Clinical trials
Agitation clinical trials
Below are recruiting agitation clinical trials, each written for real people, not researchers. We’re tracking 52 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06808984RecruitingPhase 2
Testing a new drug for agitation in Alzheimer's disease
This trial tests an investigational drug called BMS-986368 to see if it can safely reduce agitation in people with Alzheimer's disease. You may be able to join if you have Alzheimer's with confirmed biomarkers and experience agitation that has been going on for at least 4 weeks.
Homewood, AlabamaAges 55–90 - NCT06651567RecruitingPhase 2
Study of a new drug for agitation in Alzheimer's disease
This study tests an experimental medication, ITI-1284, to see if it can safely reduce agitation in people with Alzheimer's disease. Agitation can include restlessness, aggression, or irritability, and this drug aims to help manage those symptoms.
Anaheim, CaliforniaAges 55 years+ - NCT06052254RecruitingPhase 2
Skin patch for agitation in Alzheimer's dementia
This trial tests a skin patch that delivers a medicine called dexmedetomidine to help calm agitation in people with Alzheimer's disease. It might be an option for those living in a care facility who have had recent episodes of agitation.
Chino, CaliforniaAges Any age - NCT05783505Recruiting
Program to calm ICU patients and reduce restraints
This study tests a multi-step program to prevent and lessen agitation in ICU patients, with the goal of reducing the need for physical restraints. It also aims to improve comfort and safety during a longer ICU stay.
AlkmaarAges 18 years+ - NCT04516057RecruitingPhase 3
Tested medicine nabilone for agitation in Alzheimer’s dementia
This Phase 3 trial studies whether nabilone can reduce agitation (restlessness, anger, or difficult behavior) in people with Alzheimer’s dementia. It’s designed for older adults who already have agitation despite standard dementia care.
Calgary, AlbertaAges 55 years+ - NCT03082755RecruitingPhase 4
Study sleep agitation and restless legs in Alzheimer’s patients
This trial studies treatment for troubling nighttime restlessness and agitation in people with Alzheimer’s disease. It may help improve sleep and nighttime comfort and reduce nighttime behavior problems.
Austin, TexasAges 55 years+ - NCT04436081RecruitingPhase 2
CBD oil without THC for agitation in Alzheimer’s dementia
This trial studies whether a THC-free CBD oil softgel can reduce agitation in people with Alzheimer’s-related dementia. It compares CBD to a control to see if it improves difficult behaviors and is safe over the study period.
Norfolk, VirginiaAges 50–90 - NCT07799311RecruitingPhase 4
Medication to prevent waking distress after child hernia surgery
This trial tests two medicines to help children wake up calmly and comfortably after hernia surgery under anesthesia. It aims to find which one works better to reduce agitation or confusion when coming out of anesthesia.
Islamabad, FederalAges 2–12 - NCT06543602Recruiting
Monitoring agitation in ICU patients with a video camera
This trial uses a special camera to monitor ICU patients who may become agitated. By watching your face and body movements, doctors hope to detect agitation early and improve your care.
Hangzhou, ZhejiangAges 18–65 - NCT07730957Recruiting
Music program to reduce care refusal in nursing home residents
This trial tests whether a structured music program can help reduce care refusal (like agitation or aggression during bathing) in nursing home residents with memory or thinking problems. Residents who show these behaviors may be eligible.
AmiensAges 18 years+ - NCT07719985Recruiting
Removing medication from root canals using different cleaning methods
This study compares different ways of cleaning medication out of a tooth after a root canal procedure. They use a special 3D X-ray to see how well each method works, which could help improve treatment and reduce follow-up visits.
Tanta, Gharbia GovernorateAges 20–40 - NCT07689305Recruiting
Video Interaction as Comfort for Kids Before Surgery
This trial tests if a live parent-child video chat or a cartoon before surgery can reduce agitation when a child wakes up from anesthesia. It may help children aged 2-6 who are having planned surgery.
Izmir, İzmirAges 2–6 - NCT07677917Enrolling by invitationPhase 1
Medicine to reduce restlessness after sinus surgery
This trial tests two inhaled medicines, dexmedetomidine and magnesium sulfate, to see which is better at preventing agitation and restlessness as patients wake up from functional endoscopic sinus surgery. It may help you recover more calmly.
CairoAges 21–50 - NCT05044832Recruiting
Personalized music to reduce agitation after certain surgeries
This study tests whether playing personalized music during and after specific surgeries can reduce “emergence agitation,” a period of distress or confusion as a patient wakes up from anesthesia. It may help children feel calmer by using music they connect with.
Stanford, CaliforniaAges 3–9 - NCT07571707Recruiting
Lollipops to Reduce Confusion After Surgery in Young Children
This study tests whether giving children a lollipop after surgery helps prevent confusion and agitation as they wake up from anesthesia. Emergence delirium—when children are disoriented and upset after anesthesia—is common, and the researchers want to see if this simple comfort measure helps.
Denpasar, BaliAges 2–6 - NCT07576985Enrolling by invitation
IV Tylenol for Pain and Agitation After Throat Surgery in Young Children
This study tests whether giving acetaminophen (Tylenol) through an IV (a vein) instead of by mouth helps reduce pain and fussiness after tonsil and adenoid removal in children age 7 and under. The goal is to find better ways to keep children comfortable during recovery.
Cleveland, OhioAges Up to 8 years - NCT07565116Recruiting
Numbing Nose Spray vs. Calming Liquid Before Pediatric Surgery
This trial compares two safe, common ways to help children relax before surgery: a medicine sprayed in the nose versus a medicine given by mouth. The goal is to see which one works better and is easier for kids.
Diyarbakır, Outside of the USAges 2–10 - NCT05632419Recruiting
Study of extreme agitation and what it predicts
This trial looks at people who show “extreme agitation” in order to better predict what may happen next. It mainly involves observation to understand the possible causes and likely outcomes of severe agitation.
Bobigny, Île-de-France RegionAges 18 years+ - NCT07066605Recruiting
Dexmedetomidine for agitation during breathing tube removal
This trial tests whether a sedative called dexmedetomidine can reduce agitation in ICU patients when they are being weaned off a breathing tube. If you experience restlessness or agitation during the weaning process, this medication might help you stay calm.
SohagAges 19 years+ - NCT07011732RecruitingPhase 3
Testing a drug for Alzheimer's-related agitation
This study tests an experimental drug (KarXT) to see if it safely reduces agitation in people with Alzheimer's disease. It may help if you or your loved one experiences restlessness, aggression, or irritability related to Alzheimer's.
Scottsdale, ArizonaAges 55–90 - NCT07011745RecruitingPhase 3
Study of KarXT for Alzheimer's Agitation
This study tests a new drug combination (KarXT + KarX-EC) to see if it can safely reduce agitation in people with Alzheimer's disease. It may help if you or your loved one has bothersome agitation that affects daily life.
Chandler, ArizonaAges 55–90 - NCT06781333RecruitingPhase 2
Stem cells for behavior problems in Alzheimer's
This trial tests whether a single infusion of human mesenchymal stem cells (hMSC) can improve difficult behaviors like agitation, anxiety, or hallucinations in people with Alzheimer's disease. It's designed for those who have been taking antipsychotic medication for at least 4 weeks and have a study partner to help track behavior changes.
Miami, FloridaAges 55–90 - NCT06718764Recruiting
Bedside brain monitor study for sedated ICU patients
This study tests a new bedside monitoring system that tracks brain activity in ICU patients who are on a breathing machine and receiving sedative medications. It aims to help doctors better manage sedation and improve patient care.
New York, New YorkAges 18 years+ - NCT05431595RecruitingPhase 2/Phase 3
Test a less sedating plan for agitated delirium in cancer
This study looks at whether using certain sleep/behavior medicines (called neuroleptics) with anti-seizure medicines can calm agitation from delirium without needing as much of the usual “neuroleptic” medicines. It may help people with advanced cancer who are confused and very restless or hard to settle.
Houston, TexasAges 18 years+
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Common questions
- Are there clinical trials for agitation?
- Yes. Clin2 currently lists 52 recruiting agitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a agitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a agitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.