Clinical trials
Advanced clinical trials
Below are recruiting advanced clinical trials, each written for real people, not researchers. We’re tracking 3,897 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06801002RecruitingPhase 1
Safety trial of JBZ-001 for advanced cancers
This trial tests a new drug, JBZ-001, to see how safe it is for people with advanced solid tumors or certain types of lymphoma that have not improved with standard treatments. It's a first-in-human study, so participants will help doctors learn about the drug's side effects and the right dose.
Columbus, OhioAges 18 years+ - NCT06801665RecruitingPhase 2
Combination therapy for advanced colorectal cancer with liver spread
This trial tests a new combination of treatments for advanced colorectal cancer that has spread to the liver. It aims to see if this combination can shrink tumors and help patients live longer.
ChangzhouAges 18–75 - NCT06799936Recruiting
Helping older adults with kidney disease make treatment choices
This study tests a program that helps older adults with advanced chronic kidney disease talk with their doctors about treatment options, like dialysis, palliative care, or a kidney transplant. It aims to make sure patients' values and preferences are heard in these important decisions.
Hong KongAges 65 years+ - NCT06801639Recruiting
Brain stimulation at home for mood symptoms in Alzheimer's
This study tests if a gentle brain stimulation technique, called tDCS, can help improve mood symptoms like depression, anxiety, or irritability in people with Alzheimer's or mild cognitive impairment. A caregiver will help with the sessions at home, and all visits are done remotely.
San Antonio, TexasAges 60–85 - NCT04999904Recruiting
Balance training on uneven treadmill for unstable ankles
This study tests a special balance and movement training program on an uneven treadmill to improve ankle stability. It may help people whose ankles “give way” or keep getting sprained, but it requires specific timing after an ankle sprain and the ability to attend sessions for about 6 weeks.
Oceanside, CaliforniaAges 18–49 - NCT06783348RecruitingPhase 2
Radioactive treatment for advanced kidney cancer
This trial tests a radioactive treatment (called radiopharmaceutical) that targets a protein called PSMA on kidney cancer cells. It is for people with advanced clear cell kidney cancer that has already been treated with immunotherapy and targeted therapy.
CaenAges 18–100 - NCT06790693RecruitingPhase 3
Inavolisib plus hormone therapy for advanced breast cancer
This trial tests a new targeted therapy, inavolisib, combined with standard hormone therapy and a CDK4/6 inhibitor for people with a specific genetic mutation (PIK3CA) in their hormone receptor-positive, HER2-negative advanced breast cancer that has not been treated before. It compares this combination to a placebo plus the same standard treatments.
Goodyear, ArizonaAges 18 years+ - NCT06783569RecruitingPhase 1
First-in-human study for advanced solid tumors
This trial tests a new experimental drug for people with advanced solid tumors that have not responded to standard treatments. It aims to find a safe dose and see if the drug can shrink tumors.
Harbin, Heiljiang ProvinceAges 18 years+ - NCT06784752RecruitingPhase 3
Testing a targeted radiation therapy for advanced neuroendocrine tumors
This trial tests a radioactive drug called [177Lu]Lu-DOTA-TATE for people with advanced neuroendocrine tumors (GEP-NET) that have grown or spread. The drug targets tumor cells that have a specific receptor (SSTR) and delivers radiation directly to them, aiming to slow or shrink the tumors while limiting damage to healthy tissue.
Scottsdale, ArizonaAges 12–100 - NCT06787183RecruitingPhase 2
Short-course radiation with chemoimmunotherapy for rectal cancer that has spread to the liver
This trial tests whether combining short-course radiation with a chemotherapy regimen (CAPOX) and an immunotherapy drug (QL1706) can help treat rectal cancer that has spread to the liver. It is designed for patients who have not had any prior cancer treatment.
Fuzhou, FujianAges 18–75 - NCT03772561RecruitingPhase 1
Testing AZD5363, olaparib, and durvalumab for advanced solid cancers
This Phase 1 trial tests a combination of three medicines to shrink or control advanced solid tumors that are progressing or no standard options exist. It mainly focuses on safety and early signs of how well the treatment works.
Singapore, SingaporeAges 21–99 - NCT05909618RecruitingPhase 2
Crizanlizumab with nivolumab for brain-spread melanoma or glioblastoma
This Phase 2 study tests crizanlizumab alone or with nivolumab to treat people with certain brain tumors that have spread to the brain (melanoma) or glioblastoma. The goal is to see whether this approach can control the disease and improve outcomes.
Ramat Gan, IsraelAges 18 years+ - NCT06105515Recruiting
Keyhole and scope combo rescue for advanced stomach cancer
This trial tests a combined laparoscopy and endoscopy procedure as a rescue treatment for advanced stomach cancer. It is for patients who have a tumor that hasn't spread to other parts but cannot have standard stomach removal surgery.
StockholmAges 18 years+ - NCT06782997Recruiting
Using a quick eye test to check for diabetes eye damage
This trial tests if a special eye exam (electroretinogram) done by a nurse can find early signs of diabetic retinopathy in people with diabetes who have no known eye problems yet. It aims to make screening easier and more accessible.
ReimsAges 18 years+ - NCT06787313Recruiting
Precision palliative care for advanced esophageal cancer
This trial studies a personalized approach to palliative care for people with advanced or recurrent esophageal cancer who are being treated with immunotherapy. It aims to improve quality of life and symptom management.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06791512RecruitingPhase 3
Chemo Plus Targeted Therapy With or Without Immunotherapy for Colorectal Cancer
This trial compares a standard chemotherapy combination (mFOLFOX6) plus a targeted drug (bevacizumab) with or without an immunotherapy (PD-1 antibody) for locally advanced colorectal cancer. It aims to see if adding the immunotherapy improves outcomes for patients with a specific tumor type (pMMR/MSS).
Guangzhou, GuangdongAges 18–80 - NCT06788379Recruiting
Testing a new marker for egg damage in women having IVF
This trial studies a protein called CENP-V to see if it can help measure egg (oocyte) health. It includes women at different ages and those using frozen eggs, to find better ways to predict egg quality.
Seville, SEVILLAAges 18–45 - NCT05571644RecruitingPhase 2
Study compares two pre-surgery treatments for locally advanced rectal cancer
This Phase 2 trial tests whether a newer combination chemotherapy plus an immunotherapy medicine (cadonilimab/AK104) works better than standard chemotherapy before surgery for locally advanced colorectal cancer. The goal is to shrink the tumor and improve how well treatment works after surgery.
Guangzhou, GuangdongAges 18–70 - NCT06062823RecruitingPhase 2
Newer EGFR pill for advanced lung cancer with specific mutations
This trial tests a newer type of EGFR targeted therapy pill for people with advanced non-small cell lung cancer who have not had prior treatment and whose cancer has a specific genetic change called a PACC mutation. The goal is to see if the drug works well for this group.
SingaporeAges 21–99 - NCT06277154RecruitingPhase 2
MASCT-I plus chemo for first-line advanced soft tissue sarcoma
This trial tests a new immune cell therapy (MASCT-I) combined with standard chemotherapy (doxorubicin and ifosfamide) for people with advanced soft tissue sarcoma who have not had prior chemotherapy or targeted therapy. The goal is to see if the combination works better than chemo alone.
GuangzhouAges 18–70 - NCT06778863RecruitingPhase 1
A study of CLSP-1025 for adults with certain solid tumors
This trial tests a new drug called CLSP-1025 for people with advanced solid tumors that have a specific change in the p53 gene (R175H). The drug targets this change to help fight the cancer.
Scottsdale, ArizonaAges 18 years+ - NCT06774430Recruiting
Digital outreach for young people at risk of psychosis
This study tests a digital program designed to encourage young people to seek help for early signs of psychosis. It aims to see if online messages can increase connections to care.
New York, New YorkAges 12–29 - NCT06774417Recruiting
Digital strategies to help young people seek help for mental health
This trial tests a digital tool designed to help young people recognize early signs of mental health conditions and take steps toward getting help. It may be a good fit if you are between 12 and 29, live near certain research sites, and can complete a short screening questionnaire in English.
New York, New YorkAges 12–29 - NCT06208410RecruitingPhase 1/Phase 2
JS105 plus other treatments for advanced solid tumors
This trial tests a new drug called JS105 combined with other anti-cancer therapies for people with certain advanced breast, ovarian, endometrial, or cervical cancers. It aims to find out if these combinations are safe and effective.
Zhengzhou, HenanAges 18–75
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Common questions
- Are there clinical trials for advanced?
- Yes. Clin2 currently lists 3,897 recruiting advanced studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.