Clinical trials
Anterior Cruciate Ligament Reconstruction clinical trials
Below are recruiting anterior cruciate ligament reconstruction clinical trials, each written for real people, not researchers. We’re tracking 126 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05949177Recruiting
Mindfulness and graded exercise for fear after ACL surgery
This trial studies whether a combination of mindfulness practice and a step-by-step return-to-activity plan can reduce fear and improve recovery after ACL reconstruction. It may help people who feel worried about re-injury and want a structured way to get back to sports.
Chapel Hill, North CarolinaAges 14–35 - NCT05754632Recruiting
Blood flow restriction exercises after ACL surgery in teens
This trial tests whether a special type of exercise that uses a cuff (blood flow restriction training, or BFRT) can help teens recover after ACL reconstruction. It’s designed to see if adding BFRT to standard rehab improves strength and return to sport.
Farmington, ConnecticutAges 12–18 - NCT05584020Recruiting
ACL repair vs. reconstruction for a recent tear
This study compares two ways to repair a torn ACL: stitching it back together (repair) versus using a graft from another tendon (reconstruction). It is for people who have a fresh, uncomplicated ACL tear and want to see which approach works better.
Hangzhou, ZhejiangAges 18 years+ - NCT05527171Recruiting
Virtual reality mindfulness after ACL knee surgery
This study uses a virtual-reality mindfulness meditation program to help improve fear and movement quality after ACL reconstruction. It may help you feel less afraid of movement and land more safely when you return to sports.
Chapel Hill, North CarolinaAges 14–25 - NCT05461326Recruiting
Compare two tendon grafts for ACL surgery recovery
This study compares two ways to rebuild the ACL using different tendon grafts (quadriceps tendon vs patellar tendon) taken from your own body. It aims to learn which option leads to better recovery after ACL reconstruction, including strength and function.
Birmingham, AlabamaAges 14–65 - NCT05395767Recruiting
Living-donor tendon graft for ACL repair in teens
This study tests whether an ACL reconstruction using a tendon from a living donor works well and is safe in children and teens. It may help families compare this approach while closely tracking knee function after surgery.
Pembury, KentAges 8–17 - NCT05323474Recruiting
Rehab program after ACL surgery to return to competitive sport
This study tests an “optimized” rehabilitation plan after ACL reconstruction to help people safely return to competitive sports. It’s for people who had an ACL surgery and still want to play sports that involve cutting, pivoting, or contact.
Challes-les-EauxAges 18–25 - NCT04650568Enrolling by invitation
Stem cell treatment after ACL ligament surgery
This trial studies whether adding mesenchymal stem cells during ACL (knee ligament) reconstruction helps the knee heal better. You might be eligible if your ACL injury is recent and you’re having a specific type of graft surgery.
Chicago, IllinoisAges 18–60 - NCT04572256RecruitingEarly Phase 1
Montelukast after ACL surgery to protect knee cartilage
This early trial tests whether montelukast, a tablet used for allergies, can help protect knee cartilage after ACL surgery. It is specifically for people who have a meniscus injury along with their ACL tear.
Lexington, KentuckyAges 25–50 - NCT04183803Recruiting
Robot help to set the right position for ACL surgery
This study tests whether using a robot to help place the tunnel during ACL (knee ligament) reconstruction is better or more accurate than the usual approach. You may benefit if you need ACL surgery and your care team has robot experience.
AmiensAges 10 years+ - NCT03552705RecruitingPhase 2
Tranexamic acid to reduce knee inflammation after ACL injury
This Phase 2 study tests whether tranexamic acid can reduce swelling and protect knee cartilage after an ACL injury. It may help by limiting bleeding-related inflammation in the injured joint soon after injury.
Stanford, CaliforniaAges 18–30 - NCT03365908Enrolling by invitation
Pain Management After ACL Reconstruction Surgery
This study looks at ways to manage pain in adults who are getting surgery to repair a torn ACL (a knee ligament). It may help improve comfort and recovery after ACL reconstruction.
Sacramento, CaliforniaAges 18–45 - NCT02918734Recruiting
ACL surgery: compare two ways to secure the tendon graft
This study looks at two surgical methods to attach the tendon graft during ACL reconstruction, using either an Endobutton or metal interference screws. It may help patients by improving how securely the graft is fixed and how well recovery goes.
TrondheimAges 18–55 - NCT06631690Recruiting
ACL surgery and ankle joint function study
This study looks at how ACL reconstruction knee surgery might affect the mechanics of your ankle joint. It aims to understand if the surgery changes how your ankle moves and works, which could help improve rehabilitation.
CairoAges 15–45 - NCT07009392Recruiting
Bacteria in the knee during ACL surgery
This study looks for bacteria inside the knee joint during ACL (anterior cruciate ligament) surgery, either for the first time or after a previous surgery. The goal is to learn more about the knee's natural bacteria, which might help improve recovery and prevent infections.
LyonAges 18 years+ - NCT03896464Recruiting
Quadriceps tendon vs hamstring tendon for ACL surgery in teens
This trial compares using a quadriceps tendon graft versus a hamstring graft during ACL reconstruction in children and teens whose growth plates are still open. It aims to see which graft works better after ACL injury while accounting for ongoing bone growth.
Hamilton, OntarioAges 10–18 - NCT06294314Recruiting
ACL surgery with bone marrow and internal brace for return to sports
This trial studies a new way to reconstruct a torn ACL using your own bone marrow cells and a special internal brace to help you return to sports. It's for young athletes who haven't had ACL surgery before.
Huntington, West VirginiaAges 14–26 - NCT07030764Recruiting
Comparing rehab with and without a digital app after ACL surgery
This trial tests whether adding a digital therapy app to regular rehabilitation helps reduce thigh muscle weakness after ACL reconstruction. Participants will use the app on their smartphone alongside standard physical therapy.
Lyon, FranceAges 18 years+ - NCT07642752Recruiting
Balance training after ACL surgery
This study compares two types of physical therapy exercises to see which works better for reducing pain, improving movement, balance, and daily function in men who have had ACL surgery. It may help you recover more fully after your knee surgery.
Lahore, Punjab ProvinceAges 18–45 - NCT06936995Recruiting
Comparing pain relief methods for ACL surgery recovery
This trial tests two ways to manage pain after ACL reconstruction: a combination of medications (multimodal analgesia) versus a nerve block in the thigh (femoral block). The goal is to see which approach provides better pain control and recovery.
AnkaraAges 18–65 - NCT06827483Enrolling by invitation
Balance and thinking test for young adults after ACL surgery
This study looks at how thinking skills affect balance in young adults who had ACL repair surgery in the past 5-7 months, compared to healthy young adults. You will do balance tasks and answer some questions.
Durham, North CarolinaAges 18–25 - NCT06561035Enrolling by invitationPhase 3
Opioid-sparing study for ACL reconstruction
This study tests pain management options after ACL reconstruction to reduce the need for strong painkillers. It may help you recover with fewer side effects and lower risk of opioid dependence.
Skokie, IllinoisAges 14–85 - NCT06193343Recruiting
Steps to prevent osteoarthritis after ACL surgery
This study tests whether increasing your daily steps after ACL reconstruction can help prevent knee osteoarthritis. It involves walking more and tracking your activity over time.
Athens, GeorgiaAges 16–40 - NCT05924178Recruiting
Pre-surgery rehab to improve healing after knee ligament injury
This study looks at whether doing physical therapy before surgery can improve tendon healing, bone density, and joint cushioning after ACL surgery or patellar dislocation surgery. It may help you recover better and faster by optimizing your knee before the operation.
BeijingAges 18–45
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Common questions
- Are there clinical trials for anterior cruciate ligament reconstruction?
- Yes. Clin2 currently lists 126 recruiting anterior cruciate ligament reconstruction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anterior cruciate ligament reconstruction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anterior cruciate ligament reconstruction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Anterior Cruciate Ligament Reconstruction Rehabilitation
- Anterior Cruciate Ligament (ACL) Reconstruction
- Anterior Cruciate Ligament Injuries
- Anterior Cruciate Ligament Rupture
- ACL - Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament (ACL) Tear
- Anterior Cruciate Ligament
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.