Clinical trials
Advanced clinical trials
Below are recruiting advanced clinical trials, each written for real people, not researchers. We’re tracking 3,988 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06368141RecruitingPhase 2
Chemo plus immunotherapy before surgery for colon cancer
This trial tests whether giving chemotherapy followed by an immunotherapy drug (a checkpoint inhibitor) before surgery helps shrink locally advanced colon cancer. It is for people with a specific tumor type (MSS and RAS mutation) who have not had prior treatment.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06372626RecruitingPhase 1/Phase 2
ZG005 with chemo for advanced neuroendocrine cancer
This trial tests a new drug (ZG005) combined with two standard chemotherapy drugs (etoposide and cisplatin) for people with advanced neuroendocrine carcinoma that has spread or come back. The goal is to see if the combination works better than the standard treatment alone.
Beijing, Beijing MunicipalityAges 18–70 - NCT06374173RecruitingPhase 1
Study of TGI-6 for advanced solid tumors
This study tests a new drug called TGI-6 in people with advanced solid tumors, including colorectal cancer and other cancers that have a specific marker (B7-H6). The goal is to see if it is safe and effective for those who have run out of standard treatment options.
BeijingAges 18 years+ - NCT06373861Recruiting
GALAXY study: Long-term look at sex chromosome conditions
This study is following people with sex chromosome differences over time to learn more about their health and development. It is open to anyone at any age who has a confirmed genetic diagnosis.
Aurora, ColoradoAges birth–100 years - NCT06375187RecruitingPhase 1
GC203 TIL for advanced solid tumors
This trial tests an experimental TIL therapy (GC203) for people with advanced solid tumors who have no more standard options. Doctors will take a piece of your tumor, make it into a personalized cell treatment, and give it back to try to fight the cancer.
ShanghaiAges 18–75 - NCT06376721RecruitingPhase 1/Phase 2
Linperlisib combo for advanced NK/T-cell lymphoma
This trial tests a combination of three drugs (linperlisib, camrelizumab, and pegaspargase) for people with a rare type of lymphoma called ENKTL. It is for patients whose cancer has not responded to treatment or has come back, or who are newly diagnosed with advanced disease.
Beijing, Beijing MunicipalityAges 18–75 - NCT06377033Recruiting
Using health records to advance genomic medicine for all
This study uses electronic health records to learn how to improve genomic medicine across a diverse health system. It may help make DNA-based healthcare more accessible and effective for people with certain conditions.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06377735Recruiting
BAI-BACE for advanced lung squamous cell carcinoma
This trial is testing a new use of a procedure called BAI-BACE (injecting drugs or blocking blood flow through the bronchial artery) for people with advanced lung squamous cell carcinoma that hasn't responded to prior treatments. The goal is to see if this treatment can help control the cancer when it's still only in the chest.
Beijing, Beijing MunicipalityAges 18–80 - NCT06380101Recruiting
Special diet with standard therapy for rectal cancer
This trial tests a special medical food that limits certain amino acids (building blocks of protein) during standard treatment for rectal cancer. The goal is to see if this diet helps the treatment work better while reducing side effects.
Tampa, FloridaAges 18–100 - NCT06380530Recruiting
Computer-assisted surgical planning for limb deformity correction
This trial tests a new computer-assisted planning method to help surgeons better correct bone deformities in the arms or legs. It may lead to more precise surgeries and faster recovery.
Bologna, BOAges 2–40 - NCT06383559RecruitingPhase 2
Combination therapy for advanced AFP-positive gastric cancer
This trial tests a new combination of chemotherapy (XELOX) plus two immunotherapy/targeted drugs (Sintilimab and Lenvatinib) in people with advanced stomach cancer that produces a high level of a protein called AFP. It aims to see if this combination is safe and can shrink tumors when given as the first treatment.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06383767RecruitingPhase 3
A study of ESG401 for advanced HR+/HER2- breast cancer
This trial tests a new medicine called ESG401 for people with a common type of breast cancer (HR+/HER2-) that has spread and hasn't responded to at least one chemotherapy. The goal is to see if it works better than standard chemotherapy options.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06385288Recruiting
Blood and tissue study in high-risk sarcoma
This study collects blood and tissue samples from people with high-risk soft tissue sarcoma before their surgery. The goal is to learn how the immune system responds to pre-surgery treatments like radiation and hyperthermia (heat therapy).
Tübingen, Baden-WurttembergAges 18 years+ - NCT06385925RecruitingPhase 1/Phase 2
Study of TSN1611 for cancers with KRAS G12D mutation
This trial tests a new drug called TSN1611 for people with advanced solid tumors that have a specific genetic change called KRAS G12D. The goal is to see if the drug can shrink tumors or stop them from growing.
Houston, TexasAges 18–75 - NCT06386146RecruitingPhase 1/Phase 2
New pill for advanced cancers with TP53 Y220C mutation
This trial tests a new pill called JAB-30355 for people with advanced cancers that have a specific genetic change (TP53 Y220C). It's for those who have already tried other treatments and are looking for a new option.
Denver, ColoradoAges 18 years+ - NCT06386341Recruiting
Quality of life after MMA surgery for sleep apnea
This study looks at how maxillomandibular advancement (MMA) surgery affects quality of life in people with obstructive sleep apnea (OSA). It aims to see if the surgery helps improve sleep and daily well-being.
UtrechtAges 18 years+ - NCT06386705RecruitingPhase 1
Testing TSN084 for advanced cancers
This trial tests an experimental drug called TSN084 for people with advanced cancers that have not responded to standard treatments. It aims to see if the drug is safe and how well it works.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06387342RecruitingPhase 2
Namodenoson for advanced pancreatic cancer
This trial tests an oral drug called Namodenoson for people with advanced pancreatic cancer that has not responded to previous treatments. The goal is to see if the drug can help slow the cancer's growth or improve symptoms.
Petah TikvaAges 18 years+ - NCT06388031RecruitingPhase 2
Re-trying immunotherapy for advanced lung cancer after long-term success
This trial tests whether giving immunotherapy again can help people with advanced non-small cell lung cancer whose disease stayed stable for at least 2 years on their first immunotherapy but then started growing. It aims to see if a second course of treatment can work again.
BeijingAges 18–80 - NCT06389097Recruiting
SPECT Scans to Improve Treatment for Advanced Cancer
This study uses special scans (SPECT imaging) to see how radium or lutetium treatments move through your body, helping doctors plan better doses. It's for people with advanced prostate cancer (getting Radium-223) or advanced neuroendocrine tumors (getting 177Lu treatments).
Baltimore, MarylandAges 18–100 - NCT06389201Recruiting
Hydroxychloroquine before radiation and chemo for NPC
This trial tests whether taking hydroxychloroquine (HCQ) before standard radiation and chemo can help treat advanced nasopharyngeal cancer. It is for patients who have not yet started any cancer therapy.
Nantong, JiangsuAges 20–70 - NCT06389799RecruitingPhase 2
Pemigatinib and Retifanlimab for Advanced Liposarcoma
This trial tests two experimental drugs (pemigatinib and retifanlimab) for advanced dedifferentiated liposarcoma that has not responded to other treatments. It aims to see if this combination can shrink tumors or slow cancer growth.
OsloAges 18–100 - NCT06394297Recruiting
Virtual Brachytherapy Planning for Advanced Cervical Cancer
This study tests a new way to plan a type of radiation called brachytherapy for advanced cervical cancer. It uses virtual images to see if this method can treat the tumor just as well while being safer.
LisbonAges 18 years+ - NCT06394674RecruitingPhase 2
High-dose furmonertinib for lung cancer after osimertinib stops working
This trial tests a higher dose of a targeted therapy called furmonertinib for people with advanced lung cancer that has stopped responding to a previous drug called osimertinib. It may help if you have a certain EGFR mutation and your cancer has grown outside the brain.
ShanghaiAges 18–75
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Common questions
- Are there clinical trials for advanced?
- Yes. Clin2 currently lists 3,988 recruiting advanced studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.