Clinical trials
Aortic Valve Disease clinical trials
Below are recruiting aortic valve disease clinical trials, each written for real people, not researchers. We’re tracking 198 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06518681Enrolling by invitation
Testing a new polymer heart valve for aortic disease
This trial tests a new type of artificial heart valve made of polymer (a special plastic-like material) for people with severe aortic valve disease. It aims to see if the valve is safe and works well, giving you an option for a replacement valve that might last longer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05979870Enrolling by invitation
AI-enhanced heart MRI for valve disease
This study uses artificial intelligence to improve MRI scans for people with aortic or pulmonary valve disease who are scheduled for valve surgery or a non-surgical valve procedure. It aims to help doctors better assess heart function before treatment.
Gothenburg, GothenburgAges 1 week–18 years - NCT05932615Enrolling by invitation
Testing a new transcatheter valve for aortic valve narrowing
This trial studies how safe and effective the NAVITOR valve is for treating narrowed aortic valves placed through a catheter (no open-heart surgery). It may be an option if you’re at intermediate-to-low surgical risk and meet heart ultrasound/CT measurements.
Birmingham, AlabamaAges 18 years+ - NCT05927090Enrolling by invitation
Repair outcomes after acute aortic dissection surgery
This study looks at how patients do after surgery for an urgent (acute) tear of the aorta or related bleeding in the wall of the ascending aorta. It may help doctors better understand what outcomes to expect after early emergency surgery.
Saint-DenisAges 18–90 - NCT05714293Enrolling by invitation
CT measurements after surgical aortic valve replacement
This study uses a CT scan (with contrast dye) to measure the coronary artery openings after people have a new aortic valve placed surgically. It aims to see how to best plan or understand coronary blood flow after the surgery.
RomaAges 18–80 - NCT05202977Enrolling by invitation
TAVR valve replacement for older adults with aortic valve narrowing
This trial tests a newer transcatheter (catheter-based) aortic valve replacement device to improve symptoms and safety in older adults with severe aortic stenosis. You may qualify if you’re too high-risk for open-heart surgery and the valve/artery measurements fit the device.
Hefei, AnhuiAges 65 years+ - NCT04227002Recruiting
Study for people with aortic valve problems
This trial is for people with aortic valve disease (aortic valve narrowing, leakage, or a worn-out valve). It tests what the doctors learn from following these patients, and it may help improve future care.
HamburgAges 18 years+ - NCT04613193Recruiting
Lower blood pressure to study outcomes in mild valve narrowing
This trial studies whether lowering blood pressure affects health outcomes in people who have valve narrowing in the heart but no valve symptoms yet. It may help you understand which blood pressure targets are safest when the aortic valve is not fully opening.
AarhusAges 18 years+ - NCT06802016Recruiting
Study of Chinese congenital bicuspid aortic valve
This study looks at people with a bicuspid aortic valve (a valve with two flaps instead of three) in Chinese patients. It collects information about this condition to better understand it.
Shanghai, Shanghai MunicipalityAges 14–60 - NCT04634240Recruiting
Staged heart bypass plus TAVR versus TAVR alone
This study compares doing a staged coronary bypass (revascularization) along with a valve procedure (TAVR) versus doing TAVR and medical treatment alone. It aims to see which approach better helps people with both aortic valve narrowing and coronary artery disease.
Huntsville, AlabamaAges Any age - NCT06559332Recruiting
Heart artery checks during aortic valve replacement
This study tests different ways to check for blocked heart arteries in patients getting a new aortic valve through a tube in the leg. It aims to find the best approach to guide treatment.
BernAges 70 years+ - NCT02306200Recruiting
A study to improve heart and aorta health
This trial looks at ways to improve cardiovascular (heart and blood vessel) health, especially conditions that affect the aorta, such as aneurysms, or vascular problems that may run in families. If you have an aortic-related or other cardiovascular diagnosis (or you’re a healthy comparison participant), you may be invited to take part in this health-improvement program.
Ann Arbor, MichiganAges Any age - NCT06689839Recruiting
Testing a new filter to prevent stroke during heart valve replacement
This trial tests a new filter device designed to catch debris that might travel to the brain during a minimally invasive aortic valve replacement (TAVR). The goal is to see if it can help reduce the risk of stroke.
Naples, FloridaAges 50 years+ - NCT06507579Recruiting
Aortic stenosis valve replacement study with Hydra device
This trial tests a new heart valve called Hydra for people with severe aortic stenosis who need a valve replacement through a leg artery. It aims to see how well the valve works in real-world patients.
Sheffield, YorkshireAges 18–99 - NCT04162444Recruiting
Aortic valve reconstruction study for children
This trial studies a surgery approach to help fix a narrowed or leaking aortic valve in children. It aims to see how well the reconstructed valve works and how it affects the child’s heart function over time.
MoscowAges 4 weeks–12 years - NCT06342635Recruiting
Study of Hydra Heart Valve in Copenhagen
This study is testing a new heart valve system called Hydra, used during a less invasive procedure called TAVI to replace a narrowed heart valve. It may help people with severe aortic stenosis who are already candidates for TAVI.
CopenhagenAges 18–99 - NCT01756222Recruiting
Bicuspid aortic valve registry for adults
This study is a registry that collects health information from adults with bicuspid aortic valve disease. It may help doctors better understand outcomes and guide future care for patients and families affected by this condition.
Ann Arbor, MichiganAges 18 years+ - NCT04204915Recruiting
Early valve replacement for severe but symptom-free aortic narrowing
This study looks at whether replacing a narrowed heart valve early helps people who have severe aortic stenosis but no symptoms. You would be randomly assigned to early valve replacement or careful waiting with regular check-ups.
Garran, Australian Capital TerritoryAges 18 years+ - NCT07596394Recruiting
Registry of Catheter-Based Aortic Valve Replacements
This registry collects information about patients who receive a new valve inserted through a catheter (a thin tube) rather than open surgery. It tracks how well the procedure works and any side effects to help doctors understand the long-term safety and effectiveness of this less invasive approach.
Pavia, PaviaAges 18 years+ - NCT07604402Recruiting
Aortic Valve Replacement Without On-Site Surgery
This study tests a catheter-based procedure to replace a narrowed aortic valve without traditional open-heart surgery. It's designed for patients who are at higher risk for surgery due to age, health conditions, or anatomy.
AndriaAges Any age - NCT04414878Recruiting
Transcatheter aortic valve replacement for older, high-risk patients
This trial tests a new heart valve replacement done through a catheter (not open-heart surgery) in older adults with severe aortic valve narrowing. It’s mainly for people who are high-risk or not good candidates for standard surgery, to see if the new valve improves outcomes.
Beijing, Beijing MunicipalityAges 70 years+ - NCT05862558Recruiting
Lithotripsy to open blocked, calcified artery for TAVR
This trial tests whether a treatment called intravascular lithotripsy (using sound waves from inside a blood vessel) can help widen severely calcified, narrowed iliac arteries so a TAVR procedure can be done through the groin. It may help some people who are considered “high risk” for access, based on CT scan findings.
Plano, TexasAges 18–90 - NCT05093764Recruiting
Test how well debris is captured during valve-in-valve TAVR
This trial studies a device and a technique meant to capture debris during a repeat aortic valve procedure (valve-in-valve TAVR). It may help doctors understand if the approach reduces risk from material that can break loose during the procedure.
Kansas City, MissouriAges 18 years+ - NCT05487612Recruiting
MiECC heart-lung machine vs standard bypass during heart surgery
This trial compares a newer heart-lung machine setup (MiECC) with the usual bypass technique during certain heart operations. It may help see whether MiECC changes outcomes like the need for blood transfusions or recovery after surgery.
TorontoAges 18–85
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Common questions
- Are there clinical trials for aortic valve disease?
- Yes. Clin2 currently lists 198 recruiting aortic valve disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic valve disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic valve disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.