Clinical trials
Acute Brain Injury clinical trials
Below are recruiting acute brain injury clinical trials, each written for real people, not researchers. We’re tracking 146 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07127224Recruiting
Predicting recovery with smell tests in coma
This study tests whether a simple smell test can help predict recovery of consciousness in patients who remain in a coma or minimally conscious state after a severe brain injury. If you or your loved one has been unresponsive for several days after sedation is stopped, this trial may provide useful information about prognosis.
Paris, GHU Psychiatrie Et NeurosciencesAges 18 years+ - NCT06583252Recruiting
Monitoring care for severe traumatic brain injury
This study tests a special monitoring approach for people with severe traumatic brain injury who are not opening their eyes or following commands. The goal is to see if close watching and coordinated care can improve recovery.
Changsha, HunanAges 18 years+ - NCT07732374RecruitingPhase 2
Long-term results after hyperbaric oxygen therapy in veterans
This study follows veterans who previously finished a 40-session hyperbaric oxygen therapy (HBOT) program. It tracks how their memory, mood, and daily function are doing 12 weeks later, to understand long-term benefits.
Boise, IdahoAges 18 years+ - NCT06465290Recruiting
Brain recovery treatment for recent stroke with ankle stiffness
This trial tests a treatment to help your brain recover after a stroke. It focuses on improving ankle movement and leg strength using exercises that promote brain rewiring.
Baltimore, MarylandAges 30–85 - NCT04459806Recruiting
Study dose timing to improve care for brain injury
This trial studies how to time medication or treatment doses when a person has serious brain injury, using measurements from a pressure monitor in the skull. It may help doctors manage brain swelling and pressure more effectively.
Monza, MBAges 18–80 - NCT04602325Recruiting
Blood and brain injury biomarker study for inherited metabolic disorders
This trial studies blood and other measurable signs (biomarkers) that may reflect brain injury after certain inherited metabolic conditions. Results may help doctors better detect and understand brain effects from these illnesses, especially episodes that affect the brain.
Washington D.C., District of ColumbiaAges 7–18 - NCT05337618RecruitingPhase 2
Testing a medication approach to improve brain recovery after severe head injury
This Phase 2 trial is testing a combination medication strategy to improve outcomes after severe traumatic brain injury that needs emergency brain surgery soon after the injury. It may help by affecting how injured brain cells respond, aiming to improve survival or recovery.
Cincinnati, OhioAges 18–80 - NCT05533060Recruiting
Collecting brain injury data from people treated soon
This study collects medical and test information from people who have a confirmed brain injury (TBI) and arrive at the emergency room within 12 hours. Doctors hope the collected clinical and lab data will help better understand TBI and improve future care.
ShanghaiAges Any age - NCT05589064Recruiting
Diet and nutrition program for lingering concussion symptoms
This study tests whether a dietary and nutrition intervention can improve symptoms that linger after a concussion. It may help people whose post-concussion symptoms have lasted a short to medium time (at least 2 weeks).
Moncton, New BrunswickAges 16 years+ - NCT05683145Recruiting
Better sleep for people with moderate or severe TBI
This trial studies an approach to improve insomnia (trouble falling or staying asleep) in people who had a moderate-to-severe traumatic brain injury at least one year ago. If you qualify, it may help you restore more regular, efficient sleep after TBI.
Aurora, ColoradoAges 18–60 - NCT05782244RecruitingPhase 2
Sildenafil trial for long-term brain blood-flow problems after TBI
This Phase 2 study tests whether sildenafil (a medication better known for erectile function) can improve long-term symptoms and brain blood-flow issues after a past traumatic brain injury (TBI). It may help by improving blood vessel function in the brain and possibly reducing persistent post-concussion symptoms.
Philadelphia, PennsylvaniaAges 18–70 - NCT06065046RecruitingPhase 2
Baricitinib for traumatic brain bleeding
This trial tests if baricitinib, an anti-inflammatory drug, can help people with bleeding in the brain from a head injury. It is for adults with moderate to severe traumatic brain injury who are not immediately having surgery.
Xi'an, ShaanxiAges 18–80 - NCT06098833RecruitingPhase 2
Sildenafil for newborn brain injury after birth asphyxia
This trial tests whether a liquid form of the medicine sildenafil can help repair brain damage in newborns who had a difficult birth and were treated with cooling. If your baby meets the cooling criteria and has brain injury on an MRI, this study may offer an additional treatment option.
Montreal, QuebecAges birth–2 days - NCT06148324Recruiting
Wellness program for traumatic brain injury recovery
This study tests a wellness program for people who had a moderate or severe traumatic brain injury (TBI) at least a year ago. The program is done online, so you can join from home, and it aims to help you with your recovery and well-being.
New York, New YorkAges 18–70 - NCT06241482Recruiting
Enhanced recovery after brain surgery in intensive care
This study tests a special recovery program for people with serious brain injuries or strokes who need intensive care. The program focuses on helping you heal faster after surgery.
ShanghaiAges 18–75 - NCT06381674Recruiting
Wearable tech for balance rehab after concussion
This study tests whether a wearable device can help people with balance and vision problems after a mild concussion. You will use the device to guide your own exercises and help improve your recovery.
Portland, OregonAges 18–60 - NCT06454591Recruiting
Using fast MRI to understand brain injury recovery
This study uses a quick MRI scan to check brain function and predict recovery after a traumatic brain injury. It may help researchers develop better ways to assess and treat TBI patients.
Calgary, AlbertaAges 18 years+ - NCT07694258Recruiting
Testing a helmet for brain stimulation in consciousness disorders
This study tests a special helmet that uses ultrasound to stimulate the brain in people with disorders of consciousness caused by brain injury. It aims to see if the treatment is safe and possible to do.
Toronto, OntarioAges Any age - NCT03446456RecruitingPhase 1/Phase 2
Vasopressin and pain perception study
This trial tests whether vasopressin, a nasal spray, changes how your brain processes pain. You will receive either the spray or a placebo and have an MRI scan to see brain activity.
Baltimore, MarylandAges 18–65 - NCT06525584Recruiting
Ketamine to protect the brain during heart surgery in children
This study tests whether giving ketamine during heart surgery helps protect the brain in young children. It is for children aged 1 month to 5 years who are having surgery to fix a hole in the wall between the heart chambers (atrial or ventricular septal defect).
Kemerovo, Please SelectAges 1 month–5 years - NCT06562127Recruiting
Water exercise and cognitive training for veterans with TBI
This trial tests if combining water-based exercise with cognitive training over eight months can help improve thinking and memory in veterans with a past mild or moderate brain injury. It may benefit veterans aged 50-89 who have ongoing cognitive complaints.
Palo Alto, CaliforniaAges 50–89 - NCT06589362Recruiting
Nerve stimulation plus cognitive training for brain injury recovery
This study tests if a gentle, noninvasive nerve stimulation (on the neck) combined with computerized thinking exercises can help people recovering from a traumatic brain injury improve memory and attention. It is for adults currently in inpatient rehab who can use a keyboard and are medically stable.
Chicago, IllinoisAges 18–65 - NCT05277519Recruiting
Rehab retraining for walking after stroke or brain injury
This study tests a rehab program aimed at improving how the brain learns movement, to help people walk more independently after a stroke or traumatic brain injury. It may help by targeting walking and movement control of the affected leg.
ParisAges 18–70 - NCT06893029Recruiting
Dizziness from visual motion in concussion and other causes
This study looks at how people with dizziness from concussion or other causes (like vestibular migraine) react to visual motion. It tests balance during specific visual challenges to understand why dizziness happens.
Zurich, Canton of ZurichAges 18–60
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Common questions
- Are there clinical trials for acute brain injury?
- Yes. Clin2 currently lists 146 recruiting acute brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.