Clinical trials
Aortic Valve Disease clinical trials
Below are recruiting aortic valve disease clinical trials, each written for real people, not researchers. We’re tracking 189 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06596460Recruiting
Imaging study after TAVI valve replacement
This study collects extra imaging data from 40 people who are already scheduled for a routine TAVI procedure to replace a narrowed aortic heart valve. The goal is to better understand the valve's structure and function using scans.
London, EnglandAges 18 years+ - NCT06518681Enrolling by invitation
Testing a new polymer heart valve for aortic disease
This trial tests a new type of artificial heart valve made of polymer (a special plastic-like material) for people with severe aortic valve disease. It aims to see if the valve is safe and works well, giving you an option for a replacement valve that might last longer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06455787Recruiting
J-Valve study for leaky aortic valve patients
This study tests a new, less invasive device called J-Valve for people with severe aortic regurgitation (a leaky aortic valve). It is placed through a tube in the leg artery, avoiding open-heart surgery, and may help those who are at high risk for surgery.
Scottsdale, ArizonaAges 18 years+ - NCT06420830Recruiting
Study of a new heart valve in TAVR
This study follows patients with severe aortic stenosis who get a new heart valve (the SAPIEN 3 Ultra RESILIA) through a less invasive procedure (TAVR). Researchers want to see how well this valve works over time using special heart ultrasound tests.
Québec, QuebecAges 18–80 - NCT06336213Recruiting
Using a blood test to guide antibiotics in aorta surgery
This trial checks if a blood test called presepsin can help doctors decide when to use antibiotics in patients having surgery on the chest's main artery (the thoracic aorta). It is for people with an aneurysm or tear in that artery.
Moscow, MoscowAges 18–75 - NCT06286358Recruiting
Heart and aorta imaging study for valve disease
This study uses a special recording device to see if heart and aorta problems can be detected earlier. It may help people with aortic valve disease or enlarged aorta decide on treatment.
BrusselsAges 18 years+ - NCT06049654Recruiting
Comparing Allegra and Sapien valves for valve-in-valve procedure
This trial tests two different replacement heart valves (Allegra and Sapien) to see which works better for people who need a new valve placed inside a previously implanted surgical valve. It aims to help patients with a failing biological aortic valve who are already scheduled for this procedure.
AlessandriaAges 18 years+ - NCT05979870Enrolling by invitation
AI-enhanced heart MRI for valve disease
This study uses artificial intelligence to improve MRI scans for people with aortic or pulmonary valve disease who are scheduled for valve surgery or a non-surgical valve procedure. It aims to help doctors better assess heart function before treatment.
Gothenburg, GothenburgAges 1 week–18 years - NCT05913908Recruiting
Valve procedure study for severe tricuspid leakage
This trial tests how well a new catheter-based valve system works for people with severe (or worse) tricuspid valve leaking who still have symptoms despite medicines. It aims to improve outcomes by treating the leaking valve without open-heart surgery, if your heart structure and overall health fit the study.
Phoenix, ArizonaAges 18 years+ - NCT05932615Enrolling by invitation
Testing a new transcatheter valve for aortic valve narrowing
This trial studies how safe and effective the NAVITOR valve is for treating narrowed aortic valves placed through a catheter (no open-heart surgery). It may be an option if you’re at intermediate-to-low surgical risk and meet heart ultrasound/CT measurements.
Birmingham, AlabamaAges 18 years+ - NCT05927090Enrolling by invitation
Repair outcomes after acute aortic dissection surgery
This study looks at how patients do after surgery for an urgent (acute) tear of the aorta or related bleeding in the wall of the ascending aorta. It may help doctors better understand what outcomes to expect after early emergency surgery.
Saint-DenisAges 18–90 - NCT05909748Recruiting
First-in-human test of a new TAVR valve for severe aortic narrowing
This trial tests a new heart valve replacement (TAVR) system in people with severe, symptomatic aortic stenosis. If you qualify, it may offer a less invasive option compared with open-heart valve surgery, while also helping researchers understand safety and early effectiveness.
Petah TikvaAges 18–120 - NCT05851209Recruiting
Study biomarkers in people with moderate aortic valve narrowing
This study looks at blood and/or body signals (called biomarkers) to understand why aortic valve narrowing may worsen and what outcomes people have. You may be able to help researchers by undergoing regular heart care plus additional testing like MRI or CT if you qualify.
BonnAges 18 years+ - NCT05714293Enrolling by invitation
CT measurements after surgical aortic valve replacement
This study uses a CT scan (with contrast dye) to measure the coronary artery openings after people have a new aortic valve placed surgically. It aims to see how to best plan or understand coronary blood flow after the surgery.
RomaAges 18–80 - NCT05672836RecruitingPhase 4
Enavogliflozin after TAVR for heart narrowing with mild heart weakness
This trial tests enavogliflozin (a diabetes medication that may help the heart) in people who have had a TAVR procedure for severe aortic stenosis. It looks at whether the medicine can improve outcomes for people with symptoms and mildly reduced or preserved pumping function.
Bucheon-siAges 19 years+ - NCT05603026Recruiting
MRI study for people getting a valve replacement
This study uses MRI (a type of scan) in people who are scheduled for a catheter-based aortic valve replacement through the groin. It aims to see how well MRI can work for these patients and potentially improve care planning around the procedure.
Cleveland, OhioAges 18–105 - NCT05438862Recruiting
Early aortic valve surgery versus watchful waiting
This trial compares two approaches for people with a leaking aortic valve but no symptoms: early surgery or careful monitoring (“watchful waiting”). It aims to see which strategy better prevents future heart problems and when surgery is most helpful.
AalstAges 18 years+ - NCT05283356RecruitingPhase 4
Ticagrelor or aspirin after heart valve replacement
This trial compares two blood thinners (ticagrelor and aspirin) to see which one works better at preventing blood clots after a less-invasive heart valve replacement (TAVI). It is for people with severe aortic stenosis who also have diabetes, heart disease, or artery disease.
Vigo, PontevedraAges 18 years+ - NCT05172973Recruiting
New valve procedure for failing aortic bioprosthetic valves
This trial studies whether a new transcatheter aortic valve (SAPIEN X4) is safe and works well in people whose previously implanted aortic valve is now failing. It may help reduce valve symptoms in higher-surgery-risk patients who are not good candidates for open-heart valve replacement.
Newport Beach, CaliforniaAges Any age - NCT03826264Recruiting
Research registry for people getting TAVR
This is a research registry that collects information about people who receive TAVR, a procedure to help open a narrowed heart valve. It may help doctors understand outcomes and improve care, but it is not designed as a drug or device trial by itself.
Stanford, CaliforniaAges 19 years+ - NCT04864145Recruiting
Valve procedure trial for severe leaking aortic valve
This trial studies a less invasive heart valve procedure that places a new valve through a catheter, to treat severe leakage of the aortic valve. It may help people who have symptoms or heart enlargement and who are at higher risk for open-heart surgery.
Nanjing, JiangsuAges 60–90 - NCT04754217Recruiting
Follow-up study after valve graft replacement
This study looks at outcomes after certain heart valve surgeries using a valved graft. It may help doctors understand how well these grafts work over time in people who have had valve replacement surgery.
Birmingham, AlabamaAges 18 years+ - NCT04126018Recruiting
MRI scan comparison for certain leaking or narrowed heart valves
This trial studies how well different MRI images can assess heart valve problems—like leaking (regurgitation) or narrowing (stenosis). It may help doctors get clearer information, especially in people who may not respond well to cardiac resynchronization therapy (CRT).
Cleveland, OhioAges 18–90 - NCT04258488RecruitingPhase 4
Blood thinner pill vs warfarin after mechanical aortic valve
This study compares a blood thinner pill (a factor Xa inhibitor) with warfarin (vitamin K antagonist) in people who have had a mechanical aortic valve replacement. It looks at which option works better and is safer over the long term.
Bucheon-siAges 19 years+
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Common questions
- Are there clinical trials for aortic valve disease?
- Yes. Clin2 currently lists 189 recruiting aortic valve disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic valve disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic valve disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.