
Madison, WisconsinAges 20–85 - NCT06979700Recruiting
Early wake-up predictors after cardiac arrest
This study looks at patients who had a cardiac arrest outside the hospital and are still unconscious after their heartbeat returns. The goal is to find early signs that predict when someone will wake up.
Aarhus NAges 18 years+ - NCT06940258Recruiting
IVC ultrasound to guide fluids in head injury
This study uses ultrasound, a non-invasive imaging test, to measure the large vein that returns blood to the heart. This helps doctors decide how much fluid to give patients with a head injury to improve recovery.
Al MansurahAges 18–60 - NCT06893029Recruiting
Dizziness from visual motion in concussion and other causes
This study looks at how people with dizziness from concussion or other causes (like vestibular migraine) react to visual motion. It tests balance during specific visual challenges to understand why dizziness happens.
Zurich, Canton of ZurichAges 18–60 - NCT06860828Enrolling by invitation
Football players and brain health study: DIAGNOSE CTE
This study looks at brain changes in former college and professional football players, people with memory problems, and healthy controls. It aims to learn more about chronic traumatic encephalopathy (CTE) and Alzheimer's disease.
Phoenix, ArizonaAges 50 years+ - NCT06525584Recruiting
Ketamine to protect the brain during heart surgery in children
This study tests whether giving ketamine during heart surgery helps protect the brain in young children. It is for children aged 1 month to 5 years who are having surgery to fix a hole in the wall between the heart chambers (atrial or ventricular septal defect).
Kemerovo, Please SelectAges 1 month–5 years
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Common questions
- Are there clinical trials for acute brain injury?
- Yes. Clin2 currently lists 148 recruiting acute brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.